Amino acids regulate mTORC1 (Homo sapiens)

From WikiPathways

You do not have permission to edit pages, for the following reasons:

• You do not have permission to edit pages in the Pathway namespace.
• You are not allowed to execute the action you have requested.

You can view and copy the source of this page:

<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Amino acids regulate mTORC1" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">The mTORC1 complex acts as an integrator that regulates translation, lipid synthesis, autophagy, and cell growth in response to multiple inputs, notably glucose, oxygen, amino acids, and growth factors such as insulin (reviewed in Sabatini 2017, Meng et al. 2018, Kim and Guan 2019).&lt;br&gt;MTOR, the kinase subunit of mTORC1, is activated by interaction with RHEB:GTP at the cytosolic face of lysosomal membrane (Long et al. 2005, Tee et al. 2005, Long et al. 2007, Yang et al. 2017). Recruitment of mTORC1 to the lysosomal membrane is intricate and incompletely understood. At the center of the system is a complex of two small GTPases, the Rag heterodimer (RRAGA or RRAGB bound to RRAGC or RRAGD). The Rag heterodimer is tethered to the membrane by the Ragulator complex, which also binds the v-ATPase complex. The Rag heterodimer acts as a cross-regulating switch, with the binding of GTP by one subunit inhibiting the exchange of GDP for GTP by the other subunit (Shen et al. 2017). The active conformation of the Rag heterodimer that recruits mTORC1 to the lysosomal membrane is RRAGA,B:GTP:RRAGC,D:GDP while the inactive conformation, RRAGA,B:GDP:RRAGC,D:GTP, releases mTORC1 (Sancak et al. 2008, Kim et al. 2008, Sancak et al. 2010, Lawrence et al. 2018). GTPase activating proteins (GAPs) and guanyl nucleotide exchange factors (GEFs) acting upon the Rag heterodimer thereby regulate recruitment of mTORC1. RHEB:GTP at the lysosomal membrane also binds mTORC1 and directly activates mTORC1. During inactivation of mTORC1 in response to removal of amino acids, the TSC complex, a GAP for RHEB, is required in addition to the inactive Rag complex to release mTORC1 from RHEB and hence fully release mTORC1 from the lysosomal membrane (Demetriades et al. 2014).&lt;br&gt;Amino acids regulate recruitment of mTORC1 to the lysosomal membrane by at least 4 mechanisms (reviewed in Zhuang et al. 2019, Wolfson and Sabatini 2017, Yao et al. 2017). 1) Sestrin1 (SESN1) or Sestrin2 (SESN2) binds leucine and the Sestrin1,2:leucine complex is then released from the GATOR2 complex, allowing GATOR2 to positively regulate mTORC1 activation (Chantranupong et al. 2014, Parmigiani et al. 2014, Kim et al. 2015, Wolfson et al. 2016, Saxton et al. 2016). 2) CASTOR1 in a homodimer or a heterodimer with CASTOR2 binds arginine and the CASTOR1:arginine complex is likewise released from GATOR2, allowing GATOR2 to activate mTORC1 (Chantranupong et al. 2016, Saxton et al. 2016, Gai et al. 2016, Xia et al. 2016). 3) BMT2 (SAMTOR), a negative regulator of mTORC1 activation, binds S-adenosylmethionine (SAM), a derivative of methionine (Gu et al. 2017). The binding of SAM causes BMT2 to dissociate from GATOR1, allowing the activation of mTORC1. 4) The amino acid transporter SLC38A9 binds arginine and SLC38A9 then acts as a GEF to convert RRAGA,B:GDP to the active form, RRAGA,B:GTP (Rebsamen et al. 2015, Wang et al. 2015, Wyant et al. 2017, Shen and Sabatini 2018). Amino acid starvation also regulates the assembly of the V0 and V1 subunits of v-ATPase by an uncharacterized mechanism (Stransky and Forgac 2015) and v-ATPase is required for activation of mTORC1 by amino acids (Zoncu et al. 2011). Glutamine activates mTORC1 by a mechanism that is independent of the Rag GTPases, requires ARF1, but is not yet fully elucidated (Jewell et al. 2015). View original pathway at [http://www.reactome.org/PathwayBrowser/#DIAGRAM=9639288 Reactome].</Comment> <Comment Source="Reactome-Converter">Pathway is converted from Reactome ID: 9639288</Comment> <Comment Source="Reactome-version">Reactome version: 73</Comment> <Comment Source="Reactome Author">Reactome Author: May, Bruce</Comment> <BiopaxRef>ebc</BiopaxRef> <BiopaxRef>ebd</BiopaxRef> <BiopaxRef>d63</BiopaxRef> <BiopaxRef>cb9</BiopaxRef> <BiopaxRef>b4d</BiopaxRef> <BiopaxRef>cd9</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <BiopaxRef>d72</BiopaxRef> <BiopaxRef>b72</BiopaxRef> <BiopaxRef>a83</BiopaxRef> <BiopaxRef>e94</BiopaxRef> <BiopaxRef>b58</BiopaxRef> <BiopaxRef>ecc</BiopaxRef> <BiopaxRef>eea</BiopaxRef> <BiopaxRef>bb7</BiopaxRef> <BiopaxRef>f58</BiopaxRef> <BiopaxRef>f3c</BiopaxRef> <BiopaxRef>ea1</BiopaxRef> <BiopaxRef>dc9</BiopaxRef> <BiopaxRef>bcd</BiopaxRef> <BiopaxRef>f24</BiopaxRef> <BiopaxRef>f86</BiopaxRef> <BiopaxRef>dfa</BiopaxRef> <BiopaxRef>c44</BiopaxRef> <BiopaxRef>cf9</BiopaxRef> <BiopaxRef>a9c</BiopaxRef> <BiopaxRef>d85</BiopaxRef> <BiopaxRef>c91</BiopaxRef> <BiopaxRef>dda</BiopaxRef> <BiopaxRef>a31</BiopaxRef> <BiopaxRef>e8c</BiopaxRef> <BiopaxRef>f85</BiopaxRef> <BiopaxRef>bb5</BiopaxRef> <BiopaxRef>dcb</BiopaxRef> <Attribute Key="reactome_id" Value="9639288" /> <Graphics BoardWidth="1580.0" BoardHeight="2273.0" /> <DataNode TextLabel="LAMTOR1 " GraphId="a009a" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="1220.0" CenterY="1313.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6IAA8" /> </DataNode> <DataNode TextLabel="ATP6V1G3 " GraphId="a0563" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="520.0" CenterY="1673.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96LB4" /> </DataNode> <DataNode TextLabel="ATP6V1E1 " GraphId="a0d93" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="520.0" CenterY="1573.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P36543" /> </DataNode> <DataNode TextLabel="ATP6V1G2 " GraphId="a0f12" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="14" /> <Graphics CenterX="100.0" CenterY="1613.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O95670" /> </DataNode> <DataNode TextLabel="ATP6V1F " GraphId="a0fe9" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="14" /> <Graphics CenterX="1220.0" CenterY="1713.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q16864" /> </DataNode> <DataNode TextLabel="LAMTOR4 " GraphId="a103b" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1273.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q0VGL1" /> </DataNode> <DataNode TextLabel="LAMTOR4 " GraphId="a1089" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="240.0" CenterY="1373.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q0VGL1" /> </DataNode> <DataNode TextLabel="LAMTOR3 " GraphId="a1134" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="240.0" CenterY="1353.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UHA4" /> </DataNode> <DataNode TextLabel="L-Arg " GraphId="a1261" Type="Metabolite" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1413.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:32682" /> </DataNode> <DataNode TextLabel="ATP6V0D1 " GraphId="a158d" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1360.0" CenterY="1473.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P61421" /> </DataNode> <DataNode TextLabel="TCIRG1 " GraphId="a2198" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="380.0" CenterY="1633.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13488" /> </DataNode> <DataNode TextLabel="WDR59 " GraphId="a23d1" Type="Protein" GroupRef="e0c00"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640231" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1613.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6PJI9" /> </DataNode> <DataNode TextLabel="GDP " GraphId="a260e" Type="Metabolite" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="660.0" CenterY="1773.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17552" /> </DataNode> <DataNode TextLabel="ATP6V1G1 " GraphId="a2d54" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="16" /> <Graphics CenterX="380.0" CenterY="1953.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75348" /> </DataNode> <DataNode TextLabel="ATP6V0C " GraphId="a393c" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="100.0" CenterY="1313.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P27449" /> </DataNode> <DataNode TextLabel="RPTOR " GraphId="a3d38" Type="Protein" GroupRef="dbc52"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-377400" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1513.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N122" /> </DataNode> <DataNode TextLabel="ATP6V1B2 " GraphId="a3fef" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="380.0" CenterY="1813.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21281" /> </DataNode> <DataNode TextLabel="LAMTOR1 " GraphId="a41ce" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="240.0" CenterY="1313.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6IAA8" /> </DataNode> <DataNode TextLabel="LAMTOR3 " GraphId="a445b" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1253.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UHA4" /> </DataNode> <DataNode TextLabel="L-Arg " GraphId="a480a" Type="Metabolite" GroupRef="fa9e3"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9657636" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1500.0" CenterY="1293.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:32682" /> </DataNode> <DataNode TextLabel="RHEB:GTP" GraphId="a52a6" Type="Complex"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Graphics CenterX="765.0" CenterY="941.0" Width="90.0" Height="24.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-165189" /> </DataNode> <DataNode TextLabel="CASTOR1 " GraphId="a55d7" Type="Protein" GroupRef="fa9e3"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9657636" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="1500.0" CenterY="1313.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WTX7" /> </DataNode> <DataNode TextLabel="ITFG2 " GraphId="a5c78" Type="Protein" GroupRef="ed054"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9657634" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="1453.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q969R8" /> </DataNode> <DataNode TextLabel="ATP6V1G2 " GraphId="a5f24" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="14" /> <Graphics CenterX="1080.0" CenterY="2073.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O95670" /> </DataNode> <DataNode TextLabel="NPRL3 " GraphId="a609c" Type="Protein" GroupRef="fbe47"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639275" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1393.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q12980" /> </DataNode> <DataNode TextLabel="ATP6V1F " GraphId="a6605" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="1360.0" CenterY="1713.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q16864" /> </DataNode> <DataNode TextLabel="ATP6V0C " GraphId="a6b54" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="520.0" CenterY="1353.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P27449" /> </DataNode> <DataNode TextLabel="ATP6V0B " GraphId="a7114" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1293.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q99437" /> </DataNode> <DataNode TextLabel="LAMTOR5 " GraphId="a722a" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="1360.0" CenterY="1393.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O43504" /> </DataNode> <DataNode TextLabel="ATP6V0B " GraphId="a74d4" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="1220.0" CenterY="1433.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q99437" /> </DataNode> <DataNode TextLabel="ATP6V1B2 " GraphId="a79ad" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="1360.0" CenterY="1593.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21281" /> </DataNode> <DataNode TextLabel="CASTOR1 " GraphId="a8356" Type="Protein" GroupRef="ab427"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640285" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1613.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WTX7" /> </DataNode> <DataNode TextLabel="Pi" GraphId="a8486" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="835.5" CenterY="138.0" Width="27.