Type II interferon signaling (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none PCytoplasmBTORTPBTExtracellularspaceBBORPORPNucleusORPlasmamembraneBOR&APO&O-P[P]IFNGR2IFNGR1JAK1JAK2IFNG[P]STAT1STAT1[P] [P]STAT1STAT1[P]STAT1STAT1STAT2 [P]SPI1OAS1IRF8 [P]JAK2STAT1IFNGJAK1CXCL9IFNASOCS1CYBBPTPN11ICAM1IRF2GBP1TAP1IRF8HIST2H4IFNGR1IFNB1IL1BIFNGR2EIF2AK2G1P2NOS2ASTAT1 [P]G1P3IRF1CXCL10PSMB9SOCS3PRKCDIRF4HLA-BIFIT2CIITAPTPIRF9STAT1STAT1STAT1STAT1IRF9IFNGR2JAK1IFNGR1JAK2STAT1IRF9STAT1IRF9(ISGF3)STAT1STAT2IFNGIFNGSTAT1(ISGF3)IRF9STAT2IFNGJAK1JAK2IFNGR1IFNGR2STAT1STAT2Name: Type II interferon signalingOrganism: Homo sapiens


Description

Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1] Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP619).

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Quality Tags

Image:Curated.pngApproved version
Image:Wplogo_31.pngCommunity: PancCanNet
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

Bibliography

  1. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, Freeman TC; ''A logic-based diagram of signalling pathways central to macrophage activation.''; BMC Syst Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137117
Approved
view23:03, 27 February 2025KhanspersModified description
134410view20:37, 21 July 2024EweitzStandardize case
120967
CPTAC
view05:53, 4 February 2022EgonwModified title
106442
PancCanNet
view23:31, 28 August 2019KhanspersModified description
105509view06:00, 8 August 2019KhanspersModified description
71168view10:58, 11 October 2013Mkutmonfixed unconnected lines
68919view17:32, 8 July 2013MaintBotUpdated to 2013 gpml schema
67733view11:56, 26 June 2013DdiglesOntology Term : 'Type II interferon signaling pathway' added !
45027view18:45, 6 October 2011KhanspersOntology Term : 'Jak-Stat signaling pathway' added !
41066view23:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
32475view17:32, 15 August 2009MaintBotFixed text labels
32169view14:07, 14 August 2009MaintBotFixed group labels
28124view14:23, 27 January 2009Thomaschanged title
28061view12:16, 23 January 2009Thomas
28060view12:16, 23 January 2009ThomasNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
(ISGF3)GeneProduct10379 (Entrez Gene)
CIITAGeneProduct4261 (Entrez Gene)
CXCL10GeneProduct3627 (Entrez Gene)
CXCL9GeneProduct4283 (Entrez Gene)
CYBBGeneProduct1536 (Entrez Gene)
EIF2AK2GeneProduct5610 (Entrez Gene)
G1P2GeneProduct9636 (Entrez Gene)
G1P3GeneProduct2537 (Entrez Gene)
GBP1GeneProduct2633 (Entrez Gene)
HIST2H4GeneProduct8370 (Entrez Gene)
HLA-BGeneProduct3106 (Entrez Gene)
ICAM1GeneProduct3383 (Entrez Gene)
IFIT2GeneProduct3433 (Entrez Gene)
IFNAGeneProduct3440 (Entrez Gene)
IFNB1GeneProduct3456 (Entrez Gene)
IFNGGeneProduct3458 (Entrez Gene)
IFNGR1GeneProduct3459 (Entrez Gene)
IFNGR2GeneProduct3460 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IRF1GeneProduct3659 (Entrez Gene)
IRF2GeneProduct3660 (Entrez Gene)
IRF4GeneProduct3662 (Entrez Gene)
IRF8 [P]GeneProduct3394 (Entrez Gene)
IRF8GeneProduct3394 (Entrez Gene)
IRF9GeneProduct10379 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
NOS2AGeneProduct4843 (Entrez Gene)
OAS1GeneProduct4938 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PSMB9GeneProduct5698 (Entrez Gene)
PTPGeneProduct5967 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
SPI1GeneProduct6688 (Entrez Gene)
STAT1 [P]GeneProduct6772 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT2 [P]GeneProduct6773 (Entrez Gene)
STAT2GeneProduct6773 (Entrez Gene)
TAP1GeneProduct6890 (Entrez Gene)

Annotated Interactions

No annotated interactions

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