Phospholipids degradation (Saccharomyces cerevisiae)
From WikiPathways
Description
In addition to being a primary structural components of cell membranes, phospholipids may also be thought of as a reservoir of signaling molecules. Hydrolysis of phosphatidylinositol 4,5-biphosphate (PIP2) by phospholipase C, for instance, generates the signaling molecules inositol triphosphate (IP3) and diacylglycerol (DAG). S. cerevisiae catalyzes this reaction via Plc1p, a phosphatidylinositol-specific phospholipase C involved in a variety of biological processes including nutrient sensing and filamentous growth. On the other hand, degradation of phosphatidylcholine (PC) by phospholipase D (Spo14p) yields phosphatidic acid and choline; this activity generates PA required for sporulation in S. cerevisiae. A phospholipase C specific for PC has yet to be identified in S. cerevisiae, however PC may also serve as substrate for phospholipases B (Plb1-3p and Nte1p), which hydrolyze PC to yield glycerophosphocholine (GPC) and two fatty acids. Both phospholipases B and D are thought to mediate PC turnover in yeast, and phospholipase B (as Plb1p) has also been implicated in acyl chain remodeling.
Source: https://pathway.yeastgenome.org/
Quality Tags
Ontology Terms
Bibliography
- ''phospholipids degradation''; YeastPathways,
History
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External references
DataNodes
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Name ![]() | Type ![]() | Database reference ![]() | Comment ![]() |
---|---|---|---|
1,2-diacyl-sn-glycerol 3-phosphate | Metabolite | 29089 (ChEBI) ![]() | |
1,2-diacyl-sn-glycerol | Metabolite | 17815 (ChEBI) ![]() | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | Metabolite | 24742074 (PubChem-compound) ![]() | |
H+ | Metabolite | 15378 (ChEBI) ![]() | |
H20 | Metabolite | 15377 (ChEBI) ![]() | |
ISC1 | GeneProduct | S000000821 (SGD) ![]() | |
PLC1 | GeneProduct | S000006189 (SGD) ![]() | |
SPO14 | GeneProduct | S000001739 (SGD) ![]() | |
choline | Metabolite | 15354 (ChEBI) ![]() | |
inositol 1,4,5-trisphosphate | Metabolite | 203600 (ChEBI) ![]() | |
phosphatidylcholine | Metabolite | 16110 (ChEBI) ![]() | |
phosphocholine | Metabolite | 295975 (ChEBI) ![]() |
Annotated Interactions
No annotated interactions