TNF-alpha NF-kB signaling pathway (Pan troglodytes)

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Proteolytic cleavageERGolgi apparatusSumoylationDephosphorylationReaction through unknown mechanisms/moleculesMTDemethylationActivationTranslocationPalmitoylationGOUbiquitinationLigandDeubiquitinationCY ->NUECReceptorRecruitmentEN(Protein-protein interaction)Endoplasmic reticulumExtracellularMolecular associationCY ->NUCY ->NUEndosomeGlycosylationNucleusDMolecule in the pathwayNUProteins in a complex interactionDeacetylationInhibitionEnzyme complexDesumoylationCY ->NUPMAutophosphorylationPlasma membraneCYMitochondrionAcetylationControlAccession Number: NetPath 9; cellmap:9MethylationCY ->NUCytoplasmPhosphorylationTRADDPSMD13TNIP1WDR68TXLNACHUKCREBBPPMLTNFBIRC2YWHAGFADDNFKBIATNFRSF11APIAS3NFKB1GLG1TRAF6ACTL6APPP1R13LIKBKESRCDPF2TRADDKCNQ1LOC737497GeneGNB2L1RPL6GSK3BIQGAP2FLNACDC37AZI2RNF216PDCD2TNFRSF8KTN1UNC5CLGTF2IBCL7ALOC464259RPL30PSMC3RELBMAP3K3MAP3K7IP2KPNA3COPS3NFKB1TAB3MAP3K8TBK1NLRP4PSMD1POLR1BRIPK2STAT1PPP2CANFKBIZKPNA6SMARCE1Gene SymbolCASP10LOC464047POLR1CMTIF2YWHAZHIST3H3PAPOLANFKBIETRAF5YWHAHUBE2IRPL4PTPN11DDX3PSMD12TRAIPNR2C2PSMD3KPNA2RELGAB1AKT1RELTBK1EIF4A3GeneBCL3CRADDCAV1G3BP2IKBKGFAF1BTRCCHUKTRAF2UBE2D2RELAUBE2D3PPOLR1DPKN1PSMC2CUL1BIRC3MAP2K5FBXW11MAP3K7IP1POLR1EGeneLOC462950TNFRIPK1TNFCOMMD1ALPLRELBPOLR2LMAP3K14POLR2HNR2C2MCM7SMARCB1CYLDYWHABUSP11NFKB2MARK2RIPK3IKBKGNFKBIASMARCA4TNFRSF1ARPS11TNFRSF1BLRPPRCCDC34CD3EAPPEBP1TNFGeneTRAF1RPS6KB1RELAAKT2FANCD2RPL8BIRC3SMARCC1AKAP8TNFAIP3PRKACAMCCTNFCSNK2BIKBKAPHSPB1NKIRAS2TNFRSF1ATRAF4PRKCZRPS13NKIRAS1PFDN2SMARCC2IKBKBSUMO1CASP3TANKMCM5BIRC2RNF25NFKBIACAPN3TNFMAP3K2NFKBIBCFLARTIFACSNK2A1USP2RIPK1TRAF2RPS6KA5TRAF1TNIP2TRPC4APCASP7TRAF3TNFRSF1BCASP8TNFRSF1BPSMD7YWHAQPTK2PEG3FBLTNFRSF1ARELAHSP90AA1PSMB5PSMD6DAPRASAL2CSNK2A2SKP1BAG4ZFAND5CASP2POLR1ATRAF2NSMAFTRAF4HDAC6MAP3K3NFKB1PSMC1FKBP5CASP8AP2RELAMAP3K1YWHAE


Description

No description

Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 81% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
118010view11:31, 23 May 2021EweitzModified title
108150view10:36, 29 November 2019FehrhartOntology Term : 'cancer' added !
87790view11:14, 25 July 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
87789view11:14, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
69230view18:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
41534view01:57, 2 March 2011MaintBotRemoved redundant pathway information and comments
34270view21:54, 9 December 2009MaintBotAutomatic update of empty xrefs
33581view09:49, 1 December 2009MaintBotRemoved group label
31605view22:10, 13 August 2009MaintBotFixed text labels
30498view21:41, 29 July 2009MaintBotNew pathway

External references

DataNodes

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Annotated Interactions

No annotated interactions
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