Non-homologous end joining (Gallus gallus)

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XRCC5XRCC4XRCC5KU70_CHICKNbs1 ?KU70_CHICKXRCC5KU70_CHICKMRE11_CHICKXRCC5Q5W4T6_CHICKLigase VXRCC5PRKDC_CHICKKU70_CHICKKU70_CHICKNHEJ1KU70_CHICKNHEJ1KU70_CHICKPRKDC_CHICKKU70_CHICKPRKDC_CHICKXRCC5XRCC4KU70_CHICKXRCC5XRCC5PRKDC_CHICKXRCC5PRKDC_CHICKPRKDC_CHICKXRCC5PRKDC_CHICKLigase VPRKDC_CHICKKU70_CHICK


Description

(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP438(r29612) with a 91% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
87948view13:05, 25 July 2016ElisaOntology Term : 'DNA repair pathway' added !
87947view13:05, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
68810view17:15, 8 July 2013MaintBotUpdated to 2013 gpml schema
58772view22:15, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40944view22:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
35397view09:50, 12 February 2010MartijnVanIerselModified description
33439view14:57, 30 November 2009MaintBotRemoved group label
30322view20:44, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
KU70_CHICKGeneProductENSGALG00000011932 (Ensembl)
Ligase VGeneProduct
MRE11_CHICKGeneProductENSGALG00000017211 (Ensembl)
NHEJ1GeneProduct424205 (Entrez Gene)
NHEJ1GeneProductENSGALG00000011335 (Ensembl)
Nbs1 ?GeneProduct
PRKDC_CHICKGeneProductENSGALG00000012914 (Ensembl)
Q5W4T6_CHICKGeneProductENSGALG00000006794 (Ensembl)
XRCC4GeneProductENSGALG00000015620 (Ensembl)
XRCC5GeneProductENSGALG00000011492 (Ensembl)

Annotated Interactions

No annotated interactions
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