ErbB signaling pathway (Pan troglodytes)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none (EGFR)(HER2/Neu)Ca+2DGERIP3Cellular targets+pReceptor ubiquitylationDegradationDNA+pAdhesionMigrationDNA+p+pPancreaticCancerNon-smallcell lungcancerProliferationSurvivalAngiogenesisActivation by ErbB2overexpression (cancers)MAPK signalingpathwayNo signaling+pDNAAdhesionDNAMigration / InvasionPIP3ProteinsynthesisCell survivalMetabolismCell cycleprogression+pDifferentiationmTor signaling pathwayCell cycleGliomaEndometrialcancer+pERBB SIGNALING PATHWAY+p+p+pCalcium signaling pathway+p+p+p+p+p+p+p+pCellular targets+pEGFTGFAAREGBTCHBEGFEREGNRG1NRG2NRG3NRG4EGFRERBB2ERBB3ERBB4EGFREGFRERBB2ERBB2ERBB3ERBB2ERBB3ERBB4ERBB2ERBB4PLCG1CAMK2APRKCACBLSTAT5ASRCPTK2CRKABL1NCK1PAK4MAP2K7MAPK8JUNSHCGRB2SOS1HRASARAFMAP2K1MAPK1GRB2STAT5AMYCELKGAB1PIK3R5PKB/AktmTORBADGSK3BCDKN1BCDKN1ARPS6KB1EIF4EBP1ELKName: ErbB signaling pathwayOrganism: Pan troglodytes


Description

The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. In mice loss of signaling by any member of the ErbB family results in embryonic lethality with defects in organs including the lungs, skin, heart and brain. Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are found in many human cancers and their excessive signaling may be critical factors in the development and malignancy of these tumors.

The ErbB protein family consists of 4 members

   * ErbB-1, also named epidermal growth factor receptor (EGFR)
   * ErbB-2, also named HER2 in humans and neu in rodents
   * ErbB-3, also named HER3 and
   * ErbB-4, also named HER4

The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher order oligomers upon activation by a subset of potential growth factor ligands.


Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP673(r29836) with a 71% conversion rate.

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Quality Tags

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Homology Converted

Ontology Terms

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
108172view10:49, 29 November 2019FehrhartOntology Term : 'cancer' added !
108171view10:49, 29 November 2019FehrhartOntology Term : 'multiple sclerosis' added !
108170view10:49, 29 November 2019FehrhartOntology Term : 'Alzheimer's disease' added !
88000view13:26, 25 July 2016SusanOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
69263view18:37, 8 July 2013MaintBotUpdated to 2013 gpml schema
41571view02:00, 2 March 2011MaintBotRemoved redundant pathway information and comments
34299view22:04, 9 December 2009MaintBotAutomatic update of empty xrefs
31601view22:09, 13 August 2009MaintBotFixed text labels
30493view21:39, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ABL1GeneProduct464802 (Entrez Gene)
ARAFGeneProduct
AREGGeneProduct461251 (Entrez Gene)
BADGeneProduct
BTCGeneProduct461250 (Entrez Gene)
CAMK2AGeneProduct462189 (Entrez Gene)
CBLGeneProduct451690 (Entrez Gene)
CDKN1AGeneProduct747442 (Entrez Gene)
CDKN1BGeneProduct466947 (Entrez Gene)
CRKGeneProduct747142 (Entrez Gene)
EGFGeneProduct461435 (Entrez Gene)
EGFRGeneProduct463415 (Entrez Gene)
EIF4EBP1GeneProduct464114 (Entrez Gene)
ELKGeneProduct
ERBB2GeneProduct
ERBB3GeneProduct451980 (Entrez Gene)
ERBB4GeneProduct459919 (Entrez Gene)
EREGGeneProduct740028 (Entrez Gene)
GAB1GeneProduct461516 (Entrez Gene)
GRB2GeneProduct737245 (Entrez Gene)
GSK3BGeneProduct470896 (Entrez Gene)
HBEGFGeneProduct735979 (Entrez Gene)
HRASGeneProduct466302 (Entrez Gene)
JUNGeneProduct456893 (Entrez Gene)
MAP2K1GeneProduct450188 (Entrez Gene)
MAP2K7GeneProduct743199 (Entrez Gene)
MAPK1GeneProduct458680 (Entrez Gene)
MAPK8GeneProduct450445 (Entrez Gene)
MYCGeneProduct464393 (Entrez Gene)
NCK1GeneProduct460720 (Entrez Gene)
NRG1GeneProduct464102 (Entrez Gene)
NRG2GeneProduct471648 (Entrez Gene)
NRG3GeneProduct466296 (Entrez Gene)
NRG4GeneProduct453770 (Entrez Gene)
PAK4GeneProduct
PIK3R5GeneProduct455085 (Entrez Gene)
PKB/AktGeneProduct
PLCG1GeneProduct458253 (Entrez Gene)
PRKCAGeneProduct454832 (Entrez Gene)
PTK2GeneProduct464422 (Entrez Gene)
RPS6KB1GeneProduct468426 (Entrez Gene)
SHCGeneProduct
SOS1GeneProduct459171 (Entrez Gene)
SRCGeneProduct458229 (Entrez Gene)
STAT5AGeneProduct454681 (Entrez Gene)
TGFAGeneProduct737080 (Entrez Gene)
mTORGeneProduct457945 (Entrez Gene)

Annotated Interactions

No annotated interactions
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