Leptin and adiponectin (Mus musculus)

Description

Proposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in Dyck et al..

View approved pathways at the new wikipathways.org.

Dyck DJ, Heigenhauser GJ, Bruce CR; ''The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity.''; Acta Physiol (Oxf), 2006 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
120459	view	07:55, 6 December 2021	Egonw	a MIM translocation
107213	view	14:30, 17 September 2019	MaintBot	ChEBI identifier normalization
71946	view	22:18, 23 October 2013	Egonw	Replaced a random box with a mitochondrion drawing.
71945	view	22:11, 23 October 2013	Egonw	Added a ChEBI id for 'fatty acid'.
69111	view	18:13, 8 July 2013	MaintBot	Updated to 2013 gpml schema
45174	view	08:52, 7 October 2011	Thomas	Ontology Term : 'glucose metabolism disease' added !
45173	view	08:50, 7 October 2011	Thomas	Ontology Term : 'leptin system pathway' added !
45172	view	08:50, 7 October 2011	Thomas	Ontology Term : 'adiponectin signaling pathway' added !
41298	view	00:23, 2 March 2011	MaintBot	Removed redundant pathway information and comments
33406	view	14:48, 30 November 2009	MaintBot	Removed group label
29045	view	12:49, 27 March 2009	Thomas	New pathway

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Name	Type	Database reference
Acc1	GeneProduct	107476 (Entrez Gene)
Acetyl-CoA	Metabolite	CHEBI:15351 (ChEBI)
Adiponectin	GeneProduct	11450 (Entrez Gene)
Adipor1	GeneProduct	72674 (Entrez Gene)
Adipor2	GeneProduct	68465 (Entrez Gene)
Cpt1	GeneProduct	12894 (Entrez Gene)
Fatty acid	Metabolite	CHEBI:35366 (ChEBI)
Lepr	GeneProduct	16847 (Entrez Gene)
Leptin	GeneProduct	16846 (Entrez Gene)
Malonyl-CoA	Metabolite	CHEBI:15531 (ChEBI)
Prkaa1	GeneProduct	105787 (Entrez Gene)
Prkab1	GeneProduct	19079 (Entrez Gene)
Prkag1	GeneProduct	19082 (Entrez Gene)

No annotated interactions