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:18367" /> </DataNode> <DataNode TextLabel="LAMTOR4 " GraphId="a8dc1" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1693.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q0VGL1" /> </DataNode> <DataNode TextLabel="GDP" GraphId="a93cf" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="868.5" CenterY="587.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17552" /> </DataNode> <DataNode TextLabel="RRAGA " GraphId="a958c" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="1220.0" CenterY="1813.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q7L523" /> </DataNode> <DataNode TextLabel="ATP6V1D " GraphId="a96c0" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="240.0" CenterY="1653.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y5K8" /> </DataNode> <DataNode TextLabel="ATP6V1E1 " GraphId="a9d9c" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="100.0" CenterY="1533.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P36543" /> </DataNode> <DataNode TextLabel="SESN1 " GraphId="a9e9e" Type="Protein" GroupRef="fbe47"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639275" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1313.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y6P5" /> </DataNode> <DataNode TextLabel="LAMTOR3 " GraphId="a9ecd" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="1360.0" CenterY="1353.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UHA4" /> </DataNode> <DataNode TextLabel="RRAGC " GraphId="aa257" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="520.0" CenterY="1793.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9HB90" /> </DataNode> <DataNode TextLabel="ATP6V1D " GraphId="aace8" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="1080.0" CenterY="1973.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y5K8" /> </DataNode> <DataNode TextLabel="CASTOR1:L-Arg:CASTOR2" GraphId="aadc3" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="91.5" CenterY="791.0" Width="173.0" Height="26.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9640285" /> </DataNode> <DataNode TextLabel="ATP6V0C " GraphId="aaf96" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1360.0" CenterY="1453.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P27449" /> </DataNode> <DataNode TextLabel="ATP6V1G2 " GraphId="ab05e" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="240.0" CenterY="1753.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O95670" /> </DataNode> <DataNode TextLabel="ATP6V1D " GraphId="ab429" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="660.0" CenterY="1553.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y5K8" /> </DataNode> <DataNode TextLabel="ATP6V1B1 " GraphId="ab5d8" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="13" /> <Graphics CenterX="380.0" CenterY="1793.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P15313" /> </DataNode> <DataNode TextLabel="LAMTOR1 " GraphId="ac7e1" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1633.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6IAA8" /> </DataNode> <DataNode TextLabel="ATP6V1B2 " GraphId="acb0c" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="660.0" CenterY="1493.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21281" /> </DataNode> <DataNode TextLabel="v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg" GraphId="accd3" Type="Complex"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Graphics CenterX="705.5" CenterY="620.5" Width="221.0" Height="43.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9639283" /> </DataNode> <DataNode TextLabel="SEC13 " GraphId="ad1d3" Type="Protein" GroupRef="ed054"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9657634" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="1533.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P55735" /> </DataNode> <DataNode TextLabel="ATP6V1E1 " GraphId="ad44b" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="380.0" CenterY="1893.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P36543" /> </DataNode> <DataNode TextLabel="CASTOR1:L-Arg dimer" GraphId="ad44f" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="88.5" CenterY="745.0" Width="153.0" Height="26.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9657636" /> </DataNode> <DataNode TextLabel="KICSTOR:GATOR1:GATOR2" GraphId="addd8" Type="Complex"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Graphics CenterX="300.0" CenterY="667.5" Width="188.0" Height="29.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9639281" /> </DataNode> <DataNode TextLabel="WDR59 " GraphId="adf3e" Type="Protein" GroupRef="af541"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639281" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1433.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6PJI9" /> </DataNode> <DataNode TextLabel="ATP6V1G1 " GraphId="ae2d7" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="13" /> <Graphics CenterX="520.0" CenterY="1633.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75348" /> </DataNode> <DataNode TextLabel="ATP6V1C2 " GraphId="ae45a" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="1360.0" CenterY="1633.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NEY4" /> </DataNode> <DataNode TextLabel="MLST8 " GraphId="af186" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1573.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BVC4" /> </DataNode> <DataNode TextLabel="LAMTOR3 " GraphId="af1b3" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1673.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UHA4" /> </DataNode> <DataNode TextLabel="SZT2 " GraphId="af294" Type="Protein" GroupRef="e0c00"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640231" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1793.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5T011" /> </DataNode> <DataNode TextLabel="RRAGB " GraphId="af67b" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="1360.0" CenterY="1253.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5VZM2" /> </DataNode> <DataNode TextLabel="GDP " GraphId="afaf4" Type="Metabolite" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="18" /> <Graphics CenterX="1220.0" CenterY="1853.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17552" /> </DataNode> <DataNode TextLabel="ATP6V1G2 " GraphId="afcb4" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="16" /> <Graphics CenterX="1220.0" CenterY="1753.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O95670" /> </DataNode> <DataNode TextLabel="ATP6V0E2 " GraphId="afed6" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1360.0" CenterY="1533.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NHE4" /> </DataNode> <DataNode TextLabel="ATP6V0D1 " GraphId="b0187" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="1080.0" CenterY="1793.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P61421" /> </DataNode> <DataNode TextLabel="v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP" GraphId="b1555" Type="Complex"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Graphics CenterX="521.5" CenterY="1104.5" Width="249.0" Height="41.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9646467" /> </DataNode> <DataNode TextLabel="ATP6V1B2 " GraphId="b15a6" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="1080.0" CenterY="1913.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21281" /> </DataNode> <DataNode TextLabel="NPRL2 " GraphId="b19db" Type="Protein" GroupRef="af541"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639281" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1233.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WTW4" /> </DataNode> <DataNode TextLabel="C12orf66 " GraphId="b1d6c" Type="Protein" GroupRef="e0c00"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640231" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1733.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96MD2" /> </DataNode> <DataNode TextLabel="ATP6V0B " GraphId="b292c" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1333.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q99437" /> </DataNode> <DataNode TextLabel="ATP6V1G3 " GraphId="b2e2f" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="18" /> <Graphics CenterX="380.0" CenterY="1993.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96LB4" /> </DataNode> <DataNode TextLabel="ATP6V1B2 " GraphId="b34aa" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="14" /> <Graphics CenterX="1220.0" CenterY="1593.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21281" /> </DataNode> <DataNode TextLabel="LAMTOR3 " GraphId="b3679" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1213.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UHA4" /> </DataNode> <DataNode TextLabel="MLST8 " GraphId="b3d2d" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="1220.0" CenterY="1253.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BVC4" /> </DataNode> <DataNode TextLabel="ATP6V1F " GraphId="b3e3e" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="240.0" CenterY="1713.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q16864" /> </DataNode> <DataNode TextLabel="GDP " GraphId="b40bc" Type="Metabolite" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="16" /> <Graphics CenterX="100.0" CenterY="1693.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17552" /> </DataNode> <DataNode TextLabel="NPRL3 " GraphId="b4325" Type="Protein" GroupRef="e0c00"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640231" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1713.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q12980" /> </DataNode> <DataNode TextLabel="TCIRG1 " GraphId="b47c5" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1313.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13488" /> </DataNode> <DataNode TextLabel="LAMTOR2 " GraphId="b4814" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1233.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y2Q5" /> </DataNode> <DataNode TextLabel="ATP6V0C " GraphId="b4a5e" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1220.0" CenterY="1453.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P27449" /> </DataNode> <DataNode TextLabel="ATP6V1G1 " GraphId="b513a" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="1220.0" CenterY="1733.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75348" /> </DataNode> <DataNode TextLabel="MLST8 " GraphId="b52e3" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="18" /> <Graphics CenterX="1360.0" CenterY="1813.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BVC4" /> </DataNode> <DataNode TextLabel="ATP6V1G3 " GraphId="b690a" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="1080.0" CenterY="2093.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96LB4" /> </DataNode> <DataNode TextLabel="GDP " GraphId="b6a8c" Type="Metabolite" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="1360.0" CenterY="1233.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17552" /> </DataNode> <DataNode TextLabel="ATP6V1H " GraphId="b6d69" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="660.0" CenterY="1693.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UI12" /> </DataNode> <DataNode TextLabel="ATP6V1H " GraphId="b6e36" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="18" /> <Graphics CenterX="380.0" CenterY="2013.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UI12" /> </DataNode> <DataNode TextLabel="ATP6V1C1 " GraphId="b7bcf" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="240.0" CenterY="1613.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21283" /> </DataNode> <DataNode TextLabel="ATP6V1E1 " GraphId="b7eb2" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="14" /> <Graphics CenterX="1220.0" CenterY="1673.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P36543" /> </DataNode> <DataNode TextLabel="GTP " GraphId="b8200" Type="Metabolite" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="16" /> <Graphics CenterX="520.0" CenterY="1733.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15996" /> </DataNode> <DataNode TextLabel="KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2" GraphId="b8b78" Type="Complex"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Graphics CenterX="347.0" CenterY="931.5" Width="186.0" Height="37.