Senescence and autophagy in cancer (Homo sapiens)
From WikiPathways
Description
Senescense and Autophagy Pathways in Cancer.
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal
Quality Tags
Ontology Terms
Bibliography
- Wang C, Bian Z, Wei D, Zhang JG; ''miR-29b regulates migration of human breast cancer cells.''; Mol Cell Biochem, 2011 PubMed Europe PMC Scholia
- Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, Zanesi N, Kornblau SM, Marcucci G, Calin GA, Andreeff M, Croce CM; ''MicroRNA 29b functions in acute myeloid leukemia.''; Blood, 2009 PubMed Europe PMC Scholia
- Sengupta S, den Boon JA, Chen IH, Newton MA, Stanhope SA, Cheng YJ, Chen CJ, Hildesheim A, Sugden B, Ahlquist P; ''MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins.''; Proc Natl Acad Sci U S A, 2008 PubMed Europe PMC Scholia
- Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, Dessureault S, Moscinski LC, Rezania D, Dalton WS, Sotomayor E, Tao J, Cheng JQ; ''microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.''; Blood, 2010 PubMed Europe PMC Scholia
- Kuilman T, Michaloglou C, Vredeveld LC, Douma S, van Doorn R, Desmet CJ, Aarden LA, Mooi WJ, Peeper DS; ''Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.''; Cell, 2008 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
? | GeneProduct | ||
AKT1S1 | GeneProduct | ENSG00000204673 (Ensembl) | |
AMBRA1 | GeneProduct | 55626 (Entrez Gene) | |
ATG10 | GeneProduct | 83734 (Entrez Gene) | |
ATG11 | GeneProduct | ||
ATG12 | GeneProduct | 9140 (Entrez Gene) | |
ATG14 | GeneProduct | 22863 (Entrez Gene) | |
ATG16 | GeneProduct | 9474 (Entrez Gene) | |
ATG16L1 | GeneProduct | ENSG00000085978 (Ensembl) | |
ATG17 | GeneProduct | ||
ATG3 | GeneProduct | 64422 (Entrez Gene) | |
ATG4 | GeneProduct | ||
ATG5 | GeneProduct | 9474 (Entrez Gene) | |
ATG6 | GeneProduct | ||
ATG7 | GeneProduct | 10533 (Entrez Gene) | |
BCL2 | GeneProduct | 596 (Entrez Gene) | |
BECN1 | GeneProduct | 8678 (Entrez Gene) | |
BMI1 | GeneProduct | 648 (Entrez Gene) | ARF |
BMP2 | GeneProduct | 650 (Entrez Gene) | tPA |
BRAF | GeneProduct | 673 (Entrez Gene) | |
C/EBP-beta | GeneProduct | 1051 (Entrez Gene) | |
CCL3 | GeneProduct | 6348 (Entrez Gene) | |
CD44 | GeneProduct | 960 (Entrez Gene) | |
CDC25B | GeneProduct | 994 (Entrez Gene) | |
CDK2 | GeneProduct | 1029 (Entrez Gene) | ARF |
CDK4 | GeneProduct | 1029 (Entrez Gene) | ARF |
CDK6 | GeneProduct | 1029 (Entrez Gene) | ARF |
CDKN1A | GeneProduct | 1026 (Entrez Gene) | P21/CIP1/WAF1 |
CDKN1B | GeneProduct | 1027 (Entrez Gene) | P27/KIP |
CDKN2A | GeneProduct | 1029 (Entrez Gene) | |
COL10A1 | GeneProduct | 1300 (Entrez Gene) | MKK3 |
COL1A1 | GeneProduct | 1277 (Entrez Gene) | |
COL3A1 | GeneProduct | 1281 (Entrez Gene) | |
CREG1 | GeneProduct | 8804 (Entrez Gene) | |
CXCL1 | GeneProduct | 2919 (Entrez Gene) | GROa |
CXCL14 | GeneProduct | 9547 (Entrez Gene) | BRAK |
CXCL20 | GeneProduct | ||
CXCR2 | GeneProduct | 1026 (Entrez Gene) | |
E2F1 | GeneProduct | 1869 (Entrez Gene) | |
FKBP8 | GeneProduct | ENSG00000105701 (Ensembl) | |
FN1 | GeneProduct | 2335 (Entrez Gene) | |
FRAP1 | GeneProduct | 2475 (Entrez Gene) | mTOR |
GABARAP | GeneProduct | 11337 (Entrez Gene) | |
GABARAPL1 | GeneProduct | 23710 (Entrez Gene) | |
GABARAPL2 | GeneProduct | 11345 (Entrez Gene) | |
GAD45A | GeneProduct | ||
GAS | GeneProduct | DNA regulatory element | |
GBL | GeneProduct | ENSG00000167965 (Ensembl) | |
GSK3B | GeneProduct | 2932 (Entrez Gene) | |
GSN | GeneProduct | 2934 (Entrez Gene) | |
GeneProduct | GeneProduct | ||
HMGA1 | GeneProduct | 3159 (Entrez Gene) | |
HRAS | GeneProduct | 3265 (Entrez Gene) | H-RAS |
