Transforming growth factor (TGF) beta receptor signaling pathway (Pan troglodytes)

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NUNUMitochondriaCYERRecruitmentCYPlasma membraneDesumoylationNUCYDeacetylationEnzyme complexCYMTGlycosylation(Protein-protein interaction)ControlUbiquitinationNUNUReceptorNUDeubiquitinationENNU -> CYNUNUCYNUDephosphorylationNULigandMethylationGolgi apparatusExtracellularNUCYNUCYReaction through unknown mechanisms/moleculesCYCYCYCYPMGOCYCYEndoplasmic reticulumECNUNucleusPalmitoylationCYNUProteins in a complex interactionAcetylationNUNU -> CYNUCytoplasmNUCYCYCYNUCYNUNUEndosomeGlycosylationDemethylationNUNUCYCYInhibitionCYCYCYTranslocationNUNUAutophosphorylationNUCYDActivationCYAccession Number: NetPath 7; cellmap:7Molecule in the pathwayNUPhosphorylationNUCYCYSumoylationMolecular associationProteolytic cleavageSTK11IPTGFBR3SMAD3PRKCB1TGFBR2Gene SymbolSMURF1KPNB1LOC464259CAV1PIAS1CUL1CTCFARCDK4NFYCTGFBR2SMAD3UBE2D2E2F5FNTATP73NUP153AP2B1UBE2D1STRAPANAPC5TGFBR3MAPK14APC10CAMK2DTGFBR3ANAPC4SNX6YAP1SKIFOXO4MEF2CRBX1SMAD7PIK3R2ANAPC2SMURF2RBL1E2F4RBX1TGFBR1RBL2CDC23MAPK8TGFB1PRKCGTGFB3RBL2ANAPC4PRKCDSMAD7RBL1SKILNUP214TGFBR3TGFB2EIF3S2ZEB2MAP3K7CITED1CUL1PIAS2TFDP2STRAPJUNDSDC2SMURF2SMAD2E2F5PPP2R2AATF2TGFBR2TGFBR2FKBP1ALEF1HOXA9SMAD3E2F5NFYAMAP2K3HSPA8ANAPC7E2F4TGFB2MEF2ASMAD4TP53CDC27SMAD3SPARCPRKAR1BTGFB2RBX1SMAD4SKP1E2F4TCF8CDC27ESR1TGFBR2SMAD3APC10AXIN2TGFB1CDKN1ATFDP1CDC16CDC16CAMK2ATGFBR2TGFB3SMAD4TFDP2E2F5PARD3TGFBR2FOXO3ACTNNB1RUNX2E2F4SMAD3ESR1TGFB3BTRCCAMK2GPIK3R1E2F4SNX6SNW1CCNB2MAP2K6SMAD4ARRB2FZR1FOXO1BTRCATF3TGFB1AXIN1CDC23TGFB1CUL1ERBB2IPRBL1MAP3K7IP1KPNB1SNX1FOXG1BDAXXENGSMAD3SP1PRKAR2ARB1CDC27RBL1STK11EP300CRI2SMAD2UBE2D3PRB1SMAD3COPS5TGFBR1TFDP1DVL1ROCK1FOSBCCNE1GIPC1KAT2BRBL1CDC2SMAD2MAPK14SMAD4XPO1SMAD6TGFB3ACVRL1TGFBR1NCOA1SKP1JUNBDAB2TGFBR3SMAD2TGFBR2TGFBR1CREBBPANAPC1MAPK8E2F4SMAD7ANAPC2CD44SUMO1TGIF1SNX2TGFBR2DCP1AFOXH1CDK6ANAPC7CDC25AMYCDCP1AHNF4ANFYBSTAMBPL1FOSCDK2TRAP1TFDP2TFDP1TGFBR3E2F5E2F5ANAPC5RB1SMURF1CAMK2BZFYVE9ROCK1VDRSMAD3JUNTGFBR2ETS1HGSANAPC1SMAD4CCND1SNIP1SNX4


