Transformation growth factor (TGF) beta receptor signaling pathway (Gallus gallus)

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MTNUGolgi apparatusControlENActivationNUNucleusProteolytic cleavageCYCYAutophosphorylationMolecule in the pathwayNUGOAcetylationEnzyme complexInhibitionSumoylationCYCYCYNUDesumoylationECNUNU -> CYNUNUPalmitoylationCYNUGlycosylationEndoplasmic reticulumCytoplasmNUCYNUNU(Protein-protein interaction)NUNUCYCYNUERCYCYEndosomeCYNUMitochondriaMethylationCYCYLigandReaction through unknown mechanisms/moleculesNUNUTranslocationCYCYNUNU -> CYCYNUNUNUExtracellularDeacetylationGlycosylationCYNUCYCYAccession Number: NetPath 7; cellmap:7DeubiquitinationCYCYCYRecruitmentNUNUDPlasma membraneNUCYMolecular associationUbiquitinationNUPMReceptorCYDemethylationNUCYCYDephosphorylationProteins in a complex interactionPhosphorylationFOSBTGFB1E2F4PRKCDTGFB3MAPK14MAP3K7E2F4TGFB3CTNNB1PRKCBBTRCSKISMAD3MAPK8NUP153TGFBR1TGFBR1PIAS1CAMK2GDAXXFOXO3MYCSDC2RCJMB04_24l12SMAD7ANAPC1TGFBR2DCP1ARBL2CUL1TGFBR2CDC16SMURF2SMAD7JUNETS1LEF1SMAD4SMAD2TGIF1CDC16MAP2K6E2F4ROCK1SKP1ATGFBR3HSPA8CDC27RB1TGFBR2Gene SymbolCCND1TGFBR2NCOA1ANAPC10CDK4RCJMB04_8f10JUNDEP300ZEB1SMAD7TGFB3ENGNFYCCOPS5FOXO1ARCJMB04_30p22RB1SMAD3TGFBR2ATF2TGFB1SMURF2SP1SMAD3FZR1STAMBPL1TGFBR2TGFB2ZFYVE9TGFB3STK11SMAD3SMAD3TFDP2YAP1MAP3K7IP1ANAPC2RCJMB04_30p22TGFBR3HDAC1SKILRCJMB04_2d20ANAPC5RBX1TGFBR3VDRTGFB1SKP1ATFDP2UBE2D1RBL2PRKAR2AANAPC1CTCFRBL1FOSESR1SMAD3E2F4ANAPC4ANAPC7RBX1HGSACVRL1TGFBR3CD44KPNB1TFDP1NUP214SMURF1CUL1GIPC1MEF2CE2F4ANAPC4CDC27TGFBR1UBE2D3CAMK2AERBB2IPRBL1EIF3ITP53RBL1SMURF1TFDP2TGFBR2CREBBPCRI2CUL1ARTGFBR2CAV1CDC27TGFBR3SMAD3FKBP1ARCJMB04_30p22ROCK1KPNB1STRAPNFYASMAD4PIK3R1ESR1RUNX2RCJMB04_13l2SMAD2PCAFBTRCTRAP1FOXH1TP73DCP1AUBE2D2SMAD2CCNE1HOXA9SMAD4RBX1RCJMB04_5f2FOXO4SNX4FNTAZEB2RCJMB04_30p22RCJMB04_30p22TGFBR1CDC2TFDP1CDC25ASMAD3TGFB2MAPK8ARRB2FOXG1CAMK2BAXIN2TGFBR2SMAD6SMAD4TGFBR3PARD3RCJMB04_7n24HNF4ACCNB2SMAD4MAPK14E2F4SPARCRCJMB04_2g8PRKAR1BRCJMB04_13l2STRAPSMAD4SNIP1RB1ANAPC2ANAPC10MEF2ASUMO1ANAPC7CDKN1ASNW1CITED1SNX2JUNBTFDP1CDK2TGFB2ANAPC5RCJMB04_30p22TGFB1CDC23PRKCGDAB2CAMK2DAP2B1XPO1AXIN1RBL1CDC23TGFBR2ATF3PIK3R2RBL1SMAD3CDK6SMAD2SNX1