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9640231" /> </DataNode> <DataNode TextLabel="LAMTOR4 " GraphId="b9531" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1273.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q0VGL1" /> </DataNode> <DataNode TextLabel="ATP6V1B2 " GraphId="b9a6b" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="240.0" CenterY="1593.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21281" /> </DataNode> <DataNode TextLabel="RRAGA " GraphId="b9ed4" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="660.0" CenterY="1713.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q7L523" /> </DataNode> <DataNode TextLabel="CASTOR2 " GraphId="ba5a3" Type="Protein" GroupRef="e0c00"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640231" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1653.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="A6NHX0" /> </DataNode> <DataNode TextLabel="SEH1L " GraphId="baca8" Type="Protein" GroupRef="ed054"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9657634" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="1553.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96EE3" /> </DataNode> <DataNode TextLabel="NPRL3 " GraphId="bb01b" Type="Protein" GroupRef="fd29d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640224" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1753.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q12980" /> </DataNode> <DataNode TextLabel="SLC38A9 " GraphId="bb354" Type="Protein" GroupRef="c48b6"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640172" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1313.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NBW4" /> </DataNode> <DataNode TextLabel="AdoMet " GraphId="bbaac" Type="Metabolite" GroupRef="e8e7d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640252" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1233.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15414" /> </DataNode> <DataNode TextLabel="ATP6V1G2 " GraphId="bbd08" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="380.0" CenterY="1973.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O95670" /> </DataNode> <DataNode TextLabel="ATP6V1H " GraphId="bc5ce" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="1080.0" CenterY="2113.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UI12" /> </DataNode> <DataNode TextLabel="SLC38A9:L-Arg" GraphId="bca9e" Type="Complex"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Graphics CenterX="578.0" CenterY="319.5" Width="110.0" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9640172" /> </DataNode> <DataNode TextLabel="ATP6V1H " GraphId="bcb58" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="1220.0" CenterY="1793.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UI12" /> </DataNode> <DataNode TextLabel="ATP6V1F " GraphId="bcd8d" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="660.0" CenterY="1613.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q16864" /> </DataNode> <DataNode TextLabel="ATP6V0C " GraphId="bcf1b" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="660.0" CenterY="1353.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P27449" /> </DataNode> <DataNode TextLabel="ATP6V1G3 " GraphId="bd42b" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="18" /> <Graphics CenterX="240.0" CenterY="1773.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96LB4" /> </DataNode> <DataNode TextLabel="C12orf66 " GraphId="bd5ab" Type="Protein" GroupRef="fd29d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640224" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1773.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96MD2" /> </DataNode> <DataNode TextLabel="RRAGC " GraphId="bd9eb" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="1360.0" CenterY="1273.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9HB90" /> </DataNode> <DataNode TextLabel="mTORC1" GraphId="be017" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="867.5" CenterY="800.0" Width="81.0" Height="32.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-377400" /> </DataNode> <DataNode TextLabel="ATP6V1E2 " GraphId="be58e" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="14" /> <Graphics CenterX="1220.0" CenterY="1693.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96A05" /> </DataNode> <DataNode TextLabel="v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP" GraphId="be66c" Type="Complex"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Graphics CenterX="647.5" CenterY="217.5" Width="327.0" Height="33.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9640184" /> </DataNode> <DataNode TextLabel="LAMTOR1 " GraphId="be88d" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1213.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6IAA8" /> </DataNode> <DataNode TextLabel="ITFG2 " GraphId="be961" Type="Protein" GroupRef="fd29d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640224" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1793.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q969R8" /> </DataNode> <DataNode TextLabel="RRAGB " GraphId="bf40f" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="16" /> <Graphics CenterX="520.0" CenterY="1753.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5VZM2" /> </DataNode> <DataNode TextLabel="LAMTOR5 " GraphId="bfd98" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="240.0" CenterY="1393.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O43504" /> </DataNode> <DataNode TextLabel="SLC38A9 " GraphId="bff7d" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1393.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NBW4" /> </DataNode> <DataNode TextLabel="DEPDC5 " GraphId="c014e" Type="Protein" GroupRef="e0c00"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640231" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1673.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75140" /> </DataNode> <DataNode TextLabel="KICSTOR:GATOR1" GraphId="c023d" Type="Complex"> <BiopaxRef>ecc</BiopaxRef> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Graphics CenterX="277.5" CenterY="444.5" Width="127.0" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9639274" /> </DataNode> <DataNode TextLabel="ATP6V1C1 " GraphId="c03d3" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="100.0" CenterY="1473.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21283" /> </DataNode> <DataNode TextLabel="SEH1L " GraphId="c1223" Type="Protein" GroupRef="af541"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639281" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1393.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96EE3" /> </DataNode> <DataNode TextLabel="KPTN " GraphId="c23ff" Type="Protein" GroupRef="fd29d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640224" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1813.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y664" /> </DataNode> <DataNode TextLabel="FLCN " GraphId="c2ea1" Type="Protein" GroupRef="f15a9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640226" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1213.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NFG4" /> </DataNode> <DataNode TextLabel="ATP6V0D1 " GraphId="c2f53" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1220.0" CenterY="1473.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P61421" /> </DataNode> <DataNode TextLabel="ATP6V1B2 " GraphId="c3068" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="520.0" CenterY="1493.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21281" /> </DataNode> <DataNode TextLabel="RRAGC " GraphId="c3588" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="380.0" CenterY="1493.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9HB90" /> </DataNode> <DataNode TextLabel="v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg" GraphId="c35b7" Type="Complex"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Graphics CenterX="699.5" CenterY="419.0" Width="227.0" Height="44.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9640192" /> </DataNode> <DataNode TextLabel="MTOR " GraphId="c3cfd" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="18" /> <Graphics CenterX="1360.0" CenterY="1833.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P42345" /> </DataNode> <DataNode TextLabel="RRAGD " GraphId="c3df4" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="380.0" CenterY="1513.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQL2" /> </DataNode> <DataNode TextLabel="ATP6V1G2 " GraphId="c3f07" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="14" /> <Graphics CenterX="660.0" CenterY="1653.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O95670" /> </DataNode> <DataNode TextLabel="ITFG2 " GraphId="c3fb2" Type="Protein" GroupRef="fbe47"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639275" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1433.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q969R8" /> </DataNode> <DataNode TextLabel="ATP6V0C " GraphId="c46e2" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="380.0" CenterY="1673.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P27449" /> </DataNode> <DataNode TextLabel="ATP6V1C2 " GraphId="c4a3f" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="380.0" CenterY="1853.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NEY4" /> </DataNode> <DataNode TextLabel="MTOR " GraphId="c5350" Type="Protein" GroupRef="dbc52"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-377400" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1493.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P42345" /> </DataNode> <DataNode TextLabel="ATP6V1A " GraphId="c5962" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="520.0" CenterY="1453.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P38606" /> </DataNode> <DataNode TextLabel="LAMTOR2 " GraphId="c5ac6" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1653.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y2Q5" /> </DataNode> <DataNode TextLabel="TCIRG1 " GraphId="c5ba6" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1273.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13488" /> </DataNode> <DataNode TextLabel="RRAGC " GraphId="c5f06" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="1080.0" CenterY="2213.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9HB90" /> </DataNode> <DataNode TextLabel="v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP" GraphId="c65e1" Type="Complex"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Graphics CenterX="326.0" CenterY="260.0" Width="254.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9646465" /> </DataNode> <DataNode TextLabel="LAMTOR1 " GraphId="c6e9d" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1213.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6IAA8" /> </DataNode> <DataNode TextLabel="CASTOR1 " GraphId="c7b5c" Type="Protein" GroupRef="ed054"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9657634" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1500.0" CenterY="1613.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WTX7" /> </DataNode> <DataNode TextLabel="ATP6V0E1 " GraphId="c7e30" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="100.0" CenterY="1373.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15342" /> </DataNode> <DataNode TextLabel="ATP6V1C1 " GraphId="c7ed7" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="380.0" CenterY="1833.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21283" /> </DataNode> <DataNode TextLabel="ATP6V1C2 " GraphId="c813f" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="520.0" CenterY="1533.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NEY4" /> </DataNode> <DataNode TextLabel="GTP " GraphId="c81a2" Type="Metabolite" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="16" /> <Graphics CenterX="660.0" CenterY="1733.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15996" /> </DataNode> <DataNode TextLabel="TCIRG1 " GraphId="c843d" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="240.0" CenterY="1413.