Purine metabolism (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none 8 steps involvedPRPPATPXMPSAICARPAICA-ribosideAPRTAMPXanthosine2'-DeoxyadenosineInosineGDPATICRibose-5-PSAICA-ribosideADAdGDPSuccinyladenosineADSLdATPAICARP2,8-DihydroxyadeninedADPAdenosinedAMPITPPRPS1More detail:Purine metabolism and related disordersADSSHypoxanthineGuanosineADSLPRPPsIMPDH1HPRT1S-AMPXanthineADPDGUOKGTPdGTPAMPD1UratePNPITPAAdenineGuanineRRdGMPFAICARP2-DeoxyguanosineGMP2'-deoxyinosineIMPPNPPNPXORRATICADAPNPHPRT1XOPNPXOPNPName: Purine metabolismOrganism: Homo sapiens


Description

Overview of purine metabolism. Metabolic markers are highlighted in red, with graphical arrows indicating if a marker is present in higher or lower concentrations compared to normal (healthy) levels.

This pathway was inspired by Chapter 13, edition 5 of the book of Blau (in press). The full version including disorders, based on ed. 4, can be found [here](https://www.wikipathways.org/index.php/Pathway:WP4224).

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP4792).

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Quality Tags

Image:Curated.pngApproved version
Image:Wplogo_31.pngCommunity: Inborn Errors of Metabolism (IEM)
Image:Wplogo_31.pngCommunity: Rare Diseases

Ontology Terms

 

Bibliography

  1. Su, H, Lenardo, M.; ''Chapter 5 Combined Immune Deficiencies''; https://doi.org/10.1016/B978-0-12-405546-9.00005-4, 2014 DOI Scholia
  2. Blau, N., Duran, M., Gibson, K.M., Dionisi-Vici, C.; ''Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases, Chapter 11 and 41''; ISBN 978-3-642-40337-8, 2014

History

View all...
CompareRevisionActionTimeUserComment
137905
Approved
view17:28, 10 March 2025KhanspersModified description
134645
RARE
view12:25, 23 July 2024EweitzNote full pathway with related disorders
134644view12:20, 23 July 2024EweitzModified description
124888view13:57, 29 December 2022EgonwManually added the DOI identifier as identifier too
119117
IEM
view16:30, 17 June 2021FinterlyAdded ISBN for book citation
109348view12:57, 16 March 2020L DupuisConnected one unconnected line
109308view08:42, 10 March 2020DeSlOntology Term : 'DOID:5810' removed !
109256view15:18, 2 March 2020Mkutmonfixed unconnected lines
109224view09:43, 28 February 2020Mkutmonlayout adaption
108876view08:44, 4 February 2020DeSlModified description
108875view08:43, 4 February 2020DeSlModified description
108874view08:42, 4 February 2020DeSlOntology Term : 'DOID:0080121' removed !
108873view08:41, 4 February 2020DeSlOntology Term : 'PW:0001779' removed !
108870view15:12, 3 February 2020DeSlOntology Term : 'DOID:1919' removed !
108869view15:12, 3 February 2020DeSlOntology Term : 'PW:0001592' removed !
108868view15:12, 3 February 2020DeSlOntology Term : 'DOID:0060350' removed !
108867view15:10, 3 February 2020DeSlOntology Term : 'PW:0001777' removed !
108866view15:09, 3 February 2020DeSlOntology Term : 'DOID:0050762' removed !
108865view15:09, 3 February 2020DeSlOntology Term : 'PW:0001879' removed !
108864view15:08, 3 February 2020DeSlOntology Term : 'PW:0001776' removed !
108863view15:08, 3 February 2020DeSlModified description
108862view15:07, 3 February 2020DeSlModified description
108861view15:05, 3 February 2020DeSlNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
2'-DeoxyadenosineMetaboliteCHEBI:17256 (ChEBI)
2'-deoxyinosineMetaboliteCHEBI:28997 (ChEBI)
2,8-DihydroxyadenineMetaboliteQ4596812 (Wikidata)
2-DeoxyguanosineMetaboliteCHEBI:17172 (ChEBI)
ADAProteinP00813 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:456216 (ChEBI)
ADSLProteinP30566 (Uniprot-TrEMBL)
ADSSProteinP30520 (Uniprot-TrEMBL) Adenylosuccinate synthetase isozyme 2
AICA-ribosideMetaboliteCHEBI:28498 (ChEBI)
AICARPMetaboliteCHEBI:58475 (ChEBI)
AMPMetaboliteCHEBI:456215 (ChEBI)
AMPD1ProteinP23109 (Uniprot-TrEMBL)
APRTProteinP07741 (Uniprot-TrEMBL)
ATICProteinP31939 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:30616 (ChEBI)
AdenineMetaboliteCHEBI:16708 (ChEBI)
AdenosineMetaboliteCHEBI:16335 (ChEBI)
DGUOKProteinQ16854 (Uniprot-TrEMBL)
FAICARPMetaboliteCHEBI:58467 (ChEBI)
GDPMetaboliteCHEBI:58189 (ChEBI)
GMPMetaboliteCHEBI:58115 (ChEBI)
GTPMetaboliteCHEBI:37565 (ChEBI)
GuanineMetaboliteCHEBI:16235 (ChEBI)
GuanosineMetaboliteCHEBI:16750 (ChEBI)
HPRT1ProteinP00492 (Uniprot-TrEMBL)
HypoxanthineMetaboliteCHEBI:17368 (ChEBI)
IMPMetaboliteCHEBI:58053 (ChEBI)
IMPDH1ProteinP20839 (Uniprot-TrEMBL)
ITPAProteinQ9BY32 (Uniprot-TrEMBL)
ITPMetaboliteCHEBI:61402 (ChEBI) is a nucleoside triphosphate(4−)
InosineMetaboliteCHEBI:17596 (ChEBI)
More detail:

