Endochondral Ossification (Gallus gallus)

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1, 2HypertrophyintegrinsBMPsWNT signalingcanonical / non-canonicalCartilageRemoval of extracellular matrixand invasion by bone cellsOsteoblasticdifferentiation?GsChondrocyte deathDyingChondrocyte (pre)hypertrophyChondrocyte proliferationProliferationBoneVascular invastionCathepsinsand CalpainsFull differentiationMineralisationRemoval of cartilage matrixBMPR1APTCH1SOX9MMP13COL10A1ADAMTS5SOX5THRAKIF3APTHTHRAHDAC4Growth hormonePTHLHPLATRUNX2COL2A1CarminerinDDR2PTCH1ADAMTS4IFT88RUNX3MMP9Thyroid hormoneSCINVEGFAAKT1TNAPPTH1RIHHRCJMB04_17i9FGFR1TriiodothyroninePLAUTGFBIMEF2CENPP1SLC38A2FGFR3FRZBCALM1CDKN1CIGF2cAMPTIMP3SERPINH1BMP7HMGCS1RUNX2GHRADAMTS1PKAMGPSOX6IGF1ROsteopontinBapx1CHST11CTSL2OxygenSTAT5BALPLRUNX2TGFB2FGF18Thyroid hormoneIGF1BMP6ACANFGF2TGFB1GLI3CAB39


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP474(r29737) with a 78% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Belluoccio D, Bernardo BC, Rowley L, Bateman JF; ''A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage.''; Biochim Biophys Acta, 2008 PubMed Europe PMC Scholia
  2. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M; ''Endochondral ossification: how cartilage is converted into bone in the developing skeleton.''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
109470view11:01, 18 March 2020L DupuisConverted interaction lines to graphical lines where applicable
107112view14:19, 17 September 2019MaintBotChEBI identifier normalization
106127view12:02, 16 August 2019MaintBotHMDB identifier normalization
87978view13:18, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
72218view12:56, 27 October 2013EgonwFixed the ChEBI database name.
72178view22:20, 25 October 2013AlexanderPicoAdded missing metabolite identifiers.
68824view17:17, 8 July 2013MaintBotUpdated to 2013 gpml schema
40960view22:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
33887view17:55, 9 December 2009MaintBotAutomatic update of empty xrefs
33498view15:12, 30 November 2009MaintBotRemoved group label
31545view21:50, 13 August 2009MaintBotFixed text labels
30397view21:08, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACANGeneProduct395798 (Entrez Gene)
ADAMTS1GeneProduct418479 (Entrez Gene)
ADAMTS4GeneProduct
ADAMTS5GeneProduct427971 (Entrez Gene)
AKT1GeneProduct395928 (Entrez Gene)
ALPLGeneProduct396317 (Entrez Gene)
BMP6GeneProduct420868 (Entrez Gene)
BMP7GeneProduct395494 (Entrez Gene)
BMPR1AGeneProduct396308 (Entrez Gene)
Bapx1GeneProduct
CAB39GeneProduct424830 (Entrez Gene)
CALM1GeneProduct396523 (Entrez Gene)
CDKN1CGeneProduct
CHST11GeneProduct418081 (Entrez Gene)
COL10A1GeneProduct100126150 (Entrez Gene)
COL2A1GeneProduct395069 (Entrez Gene)
CTSL2GeneProduct427466 (Entrez Gene) Taken as homologue to mouse Cathepsin L (Ctsl)
CarminerinGeneProduct
  • Taken as human homologue of mouse Cst10
  • PMID: 13679380
DDR2GeneProduct396404 (Entrez Gene)
ENPP1GeneProduct426929 (Entrez Gene)
FGF18GeneProduct395453 (Entrez Gene)
FGF2GeneProduct396413 (Entrez Gene)
FGFR1GeneProduct396516 (Entrez Gene)
FGFR3GeneProduct396515 (Entrez Gene)
FRZBGeneProduct395545 (Entrez Gene)
GHRGeneProduct408184 (Entrez Gene)
GLI3GeneProduct420769 (Entrez Gene)
Growth hormoneGeneProduct
HDAC4GeneProduct374207 (Entrez Gene)
HMGCS1GeneProduct396379 (Entrez Gene)
IFT88GeneProduct418952 (Entrez Gene)
IGF1GeneProduct418090 (Entrez Gene)
IGF1RGeneProduct395889 (Entrez Gene)
IGF2GeneProduct395097 (Entrez Gene)
IHHGeneProduct395801 (Entrez Gene)
KIF3AGeneProduct416332 (Entrez Gene)
MEF2CGeneProduct769007 (Entrez Gene)
MGPGeneProduct395912 (Entrez Gene)
MMP13GeneProduct772008 (Entrez Gene)
MMP9GeneProduct395387 (Entrez Gene)
OsteopontinGeneProduct
OxygenMetaboliteHMDB0001377 (HMDB)
PKAGeneProduct
PLATGeneProduct426791 (Entrez Gene)
PLAUGeneProduct396424 (Entrez Gene)
PTCH1GeneProduct395806 (Entrez Gene)
PTH1RGeneProduct420401 (Entrez Gene)
PTHGeneProduct396436 (Entrez Gene)
PTHLHGeneProduct396281 (Entrez Gene)
RCJMB04_17i9GeneProduct424044 (Entrez Gene)
RUNX2GeneProduct373919 (Entrez Gene)
RUNX3GeneProduct769687 (Entrez Gene)
SCINGeneProduct420588 (Entrez Gene) PMID: 17097081
SERPINH1GeneProduct396228 (Entrez Gene)
SLC38A2GeneProduct417807 (Entrez Gene)
SOX5GeneProduct418195 (Entrez Gene)
SOX6GeneProduct423068 (Entrez Gene)
SOX9GeneProduct374148 (Entrez Gene)
STAT5BGeneProduct395556 (Entrez Gene)
TGFB1GeneProduct
TGFB2GeneProduct421352 (Entrez Gene)
TGFBIGeneProduct395897 (Entrez Gene)
THRAGeneProduct396251 (Entrez Gene)
TIMP3GeneProduct396483 (Entrez Gene)
TNAPGeneProduct
Thyroid hormoneMetaboliteCHEBI:60311 (ChEBI)
Thyroid hormoneMetaboliteT4
TriiodothyronineMetaboliteCHEBI:24864 (ChEBI)
VEGFAGeneProduct395909 (Entrez Gene)
cAMPMetaboliteHMDB0000058 (HMDB)

Annotated Interactions

No annotated interactions
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