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13488" /> </DataNode> <DataNode TextLabel="MLST8 " GraphId="c8627" Type="Protein" GroupRef="dbc52"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-377400" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1473.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BVC4" /> </DataNode> <DataNode TextLabel="ATP6V1C2 " GraphId="c865f" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="1080.0" CenterY="1953.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NEY4" /> </DataNode> <DataNode TextLabel="KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1" GraphId="c8c89" Type="Complex"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Graphics CenterX="346.5" CenterY="851.0" Width="189.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9657634" /> </DataNode> <DataNode TextLabel="ATP6V1G1 " GraphId="c9058" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="13" /> <Graphics CenterX="100.0" CenterY="1593.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75348" /> </DataNode> <DataNode TextLabel="ATP6V0E2 " GraphId="c9b44" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="240.0" CenterY="1533.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NHE4" /> </DataNode> <DataNode TextLabel="LAMTOR5 " GraphId="c9d52" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="380.0" CenterY="1613.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O43504" /> </DataNode> <DataNode TextLabel="ATP6V1H " GraphId="c9da8" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="18" /> <Graphics CenterX="1360.0" CenterY="1793.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UI12" /> </DataNode> <DataNode TextLabel="ATP6V1A " GraphId="c9fb1" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="660.0" CenterY="1453.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P38606" /> </DataNode> <DataNode TextLabel="LAMTOR5 " GraphId="ca0c1" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="1220.0" CenterY="1393.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O43504" /> </DataNode> <DataNode TextLabel="SZT2 " GraphId="ca39c" Type="Protein" GroupRef="fbe47"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639275" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1473.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5T011" /> </DataNode> <DataNode TextLabel="ATP6V1C1 " GraphId="ca3a0" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="1080.0" CenterY="1933.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21283" /> </DataNode> <DataNode TextLabel="ATP6V0E2 " GraphId="ca6fa" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1220.0" CenterY="1533.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NHE4" /> </DataNode> <DataNode TextLabel="ATP6V0D1 " GraphId="cac98" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="240.0" CenterY="1473.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P61421" /> </DataNode> <DataNode TextLabel="KPTN " GraphId="cb45a" Type="Protein" GroupRef="e0c00"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640231" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1773.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y664" /> </DataNode> <DataNode TextLabel="RRAGC " GraphId="cbc06" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="240.0" CenterY="1273.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9HB90" /> </DataNode> <DataNode TextLabel="TCIRG1 " GraphId="cbf06" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1313.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13488" /> </DataNode> <DataNode TextLabel="v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1" GraphId="cbf19" Type="Complex"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Graphics CenterX="700.5" CenterY="895.5" Width="223.0" Height="39.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9645607" /> </DataNode> <DataNode TextLabel="GDP " GraphId="cbfd9" Type="Metabolite" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="240.0" CenterY="1233.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17552" /> </DataNode> <DataNode TextLabel="ATP6V0B " GraphId="cc08d" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="1360.0" CenterY="1433.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q99437" /> </DataNode> <DataNode TextLabel="RRAGC " GraphId="cc3c5" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="16" /> <Graphics CenterX="100.0" CenterY="1733.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9HB90" /> </DataNode> <DataNode TextLabel="ATP6V1G1 " GraphId="cc772" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="13" /> <Graphics CenterX="660.0" CenterY="1633.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75348" /> </DataNode> <DataNode TextLabel="SZT2 " GraphId="ccde5" Type="Protein" GroupRef="d3800"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639274" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1413.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5T011" /> </DataNode> <DataNode TextLabel="MIOS " GraphId="cd37d" Type="Protein" GroupRef="e0c00"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640231" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1533.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NXC5" /> </DataNode> <DataNode TextLabel="GTP" GraphId="cd977" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="838.5" CenterY="174.0" Width="41.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15996" /> </DataNode> <DataNode TextLabel="NPRL3 " GraphId="cdcda" Type="Protein" GroupRef="af541"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639281" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1253.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q12980" /> </DataNode> <DataNode TextLabel="ATP6V1A " GraphId="cdd5d" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="10" /> <Graphics CenterX="1220.0" CenterY="1553.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P38606" /> </DataNode> <DataNode TextLabel="SZT2 " GraphId="ce068" Type="Protein" GroupRef="af541"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639281" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1333.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5T011" /> </DataNode> <DataNode TextLabel="GTP " GraphId="ce18d" Type="Metabolite" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="18" /> <Graphics CenterX="1360.0" CenterY="1873.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15996" /> </DataNode> <DataNode TextLabel="KICSTOR:GATOR1:BMT2" GraphId="ce456" Type="Complex"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Graphics CenterX="295.0" CenterY="501.5" Width="176.0" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9640224" /> </DataNode> <DataNode TextLabel="ATP6V1E1 " GraphId="ce7cd" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="1080.0" CenterY="1993.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P36543" /> </DataNode> <DataNode TextLabel="ATP6V1E2 " GraphId="ce8f0" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="520.0" CenterY="1593.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96A05" /> </DataNode> <DataNode TextLabel="SZT2 " GraphId="cf19c" Type="Protein" GroupRef="fd29d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640224" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1833.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5T011" /> </DataNode> <DataNode TextLabel="SZT2 " GraphId="cf3ed" Type="Protein" GroupRef="ed054"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9657634" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="1493.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5T011" /> </DataNode> <DataNode TextLabel="ATP6V1B1 " GraphId="cf4a5" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="13" /> <Graphics CenterX="1360.0" CenterY="1573.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P15313" /> </DataNode> <DataNode TextLabel="L-Leu " GraphId="cf4b6" Type="Metabolite" GroupRef="d0c75"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639290" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1533.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57427" /> </DataNode> <DataNode TextLabel="ATP6V0D2 " GraphId="cf8ab" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="380.0" CenterY="1713.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N8Y2" /> </DataNode> <DataNode TextLabel="CASTOR1 " GraphId="d0665" Type="Protein" GroupRef="e0c00"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640231" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1633.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WTX7" /> </DataNode> <DataNode TextLabel="ATP6V0E1 " GraphId="d0a05" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="240.0" CenterY="1513.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15342" /> </DataNode> <DataNode TextLabel="LAMTOR5 " GraphId="d13a2" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1293.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O43504" /> </DataNode> <DataNode TextLabel="GDP " GraphId="d180a" Type="Metabolite" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="1080.0" CenterY="2193.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17552" /> </DataNode> <DataNode TextLabel="ATP6V0E1 " GraphId="d24ce" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="660.0" CenterY="1413.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15342" /> </DataNode> <DataNode TextLabel="BMT2 " GraphId="d2ed5" Type="Protein" GroupRef="fd29d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640224" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1693.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q1RMZ1" /> </DataNode> <DataNode TextLabel="ATP6V1D " GraphId="d34e4" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="100.0" CenterY="1513.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y5K8" /> </DataNode> <DataNode TextLabel="ATP6V1C1 " GraphId="d3617" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="1360.0" CenterY="1613.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21283" /> </DataNode> <DataNode TextLabel="ATP6V0B " GraphId="d4525" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="240.0" CenterY="1433.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q99437" /> </DataNode> <DataNode TextLabel="RRAGB " GraphId="d4a03" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="16" /> <Graphics CenterX="660.0" CenterY="1753.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5VZM2" /> </DataNode> <DataNode TextLabel="ATP6V0E1 " GraphId="d4ae5" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1220.0" CenterY="1513.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15342" /> </DataNode> <DataNode TextLabel="RPTOR " GraphId="d506f" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1613.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N122" /> </DataNode> <DataNode TextLabel="RRAGD " GraphId="d5397" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="1080.0" CenterY="2233.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQL2" /> </DataNode> <DataNode TextLabel="DEPDC5 " GraphId="d5735" Type="Protein" GroupRef="fd29d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640224" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1713.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75140" /> </DataNode> <DataNode TextLabel="LAMTOR1 " GraphId="d5bc3" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1173.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6IAA8" /> </DataNode> <DataNode TextLabel="NPRL2 " GraphId="d5e22" Type="Protein" GroupRef="ed054"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9657634" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="1393.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WTW4" /> </DataNode> <DataNode TextLabel="SESN2 " GraphId="d5ff5" Type="Protein" GroupRef="fbe47"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639275" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1333.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P58004" /> </DataNode> <DataNode TextLabel="LAMTOR3 " GraphId="d5ffc" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1253.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UHA4" /> </DataNode> <DataNode TextLabel="SEC13 " GraphId="d6144" Type="Protein" GroupRef="fbe47"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639275" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1233.