Phospholipids degradation (Saccharomyces cerevisiae)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphatePLC1H+ISC1SPO14inositol 1,4,5-trisphosphate1,2-diacyl-sn-glycerolH20phosphatidylcholinephosphocholineH+H201,2-diacyl-sn-glycerol 3-phosphatecholineH+H20Name: Phospholipids degradationOrganism: Saccharomyces cerevisiae


Description

In addition to being a primary structural components of cell membranes, phospholipids may also be thought of as a reservoir of signaling molecules. Hydrolysis of phosphatidylinositol 4,5-biphosphate (PIP2) by phospholipase C, for instance, generates the signaling molecules inositol triphosphate (IP3) and diacylglycerol (DAG). S. cerevisiae catalyzes this reaction via Plc1p, a phosphatidylinositol-specific phospholipase C involved in a variety of biological processes including nutrient sensing and filamentous growth. On the other hand, degradation of phosphatidylcholine (PC) by phospholipase D (Spo14p) yields phosphatidic acid and choline; this activity generates PA required for sporulation in S. cerevisiae. A phospholipase C specific for PC has yet to be identified in S. cerevisiae, however PC may also serve as substrate for phospholipases B (Plb1-3p and Nte1p), which hydrolyze PC to yield glycerophosphocholine (GPC) and two fatty acids. Both phospholipases B and D are thought to mediate PC turnover in yeast, and phospholipase B (as Plb1p) has also been implicated in acyl chain remodeling. Source: https://pathway.yeastgenome.org/

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

 

Bibliography

  1. ''phospholipids degradation''; YeastPathways,

History

View all...
CompareRevisionActionTimeUserComment
136181
Approved
view22:50, 23 December 2024Khanspers
136180view22:45, 23 December 2024KhanspersOntology Term : 'classic metabolic pathway' added !
136179view22:45, 23 December 2024KhanspersModified description
136178view22:44, 23 December 2024Khanspersremove GenMAPP comments and update reference
136177view22:43, 23 December 2024Khanspersoverhaul
70049view05:57, 12 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69611view20:33, 8 July 2013MaintBotUpdated to 2013 gpml schema
67434view11:01, 26 June 2013DdiglesOntology Term : 'glycerophospholipid metabolic pathway' added !
53897view17:07, 15 November 2012EgonwAdded some dots...
41843view04:50, 2 March 2011MaintBotRemoved redundant pathway information and comments
20827view11:30, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Lipases Biosynthesis]] moved to [[Pathway:WP71]]: Moved to stable identifier
12768view08:01, 17 May 2008MaintBotautomated metabolite conversion
8813view14:09, 7 January 2008MaintBotAdded to category $category
8811view14:09, 7 January 2008J.HeckmanUploaded new pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
1,2-diacyl-sn-glycerol 3-phosphateMetabolite29089 (ChEBI)
1,2-diacyl-sn-glycerolMetabolite17815 (ChEBI)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphateMetabolite24742074 (PubChem-compound)
H+Metabolite15378 (ChEBI)
H20Metabolite15377 (ChEBI)
ISC1GeneProductS000000821 (SGD)
PLC1GeneProductS000006189 (SGD)
SPO14GeneProductS000001739 (SGD)
cholineMetabolite15354 (ChEBI)
inositol 1,4,5-trisphosphateMetabolite203600 (ChEBI)
phosphatidylcholineMetabolite16110 (ChEBI)
phosphocholineMetabolite295975 (ChEBI)

Annotated Interactions

No annotated interactions

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