DNA replication (Drosophila melanogaster)

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1, 25. Leading/lagging strand synthesisRNA primer-DNA primer:origin duplex:PCNAOrc5Mcm10p49Cdt1ATPMcm3Orc4Mcm5Degraded by proteasome in cytosolOrc3Mcm5dUTPRFC140Mcm 4,6,7 trimer forms and associatesOrc complexRNA primer-DNA primerDegraded by proteasome in cytosolUbiquitinated Orc1Processive complexCTPPhosphorylated Orc11. Assembly of the pre-replicative complexUTPCdt1DNA polymerase alpha: primase: origin complexMcm3Orc5Orc5Orc3Mcm7dCTPRFC38ADPOriginMcm6RNA primer-DNA primerp180RFC36Cdc6ATPGemininATPMcm4Mcm2ADPUbiquitinated Cdc6DNA PolymeraseOrc3Orc complexdATPRNA Primerp58Orc44. Switching of origins to post-replicative statep70dGTPPCNA homotrimerGTPOrc1UbiquitinOrc2Cdc6Cdt1Pre-replicative complexUbiquitinOrc complexPre-replicative complexPrimaseCdc6Orc2Cdc6DNA polymerase alpha: primase: origin complexRFC Heteropentamer:RNA primer-DNA primer:2. Activation of the pre-replicative complexCdt1Orc ComplexaPhosphorylated Cdc6Mcm7Orc complexCdt1Mcm2Orc2RFC40Mcm6Orc3ATPRFC Heteropentamer:RNA primer-DNA primerMcm4RFC37Phosphorylation of Mcm 2-7 complexOrc2with the replication fork3. DNA replication initiationDNApol-deltaGnf1RfC40Mcm3DNApol-alpha73RfC38CDC45LOrc1CDK2latDNAprimRPA4DNApol-alpha180RPA3Mcm2Mcm6Mcm7Orc2ASKPole2RpA-70Orc5Mcm10CG8142CG9273mus209Orc4CG5971POLD3CG12018Mcm5dpaUbi-p63EGMNNRpL40DNApol-alpha50POLD4dupOrc6RfC3l(1)G0148DNApol-epsilon


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116917view11:58, 15 May 2021EweitzModified title
77446view20:30, 8 September 2014MaintBot
71551view19:25, 17 October 2013MaintBotAutomated update of data sources
67164view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62530view13:38, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62523view12:47, 29 April 2013EgonwConnected dots.
40888view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35216view15:48, 11 February 2010Thomasadded literature
35212view15:45, 11 February 2010ThomasModified description
35202view15:40, 11 February 2010ThomasModified description
21870view11:32, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:DNA replication Reactome]] moved to [[Pathway:WP565]]: Moved to stable identifier
8513view14:01, 7 January 2008MaintBotAdded to category $category
19416view14:01, 7 January 2008D.KorenUploaded new pathway
8511view14:01, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ASKGeneProduct
ATPMetabolite
CDC45LGeneProduct31052 (Entrez Gene)
CDK2GeneProduct
CG12018GeneProduct38228 (Entrez Gene)
CG5971GeneProduct38989 (Entrez Gene)
CG8142GeneProduct32763 (Entrez Gene)
CG9273GeneProduct35364 (Entrez Gene)
CTPMetabolite
DNApol-alpha180GeneProduct42553 (Entrez Gene)
DNApol-alpha50GeneProduct38942 (Entrez Gene)
DNApol-alpha73GeneProduct43278 (Entrez Gene)
DNApol-deltaGeneProduct39746 (Entrez Gene)
DNApol-epsilonGeneProduct42758 (Entrez Gene)
DNAprimGeneProduct44915 (Entrez Gene)
GMNNGeneProduct
GTPMetabolite
Gnf1GeneProduct40607 (Entrez Gene)
Mcm10GeneProduct35390 (Entrez Gene)
Mcm2GeneProduct40973 (Entrez Gene)
Mcm3GeneProduct31449 (Entrez Gene)
Mcm5GeneProduct41296 (Entrez Gene)
Mcm6GeneProduct31603 (Entrez Gene)
Mcm7GeneProduct39014 (Entrez Gene)
Orc1GeneProduct35686 (Entrez Gene)
Orc2GeneProduct41703 (Entrez Gene)
Orc4GeneProduct37970 (Entrez Gene)
Orc5GeneProduct34794 (Entrez Gene)
Orc6GeneProduct36017 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
Pole2GeneProduct38661 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RfC3GeneProduct34423 (Entrez Gene)
RfC38GeneProduct34550 (Entrez Gene)
RfC40GeneProduct38492 (Entrez Gene)
RpA-70GeneProduct40972 (Entrez Gene)
RpL40GeneProduct33629 (Entrez Gene)
UTPMetabolite
Ubi-p63EGeneProduct38456 (Entrez Gene)
UbiquitinMetabolite
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite
dpaGeneProduct35679 (Entrez Gene)
dupGeneProduct47121 (Entrez Gene)
l(1)G0148GeneProduct31598 (Entrez Gene)
latGeneProduct36454 (Entrez Gene)
mus209GeneProduct37290 (Entrez Gene)

Annotated Interactions

No annotated interactions
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