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P55735" /> </DataNode> <DataNode TextLabel="ATP6V0E2 " GraphId="d6639" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="1080.0" CenterY="1853.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NHE4" /> </DataNode> <DataNode TextLabel="MTOR " GraphId="d68ec" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1593.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P42345" /> </DataNode> <DataNode TextLabel="GTP " GraphId="d6c22" Type="Metabolite" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="100.0" CenterY="1753.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15996" /> </DataNode> <DataNode TextLabel="TCIRG1 " GraphId="d764f" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="1220.0" CenterY="1413.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13488" /> </DataNode> <DataNode TextLabel="TCIRG1 " GraphId="d7844" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1733.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13488" /> </DataNode> <DataNode TextLabel="FNIP1 " GraphId="d7c6a" Type="Protein" GroupRef="f15a9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640226" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1233.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8TF40" /> </DataNode> <DataNode TextLabel="LAMTOR2 " GraphId="d8235" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1193.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y2Q5" /> </DataNode> <DataNode TextLabel="ATP6V1F " GraphId="d8824" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="100.0" CenterY="1573.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q16864" /> </DataNode> <DataNode TextLabel="RRAGD " GraphId="d896a" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="520.0" CenterY="1813.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQL2" /> </DataNode> <DataNode TextLabel="ATP6V1D " GraphId="d94e7" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="14" /> <Graphics CenterX="1220.0" CenterY="1653.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y5K8" /> </DataNode> <DataNode TextLabel="ATP6V0B " GraphId="d96d2" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1333.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q99437" /> </DataNode> <DataNode TextLabel="AdoMet" GraphId="d9dce" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="74.5" CenterY="506.0" Width="59.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15414" /> </DataNode> <DataNode TextLabel="WDR24 " GraphId="d9f33" Type="Protein" GroupRef="e0c00"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640231" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1593.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96S15" /> </DataNode> <DataNode TextLabel="ATP6V1F " GraphId="da04e" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="520.0" CenterY="1613.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q16864" /> </DataNode> <DataNode TextLabel="ATP6V1G3 " GraphId="da0d0" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="18" /> <Graphics CenterX="1360.0" CenterY="1773.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96LB4" /> </DataNode> <DataNode TextLabel="LAMTOR4 " GraphId="da2b7" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="380.0" CenterY="1593.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q0VGL1" /> </DataNode> <DataNode TextLabel="ATP6V1E1 " GraphId="da4f6" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="240.0" CenterY="1673.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P36543" /> </DataNode> <DataNode TextLabel="ITFG2 " GraphId="da600" Type="Protein" GroupRef="d3800"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639274" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1373.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q969R8" /> </DataNode> <DataNode TextLabel="ATP6V1C2 " GraphId="da857" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="14" /> <Graphics CenterX="1220.0" CenterY="1633.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NEY4" /> </DataNode> <DataNode TextLabel="RRAGB " GraphId="daaa1" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="240.0" CenterY="1253.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5VZM2" /> </DataNode> <DataNode TextLabel="ATP6V1D " GraphId="db2d4" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="1360.0" CenterY="1653.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y5K8" /> </DataNode> <DataNode TextLabel="LAMTOR3 " GraphId="db2eb" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="1220.0" CenterY="1353.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UHA4" /> </DataNode> <DataNode TextLabel="ATP6V0D1 " GraphId="db3ee" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="380.0" CenterY="1693.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P61421" /> </DataNode> <DataNode TextLabel="ATP6V1G2 " GraphId="db494" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="14" /> <Graphics CenterX="520.0" CenterY="1653.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O95670" /> </DataNode> <DataNode TextLabel="ATP6V1G3 " GraphId="db56c" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="100.0" CenterY="1633.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96LB4" /> </DataNode> <DataNode TextLabel="C12orf66 " GraphId="db70b" Type="Protein" GroupRef="fbe47"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639275" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1413.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96MD2" /> </DataNode> <DataNode TextLabel="KPTN " GraphId="dba50" Type="Protein" GroupRef="fbe47"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639275" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1453.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y664" /> </DataNode> <DataNode TextLabel="ATP6V0E1 " GraphId="dbc67" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="520.0" CenterY="1413.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15342" /> </DataNode> <DataNode TextLabel="L-Arg " GraphId="dbc83" Type="Metabolite" GroupRef="c48b6"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640172" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1333.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:32682" /> </DataNode> <DataNode TextLabel="WDR24 " GraphId="dbe65" Type="Protein" GroupRef="af541"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639281" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1413.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96S15" /> </DataNode> <DataNode TextLabel="ATP6V1G1 " GraphId="dbeae" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="16" /> <Graphics CenterX="240.0" CenterY="1733.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75348" /> </DataNode> <DataNode TextLabel="L-Arg" GraphId="dc248" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="91.0" CenterY="958.5" Width="62.0" Height="39.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:32682" /> </DataNode> <DataNode TextLabel="RPTOR " GraphId="dc567" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="18" /> <Graphics CenterX="1360.0" CenterY="1853.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N122" /> </DataNode> <DataNode TextLabel="RRAGA " GraphId="dc83f" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1360.0" CenterY="1213.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q7L523" /> </DataNode> <DataNode TextLabel="RRAGA " GraphId="dca37" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1433.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q7L523" /> </DataNode> <DataNode TextLabel="DEPDC5 " GraphId="dca96" Type="Protein" GroupRef="af541"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639281" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1213.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75140" /> </DataNode> <DataNode TextLabel="ATP6V1C1 " GraphId="dd12a" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="520.0" CenterY="1513.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21283" /> </DataNode> <DataNode TextLabel="SESN1 " GraphId="ddbcd" Type="Protein" GroupRef="d0c75"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639290" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1493.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y6P5" /> </DataNode> <DataNode TextLabel="NPRL2 " GraphId="ddce0" Type="Protein" GroupRef="fbe47"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639275" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1373.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WTW4" /> </DataNode> <DataNode TextLabel="KPTN " GraphId="ddf95" Type="Protein" GroupRef="af541"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639281" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1313.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y664" /> </DataNode> <DataNode TextLabel="LAMTOR2 " GraphId="ddfb9" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="1360.0" CenterY="1333.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y2Q5" /> </DataNode> <DataNode TextLabel="GTP " GraphId="de327" Type="Metabolite" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="16" /> <Graphics CenterX="1080.0" CenterY="2153.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15996" /> </DataNode> <DataNode TextLabel="ATP6V1A " GraphId="de501" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="11" /> <Graphics CenterX="1360.0" CenterY="1553.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P38606" /> </DataNode> <DataNode TextLabel="LAMTOR5 " GraphId="de63b" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1293.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O43504" /> </DataNode> <DataNode TextLabel="NPRL2 " GraphId="de73d" Type="Protein" GroupRef="e0c00"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640231" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1693.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WTW4" /> </DataNode> <DataNode TextLabel="L-Arg " GraphId="df1aa" Type="Metabolite" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="520.0" CenterY="1853.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:32682" /> </DataNode> <DataNode TextLabel="ATP6V0E1 " GraphId="df40b" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="380.0" CenterY="1733.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15342" /> </DataNode> <DataNode TextLabel="MTOR " GraphId="df9f8" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="1220.0" CenterY="1273.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P42345" /> </DataNode> <DataNode TextLabel="ATP6V1A " GraphId="dfb4e" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="100.0" CenterY="1413.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P38606" /> </DataNode> <DataNode TextLabel="ATP6V0E1 " GraphId="e0999" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="1080.0" CenterY="1833.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15342" /> </DataNode> <DataNode TextLabel="ATP6V1B1 " GraphId="e0bbb" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="13" /> <Graphics CenterX="240.0" CenterY="1573.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P15313" /> </DataNode> <DataNode TextLabel="LAMTOR2 " GraphId="e0c2d" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="240.0" CenterY="1333.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y2Q5" /> </DataNode> <DataNode TextLabel="ATP6V0D1 " GraphId="e11ea" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="100.0" CenterY="1333.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P61421" /> </DataNode> <DataNode TextLabel="CASTOR2 " GraphId="e192b" Type="Protein" GroupRef="ab427"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640285" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1633.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="A6NHX0" /> </DataNode> <DataNode TextLabel="ATP6V1E2 " GraphId="e1c0d" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="1360.0" CenterY="1693.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96A05" /> </DataNode> <DataNode TextLabel="LAMTOR1 " GraphId="e1c35" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="1360.0" CenterY="1313.