Aflatoxin B1 metabolism (Pan troglodytes)

From WikiPathways

Jump to: navigation, search
1-5, 7, 8, 106, 96, 9nonenzymatic(pH-dependent)DNA adductsnonenzymaticAflatoxin B1 C6-monoalcoholCYP2A13Aflatoxin B1-6,8-dialcoholAflatoxin B1 exo-8,9-epoxideAflatoxin M1 epoxideQ9N256_PANTRaflatoxin B1Aflatoxin B1 8,9-dihydrodiolAflatoxin B1 exo-8,9-epoxide-GSHAflatoxin B1 dialdehydeB1NL93_PANTRB1NL93_PANTRAflatoxin-endo-B1-8,9-epoxideQ9N256_PANTRAflatoxin B1 C8-monoalcoholAflatoxin B1 C8-monoaldehydeAflatoxin Q1AKR7A2XR_022976.1Q9N256_PANTRGSTT1CYP2A13GSTM1AKR7A3Aflatoxin M1Aflatoxin B1 C6-monoaldehyde


Description

Aflatoxins are naturally occurring mycotoxins that are produced by many species of Aspergillus, a fungus, most notably Aspergillus flavus and Aspergillus parasiticus. After entering the body, aflatoxins are metabolized by the liver to a reactive intermediate, aflatoxin M1, an epoxide. Aflatoxin B1 is considered the most toxic and is produced by both Aspergillus flavus and Aspergillus parasiticus. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP699(r30253) with a 83% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Stewart RK, Smith GB, Donnelly PJ, Reid KR, Petsikas D, Conlan AA, Massey TE; ''Glutathione S-transferase-catalyzed conjugation of bioactivated aflatoxin B(1) in human lung: differential cellular distribution and lack of significance of the GSTM1 genetic polymorphism.''; Carcinogenesis, 1999 PubMed Europe PMC Scholia
  2. Jin Y, Penning TM; ''Aldo-keto reductases and bioactivation/detoxication.''; Annu Rev Pharmacol Toxicol, 2007 PubMed Europe PMC Scholia
  3. Guengerich FP; ''Cytochrome P450s and other enzymes in drug metabolism and toxicity.''; AAPS J, 2006 PubMed Europe PMC Scholia
  4. Guengerich FP, Cai H, McMahon M, Hayes JD, Sutter TR, Groopman JD, Deng Z, Harris TM; ''Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases.''; Chem Res Toxicol, 2001 PubMed Europe PMC Scholia
  5. Tiemersma EW, Omer RE, Bunschoten A, van't Veer P, Kok FJ, Idris MO, Kadaru AM, Fedail SS, Kampman E; ''Role of genetic polymorphism of glutathione-S-transferase T1 and microsomal epoxide hydrolase in aflatoxin-associated hepatocellular carcinoma.''; Cancer Epidemiol Biomarkers Prev, 2001 PubMed Europe PMC Scholia
  6. He XY, Tang L, Wang SL, Cai QS, Wang JS, Hong JY; ''Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract.''; Int J Cancer, 2006 PubMed Europe PMC Scholia
  7. Kensler TW, Qian GS, Chen JG, Groopman JD; ''Translational strategies for cancer prevention in liver.''; Nat Rev Cancer, 2003 PubMed Europe PMC Scholia
  8. Guengerich FP, Arneson KO, Williams KM, Deng Z, Harris TM; ''Reaction of aflatoxin B(1) oxidation products with lysine.''; Chem Res Toxicol, 2002 PubMed Europe PMC Scholia
  9. Zhu LR, Thomas PE, Lu G, Reuhl KR, Yang GY, Wang LD, Wang SL, Yang CS, He XY, Hong JY; ''CYP2A13 in human respiratory tissues and lung cancers: an immunohistochemical study with a new peptide-specific antibody.''; Drug Metab Dispos, 2006 PubMed Europe PMC Scholia
  10. Barski OA, Tipparaju SM, Bhatnagar A; ''The aldo-keto reductase superfamily and its role in drug metabolism and detoxification.''; Drug Metab Rev, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106938view13:40, 17 September 2019MaintBotHMDB identifier normalization
69252view18:36, 8 July 2013MaintBotUpdated to 2013 gpml schema
67033view09:56, 26 June 2013Christine ChichesterOntology Term : 'aflatoxin metabolic pathway' added !
58907view04:48, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
57008view14:19, 19 January 2013EgonwCorrected to the correct PubChem-compound data source.
57007view14:19, 19 January 2013EgonwHorizontally aligned to top boxes.
41559view01:59, 2 March 2011MaintBotRemoved redundant pathway information and comments
35015view08:25, 11 February 2010ThomasModified description
33579view09:49, 1 December 2009MaintBotRemoved group label
31602view22:09, 13 August 2009MaintBotFixed text labels
30494view21:40, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKR7A2GeneProductENSPTRG00000000265 (Ensembl)
AKR7A3GeneProductENSPTRG00000000264 (Ensembl)
Aflatoxin B1 8,9-dihydrodiolMetabolite3035008 (PubChem-compound)
Aflatoxin B1 C6-monoalcoholMetabolite
Aflatoxin B1 C6-monoaldehydeMetabolite
Aflatoxin B1 C8-monoalcoholMetabolite
Aflatoxin B1 C8-monoaldehydeMetabolite
Aflatoxin B1 dialdehydeMetabolite
Aflatoxin B1 exo-8,9-epoxide-GSHMetabolite5460816 (PubChem-compound)
Aflatoxin B1 exo-8,9-epoxideMetabolite104756 (PubChem-compound)
Aflatoxin B1-6,8-dialcoholMetabolite
Aflatoxin M1 epoxideMetabolite
Aflatoxin M1Metabolite15558498 (PubChem-compound)
Aflatoxin Q1Metabolite104757 (PubChem-compound)
Aflatoxin-endo-B1-8,9-epoxideMetabolite
B1NL93_PANTRGeneProductENSPTRG00000019460 (Ensembl)
CYP2A13GeneProduct
GSTM1GeneProductENSPTRG00000001061 (Ensembl)
GSTT1GeneProductENSPTRG00000014166 (Ensembl)
Q9N256_PANTRGeneProductENSPTRG00000007281 (Ensembl)
XR_022976.1GeneProductENSPTRG00000002039 (Ensembl)
aflatoxin B1MetaboliteHMDB0006552 (HMDB)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP925"
Personal tools