TNF-alpha NF-kB signaling pathway (Gallus gallus)

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PhosphorylationECMolecule in the pathwayEndosomeUbiquitinationPMMolecular associationERGlycosylationDesumoylationRecruitmentMethylationENAccession Number: NetPath 9; cellmap:9DephosphorylationCY ->NUSumoylationEndoplasmic reticulumPalmitoylationCY ->NUDeubiquitinationCYEnzyme complexExtracellularTranslocationProteins in a complex interactionGolgi apparatusCY ->NUCytoplasmAcetylationAutophosphorylation(Protein-protein interaction)Plasma membraneReceptorNUProteolytic cleavageLigandInhibitionCY ->NUGOReaction through unknown mechanisms/moleculesMitochondrionDemethylationDActivationNucleusDeacetylationCY ->NUControlMTTRAF2PSMD12RCJMB04_11l21TANKCAV1DBC1HSPCBPAPOLATNFRSF1ADAPTXLNAPSMC1CFLARCRADDRCJMB04_14f8PSMC3IQGAP2TNFRSF11AAKAP8TRAF5RCJMB04_19h23ACTL6ANFKBIAHDAC1SUMO1Gene SymbolUSP2SMARCC1USP11BCL3RELBRPS13TRAIPNKIRAS1TRPC4APFBLHDAC6PEG3GLG1RPL6TIFARCJMB04_4j14UBE2INR2C2HDAC2TBK1SRCKPNA2WDR68SMARCB1NSMAFPSMD13PDCD2DPF2FAF1RELAMARK2PKN1TRAF1TRAF4CSNK2BPOLR2LRASAL2LRPPRCYWHAHPPP2CAFADDPOLR1ERPS11YWHABMAP3K1MAP3K14FKBP5PMLPSMD7EIF4A3GenePEBP1TRADDUNC5CLFLNAMAP3K3AKT2RELBCYLDIKBKGGenePSMC2GNB2L1PIAS3SKP1AIKBKBKPNA3CUL1TNIP2TRAF6BIRC3UBCH5CBTRCPRKACAPOLR1ASMARCC2RCJMB04_17i9CASP3TRAF3MAP3K8NFKB1NR2C2RCJMB04_19h23NFKB1SMARCA4ALPLBIRC2TNFNFKBIEMAP3K7IP1PSMD1POLR1DHSP90AA1POLR1BRIPK2COMMD1BCL7ARELGAB1RCJMB04_2a4PSMD3MAP3K3PPP1R13LNFKB1POLR1CCDC37TNFRSF1BKTN1RIPK1ASE1MAP3K2G3BP2RIPK3TNFGeneTNFRSF1BTRAF2TRAF4TNIP1TNFRPL4TRADDRPL30CASP2YWHAQPRKCZNFKBIBTNFRSF1ACSNK2A1MCM7TNFRSF8MTIF2TNFRSF1BRELATNFRPL8MCCRCJMB04_5e12COPS3POLR2HMCM5PTK2AZI2NFKBIACASP8AKT1CAPN3CASP7TNFUBE2D2RELABIRC3NFKB2RELARPS6KA5GeneCSNK2A2CDC34RCJMB04_36h7GSK3BTNFAIP3PSMD6HIST3H3CASP10CASP8AP2RIPK1HSPB1TRAF2YWHAEBIRC2MAP3K7IP3PTPN11MAP3K7IP2RNF25CREBBPKCNQ1TBK1TNFRSF1AIKBKGRCJMB04_34f17NFKBIATRAF1RCJMB04_17o18NALP4NKIRAS2FANCD2NFKBIZBAG4SMARCE1GTF2IRELPSMB5ZFAND5RNF216TNFIKBKEPFDN2


Description

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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 69% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
118011view11:32, 23 May 2021EweitzModified title
108152view10:37, 29 November 2019FehrhartOntology Term : 'cancer' added !
87787view11:14, 25 July 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
87785view11:13, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
68867view17:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
41006view22:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
33927view18:09, 9 December 2009MaintBotAutomatic update of empty xrefs
33485view15:08, 30 November 2009MaintBotRemoved group label
31535view21:45, 13 August 2009MaintBotFixed text labels
30380view21:02, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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AKAP8GeneProduct426167 (Entrez Gene)
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ASE1GeneProduct
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BAG4GeneProduct426776 (Entrez Gene)
BCL3GeneProduct
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BIRC3GeneProduct
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CASP7GeneProduct423901 (Entrez Gene)
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CASP8AP2GeneProduct421810 (Entrez Gene)
CAV1GeneProduct373996 (Entrez Gene)
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EIF4A3GeneProduct416704 (Entrez Gene)
FADDGeneProduct776859 (Entrez Gene)
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FBLGeneProduct
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FLNAGeneProduct
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GAB1GeneProduct422456 (Entrez Gene)
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MARK2GeneProduct
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NALP4GeneProduct
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NFKBIAGeneProduct396093 (Entrez Gene)
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RASAL2GeneProduct429069 (Entrez Gene)
RCJMB04_11l21GeneProduct425619 (Entrez Gene)
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RCJMB04_17i9GeneProduct424044 (Entrez Gene)
RCJMB04_17o18GeneProduct427375 (Entrez Gene)
RCJMB04_19h23GeneProduct423669 (Entrez Gene)
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TNFGeneProduct
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TNFRSF11AGeneProduct769909 (Entrez Gene)
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UBCH5CGeneProduct
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YWHAQGeneProduct421932 (Entrez Gene)
ZFAND5GeneProduct427254 (Entrez Gene)

Annotated Interactions

No annotated interactions
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