Portal:OpenPHACTS
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Open PHACTS at WikiPathways
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The Open PHACTS consortium, funded by the Innovative Medicines Initiative, will reduce the barriers to drug discovery by applying semantic technologies to available data resources, creating an Open Pharmacological Space.
Open PHACTS (the Open Pharmacological Concepts Triple Store) will deliver a single view across available data resources, and will be freely available to users. Scientific text, difficult to analyse by computer, will have factual assertions extracted as semantic triples, allowing for the first time the prospect of querying textual and database data together to give answers needed to identify new drug targets and pharmacological interactions. While the semantic approach has been delivered in small-scale and targeted approaches so far, its promise for multiscale data integration has remained largely unfulfilled - Open PHACTS is a major project including many of the top semantic web experts, committed to deliver on this promise.
Community Curation Initiative
Description of Open PHACTS curation effort.
Contributors:
About Open PHACTS
Drug discovery is data-hungry and all major pharmaceutical companies maintain extensive in-house instances of public data. Analysis and hypothesis generation for drug-discovery projects requires assembly, overlay and comparison of data from many sources and requiring shared identifiers and common semantics. Expression profiles need to be overlaid with gene or pathway identifiers and reports on compound pharmacology. Alignment and integration of internal and public data and information sources requires a significant effort and the process is repeated across companies, institutes and academic laboratories. This represents significant waste and increases opportunity cost. To address these challenges, the Open PHACTS project will develop an open access innovation platform, called Open Pharmacological Space (OPS), via a semantic web approach. OPS will be comprised of data, vocabularies and infrastructure needed to accelerate drug-oriented research. The aim is to develop an enabling resource for drug discovery projects which is open to all users and freely available in the public domain.
The Open PHACTS consortium comprises 14 European academic and SME partners, with leading experts in the fields of data mining, annotation, small molecule data storage and manipulation, target bioinformatics, RDF information handling, massive in silico reasoning and chemical biology.
Open PHACTS is funded by Innovative Medicines Initiative, a public-private partnership between the European Union and the EFPIA.
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