EGFR1 signaling pathway (Gallus gallus)

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1CYCYControlCYCytoplasm(Protein-protein interaction)MACYCYReaction through unknown mechanisms/moleculesPMCYNUMADesumoylationMAMAProteins in a complex interactionERNUNUMAPMPMCYMADPhosphorylationProteolytic cleavageExtracellularTranslocationPMMAMAPMPMCYMAUbiquitinationNUAccession Number : NetPath 4; cellmap:4MethylationEndoplasmic reticulumNUCYLigandPalmitoylationActivationCYCYDeubiquitinationPMCYDeacetylationGlycosylationCYCYEnzyme complexNUCYPMMAPMCYCYENPMNUCYCYENCYPMPMEndosomePMCYMAMANUCYECGene SymbolPMInhibitionCYPlasma membraneMolecular associationGolgi apparatusPMCYCYDemethylationMANUDNUCYMACYPMMADephosphorylationNUNUGOMANUPMCYMANUNUDSumoylationPMAutodephosphorylationMANUPMCYPMRecruitmentCYMAReceptorMitochondrionNUNucleusCYNUCYMolecule in the pathwayNUENPMNUCYPMMAMAAcetylationCYCYMTAutophosphorylationPTPN5RCJMB04_16p24PRKAR1ASTXBP1EGFAPPL1FOXO1AMAP3K4GRB14APPL1RAC1KLF11PEBP1SHC1ELK1JAK1RCJMB04_17i9RCJMB04_13d16HRASPTPN12MAPK3SRCMAPK14DNM1PRKCBWASLCREB1CAV1RCJMB04_17i9FOSTNIP1APPL2CEBPBSH3GL2VAV1KRT18PIK3CBCSKEPN1MAP3K2MCF2NDUFA13STAT3ARAFJUNDRAF1SH3GL2SH2D3CRCJMB04_8f10SMAD3EPS8BCAR1HIP1PLD1EGFRPIK3CAMAP2K1GRB2MAP2K7CEACAM1CBLCGIT1APPL2STAT2CBLBRFXANKELK4ZNF259ATF1PITPNARCJMB04_12k21MAP3K1RAF1RCJMB04_36h7RPS6KA3RCJMB04_17i9PTPN11BCAR1EPS15L1CAMK2ASH3GL3TNK2VAV3KRT8PLEC1CDC42SOCS3PIK3R2STAT5BRGS16ZNF259CRKELF3SHC1HTTTGIF1USP6NLRCJMB04_5a10SH3KBP1SH2D3CRIPK1PIK3C2BSPRY2PTK2BGAB2EGFRMAP2K2STAT3PTPN6PIK3CDEPPK1PIK3R1VAV2RPS6KA3MYCKRT7STAT2CRKLCAV2SHOC2RASA1MAP3K3STAT3DUSP1MTA2STAT5ASMAD2DOK2SOCS1SIN3ASTAT5AGRB10SH3BGRLPRKCZHIST3H3NRASMAP2K1ELF3EEF1A1EGFRRPS6KA5MAP3K2KRT17MAPK1GRB7PTPN6WNK1INPPL1SNCAYWHABPLSCR1PLCG2CBLPLCG2PKN2AP2A1PTK6SNRPD2FOXO1ASP1STXBP1KRASGJA1MAP3K14DUSP1ARF4RALGDSHAT1EGFEGFSMAD3PLCG1JUNSPRY2PRKCGGAB1SMAD2RCJMB04_25c5ARF4ARF4EEF1A1SOS2RPS6KA1PIK3R3EGFRPLCG1PTPRRGAB1RCJMB04_4o17PXNMAPK7RPS6KA2REPS1CASP9ERRFI1PLD2DDEF1AKT1PAK1RCJMB04_21j12RCJMB04_5a10RALBMAPK1REPS2APPL1NCK1ITCHSOS1RCJMB04_1d5CEBPAJAK2HDAC1PIK3CGRCJMB04_1d5RAB5APLD1MAPK8RBBP7


Description

The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_4

Comments

GenMAPP notes 
NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP437(r21600) with a 77% conversion rate.