Description

No description

Comments

GenMAPP notes 
NetPath 7; cellmap:7 - TGF-beta Receptor Signaling Pathway

The TGF-beta Receptor Signaling pathway was kindly reviewed by Van Le Hong, Wei He and other members of Joan Massague’s lab. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP366(r21445) with a 88% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
118021view11:36, 23 May 2021EweitzModified title
87746view09:48, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
87744view09:47, 25 July 2016MirellaKalafatiModified title
69312view18:43, 8 July 2013MaintBotUpdated to 2013 gpml schema
41622view02:03, 2 March 2011MaintBotRemoved redundant pathway information and comments
34350view22:22, 9 December 2009MaintBotAutomatic update of empty xrefs
31603view22:09, 13 August 2009MaintBotFixed text labels
30495view21:40, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACVRL1GeneProduct451910 (Entrez Gene)
ANAPC1GeneProduct735949 (Entrez Gene)
ANAPC2GeneProduct465174 (Entrez Gene)
ANAPC4GeneProduct461149 (Entrez Gene)
ANAPC5GeneProduct452321 (Entrez Gene)
ANAPC7GeneProduct467128 (Entrez Gene)
AP2B1GeneProduct454587 (Entrez Gene)
APC10GeneProduct
ARGeneProduct747460 (Entrez Gene)
ARRB2GeneProduct454450 (Entrez Gene)
ATF2GeneProduct
ATF3GeneProduct469143 (Entrez Gene)
AXIN1GeneProduct453789 (Entrez Gene)
AXIN2GeneProduct468301 (Entrez Gene)
BTRCGeneProduct450685 (Entrez Gene)
CAMK2AGeneProduct462189 (Entrez Gene)
CAMK2BGeneProduct
CAMK2DGeneProduct461445 (Entrez Gene)
CAMK2GGeneProduct738330 (Entrez Gene)
CAV1GeneProduct463670 (Entrez Gene)
CCNB2GeneProduct453478 (Entrez Gene)
CCND1GeneProduct747688 (Entrez Gene)
CCNE1GeneProduct455914 (Entrez Gene)
CD44GeneProduct451122 (Entrez Gene)
CDC16GeneProduct452688 (Entrez Gene)
CDC23GeneProduct462092 (Entrez Gene)
CDC2GeneProduct450481 (Entrez Gene)
CDC25AGeneProduct460341 (Entrez Gene)
CDC27GeneProduct454815 (Entrez Gene)
CDK2GeneProduct467032 (Entrez Gene)
CDK4GeneProduct452025 (Entrez Gene)
CDK6GeneProduct746968 (Entrez Gene)
CDKN1AGeneProduct747442 (Entrez Gene)
CITED1GeneProduct465711 (Entrez Gene)
COPS5GeneProduct744682 (Entrez Gene)
CREBBPGeneProduct467891 (Entrez Gene)
CRI2GeneProduct
CTCFGeneProduct454169 (Entrez Gene)
CTNNB1GeneProduct450183 (Entrez Gene)
CUL1GeneProduct463821 (Entrez Gene)
DAB2GeneProduct461905 (Entrez Gene)
DAXXGeneProduct462613 (Entrez Gene)
DCP1AGeneProduct460444 (Entrez Gene)
DVL1GeneProduct457191 (Entrez Gene)
E2F4GeneProduct454158 (Entrez Gene)
E2F5GeneProduct747256 (Entrez Gene)
EIF3S2GeneProduct
ENGGeneProduct741046 (Entrez Gene)
EP300GeneProduct458862 (Entrez Gene)
ERBB2IPGeneProduct471527 (Entrez Gene)
ESR1GeneProduct463079 (Entrez Gene)
ETS1GeneProduct
FKBP1AGeneProduct749347 (Entrez Gene)
FNTAGeneProduct472929 (Entrez Gene)
FOSGeneProduct453047 (Entrez Gene)
FOSBGeneProduct456127 (Entrez Gene)
FOXG1BGeneProduct
FOXH1GeneProduct464468 (Entrez Gene)
FOXO1GeneProduct467352 (Entrez Gene)
FOXO3AGeneProduct
FOXO4GeneProduct473659 (Entrez Gene)
FZR1GeneProduct
GIPC1GeneProduct747668 (Entrez Gene)
Gene SymbolGeneProduct
HGSGeneProduct454966 (Entrez Gene)
HNF4AGeneProduct458269 (Entrez Gene)
