Pathway Talk:WP3652

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Nice work! (3)

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Looks good and is clear. Regarding the +/- signs in the original figure denoting positive/negative regulation, I think it is actually regulation from NF-kBs on its targets, so one step higher than what you currently have. So for example, the NF-kB to BMP should be inhibitory. And the final interactions going from BMP etc to the labels should all be simple arrows.