Biogenic amine synthesis (Bos taurus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Biogenic Amine Synthesis" Organism="Bos taurus" License="CC BY 2.0"> <Comment Source="GenMAPP remarks">reference web site at end of Notes</Comment> <Comment Source="WikiPathways-category">Metabolic Process</Comment> <Comment Source="WikiPathways-description">Biogenic amines are one of two broad classes of classical neurotransmitters (the other being amino acids) and include: acetylcholine, serotonin, histamine, and the catecholamines epinephrine, norepinephrine, and dopamine. Source: http://www.whatislife.com/reader2/Metabolism/pathway/Neurotransmitter.html</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP550_r73391 WP550(73391)] with a 100.0% conversion rate.</Comment> <BiopaxRef>d64</BiopaxRef> <Graphics BoardWidth="837.6666666666664" BoardHeight="678.0" /> <DataNode TextLabel="GAD2" GraphId="a07" Type="GeneProduct" GroupRef="e4dfc"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2572</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GAD2 | glutamate decarboxylase 2 (pancreatic is..." /> <Graphics CenterX="401.9999999999999" CenterY="292.0333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000008056" /> </DataNode> <DataNode TextLabel="DDC" GraphId="a57" Type="GeneProduct" GroupRef="da2ca"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1644</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="DDC | dopa decarboxylase (aromatic L-amino acid..." /> <Graphics CenterX="170.33333333333337" CenterY="293.03333333333313" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000020869" /> </DataNode> <DataNode TextLabel="Choline" GraphId="a7b" Type="Metabolite"> <Graphics CenterX="65.33333333333333" CenterY="235.03333333333333" Width="64.33333333333333" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="62-49-7" /> </DataNode> <DataNode TextLabel="Epinephrine" GraphId="b1e2d" Type="Metabolite"> <Graphics CenterX="695.333333333333" CenterY="516.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB0000068" /> </DataNode> <DataNode TextLabel="5-hydroxy-tryptophan" GraphId="b36" Type="Metabolite"> <Graphics CenterX="536.1666666666667" CenterY="250.03333333333333" Width="126.33333333333333" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="4350-09-8" /> </DataNode> <DataNode TextLabel="TPH1" GraphId="b44" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7166</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TPH1 | tryptophan hydroxylase 1 (tryptophan 5-m..." /> <Graphics CenterX="595.6666666666666" CenterY="195.36666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000005343" /> </DataNode> <DataNode TextLabel="Acetylserotonin" GraphId="b72" Type="Metabolite"> <Graphics CenterX="536.1666666666667" CenterY="422.3666666666667" Width="90.33333333333333" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="1210-83-9" /> </DataNode> <DataNode TextLabel="GABA" GraphId="b7962" Type="Metabolite"> <Graphics CenterX="343.6666666666665" CenterY="346.66666666666663" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB0000112" /> </DataNode> <DataNode TextLabel="HDC" GraphId="beb" Type="GeneProduct" GroupRef="da2ca"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3067</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="HDC | histidine decarboxylase" /> <Graphics CenterX="170.33333333333337" CenterY="273.03333333333313" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000009911" /> </DataNode> <DataNode TextLabel="DBH" GraphId="bf8" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1621</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="DBH | dopamine beta-hydroxylase (dopamine beta-..." /> <Graphics CenterX="652.4999999999998" CenterY="372.7" Width="38.333333333333485" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000004508" /> </DataNode> <DataNode TextLabel="DDC" GraphId="c29" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1644</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="DDC | dopa decarboxylase (aromatic L-amino acid..." /> <Graphics CenterX="595.6666666666666" CenterY="285.7" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000020869" /> </DataNode> <DataNode TextLabel="TH" GraphId="c51" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7054</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TH | tyrosine hydroxylase" /> <Graphics CenterX="758.6666666666664" CenterY="195.7" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000026768" /> </DataNode> <DataNode TextLabel="L-DOPA" GraphId="c6b" Type="Metabolite"> <Graphics CenterX="693.9999999999997" CenterY="250.03333333333333" Width="66.33333333333333" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="59-92-7" /> </DataNode> <DataNode TextLabel="Histidine" GraphId="c6d" Type="Metabolite"> <Graphics CenterX="233.33333333333337" CenterY="237.7000000000001" Width="72.33333333333333" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="71-00-1" /> </DataNode> <DataNode TextLabel="PNMT" GraphId="ce1" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5409</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PNMT | phenylethanolamine N-methyltransferase" /> <Graphics