Eukaryotic transcription initiation (Pan troglodytes)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none TATA5353dsDNAGroup objectTATA5335TFIIDTFIIBGroup object5353TFIIFTATAGroup object5353Group object35Primary RNA transcriptGroup objectTFIIFRNA pol IIGroup objectRNA polymerase II(mRNA, snRNPs)RNA polymerase I(large ribosomal RNAs)RNA polymerase III(small stable RNAs)POLR1BPOLR3BPOLR2APOLR2FPOLR2CPOLR2EPOLR2KPOLR3DPOLR3EPOLR3HPOLR3KPOLR1APOLR2IPOLR2GPOLR2HPOLR2JPOLR2BPOLR1EPOLR1D5cell growthGene Regulatory Proteins(recognize surface DNA geometry)Transcription Initiation Factors (TIFs)TFIIHTFIIETATA Box bindingproteinSteps 1) TBP binds TATA boxSteps 2) Association of TIFs and RNA polymeraseSteps 3) DNA melting by association with TFIIHSteps 4) Transcription elongation by NTPsSteps 5) RNA elongation with CDT phosphorylationTFIIATFIIHCDK7GTF2H1GTF2H2GTF2H4ERCC3ERCC2CCNHMNAT1GTF2H3TFIIFGTF2F2TFIIAGTF2A2TFIIEGTF2E1GTF2E2TFIIBGTF2BTFIIDTAF5TAF6TAF7LOC100612178ILKTAF12TAF13TBPName: Eukaryotic transcription initiationLicense: CC BY 2.0Last Modified: 5/9/2012Organism: Pan troglodytes


Description

In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: [Wikipedia](https://en.wikipedia.org/wiki/Transcription_(biology))

Comments

GenMAPP notes 
Reference: http://www.web-books.com/MoBio/Free/Ch4E.htm
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP405(r41116) with a 92% conversion rate.

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Quality Tags

Image:Curated.pngApproved version
Image:Unconnected.pngFix interactions
Image:MissingXref.pngAnnotate nodes
Homology Converted

Ontology Terms

 

Bibliography

  1. Lemon B, Tjian R; ''Orchestrated response: a symphony of transcription factors for gene control.''; Genes Dev, 2000 PubMed Europe PMC Scholia
  2. Lee TI, Young RA; ''Regulation of gene expression by TBP-associated proteins.''; Genes Dev, 1998 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
136953
Approved
view19:50, 26 February 2025KhanspersModified description
117391view10:32, 21 May 2021EweitzModified title
69257view18:37, 8 July 2013MaintBotUpdated to 2013 gpml schema
67218view10:22, 26 June 2013Christine ChichesterOntology Term : 'transcription pathway' added !
48168view20:29, 9 May 2012MaintBotUpdating from human to fix xrefs
41564view01:59, 2 March 2011MaintBotRemoved redundant pathway information and comments
35526view13:57, 12 February 2010Thomasadded literature
35514view13:49, 12 February 2010ThomasModified description
34293view22:02, 9 December 2009MaintBotAutomatic update of empty xrefs
33597view09:55, 1 December 2009MaintBotRemoved group label
31618view22:17, 13 August 2009MaintBotFixed text labels
30517view21:48, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
CCNHGeneProduct739351 (Entrez Gene)
CDK7GeneProduct462378 (Entrez Gene)
ERCC2GeneProduct456124 (Entrez Gene)
ERCC3GeneProduct470526 (Entrez Gene)
GTF2A2GeneProduct453483 (Entrez Gene)
GTF2BGeneProduct743356 (Entrez Gene)
GTF2E1GeneProduct
GTF2E2GeneProduct464098 (Entrez Gene)
GTF2F2GeneProduct741868 (Entrez Gene)
GTF2H1GeneProduct748842 (Entrez Gene)
GTF2H2GeneProduct461830 (Entrez Gene)
GTF2H3GeneProduct452352 (Entrez Gene)
GTF2H4GeneProduct462549 (Entrez Gene)
ILKGeneProduct748941 (Entrez Gene)
LOC100612178GeneProduct100612178 (Entrez Gene)
MNAT1GeneProduct452954 (Entrez Gene)
POLR1AGeneProduct459373 (Entrez Gene)
POLR1BGeneProduct459495 (Entrez Gene)
POLR1DGeneProduct
POLR1EGeneProduct747551 (Entrez Gene)
POLR2AGeneProduct454463 (Entrez Gene)
POLR2BGeneProduct461305 (Entrez Gene)
POLR2CGeneProduct454119 (Entrez Gene)
POLR2EGeneProduct456359 (Entrez Gene)
POLR2FGeneProduct458824 (Entrez Gene)
POLR2GGeneProduct740537 (Entrez Gene)
POLR2HGeneProduct471027 (Entrez Gene)
POLR2IGeneProduct746261 (Entrez Gene)
POLR2JGeneProduct
POLR2KGeneProduct741257 (Entrez Gene)
POLR3BGeneProduct452201 (Entrez Gene)
POLR3DGeneProduct464043 (Entrez Gene)
POLR3EGeneProduct454351 (Entrez Gene)
POLR3HGeneProduct745514 (Entrez Gene)
POLR3KGeneProduct744386 (Entrez Gene)
TAF12GeneProduct456686 (Entrez Gene)
TAF13GeneProduct738503 (Entrez Gene)
TAF5GeneProduct735428 (Entrez Gene)
TAF6GeneProduct463588 (Entrez Gene)
TAF7GeneProduct471669 (Entrez Gene)
TBPGeneProduct738472 (Entrez Gene)

Annotated Interactions

No annotated interactions
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