HOXA9GeneProduct745701 (Entrez Gene)
HSPA8GeneProduct451629 (Entrez Gene)
JUNGeneProduct456893 (Entrez Gene)
JUNBGeneProduct468739 (Entrez Gene)
JUNDGeneProduct748667 (Entrez Gene)
KAT2BGeneProduct460219 (Entrez Gene)
KPNB1GeneProduct455176 (Entrez Gene)
LEF1GeneProduct461425 (Entrez Gene)
LOC464259GeneProduct464259 (Entrez Gene)
MAP2K3GeneProduct454515 (Entrez Gene)
MAP2K6GeneProduct468310 (Entrez Gene)
MAP3K7GeneProduct462888 (Entrez Gene)
MAP3K7IP1GeneProduct458845 (Entrez Gene)
MAPK14GeneProduct450161 (Entrez Gene)
MAPK8GeneProduct450445 (Entrez Gene)
MEF2AGeneProduct453680 (Entrez Gene)
MEF2CGeneProduct461760 (Entrez Gene)
MYCGeneProduct464393 (Entrez Gene)
NCOA1GeneProduct459068 (Entrez Gene)
NFYAGeneProduct748395 (Entrez Gene)
NFYBGeneProduct452191 (Entrez Gene)
NFYCGeneProduct456799 (Entrez Gene)
NUP153GeneProduct462455 (Entrez Gene)
NUP214GeneProduct464807 (Entrez Gene)
PARD3GeneProduct450398 (Entrez Gene)
PIAS1GeneProduct467715 (Entrez Gene)
PIAS2GeneProduct455403 (Entrez Gene)
PIK3R1GeneProduct461836 (Entrez Gene)
PIK3R2GeneProduct455855 (Entrez Gene)
PPP2R2AGeneProduct464068 (Entrez Gene)
PRKAR1BGeneProduct
PRKAR2AGeneProduct
PRKCB1GeneProduct
PRKCDGeneProduct
PRKCGGeneProduct456276 (Entrez Gene)
RB1GeneProduct452715 (Entrez Gene)
RBL1GeneProduct735916 (Entrez Gene)
RBL2GeneProduct467978 (Entrez Gene)
RBX1GeneProduct458860 (Entrez Gene)
ROCK1GeneProduct455326 (Entrez Gene)
RUNX2GeneProduct472017 (Entrez Gene)
SDC2GeneProduct
SKIGeneProduct
SKILGeneProduct460844 (Entrez Gene)
SKP1GeneProduct462063 (Entrez Gene)
SMAD2GeneProduct455407 (Entrez Gene)
SMAD3GeneProduct748161 (Entrez Gene)
SMAD4GeneProduct468537 (Entrez Gene)
SMAD6GeneProduct467711 (Entrez Gene)
SMAD7GeneProduct455411 (Entrez Gene)
SMURF1GeneProduct472670 (Entrez Gene)
SMURF2GeneProduct454761 (Entrez Gene)
SNIP1GeneProduct456759 (Entrez Gene)
SNW1GeneProduct453073 (Entrez Gene)
SNX1GeneProduct453503 (Entrez Gene)
SNX2GeneProduct462022 (Entrez Gene)
SNX4GeneProduct460652 (Entrez Gene)
SNX6GeneProduct467421 (Entrez Gene)
SP1GeneProduct451939 (Entrez Gene)
SPARCGeneProduct471709 (Entrez Gene)
STAMBPL1GeneProduct466147 (Entrez Gene)
STK11GeneProduct468641 (Entrez Gene)
STK11IPGeneProduct459968 (Entrez Gene)
STRAPGeneProduct465315 (Entrez Gene)
SUMO1GeneProduct459882 (Entrez Gene)
TCF8GeneProduct
TFDP1GeneProduct465967 (Entrez Gene)
TFDP2GeneProduct460743 (Entrez Gene)
TGFB1GeneProduct456060 (Entrez Gene)
TGFB2GeneProduct457742 (Entrez Gene)
TGFB3GeneProduct453054 (Entrez Gene)
TGFBR1GeneProduct472992 (Entrez Gene)
TGFBR2GeneProduct460243 (Entrez Gene)
TGFBR3GeneProduct457016 (Entrez Gene)
TGIF1GeneProduct455312 (Entrez Gene)
TP53GeneProduct455214 (Entrez Gene)
TP73GeneProduct
TRAP1GeneProduct453868 (Entrez Gene)
UBE2D1GeneProduct745141 (Entrez Gene)
UBE2D2GeneProduct462108 (Entrez Gene)
UBE2D3PGeneProduct745118 (Entrez Gene)
VDRGeneProduct
XPO1GeneProduct459534 (Entrez Gene)
YAP1GeneProduct451506 (Entrez Gene)
ZEB2GeneProduct459644 (Entrez Gene)
ZFYVE9GeneProduct456855 (Entrez Gene)

Annotated Interactions

No annotated interactions
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