CenterX="650.4999999999998" CenterY="471.7" Width="44.333333333333485" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000011731" /> </DataNode> <DataNode TextLabel="Dopamine" GraphId="d52" Type="Metabolite"> <Graphics CenterX="693.9999999999997" CenterY="333.3666666666667" Width="83.33333333333333" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="62-31-7" /> </DataNode> <DataNode TextLabel="ACHE" GraphId="d77" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:43</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACHE | acetylcholinesterase (YT blood group)" /> <Graphics CenterX="121.33333333333331" CenterY="374.7" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000001139" /> </DataNode> <DataNode TextLabel="Acetylcholine" GraphId="d7b" Type="Metabolite"> <Graphics CenterX="65.58333333333333" CenterY="339.3666666666667" Width="80.83333333333333" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="51-84-3" /> </DataNode> <DataNode TextLabel="COMT" GraphId="d8e" Type="GeneProduct" GroupRef="d082a"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1312</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="COMT | catechol-O-methyltransferase" /> <Graphics CenterX="777.6666666666664" CenterY="602.7" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000019516" /> </DataNode> <DataNode TextLabel="PAH" GraphId="da0" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5053</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PAH | phenylalanine hydroxylase" /> <Graphics CenterX="756.6666666666664" CenterY="100.36666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000012794" /> </DataNode> <DataNode TextLabel="Tyrosine" GraphId="db9" Type="Metabolite"> <Graphics CenterX="693.9999999999997" CenterY="156.7" Width="72.33333333333333" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="60-18-4" /> </DataNode> <DataNode TextLabel="CHAT" GraphId="dbf" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1103</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CHAT | choline acetyltransferase" /> <Graphics CenterX="100.66666666666666" CenterY="278.3666666666667" Width="36.666666666666686" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000016814" /> </DataNode> <DataNode TextLabel="Serotonin" GraphId="dc9" Type="Metabolite"> <Graphics CenterX="535.6666666666667" CenterY="333.3666666666667" Width="80.33333333333333" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="50-67-9" /> </DataNode> <DataNode TextLabel="AANAT" GraphId="dd5" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:15</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="AANAT | arylalkylamine N-acetyltransferase" /> <Graphics CenterX="590.6666666666667" CenterY="378.03333333333336" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000014682" /> </DataNode> <DataNode TextLabel="Phenylalanine" GraphId="ddb" Type="Metabolite"> <Graphics CenterX="693.9999999999997" CenterY="60.03333333333333" 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CenterX="343.3333333333334" CenterY="236.70000000000002" Width="82.33333333333333" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="56-86-0" /> </DataNode> <DataNode TextLabel="MAOA" GraphId="e9e" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4128</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAOA | monoamine oxidase A" /> <Graphics CenterX="531.6666666666667" CenterY="586.7" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000016206" /> </DataNode> <DataNode TextLabel="Tryptophan" GraphId="f3d" Type="Metabolite"> <Graphics CenterX="536.0000000000001" CenterY="156.7" Width="94.33333333333333" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="73-22-3" /> </DataNode> <DataNode TextLabel="ASMT" GraphId="f4d" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:438</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ASMT | acetylserotonin O-methyltransferase" /> <Graphics CenterX="460.6666666666668" CenterY="465.7" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000047124" /> </DataNode> <DataNode TextLabel="Norepinephrine" GraphId="f5c" Type="Metabolite"> <Graphics CenterX="694.4166666666664" CenterY="426.3666666666667" Width="85.83333333333333" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="51-41-2" /> </DataNode> <DataNode TextLabel="Histamine" GraphId="f6f" Type="Metabolite"> <Graphics CenterX="233.33333333333337" CenterY="349.03333333333313" Width="81.33333333333333" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="51-45-6" /> </DataNode> <DataNode TextLabel="MAOA" GraphId="fc6" Type="GeneProduct" GroupRef="d082a"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4128</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAOA | monoamine oxidase A" /> <Graphics CenterX="777.6666666666664" CenterY="582.7" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000016206" /> </DataNode> <DataNode TextLabel="DDC" GraphId="fd9" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1644</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="DDC | dopa decarboxylase (aromatic L-amino acid..." /> <Graphics CenterX="754.6666666666664" CenterY="290.7" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000020869" /> </DataNode> <Interaction GraphId="a32da"> <Graphics ZOrder="12288" 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