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6IAA8" /> </DataNode> <DataNode TextLabel="RRAGA " GraphId="e1e97" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1213.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q7L523" /> </DataNode> <DataNode TextLabel="ATP6V0D2 " GraphId="e2417" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1360.0" CenterY="1493.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N8Y2" /> </DataNode> <DataNode TextLabel="LAMTOR5 " GraphId="e2b48" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1713.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O43504" /> </DataNode> <DataNode TextLabel="SLC38A9 " GraphId="e3913" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="520.0" CenterY="1833.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NBW4" /> </DataNode> <DataNode TextLabel="RRAGB " GraphId="e3989" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="16" /> <Graphics CenterX="100.0" CenterY="1713.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5VZM2" /> </DataNode> <DataNode TextLabel="DEPDC5 " GraphId="e3a02" Type="Protein" GroupRef="ed054"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9657634" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="1373.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75140" /> </DataNode> <DataNode TextLabel="ATP6V0D2 " GraphId="e3f0c" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="240.0" CenterY="1493.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N8Y2" /> </DataNode> <DataNode TextLabel="ATP6V1B1 " GraphId="e4094" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="1220.0" CenterY="1573.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P15313" /> </DataNode> <DataNode TextLabel="TCIRG1 " GraphId="e4239" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="1360.0" CenterY="1413.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13488" /> </DataNode> <DataNode TextLabel="ATP6V1G1 " GraphId="e432e" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="13" /> <Graphics CenterX="1080.0" CenterY="2053.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75348" /> </DataNode> <DataNode TextLabel="ATP6V1G3 " GraphId="e4453" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="660.0" CenterY="1673.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96LB4" /> </DataNode> <DataNode TextLabel="ATP6V1B1 " GraphId="e448a" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="10" /> <Graphics CenterX="1080.0" CenterY="1893.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P15313" /> </DataNode> <DataNode TextLabel="DEPDC5 " GraphId="e4957" Type="Protein" GroupRef="fbe47"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639275" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1353.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75140" /> </DataNode> <DataNode TextLabel="ATP6V0E2 " GraphId="e4a25" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="380.0" CenterY="1753.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NHE4" /> </DataNode> <DataNode TextLabel="DEPDC5 " GraphId="e4b52" Type="Protein" GroupRef="d3800"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639274" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1293.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75140" /> </DataNode> <DataNode TextLabel="LAMTOR5 " GraphId="e4c22" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1253.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O43504" /> </DataNode> <DataNode TextLabel="ATP6V1E2 " GraphId="e5450" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="1080.0" CenterY="2013.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96A05" /> </DataNode> <DataNode TextLabel="L-Arg " GraphId="e579f" Type="Metabolite" GroupRef="ab427"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640285" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1593.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:32682" /> </DataNode> <DataNode TextLabel="ATP6V0E2 " GraphId="e5e59" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="660.0" CenterY="1433.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NHE4" /> </DataNode> <DataNode TextLabel="RRAGA " GraphId="e5ffc" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="520.0" CenterY="1713.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q7L523" /> </DataNode> <DataNode TextLabel="WDR59 " GraphId="e60e9" Type="Protein" GroupRef="ed054"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9657634" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="1593.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6PJI9" /> </DataNode> <DataNode TextLabel="LAMTOR2 " GraphId="e6304" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="1220.0" CenterY="1333.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y2Q5" /> </DataNode> <DataNode TextLabel="NPRL2 " GraphId="e666d" Type="Protein" GroupRef="fd29d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640224" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1733.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WTW4" /> </DataNode> <DataNode TextLabel="RRAGC " GraphId="e670b" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="18" /> <Graphics CenterX="1220.0" CenterY="1873.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9HB90" /> </DataNode> <DataNode TextLabel="ATP6V1C2 " GraphId="e69d4" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="240.0" CenterY="1633.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NEY4" /> </DataNode> <DataNode TextLabel="ATP6V1B1 " GraphId="e6a0e" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="10" /> <Graphics CenterX="660.0" CenterY="1473.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P15313" /> </DataNode> <DataNode TextLabel="ATP6V0B " GraphId="e6a62" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="380.0" CenterY="1653.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q99437" /> </DataNode> <DataNode TextLabel="NPRL3 " GraphId="e6b85" Type="Protein" GroupRef="ed054"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9657634" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="1413.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q12980" /> </DataNode> <DataNode TextLabel="ATP6V0E2 " GraphId="e6dce" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="100.0" CenterY="1393.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NHE4" /> </DataNode> <DataNode TextLabel="MIOS " GraphId="e70bc" Type="Protein" GroupRef="af541"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639281" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1353.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NXC5" /> </DataNode> <DataNode TextLabel="ATP6V0D2 " GraphId="e71f6" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="520.0" CenterY="1393.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N8Y2" /> </DataNode> <DataNode TextLabel="ATP6V1A " GraphId="e7a5e" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1080.0" CenterY="1873.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P38606" /> </DataNode> <DataNode TextLabel="SH3BP4" GraphId="e7aee" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="865.5" CenterY="521.5" Width="73.0" Height="23.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9P0V3" /> </DataNode> <DataNode TextLabel="KPTN " GraphId="e7d36" Type="Protein" GroupRef="d3800"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639274" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1393.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y664" /> </DataNode> <DataNode TextLabel="ATP6V0D2 " GraphId="e81a3" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1220.0" CenterY="1493.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N8Y2" /> </DataNode> <DataNode TextLabel="RRAGD " GraphId="e8db7" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="18" /> <Graphics CenterX="1220.0" CenterY="1893.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQL2" /> </DataNode> <DataNode TextLabel="ATP6V1G1 " GraphId="e94cf" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="16" /> <Graphics CenterX="1360.0" CenterY="1733.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75348" /> </DataNode> <DataNode TextLabel="NPRL3 " GraphId="e9dc6" Type="Protein" GroupRef="d3800"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639274" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1333.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q12980" /> </DataNode> <DataNode TextLabel="LAMTOR3 " GraphId="eaaf2" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="380.0" CenterY="1573.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UHA4" /> </DataNode> <DataNode TextLabel="LAMTOR4 " GraphId="eae9e" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="1360.0" CenterY="1373.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q0VGL1" /> </DataNode> <DataNode TextLabel="RHEB " GraphId="eb227" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="1220.0" CenterY="1233.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15382" /> </DataNode> <DataNode TextLabel="ATP6V1H " GraphId="ebaae" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="18" /> <Graphics CenterX="240.0" CenterY="1793.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UI12" /> </DataNode> <DataNode TextLabel="ITFG2 " GraphId="ec3b9" Type="Protein" GroupRef="e0c00"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640231" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1753.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q969R8" /> </DataNode> <DataNode TextLabel="GTP" GraphId="ec79d" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="877.5" CenterY="463.0" Width="41.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15996" /> </DataNode> <DataNode TextLabel="ATP6V0D2 " GraphId="ec7a3" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="1080.0" CenterY="1813.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N8Y2" /> </DataNode> <DataNode TextLabel="ATP6V1C2 " GraphId="ecee4" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="660.0" CenterY="1533.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NEY4" /> </DataNode> <DataNode TextLabel="ATP6V1C2 " GraphId="ed38b" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="100.0" CenterY="1493.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NEY4" /> </DataNode> <DataNode TextLabel="ITFG2 " GraphId="ed7e8" Type="Protein" GroupRef="af541"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639281" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1293.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q969R8" /> </DataNode> <DataNode TextLabel="ATP6V1E2 " GraphId="ee752" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="100.0" CenterY="1553.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96A05" /> </DataNode> <DataNode TextLabel="SEH1L " GraphId="eeaad" Type="Protein" GroupRef="fbe47"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639275" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1253.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96EE3" /> </DataNode> <DataNode TextLabel="FNIP2 " GraphId="eedcc" Type="Protein" GroupRef="f15a9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640226" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1253.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9P278" /> </DataNode> <DataNode TextLabel="FLCN:FNIP1,2" GraphId="ef2ec" Type="Complex"> <BiopaxRef>a33</BiopaxRef> <BiopaxRef>fca</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="689.0" CenterY="27.5" Width="106.0" Height="21.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9640226" /> </DataNode> <DataNode TextLabel="RPTOR " GraphId="ef3b8" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="1220.0" CenterY="1293.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N122" /> </DataNode> <DataNode TextLabel="LAMTOR2 " GraphId="ef980" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1233.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y2Q5" /> </DataNode> <DataNode TextLabel="WDR24 " GraphId="efe09" Type="Protein" GroupRef="fbe47"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639275" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1273.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96S15" /> </DataNode> <DataNode TextLabel="MIOS " GraphId="efe6b" Type="Protein" GroupRef="fbe47"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639275" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1213.