FAS pathway and stress induction of HSP regulation (Gallus gallus)
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3x-P
3x-P
Proteasome
Apoptosome
FAS Pathway
Inhibition
Nucleus
Extracellular
Self-activation
ROS
3x-P
Cell Survival
Mitochondria Pathway
Necrosis
Stress
NFK-B Pathway
Apoptosis
Stress Induction of HSP regulation
Cut
DNA presentation
Cytoplasm
Activate
CASP8
MAPK8
HSPB1
HSPB1
Phosphate
FAP1
MAP3K7
BCL2
RB1
JUN
PRKDC
Phosphate
SPTAN1
CASP6
DFFB
HSPB1
DFFA
MAP3K1
IL1A
CASP9
HSPB1
PAK1
Phosphate
Phosphate
PARP1
MAP2K4
LMNA
DAXX
FASLG
HSPB1
FAS
Phosphate
Ceramide
ARHGDIB
MAPKAPK3
FAF1
HSPB1
LMNB1
CASP3
MAPKAPK2
APAF1
CYCS
CASP8
Glutathione
CASP10
CASP3
actin
FADD
RIPK2
HSPB1
LMNB2
Phosphate
DFFB
TNF
Phosphate
Phosphate
HSPB1
DAXX
PAK2
FAF1
CASP7
CFLAR
APAF1
Description
This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info:
BioCarta
.
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP314(r21341)
with a 79% conversion rate.
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Quality Tags
Ontology Terms
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Bibliography
Creagh EM, Sheehan D, Cotter TG; ''Heat shock proteins--modulators of apoptosis in tumour cells.''; Leukemia, 2000
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
117196
view
10:32, 18 May 2021
Eweitz
Modified title
109460
view
10:41, 18 March 2020
L Dupuis
Converted interactions to graphical lines where applicable
106117
view
12:02, 16 August 2019
MaintBot
HMDB identifier normalization
74234
view
16:38, 8 April 2014
Egonw
Removed a data source where no ID was given.
72376
view
13:05, 13 November 2013
Egonw
Added a metabolite ID.
68807
view
17:15, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67224
view
10:23, 26 June 2013
Christine Chichester
Ontology Term : 'FasL mediated signaling pathway' added !
47790
view
16:27, 6 April 2012
Khanspers
updated xref
40940
view
22:52, 1 March 2011
MaintBot
Removed redundant pathway information and comments
38242
view
21:20, 27 August 2010
Khanspers
Removed receptor and protein complex graphics
35562
view
15:03, 12 February 2010
Thomas
added literature
35558
view
15:01, 12 February 2010
Thomas
Modified description
33869
view
17:49, 9 December 2009
MaintBot
Automatic update of empty xrefs
33466
view
15:04, 30 November 2009
MaintBot
Removed group label
31517
view
21:39, 13 August 2009
MaintBot
Fixed text labels
30357
view
20:54, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
APAF1
GeneProduct
417926 (Entrez Gene)
ARHGDIB
GeneProduct
417941 (Entrez Gene)
Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
BCL2
GeneProduct
396282 (Entrez Gene)
CASP10
GeneProduct
424081 (Entrez Gene)
CASP3
GeneProduct
395476 (Entrez Gene)
CASP6
GeneProduct
395477 (Entrez Gene)
CASP7
GeneProduct
423901 (Entrez Gene)
CASP8
GeneProduct
395284 (Entrez Gene)
CASP9
GeneProduct
426970 (Entrez Gene)
CFLAR
GeneProduct
424080 (Entrez Gene)
CYCS
GeneProduct
420624 (Entrez Gene)
Ceramide
Metabolite
CHEBI:17761 (ChEBI)
DAXX
GeneProduct
DFFA
GeneProduct
419451 (Entrez Gene)
DFFB
GeneProduct
374158 (Entrez Gene)
FADD
GeneProduct
776859 (Entrez Gene)
FAF1
GeneProduct
424629 (Entrez Gene)
FAP1
GeneProduct
FAS
GeneProduct
395274 (Entrez Gene)
FASLG
GeneProduct
776371 (Entrez Gene)
Glutathione
Metabolite
HMDB0000125 (HMDB)
HSPB1
GeneProduct
396227 (Entrez Gene)
IL1A
GeneProduct
JUN
GeneProduct
424673 (Entrez Gene)
LMNA
GeneProduct
396224 (Entrez Gene)
LMNB1
GeneProduct
396223 (Entrez Gene)
LMNB2
GeneProduct
396222 (Entrez Gene)
MAP2K4
GeneProduct
417312 (Entrez Gene)
MAP3K1
GeneProduct
427144 (Entrez Gene)
MAP3K7
GeneProduct
421808 (Entrez Gene)
MAPK8
GeneProduct
423778 (Entrez Gene)
MAPKAPK2
GeneProduct
419847 (Entrez Gene)
MAPKAPK3
GeneProduct
415917 (Entrez Gene)
PAK1
GeneProduct
419083 (Entrez Gene)
PAK2
GeneProduct
424860 (Entrez Gene)
PARP1
GeneProduct
396199 (Entrez Gene)
PRKDC
GeneProduct
395376 (Entrez Gene)
Phosphate
Metabolite
HMDB0001429 (HMDB)
RB1
GeneProduct
386582 (Entrez Gene)
RIPK2
GeneProduct
420215 (Entrez Gene)
receptor (TNFRSF)-interacting serine-threonine kinase 2
SPTAN1
GeneProduct
374234 (Entrez Gene)
Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
TNF
GeneProduct
actin
GeneProduct
Annotated Interactions
No annotated interactions
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Discussion
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
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External references
DataNodes
Annotated Interactions
No annotated interactions