Estrogen signaling pathway (Bos taurus)

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1-3NucleusIKK ComplexInhibitionGene expression(Cyc D, IGFR1 etc.)Genomic function of ER (Slow)ActivationGene expression(pS2, Complement 3 etc.)MitochondrionNon-genomic function of ER (fast)MAPKsTranslocationcell proliferation and progressionMTOR signaling etc.Gene expression(anti apoptotic and proliferation)FOSSP1ESR1EstradiolESR1ELK1MAPK1ESR1ESR1EstradiolGPER1JUNPIK3CAEstradiolGrowth factorsNFKB1ESR1BCL2ESR1GNGT1Cyclic AMPGNB1AKT1CREB1BRAFMAPK9ESR1GNASMAPK14MAP2K1PRKACANFKB1CREB1CHUKESR1ESR1IKBKBIKBKG


Description

Estrogen receptor refers to a group of receptors which are activated by the hormone 17-beta-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP712(78491) with a 100.0% conversion rate.

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Bibliography

  1. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  2. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  3. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.''; J Leukoc Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
105997view11:52, 16 August 2019MaintBotHMDB identifier normalization
80825view15:27, 30 June 2015Mkutmonhomology conversion
72369view09:49, 13 November 2013EgonwFixed a typo.
72368view09:48, 13 November 2013EgonwFixed the PubChem-compound database name.
70170view00:31, 13 July 2013AlexanderPicoModified title
63371view23:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
58820view23:18, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40543view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
33784view00:10, 9 December 2009MaintBotAutomatic update of empty xrefs
33629view10:04, 1 December 2009MaintBotRemoved group label
31640view22:26, 13 August 2009MaintBotFixed text labels
30555view22:01, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
BCL2GeneProductENSBTAG00000019302 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:596
BRAFGeneProductENSBTAG00000021761 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673
CHUKGeneProductENSBTAG00000007591 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1147
CREB1GeneProductENSBTAG00000005474 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385
Cyclic AMPMetaboliteHMDB0000058 (HMDB)
ELK1GeneProductENSBTAG00000015817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002
ESR1GeneProductENSBTAG00000007159 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2099
EstradiolMetaboliteHMDB0000151 (HMDB)
FOSGeneProductENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
GNASGeneProductENSBTAG00000017475 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2778
GNB1GeneProductENSBTAG00000000215 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2782
GNGT1GeneProductENSBTAG00000002674 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2792
GPER1GeneProductENSBTAG00000048154 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2852
Growth factorsMetaboliteHMDB0000151 (HMDB)
IKBKBGeneProductENSBTAG00000007599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3551
IKBKGGeneProductENSBTAG00000006268 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8517
JUNGeneProductENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
MAP2K1GeneProductENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169032
MAPK14GeneProductENSBTAG00000020783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030
MAPK9GeneProductENSBTAG00000004709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
NFKB1GeneProductENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
PIK3CAGeneProductENSBTAG00000009232 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
PRKACAGeneProductENSBTAG00000006642 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5566
SP1GeneProductENSBTAG00000003021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6667

Annotated Interactions

No annotated interactions
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