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NXC5" /> </DataNode> <DataNode TextLabel="RRAGB " GraphId="eff0f" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="380.0" CenterY="1473.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5VZM2" /> </DataNode> <DataNode TextLabel="ATP6V1B2 " GraphId="f0188" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="100.0" CenterY="1453.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21281" /> </DataNode> <DataNode TextLabel="RRAGA " GraphId="f01b6" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="1080.0" CenterY="2133.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q7L523" /> </DataNode> <DataNode TextLabel="RHEB " GraphId="f0845" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="18" /> <Graphics CenterX="1360.0" CenterY="1893.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15382" /> </DataNode> <DataNode TextLabel="ATP6V0E1 " GraphId="f0865" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1360.0" CenterY="1513.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15342" /> </DataNode> <DataNode TextLabel="LAMTOR2 " GraphId="f0cf6" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="380.0" CenterY="1553.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y2Q5" /> </DataNode> <DataNode TextLabel="ATP6V1D " GraphId="f135c" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="520.0" CenterY="1553.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y5K8" /> </DataNode> <DataNode TextLabel="KICSTOR:GATOR1:GATOR2:SESN1,2" GraphId="f1525" Type="Complex"> <BiopaxRef>ebc</BiopaxRef> <BiopaxRef>a07</BiopaxRef> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Graphics CenterX="267.0" CenterY="592.5" Width="128.0" Height="39.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9639275" /> </DataNode> <DataNode TextLabel="SEC13 " GraphId="f160a" Type="Protein" GroupRef="e0c00"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640231" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1553.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P55735" /> </DataNode> <DataNode TextLabel="ATP6V0D2 " GraphId="f1659" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="100.0" CenterY="1353.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N8Y2" /> </DataNode> <DataNode TextLabel="LAMTOR4 " GraphId="f186a" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1233.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q0VGL1" /> </DataNode> <DataNode TextLabel="ATP6V0D1 " GraphId="f189d" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="660.0" CenterY="1373.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P61421" /> </DataNode> <DataNode TextLabel="ATP6V0D1 " GraphId="f1d91" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="520.0" CenterY="1373.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P61421" /> </DataNode> <DataNode TextLabel="LAMTOR4 " GraphId="f1f40" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="1220.0" CenterY="1373.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q0VGL1" /> </DataNode> <DataNode TextLabel="ATP6V1G3 " GraphId="f1fa4" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="1220.0" CenterY="1773.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96LB4" /> </DataNode> <DataNode TextLabel="BMT2:AdoMet" GraphId="f214e" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="85.0" CenterY="447.5" Width="106.0" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9640252" /> </DataNode> <DataNode TextLabel="ATP6V0D2 " GraphId="f2336" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="660.0" CenterY="1393.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N8Y2" /> </DataNode> <DataNode TextLabel="ATP6V0C " GraphId="f2699" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="1080.0" CenterY="1773.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P27449" /> </DataNode> <DataNode TextLabel="C12orf66 " GraphId="f27a3" Type="Protein" GroupRef="af541"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639281" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1273.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96MD2" /> </DataNode> <DataNode TextLabel="ATP6V1G2 " GraphId="f2aa2" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="1360.0" CenterY="1753.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O95670" /> </DataNode> <DataNode TextLabel="ATP6V1F " GraphId="f2b67" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="380.0" CenterY="1933.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q16864" /> </DataNode> <DataNode TextLabel="Pi" GraphId="f2ebb" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="155.5" CenterY="299.0" Width="35.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:18367" /> </DataNode> <DataNode TextLabel="GTP " GraphId="f2fb5" Type="Metabolite" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="1220.0" CenterY="1213.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15996" /> </DataNode> <DataNode TextLabel="LAMTOR1 " GraphId="f3495" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="380.0" CenterY="1533.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6IAA8" /> </DataNode> <DataNode TextLabel="ATP6V1B1 " GraphId="f3b43" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="10" /> <Graphics CenterX="520.0" CenterY="1473.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P15313" /> </DataNode> <DataNode TextLabel="WDR59 " GraphId="f4169" Type="Protein" GroupRef="fbe47"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639275" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1293.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6PJI9" /> </DataNode> <DataNode TextLabel="BMT2 " GraphId="f436c" Type="Protein" GroupRef="e8e7d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640252" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1213.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q1RMZ1" /> </DataNode> <DataNode TextLabel="RRAGC " GraphId="f453a" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="660.0" CenterY="1793.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9HB90" /> </DataNode> <DataNode TextLabel="ATP6V1C1 " GraphId="f4549" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="14" /> <Graphics CenterX="1220.0" CenterY="1613.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21283" /> </DataNode> <DataNode TextLabel="KPTN " GraphId="f4709" Type="Protein" GroupRef="ed054"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9657634" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="1473.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y664" /> </DataNode> <DataNode TextLabel="ATP6V1C1 " GraphId="f4a3a" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="660.0" CenterY="1513.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21283" /> </DataNode> <DataNode TextLabel="NPRL2 " GraphId="f4a7b" Type="Protein" GroupRef="d3800"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639274" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1313.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WTW4" /> </DataNode> <DataNode TextLabel="ATP6V1D " GraphId="f4ab7" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="380.0" CenterY="1873.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y5K8" /> </DataNode> <DataNode TextLabel="ATP6V1B1 " GraphId="f4bdf" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="10" /> <Graphics CenterX="100.0" CenterY="1433.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P15313" /> </DataNode> <DataNode TextLabel="SESN2 " GraphId="f4d5c" Type="Protein" GroupRef="d0c75"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639290" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1513.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P58004" /> </DataNode> <DataNode TextLabel="ATP6V0B " GraphId="f53c7" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1753.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q99437" /> </DataNode> <DataNode TextLabel="RRAGB " GraphId="f541e" Type="Protein" GroupRef="c939f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646467" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="1220.0" CenterY="1833.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5VZM2" /> </DataNode> <DataNode TextLabel="RHEB " GraphId="f55e4" Type="Protein" GroupRef="f4a43"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-165189" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="1233.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15382" /> </DataNode> <DataNode TextLabel="ATP6V1H " GraphId="f5727" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="100.0" CenterY="1653.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UI12" /> </DataNode> <DataNode TextLabel="RRAGD " GraphId="f5bb9" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="660.0" CenterY="1813.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQL2" /> </DataNode> <DataNode TextLabel="MIOS " GraphId="f5e06" Type="Protein" GroupRef="ed054"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9657634" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="1513.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NXC5" /> </DataNode> <DataNode TextLabel="ATP6V1A " GraphId="f65e1" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="11" /> <Graphics CenterX="240.0" CenterY="1553.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P38606" /> </DataNode> <DataNode TextLabel="L-Leu" GraphId="f7094" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="105.5" CenterY="595.0" Width="53.0" Height="34.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57427" /> </DataNode> <DataNode TextLabel="ATP6V1E1 " GraphId="f7163" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="660.0" CenterY="1573.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P36543" /> </DataNode> <DataNode TextLabel="ATP6V1E2 " GraphId="f7518" Type="Protein" GroupRef="ce8c2"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639277" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="660.0" CenterY="1593.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96A05" /> </DataNode> <DataNode TextLabel="ATP6V1A " GraphId="f89f7" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="11" /> <Graphics CenterX="380.0" CenterY="1773.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P38606" /> </DataNode> <DataNode TextLabel="v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP" GraphId="f962d" Type="Complex"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Graphics CenterX="402.5" CenterY="67.5" Width="325.0" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9640174" /> </DataNode> <DataNode TextLabel="RRAGD " GraphId="f992c" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="240.0" CenterY="1293.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQL2" /> </DataNode> <DataNode TextLabel="ATP6V1F " GraphId="f9dc0" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="1080.0" CenterY="2033.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q16864" /> </DataNode> <DataNode TextLabel="ATP6V0E2 " GraphId="fab0c" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="520.0" CenterY="1433.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NHE4" /> </DataNode> <DataNode TextLabel="C12orf66 " GraphId="fad35" Type="Protein" GroupRef="d3800"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639274" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="1353.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96MD2" /> </DataNode> <DataNode TextLabel="ATP6V1E2 " GraphId="fb3db" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="240.0" CenterY="1693.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96A05" /> </DataNode> <DataNode TextLabel="GDP " GraphId="fbc59" Type="Metabolite" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="380.0" CenterY="1453.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17552" /> </DataNode> <DataNode TextLabel="RRAGA " GraphId="fc3fe" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="100.0" CenterY="1673.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q7L523" /> </DataNode> <DataNode TextLabel="ATP6V1H " GraphId="fc7d6" Type="Protein" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="520.0" CenterY="1693.