FAS pathway and stress induction of HSP regulation (Mus musculus)
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Self-activation
Cytoplasm
Necrosis
3x-P
Apoptosis
Mitochondria Pathway
Cut
FAS Pathway
NFK-B Pathway
Activate
Extracellular
Stress Induction of HSP regulation
Proteasome
Stress
Apoptosome
Cell Survival
3x-P
DNA presentation
Inhibition
ROS
3x-P
Nucleus
Fas
Glutathione
Rb1
Fasl
Ceramide
CASP10
Phosphate
Hspb1
Daxx
Fadd
Phosphate
Casp3
Hspb1
Jun
Casp7
Lmna
Mapkapk2
Cflar
Map3k7
Hspb1
Il1a
Hspb1
Hspb1
Faf1
Hspb1
Daxx
Mapk8
Prkdc
Pak1
Phosphate
Map2k4
Dffb
Phosphate
Parp1
Phosphate
Spna2
Map3k1
Apaf1
Bcl2
Apaf1
Ripk2
Dffa
Arhgdib
Dffb
Casp8
Phosphate
Hspb1
Gm10108
Faf1
Mapkapk3
Pak2
Phosphate
FAP-1
Casp3
Lmnb1
Casp8
actin
Lmnb2
Hspb1
Tnf
Phosphate
Casp9
Casp6
Description
This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info:
BioCarta
.
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP314(r21341)
with a 94% conversion rate.
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Quality Tags
Ontology Terms
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Bibliography
Creagh EM, Sheehan D, Cotter TG; ''Heat shock proteins--modulators of apoptosis in tumour cells.''; Leukemia, 2000
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
117883
view
10:22, 23 May 2021
Eweitz
Modified title
114035
view
15:55, 17 December 2020
Ddigles
Connected a line. Changed labels to pathways.
109410
view
18:17, 16 March 2020
L Dupuis
Fixed interactions
109379
view
15:24, 16 March 2020
L Dupuis
Converted interactions to graphical lines
106905
view
13:38, 17 September 2019
MaintBot
HMDB identifier normalization
71736
view
20:17, 17 October 2013
MaintBot
Automated update of data sources
69119
view
18:14, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67223
view
10:23, 26 June 2013
Christine Chichester
Ontology Term : 'FasL mediated signaling pathway' added !
47743
view
19:15, 5 April 2012
Thomas
fixed wrongly annotated gene
41305
view
00:23, 2 March 2011
MaintBot
Removed redundant pathway information and comments
38241
view
21:19, 27 August 2010
Khanspers
Removed receptor and protein complex graphics
38240
view
21:18, 27 August 2010
Khanspers
Reverted to version '15:06, 12 February 2010' by
Khanspers
38190
view
00:29, 24 August 2010
Khanspers
35565
view
15:06, 12 February 2010
Thomas
added literature
35560
view
15:01, 12 February 2010
Thomas
Modified description
34390
view
22:52, 9 December 2009
MaintBot
Automatic update of empty xrefs
32872
view
22:02, 16 September 2009
MaintBot
NA
32468
view
17:29, 15 August 2009
MaintBot
Fixed text labels
32154
view
14:02, 14 August 2009
MaintBot
Fixed group labels
31479
view
21:23, 13 August 2009
MaintBot
Fixed text labels
30859
view
00:10, 30 July 2009
MaintBot
Converted from Homo sapiens
21882
view
11:32, 14 November 2008
MaintBot
[[Pathway:Mus musculus:Fas Pathway and Stress Induction of HSP Regulation Biocarta]] moved to [[Pathway:WP571]]: Moved to stable identifier
8018
view
13:46, 7 January 2008
MaintBot
[[Pathway:Mouse:Fas Pathway and Stress Induction of HSP Regulation Biocarta]] moved to [[Pathway:Mus musculus:Fas Pathway and Stress Induction of HSP Regulation Biocarta]]: Renaming species
7632
view
16:06, 18 December 2007
MaintBot
fixed category names
7220
view
12:41, 4 November 2007
MaintBot
Added categories to GPML
6436
view
22:18, 22 May 2007
169.230.77.174
gpml file for [[Mouse:Fas_Pathway_and_Stress_Induction_of_HSP_Regulation_Biocarta]]
External references
DataNodes
View all...
Name
Type
Database reference
Comment
Apaf1
GeneProduct
11783 (Entrez Gene)
Apoptosis
Pathway
Arhgdib
GeneProduct
11857 (Entrez Gene)
Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
Bcl2
GeneProduct
12043 (Entrez Gene)
CASP10
GeneProduct
Casp3
GeneProduct
12367 (Entrez Gene)
Casp6
GeneProduct
12368 (Entrez Gene)
Casp7
GeneProduct
12369 (Entrez Gene)
Casp8
GeneProduct
12370 (Entrez Gene)
Casp9
GeneProduct
12371 (Entrez Gene)
Cell Survival
Pathway
Ceramide
Metabolite
Cflar
GeneProduct
12633 (Entrez Gene)
Daxx
GeneProduct
13163 (Entrez Gene)
Dffa
GeneProduct
13347 (Entrez Gene)
Dffb
GeneProduct
13368 (Entrez Gene)
FAP-1
GeneProduct
19249 (Entrez Gene)
Fadd
GeneProduct
14082 (Entrez Gene)
Faf1
GeneProduct
14084 (Entrez Gene)
Fas
GeneProduct
14102 (Entrez Gene)
Fasl
GeneProduct
14103 (Entrez Gene)
Glutathione
Metabolite
HMDB0000125 (HMDB)
Gm10108
GeneProduct
670717 (Entrez Gene)
Hspb1
GeneProduct
15507 (Entrez Gene)
Il1a
GeneProduct
16175 (Entrez Gene)
Jun
GeneProduct
16476 (Entrez Gene)
Lmna
GeneProduct
16905 (Entrez Gene)
Lmnb1
GeneProduct
16906 (Entrez Gene)
Lmnb2
GeneProduct
16907 (Entrez Gene)
Map2k4
GeneProduct
26398 (Entrez Gene)
Map3k1
GeneProduct
26401 (Entrez Gene)
Map3k7
GeneProduct
26409 (Entrez Gene)
Mapk8
GeneProduct
26419 (Entrez Gene)
Mapkapk2
GeneProduct
17164 (Entrez Gene)
Mapkapk3
GeneProduct
102626 (Entrez Gene)
NFK-B Pathway
Pathway
Pak1
GeneProduct
18479 (Entrez Gene)
Pak2
GeneProduct
224105 (Entrez Gene)
Parp1
GeneProduct
11545 (Entrez Gene)
Phosphate
Metabolite
HMDB0001429 (HMDB)
Prkdc
GeneProduct
19090 (Entrez Gene)
Rb1
GeneProduct
19645 (Entrez Gene)
Ripk2
GeneProduct
192656 (Entrez Gene)
receptor (TNFRSF)-interacting serine-threonine kinase 2
Spna2
GeneProduct
20740 (Entrez Gene)
Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
Tnf
GeneProduct
21926 (Entrez Gene)
actin
GeneProduct
Annotated Interactions
No annotated interactions
Views
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Discussion
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DataNodes
Annotated Interactions
No annotated interactions