p38 MAPK signaling pathway (Pan troglodytes)

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1-8?TranslationCytokines Production,Apoptosis, etc.??Growth Factors, UVTrophic Factors, etc.Stress: Osmotic shockg-radiation, Anisomycin??FASL, InflammatoryCytokines, UV, etc.DNA transcriptionMAPKAPK5MAPKAPK2MEF2DDDIT3ATF2HSPB1MAP3K9TRADDPLA2G4ARAC1GRB2TGFBR1MAP2K4MAXMAP2K6MAP3K1ELK1SHC1ApoptosisTGFB2STAT1HRASRPS6KA5RASGRF1MAP3K7DAXXHMGN1CDC42TRAF2CREB1MAPKAPK2MAPK14MKNK1MAPK14RIPK1MYCMAP3K5Transcription factors


Description

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP400 (r95117) with a 100.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG; ''Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry.''; Mol Cell, 2000 PubMed Europe PMC Scholia
  2. Kyriakis JM; ''Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses.''; Biochem Soc Symp, 1999 PubMed Europe PMC Scholia
  3. Li S, Wattenberg EV; ''Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin.''; Toxicol Appl Pharmacol, 1999 PubMed Europe PMC Scholia
  4. Roberson MS, Zhang T, Li HL, Mulvaney JM; ''Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone.''; Endocrinology, 1999 PubMed Europe PMC Scholia
  5. Herlaar E, Brown Z; ''p38 MAPK signalling cascades in inflammatory disease.''; Mol Med Today, 1999 PubMed Europe PMC Scholia
  6. Ichijo H; ''From receptors to stress-activated MAP kinases.''; Oncogene, 1999 PubMed Europe PMC Scholia
  7. Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ; ''Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.''; Proc Natl Acad Sci U S A, 1999 PubMed Europe PMC Scholia
  8. Tibbles LA, Woodgett JR; ''The stress-activated protein kinase pathways.''; Cell Mol Life Sci, 1999 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116818view10:15, 14 May 2021EweitzModified title
111162view09:24, 21 July 2020EgonwMade another pathway clickable
95746view13:50, 19 January 2018MkutmonHomology conversion update
95121view15:04, 16 November 2017Mkutmonadded missing homology converter comment source
71864view21:20, 18 October 2013MaintBotModified title
69264view18:38, 8 July 2013MaintBotUpdated to 2013 gpml schema
67572view11:27, 26 June 2013DdiglesOntology Term : 'p38 MAPK signaling pathway' added !
41572view02:00, 2 March 2011MaintBotRemoved redundant pathway information and comments
38248view21:26, 27 August 2010KhanspersRemoved receptor and protein complex graphics
38247view21:25, 27 August 2010Khanspers
35700view23:12, 12 February 2010KhanspersDescription and Bibliography
34300view22:05, 9 December 2009MaintBotAutomatic update of empty xrefs
33574view09:47, 1 December 2009MaintBotRemoved group label
31599view22:08, 13 August 2009MaintBotFixed text labels
30487view21:37, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATF2GeneProductENSPTRG00000012660 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1386
ApoptosisPathwayWP254 (WikiPathways)
CDC42GeneProductENSPTRG00000051031 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:998
CREB1GeneProductENSPTRG00000043959 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1385
DAXXGeneProductENSPTRG00000018045 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1616
DDIT3GeneProductENSPTRG00000022781 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1649
ELK1GeneProductENSPTRG00000021850 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2002
GRB2GeneProductENSPTRG00000009642 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2885
HMGN1GeneProductENSPTRG00000031426 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3150
HRASGeneProductENSPTRG00000034469 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3265
HSPB1GeneProductENSPTRG00000019319 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3315
MAP2K4GeneProductENSPTRG00000008783 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6416
MAP2K6GeneProductENSPTRG00000009588 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5608
MAP3K1GeneProductENSPTRG00000016891 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4214
MAP3K5GeneProductENSPTRG00000024326 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4217
MAP3K7GeneProductENSPTRG00000018427 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6885
MAP3K9GeneProductENSPTRG00000006499 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4293
MAPK14GeneProductENSPTRG00000018097 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1432
MAPKAPK2GeneProductENSPTRG00000001915 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9261
MAPKAPK5GeneProductENSPTRG00000005465 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8550
MAXGeneProductENSPTRG00000006449 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4149
MEF2DGeneProductENSPTRG00000001460 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4209
MKNK1GeneProductENSPTRG00000046874 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8569
MYCGeneProductENSPTRG00000020581 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4609
PLA2G4AGeneProductENSPTRG00000001787 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5321
RAC1GeneProductENSPTRG00000052694 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5879
RASGRF1GeneProductENSPTRG00000007353 (Ensembl)
  • PDZ domain containing guanine nucleotide exchange
  • Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5923
RIPK1GeneProductENSPTRG00000017672 (Ensembl)
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
  • Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8737
RPS6KA5GeneProductENSPTRG00000006631 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9252
SHC1GeneProductENSPTRG00000001397 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6464
STAT1GeneProductENSPTRG00000012749 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6772
TGFB2GeneProductENSPTRG00000001992 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7042
TGFBR1GeneProductENSPTRG00000021182 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7046
TRADDGeneProductENSPTRG00000008215 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8717
TRAF2GeneProductENSPTRG00000021578 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7186

Annotated Interactions

No annotated interactions
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