Purine metabolism and

related disorders		PathwayWP4224 (WikiPathways)
PNPProteinP00491 (Uniprot-TrEMBL)
PRPPMetaboliteCHEBI:17111 (ChEBI)
PRPPsProtein2.7.6.1 (Enzyme Nomenclature)
PRPS1ProteinP60891 (Uniprot-TrEMBL)
RRProtein1.17.4.1 (Enzyme Nomenclature)
Ribose-5-PMetaboliteCHEBI:52742 (ChEBI)
S-AMPMetaboliteCHEBI:57567 (ChEBI) succinyladenosine monophosphate
SAICA-ribosideMetaboliteCHEBI:18319 (ChEBI)
SAICARPMetaboliteCHEBI:58443 (ChEBI)
SuccinyladenosineMetaboliteCHEBI:71169 (ChEBI)
UrateMetaboliteCHEBI:17775 (ChEBI)
XMPMetaboliteCHEBI:57464 (ChEBI)
XOProteinP47989 (Uniprot-TrEMBL)
XanthineMetaboliteCHEBI:17712 (ChEBI)
XanthosineMetaboliteCHEBI:18107 (ChEBI)
dADPMetaboliteCHEBI:57667 (ChEBI)
dAMPMetaboliteCHEBI:58245 (ChEBI)
dATPMetaboliteCHEBI:61404 (ChEBI)
dGDPMetaboliteCHEBI:58595 (ChEBI)
dGMPMetaboliteCHEBI:57673 (ChEBI)
dGTPMetaboliteCHEBI:16497 (ChEBI)

Annotated Interactions

View all...
Source  ↓Target  ↓Type  ↓Database reference  ↓Comment  ↓
2'-Deoxyadenosine2'-deoxyinosinemim-conversion28191 (Rhea)
2'-DeoxyadenosineAdeninemim-conversion27743 (Rhea)
2'-deoxyinosineHypoxanthinemim-conversion27751 (Rhea)
2-DeoxyguanosineGuaninemim-conversion27739 (Rhea)
2-DeoxyguanosinedGMPmim-conversion19202 (Rhea)
ADPATPmim-conversion30657 (Rhea)
ADPdADPmim-conversion28036 (Rhea)
AICARPFAICARPmim-conversion22193 (Rhea)
AMPADPmim-conversion11462 (Rhea)
AMPAdenosinemim-conversion29376 (Rhea)
AMPIMPmim-conversion14778 (Rhea)
AdenineAMPmim-conversion16611 (Rhea)
AdenosineAdeninemim-conversion18670 (Rhea)
AdenosineInosinemim-conversion24409 (Rhea)
FAICARPIMPmim-conversion18447 (Rhea)
GDPGTPmim-conversion29865 (Rhea)
GDPdGDPmim-conversion28032 (Rhea)
GMPGDPmim-conversion20781 (Rhea)
GMPGuanosinemim-conversion27715 (Rhea)
Guaninemim-conversion14666 (Rhea)
Guaninemim-conversion25426 (Rhea)
GuanosineGuaninemim-conversion13234 (Rhea)
HypoxanthineXanthinemim-conversion24671 (Rhea)
Hypoxanthinemim-conversion17975 (Rhea)
IMPInosinemim-conversion27719 (Rhea)
IMPS-AMPmim-conversion15754 (Rhea)
IMPXMPmim-conversion11709 (Rhea)
ITPIMPmim-conversion29400 (Rhea)
InosineHypoxanthinemim-conversion16658 (Rhea)
S-AMPAMPmim-conversion16854 (Rhea)
SAICARPAICARPmim-conversion23921 (Rhea)
XMPGMPmim-conversion18302 (Rhea)
XMPXanthosinemim-conversion28531 (Rhea)
XanthineUratemim-conversion16670 (Rhea)
XanthosineXanthinemim-conversion27639 (Rhea)
dADPdAMPmim-conversion23102 (Rhea)
dADPdATPmim-conversion27675 (Rhea)
dAMP2'-Deoxyadenosinemim-conversion29372 (Rhea)
dGDPdGMPmim-conversion12699 (Rhea)
dGDPdGTPmim-conversion27691 (Rhea)
dGMP2-Deoxyguanosinemim-conversion19203 (Rhea)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4792"
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