Purine metabolism (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Purine metabolism" Version="20161102" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">Overview of purine metabolism; metabolic markers are highlighted in red, with graphical arrows indicating if a marker is present in higher or lower concentrations compared to normal (healthy) levels. This pathway was inspired by Chapter 13, edition 5 of the book of Blau (in press). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP4792 CPTAC Assay Portal]</Comment> <BiopaxRef>c52</BiopaxRef> <Graphics BoardWidth="1274.0518749417192" BoardHeight="797.3982843472713"/> <DataNode TextLabel="PRPP" GraphId="a21c1" Type="Metabolite"> <Graphics CenterX="693.168949243494" CenterY="37.722452515371955" Width="61.05226904376014" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17111"/> </DataNode> <DataNode TextLabel="ATP" GraphId="a287d" Type="Metabolite"> <Graphics CenterX="353.5205567178725" CenterY="181.43405486726323" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:30616"/> </DataNode> <DataNode TextLabel="XMP" GraphId="a2a9d" Type="Metabolite"> <Graphics CenterX="846.2994119802482" CenterY="364.91197852408806" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:57464"/> </DataNode> <DataNode TextLabel="SAICARP" GraphId="a83ae" Type="Metabolite"> <Graphics CenterX="693.1689492434939" CenterY="113.4912933979909" Width="61.1950664800561" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:58443"/> </DataNode> <DataNode TextLabel="AICA-riboside" GraphId="ab7ab" Type="Metabolite"> <Graphics CenterX="870.4384115041186" CenterY="180.44068354222298" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" LineThickness="2.0" Color="ff6666"/> <Xref Database="ChEBI" ID="CHEBI:28498"/> </DataNode> <DataNode TextLabel="APRT" GraphId="adff4" Type="Protein"> <Graphics CenterX="235.14216725176394" CenterY="428.5984107421859" Width="41.35342217879203" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P07741"/> </DataNode> <DataNode TextLabel="AMP" GraphId="b0d7f" Type="Metabolite"> <Graphics CenterX="353.5205567178725" CenterY="359.110084205593" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:456215"/> </DataNode> <DataNode TextLabel="Xanthosine" GraphId="b1315" Type="Metabolite"> <Graphics CenterX="846.2994119802482" CenterY="467.4485726675666" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:18107"/> </DataNode> <DataNode TextLabel="2'-Deoxyadenosine" GraphId="b1f3c" Type="Metabolite"> <Graphics CenterX="158.50507786644994" CenterY="460.8187384134227" Width="123.41614420062683" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" LineThickness="2.0" Color="ff6666"/> <Xref Database="ChEBI" ID="CHEBI:17256"/> </DataNode> <DataNode TextLabel="Inosine" GraphId="b23fd" Type="Metabolite"> <Graphics CenterX="693.168949243494" CenterY="467.4485726675666" Width="90.0" Height="25.0" ZOrder="32768" 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rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Duran, M.</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gibson, K.M.</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dionisi-Vici, C.</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lesch-Nyhan syndrome</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:1919</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">adenosine monophosphate deaminase deficiency pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0001779</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d0e"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chapter 5 Combined Immune Deficiencies</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">https://doi.org/10.1016/B978-0-12-405546-9.00005-4</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Su, H</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lenardo, M.</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">adenine phosphoribosyltransferase deficiency</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0060350</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">xanthinuria disease pathway, type II</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0001592</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mitochondrial DNA depletion syndrome 3</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0080121</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> </bp:openControlledVocabulary> </Biopax> </Pathway>

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