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Bibliography

  1. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV; ''Control of MAPK signalling: from complexity to what really matters.''; Oncogene, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117193view10:32, 18 May 2021EweitzModified title
68850view17:19, 8 July 2013MaintBotUpdated to 2013 gpml schema
67179view10:17, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
40988view22:55, 1 March 2011MaintBotRemoved redundant pathway information and comments
35719view23:29, 12 February 2010AlexanderPico
35437view11:34, 12 February 2010MichielAdded ref
33910view18:03, 9 December 2009MaintBotAutomatic update of empty xrefs
30321view20:43, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct395928 (Entrez Gene)
AP2A1GeneProduct
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ARAFGeneProduct
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ATF1GeneProduct426873 (Entrez Gene)
BCAR1GeneProduct415691 (Entrez Gene)
CAMK2AGeneProduct374175 (Entrez Gene)
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CAV1GeneProduct373996 (Entrez Gene)
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CBLCGeneProduct
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CEACAM1GeneProduct
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CREB1GeneProduct395099 (Entrez Gene)
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CSKGeneProduct396396 (Entrez Gene)
DDEF1GeneProduct428385 (Entrez Gene)
DNM1GeneProduct417217 (Entrez Gene)
DOK2GeneProduct
DUSP1GeneProduct374192 (Entrez Gene)
EEF1A1GeneProduct373963 (Entrez Gene)
EGFGeneProduct408035 (Entrez Gene)
EGFRGeneProduct396494 (Entrez Gene)
ELF3GeneProduct421177 (Entrez Gene)
ELK1GeneProduct
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EPN1GeneProduct
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HIST3H3GeneProduct
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JUNDGeneProduct
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PRKCGGeneProduct
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PTK2BGeneProduct421998 (Entrez Gene)
PTK6GeneProduct
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RAB5AGeneProduct420649 (Entrez Gene)
RAC1GeneProduct395871 (Entrez Gene)
RAF1GeneProduct396245 (Entrez Gene)
RALBGeneProduct424237 (Entrez Gene)
RALGDSGeneProduct427758 (Entrez Gene)
RASA1GeneProduct427327 (Entrez Gene)
RBBP7GeneProduct395390 (Entrez Gene)
RCJMB04_12k21GeneProduct423302 (Entrez Gene)
RCJMB04_13d16GeneProduct418727 (Entrez Gene)
RCJMB04_16p24GeneProduct424991 (Entrez Gene)
RCJMB04_17i9GeneProduct424044 (Entrez Gene)
RCJMB04_1d5GeneProduct424633 (Entrez Gene)
RCJMB04_21j12GeneProduct428852 (Entrez Gene)
RCJMB04_25c5GeneProduct420489 (Entrez Gene)
RCJMB04_36h7GeneProduct415557 (Entrez Gene)
RCJMB04_4o17GeneProduct429466 (Entrez Gene)
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REPS1GeneProduct421678 (Entrez Gene)
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SH3BGRLGeneProduct422277 (Entrez Gene)
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SHOC2GeneProduct423894 (Entrez Gene)
SIN3AGeneProduct415307 (Entrez Gene)
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SMAD3GeneProduct395132 (Entrez Gene)
SNCAGeneProduct395393 (Entrez Gene)
SNRPD2GeneProduct
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STAT2GeneProduct
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STAT5AGeneProduct
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TNK2GeneProduct431014 (Entrez Gene)
USP6NLGeneProduct423110 (Entrez Gene)
VAV1GeneProduct
VAV2GeneProduct373938 (Entrez Gene)
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WASLGeneProduct417750 (Entrez Gene)
WNK1GeneProduct427925 (Entrez Gene)
YWHABGeneProduct419190 (Entrez Gene)
ZNF259GeneProduct428256 (Entrez Gene)

Annotated Interactions

No annotated interactions
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