Description

No description

Comments

GenMAPP notes 
NetPath 7; cellmap:7 - TGF-beta Receptor Signaling Pathway

The TGF-beta Receptor Signaling pathway was kindly reviewed by Van Le Hong, Wei He and other members of Joan Massague’s lab. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP366(r21445) with a 82% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
118013view11:33, 23 May 2021EweitzModified title
87763view09:59, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
87761view09:58, 25 July 2016MirellaKalafatiModified title
68795view17:14, 8 July 2013MaintBotUpdated to 2013 gpml schema
40927view22:51, 1 March 2011MaintBotRemoved redundant pathway information and comments
33858view17:44, 9 December 2009MaintBotAutomatic update of empty xrefs
31532view21:44, 13 August 2009MaintBotFixed text labels
30378view21:01, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACVRL1GeneProduct
ANAPC10GeneProduct422461 (Entrez Gene)
ANAPC1GeneProduct421228 (Entrez Gene)
ANAPC2GeneProduct417258 (Entrez Gene)
ANAPC4GeneProduct422805 (Entrez Gene)
ANAPC5GeneProduct416842 (Entrez Gene)
ANAPC7GeneProduct416838 (Entrez Gene)
AP2B1GeneProduct417525 (Entrez Gene)
ARGeneProduct422165 (Entrez Gene)
ARRB2GeneProduct
ATF2GeneProduct395727 (Entrez Gene)
ATF3GeneProduct421369 (Entrez Gene)
AXIN1GeneProduct395786 (Entrez Gene)
AXIN2GeneProduct395152 (Entrez Gene)
BTRCGeneProduct423854 (Entrez Gene)
CAMK2AGeneProduct374175 (Entrez Gene)
CAMK2BGeneProduct374174 (Entrez Gene)
CAMK2DGeneProduct422688 (Entrez Gene)
CAMK2GGeneProduct423737 (Entrez Gene)
CAV1GeneProduct373996 (Entrez Gene)
CCNB2GeneProduct415400 (Entrez Gene)
CCND1GeneProduct396341 (Entrez Gene)
CCNE1GeneProduct426117 (Entrez Gene)
CD44GeneProduct395666 (Entrez Gene)
CDC16GeneProduct418735 (Entrez Gene)
CDC23GeneProduct771857 (Entrez Gene)
CDC2GeneProduct396252 (Entrez Gene)
CDC25AGeneProduct420375 (Entrez Gene)
CDC27GeneProduct419960 (Entrez Gene)
CDK2GeneProduct
CDK4GeneProduct
CDK6GeneProduct420558 (Entrez Gene)
CDKN1AGeneProduct
CITED1GeneProduct
COPS5GeneProduct426579 (Entrez Gene)
CREBBPGeneProduct416667 (Entrez Gene)
CRI2GeneProduct
CTCFGeneProduct396274 (Entrez Gene)
CTNNB1GeneProduct395964 (Entrez Gene)
CUL1GeneProduct420783 (Entrez Gene)
DAB2GeneProduct
DAXXGeneProduct
DCP1AGeneProduct415992 (Entrez Gene)
E2F4GeneProduct769430 (Entrez Gene)
EIF3IGeneProduct419653 (Entrez Gene)
ENGGeneProduct771557 (Entrez Gene)
EP300GeneProduct418000 (Entrez Gene)
ERBB2IPGeneProduct431583 (Entrez Gene)
ESR1GeneProduct396099 (Entrez Gene)
ETS1GeneProduct768354 (Entrez Gene)
FKBP1AGeneProduct374233 (Entrez Gene)
FNTAGeneProduct427299 (Entrez Gene)
FOSGeneProduct396512 (Entrez Gene)
FOSBGeneProduct
FOXG1GeneProduct396110 (Entrez Gene)
FOXH1GeneProduct
FOXO1AGeneProduct374231 (Entrez Gene)
FOXO3GeneProduct421769 (Entrez Gene)
FOXO4GeneProduct428703 (Entrez Gene)
FZR1GeneProduct373959 (Entrez Gene)
GIPC1GeneProduct
Gene SymbolGeneProduct
HDAC1GeneProduct373961 (Entrez Gene)
HGSGeneProduct428675 (Entrez Gene)
HNF4AGeneProduct419198 (Entrez Gene)
HOXA9GeneProduct396096 (Entrez Gene)
HSPA8GeneProduct395853 (Entrez Gene)