IFI16 | GeneProduct | 3428 (Entrez Gene) | |
IFNB1 | GeneProduct | 3456 (Entrez Gene) | |
IFNG | GeneProduct | 3458 (Entrez Gene) | |
IGF1 | GeneProduct | 3479 (Entrez Gene) | |
IGF1R | GeneProduct | 3480 (Entrez Gene) | |
IGFBP3 | GeneProduct | 3486 (Entrez Gene) | |
IGFBP5 | GeneProduct | 3488 (Entrez Gene) | |
IGFBP7 | GeneProduct | 3490 (Entrez Gene) | ARF |
IL1A | GeneProduct | 3552 (Entrez Gene) | |
IL1B | GeneProduct | 3553 (Entrez Gene) | |
IL24 | GeneProduct | 11009 (Entrez Gene) | |
IL3 | GeneProduct | 3562 (Entrez Gene) | |
IL6 | GeneProduct | 3569 (Entrez Gene) | |
IL6R | GeneProduct | 3570 (Entrez Gene) | |
IL6ST | GeneProduct | 3572 (Entrez Gene) | |
IL8 | GeneProduct | 3576 (Entrez Gene) | |
ING1 | GeneProduct | 3621 (Entrez Gene) | |
ING2 | GeneProduct | 3622 (Entrez Gene) | |
INHBA | GeneProduct | 3624 (Entrez Gene) | |
INS | GeneProduct | 3630 (Entrez Gene) | BRAK |
IRF1 | GeneProduct | 3659 (Entrez Gene) | |
IRF5 | GeneProduct | 3663 (Entrez Gene) | |
IRF7 | GeneProduct | 3665 (Entrez Gene) | |
ISRE | GeneProduct | TFBS | DNA regulatory element |
JUN | GeneProduct | 3725 (Entrez Gene) | P21/CIP1/WAF1 |
KIAA0652 | GeneProduct | ENSG00000175224 (Ensembl) | |
LAMP1 | GeneProduct | 3916 (Entrez Gene) | |
LAMP2 | GeneProduct | 3920 (Entrez Gene) | |
MAP1LC3A | GeneProduct | 84557 (Entrez Gene) | |
MAP1LC3B | GeneProduct | 81631 (Entrez Gene) | |
MAP1LC3C | GeneProduct | 440738 (Entrez Gene) | |
MAP2K1 | GeneProduct | 5604 (Entrez Gene) | MEK |
MAP2K3 | GeneProduct | 5606 (Entrez Gene) | MKK3 |
MAP2K6 | GeneProduct | 5606 (Entrez Gene) | MEK6 |
MAPK14 | GeneProduct | 1432 (Entrez Gene) | P38a |
MAPK1 | GeneProduct | 5594 (Entrez Gene) | ERK |
MDM2 | GeneProduct | 4193 (Entrez Gene) | |
MIR29B1 | Rna | ENSG00000265410 (Ensembl) | |
MIR29B2 | Rna | ENSG00000207790 (Ensembl) | |
MIR29C | Rna | ENSG00000203709 (Ensembl) | |
MLL | GeneProduct | 4297 (Entrez Gene) | ARF |
MMP-3 | GeneProduct | ||
MMP14 | GeneProduct | 4323 (Entrez Gene) | |
NFKB | GeneProduct | 1026 (Entrez Gene) | P21/CIP1/WAF1 |
PCNA | GeneProduct | 5111 (Entrez Gene) | |
PI3K? | GeneProduct | ||
PIK3C3 | GeneProduct | 5289 (Entrez Gene) | VPS34 |
PIK3C3 | GeneProduct | ENSG00000078142 (Ensembl) | |
PIP3(16:0/16:0) | Metabolite | HMDB0010147 (HMDB) | |
PLAT | GeneProduct | 5327 (Entrez Gene) | tPA |
PLAU | GeneProduct | 5328 (Entrez Gene) | uPA |
PTEN | GeneProduct | 5728 (Entrez Gene) | |
RAF1 | GeneProduct | 5894 (Entrez Gene) | |
RB1 | GeneProduct | 5925 (Entrez Gene) | |
RB1CC1 | GeneProduct | ENSG00000023287 (Ensembl) | |
RNASEL | GeneProduct | 6041 (Entrez Gene) | |
RSL1D1 | GeneProduct | 26156 (Entrez Gene) | |
SERPINB2 | GeneProduct | 5055 (Entrez Gene) | |
SERPINE1 | GeneProduct | 5054 (Entrez Gene) | PAI1 |
SH3GLB1 | GeneProduct | 51100 (Entrez Gene) | BIF1 |
SLC39A1 | GeneProduct | 27173 (Entrez Gene) | |
SLC39A2 | GeneProduct | 29986 (Entrez Gene) | |
SLC39A3 | GeneProduct | 29985 (Entrez Gene) | |
SLC39A4 | GeneProduct | 55630 (Entrez Gene) | |
SMAD3 | GeneProduct | 4088 (Entrez Gene) | |
SMAD4 | GeneProduct | 4089 (Entrez Gene) | |
SPARC | GeneProduct | 6678 (Entrez Gene) | |
SQSTM1 | GeneProduct | 8878 (Entrez Gene) | |
SRC | GeneProduct | 6714 (Entrez Gene) | |
TGFB1 | GeneProduct | 7040 (Entrez Gene) | |
THBS1 | GeneProduct | 7057 (Entrez Gene) | |
TNFSF15 | GeneProduct | 9966 (Entrez Gene) | |
TP53 | GeneProduct | 7157 (Entrez Gene) | |
ULK1 | GeneProduct | 8408 (Entrez Gene) | ATG1 |
UVRAG | GeneProduct | 7405 (Entrez Gene) | |
VTN | GeneProduct | 7448 (Entrez Gene) | |
bcl-xL | GeneProduct | ||
pkb? | GeneProduct |
Annotated Interactions
No annotated interactions