JUNGeneProduct424673 (Entrez Gene)
JUNBGeneProduct
JUNDGeneProduct
KPNB1GeneProduct777455 (Entrez Gene)
LEF1GeneProduct395865 (Entrez Gene)
MAP2K6GeneProduct
MAP3K7GeneProduct421808 (Entrez Gene)
MAP3K7IP1GeneProduct418014 (Entrez Gene)
MAPK14GeneProduct421183 (Entrez Gene)
MAPK8GeneProduct423778 (Entrez Gene)
MEF2AGeneProduct395670 (Entrez Gene)
MEF2CGeneProduct769007 (Entrez Gene)
MYCGeneProduct420332 (Entrez Gene)
NCOA1GeneProduct422016 (Entrez Gene)
NFYAGeneProduct419917 (Entrez Gene)
NFYCGeneProduct419642 (Entrez Gene)
NUP153GeneProduct420848 (Entrez Gene)
NUP214GeneProduct427760 (Entrez Gene)
PARD3GeneProduct420468 (Entrez Gene)
PCAFGeneProduct428441 (Entrez Gene)
PIAS1GeneProduct427514 (Entrez Gene)
PIK3R1GeneProduct427171 (Entrez Gene)
PIK3R2GeneProduct771142 (Entrez Gene)
PRKAR1BGeneProduct416446 (Entrez Gene)
PRKAR2AGeneProduct416062 (Entrez Gene)
PRKCBGeneProduct416567 (Entrez Gene)
PRKCDGeneProduct415905 (Entrez Gene)
PRKCGGeneProduct
RB1GeneProduct386582 (Entrez Gene)
RBL1GeneProduct419126 (Entrez Gene)
RBL2GeneProduct415721 (Entrez Gene)
RBX1GeneProduct418001 (Entrez Gene)
RCJMB04_13l2GeneProduct771038 (Entrez Gene)
RCJMB04_24l12GeneProduct416383 (Entrez Gene)
RCJMB04_2d20GeneProduct419416 (Entrez Gene)
RCJMB04_2g8GeneProduct424195 (Entrez Gene)
RCJMB04_30p22GeneProduct420206 (Entrez Gene)
RCJMB04_5f2GeneProduct419523 (Entrez Gene)
RCJMB04_7n24GeneProduct396205 (Entrez Gene)
RCJMB04_8f10GeneProduct416496 (Entrez Gene)
ROCK1GeneProduct373970 (Entrez Gene)
RUNX2GeneProduct373919 (Entrez Gene)
SDC2GeneProduct374102 (Entrez Gene)
SKIGeneProduct428181 (Entrez Gene)
SKILGeneProduct396087 (Entrez Gene)
SKP1AGeneProduct
SMAD2GeneProduct395247 (Entrez Gene)
SMAD3GeneProduct395132 (Entrez Gene)
SMAD4GeneProduct
SMAD6GeneProduct374096 (Entrez Gene)
SMAD7GeneProduct429683 (Entrez Gene)
SMURF1GeneProduct416487 (Entrez Gene)
SMURF2GeneProduct427809 (Entrez Gene)
SNIP1GeneProduct419616 (Entrez Gene)
SNW1GeneProduct423381 (Entrez Gene)
SNX1GeneProduct427480 (Entrez Gene)
SNX2GeneProduct426797 (Entrez Gene)
SNX4GeneProduct424260 (Entrez Gene)
SP1GeneProduct395303 (Entrez Gene)
SPARCGeneProduct386571 (Entrez Gene)
STAMBPL1GeneProduct
STK11GeneProduct420105 (Entrez Gene)
STRAPGeneProduct418175 (Entrez Gene)
SUMO1GeneProduct373930 (Entrez Gene)
TFDP1GeneProduct418739 (Entrez Gene)
TFDP2GeneProduct424780 (Entrez Gene)
TGFB1GeneProduct
TGFB2GeneProduct421352 (Entrez Gene)
TGFB3GeneProduct396438 (Entrez Gene)
TGFBR1GeneProduct374094 (Entrez Gene)
TGFBR2GeneProduct396399 (Entrez Gene)
TGFBR3GeneProduct374251 (Entrez Gene)
TGIF1GeneProduct396339 (Entrez Gene)
TP53GeneProduct396200 (Entrez Gene)
TP73GeneProduct419382 (Entrez Gene)
TRAP1GeneProduct416666 (Entrez Gene)
UBE2D1GeneProduct423641 (Entrez Gene)
UBE2D2GeneProduct416137 (Entrez Gene)
UBE2D3GeneProduct
VDRGeneProduct395988 (Entrez Gene)
XPO1GeneProduct421192 (Entrez Gene)
YAP1GeneProduct396171 (Entrez Gene)
ZEB1GeneProduct396029 (Entrez Gene)
ZEB2GeneProduct424306 (Entrez Gene)
ZFYVE9GeneProduct424639 (Entrez Gene)

Annotated Interactions

No annotated interactions
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