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UI12" /> </DataNode> <DataNode TextLabel="RRAGD " GraphId="fcdd6" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="1360.0" CenterY="1293.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQL2" /> </DataNode> <DataNode TextLabel="GDP" GraphId="fceec" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="604.5" CenterY="35.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17552" /> </DataNode> <DataNode TextLabel="C12orf66 " GraphId="fd24b" Type="Protein" GroupRef="ed054"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9657634" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="1433.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96MD2" /> </DataNode> <DataNode TextLabel="SEC13 " GraphId="fd327" Type="Protein" GroupRef="af541"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9639281" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1373.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P55735" /> </DataNode> <DataNode TextLabel="GDP " GraphId="fd634" Type="Metabolite" GroupRef="fb14d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9639283" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="520.0" CenterY="1773.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17552" /> </DataNode> <DataNode TextLabel="WDR24 " GraphId="fda77" Type="Protein" GroupRef="ed054"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9657634" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="1573.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96S15" /> </DataNode> <DataNode TextLabel="GTP " GraphId="fdc06" Type="Metabolite" GroupRef="f4a43"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-165189" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="1213.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15996" /> </DataNode> <DataNode TextLabel="RRAGB " GraphId="fdfc4" Type="Protein" GroupRef="d562c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9645607" /> <Attribute Key="copies_num" Value="16" /> <Graphics CenterX="1080.0" CenterY="2173.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5VZM2" /> </DataNode> <DataNode TextLabel="RRAGD " GraphId="fe2c7" Type="Protein" GroupRef="db9de"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640174" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="100.0" CenterY="1773.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQL2" /> </DataNode> <DataNode TextLabel="v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP" GraphId="fe68e" Type="Complex"> <BiopaxRef>ffe</BiopaxRef> <BiopaxRef>ed0</BiopaxRef> <BiopaxRef>c15</BiopaxRef> <BiopaxRef>dff</BiopaxRef> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Graphics CenterX="694.0" CenterY="757.0" Width="234.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9639277" /> </DataNode> <DataNode TextLabel="ATP6V0C " GraphId="fe79b" Type="Protein" GroupRef="c8dac"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640184" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="240.0" CenterY="1453.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P27449" /> </DataNode> <DataNode TextLabel="SESN1,2:L-Leu" GraphId="fecc3" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="65.5" CenterY="646.0" Width="113.0" Height="26.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9639290" /> </DataNode> <DataNode TextLabel="ATP6V1E1 " GraphId="fee62" Type="Protein" GroupRef="d0ad9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9646465" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="1360.0" CenterY="1673.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P36543" /> </DataNode> <DataNode TextLabel="ATP6V1E2 " GraphId="ff54e" Type="Protein" GroupRef="e8fef"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-9640192" /> <Attribute Key="copies_num" Value="15" /> <Graphics CenterX="380.0" CenterY="1913.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96A05" /> </DataNode> <DataNode TextLabel="SEH1L " GraphId="ffaff" Type="Protein" GroupRef="e0c00"> <Attribute Key="cellular_location" Value="lysosomal membrane" /> <Attribute Key="complex_id" Value="R-HSA-9640231" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1573.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96EE3" /> </DataNode> <Interaction GraphId="a1534"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="224.0" Y="807.0" GraphRef="daf01" RelX="0.0" RelY="-1.1499999999999773" /> <Point X="206.0" Y="667.0" GraphRef="addd8" RelX="-1.0" RelY="-0.034482758620689655" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640237" /> </Interaction> <Interaction GraphId="a4269"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="207.0" Y="501.0" GraphRef="ce456" RelX="-1.0" RelY="-0.04" /> <Point X="166.0" Y="494.0" GraphRef="e3b5f" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640254" /> </Interaction> <Interaction GraphId="a57db"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="331.0" Y="592.0" GraphRef="b8b78" RelX="-0.17204301075268819" RelY="-18.35135135135135" /> <Point X="441.0" Y="584.0" GraphRef="f2512" RelX="23.0" RelY="-119.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640195" /> </Interaction> <Interaction GraphId="a5c0f"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="550.0" Y="1081.0" GraphRef="c5487" RelX="-1.4700000000000273" RelY="1.3099999999999454" /> <Point X="521.0" Y="1084.0" GraphRef="b1555" RelX="-0.004016064257028112" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9646468" /> </Interaction> <Interaction GraphId="a5e48"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="521.0" Y="1084.0" GraphRef="b1555" RelX="-0.004016064257028112" RelY="-1.0" /> <Point X="510.0" Y="1081.0" GraphRef="ccfd5" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640195" /> </Interaction> <Interaction GraphId="a6efa"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="326.0" Y="325.0" GraphRef="e7551" RelX="-1.8400000000000318" RelY="-7.560000000000059" /> <Point X="326.0" Y="278.0" GraphRef="c65e1" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640195" /> </Interaction> <Interaction GraphId="a9e7a"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="217.0" Y="752.0" GraphRef="fc6c5" RelX="0.05000000000001137" RelY="-1.6200000000000045" /> <Point X="164.0" Y="745.0" GraphRef="ad44f" RelX="0.9869281045751634" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9657619" /> </Interaction> <Interaction GraphId="a9f21"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="224.0" Y="807.0" GraphRef="daf01" RelX="0.0" RelY="-1.1499999999999773" /> <Point X="177.0" Y="791.0" GraphRef="aadc3" RelX="0.9884393063583815" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640237" /> </Interaction> <Interaction GraphId="aa189"> <Comment Source="Reactome">RRAGA:GTP (RagA:GTP) binds poorly to SLC38A9, therefore SLC39A9 is believed to dissociate from RRAGA:GTP after RRAGA exchanges GDP for GTP (Shen and Sabatini 2018). In this way one molecule of SLC38A9 can enhance the exchange of GDP for GTP for many molecules of RRAGA (Shen and Sabatini 2018).</Comment> <BiopaxRef>c44</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="705.0" Y="645.0" /> <Point X="705.0" Y="706.0" /> <Anchor Position="0.0" Shape="None" GraphId="ad064" /> <Anchor Position="0.99" Shape="None" GraphId="c7be0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640168" /> </Interaction> <Interaction GraphId="acae4"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="647.0" Y="233.0" GraphRef="be66c" RelX="-0.0030581039755351682" RelY="0.9393939393939394" /> <Point X="702.0" Y="314.0" GraphRef="a7af6" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640175" /> </Interaction> <Interaction GraphId="acea4"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="645.0" Y="155.0" GraphRef="de399" RelX="0.32000000000005" RelY="0.4900000000000091" /> <Point X="818.0" Y="174.0" GraphRef="cd977" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9639286" /> </Interaction> <Interaction GraphId="aef95"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="662.0" Y="135.0" GraphRef="afdab" RelX="1.8400000000000318" RelY="0.5199999999999818" /> <Point X="647.0" Y="201.0" GraphRef="be66c" RelX="-0.0030581039755351682" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9645598" /> </Interaction> <Interaction GraphId="b2718"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="331.0" Y="592.0" GraphRef="ce456" RelX="0.4090909090909091" RelY="7.24" /> <Point X="441.0" Y="584.0" GraphRef="f2512" RelX="23.0" RelY="-119.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640195" /> </Interaction> <Interaction GraphId="b6b49"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="122.0" Y="958.0" GraphRef="dc248" RelX="1.0" RelY="-0.02564102564102564" /> <Point X="224.0" Y="922.0" GraphRef="a5a29" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640237" /> </Interaction> <Interaction GraphId="b6e20"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="829.0" Y="521.0" GraphRef="e7aee" RelX="-1.0" RelY="-0.043478260869565216" /> <Point X="703.0" Y="510.0" GraphRef="f5779" RelX="-6.0" RelY="-4.5" ArrowHead="TBar" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640167" /> </Interaction> <Interaction GraphId="bcb5b"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="103.0" Y="506.0" GraphRef="d9dce" RelX="0.9661016949152542" RelY="0.0" /> <Point X="166.0" Y="494.0" GraphRef="e3b5f" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640254" /> </Interaction> <Interaction GraphId="bdb27"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="633.0" Y="319.0" GraphRef="bca9e" RelX="1.0" RelY="-0.04" /> <Point X="702.0" Y="314.0" GraphRef="a7af6" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640175" /> </Interaction> <Interaction GraphId="be874"> <Comment Source="Reactome">BMT2 (SAMTOR) binds GATOR1 and acts upstream of GATOR1 and KICSTOR to inhibit mTORC1 activation (Gu et al. 2017). Upon binding S-adenosymethionine, a metabolic derivative of the amino acid methionine, SAMTOR dissociates from GATOR1 and mTORC1 activity is increased through an uncharacterized mechanism (Gu et al. 2017). GATOR1 is recruited to the lysosomal membrane by the KICSTOR complex (Wolfson et al. 2017).</Comment> <BiopaxRef>ea1</BiopaxRef> <BiopaxRef>ecc</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="166.0" Y="494.0" /> <Point X="163.0" Y="453.0" /> <Anchor Position="0.0" Shape="None" GraphId="e3b5f" /> <Anchor Position="0.99" Shape="None" GraphId="abb47" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640254" /> </Interaction> <Interaction GraphId="bf763"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="402.0" Y="79.0" GraphRef="f962d" RelX="-0.003076923076923077" RelY="0.92" /> <Point X="478.0" Y="83.0" GraphRef="eaf67" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9645598" /> </Interaction> <Interaction GraphId="c2c7c"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="827.0" Y="800.0" GraphRef="be017" RelX="-1.0" RelY="0.0" /> <Point X="704.0" Y="813.0" GraphRef="d3139" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9645608" /> </Interaction> <Interaction GraphId="c2e12"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="163.0" Y="453.0" GraphRef="abb47" RelX="-0.030000000000001137" RelY="-0.410000000000025" /> <Point X="138.0" Y="447.0" GraphRef="f214e" RelX="1.0" RelY="-0.04" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640254" /> </Interaction> <Interaction GraphId="c33cd"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="203.0" Y="592.0" GraphRef="f1525" RelX="-1.0" RelY="-0.02564102564102564" /> <Point X="187.0" Y="600.0" GraphRef="b74de" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9639287" /> </Interaction> <Interaction GraphId="c424c"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="705.0" Y="547.0" GraphRef="e25db" RelX="-0.08000000000004093" RelY="0.6499999999999773" /> <Point X="705.0" Y="599.0" GraphRef="accd3" RelX="-0.004524886877828055" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640167" /> </Interaction> <Interaction GraphId="c534e"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="857.0" Y="463.0" GraphRef="ec79d" RelX="-1.0" RelY="0.0" /> <Point X="713.0" Y="482.0" GraphRef="d6cc1" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640167" /> </Interaction> <Interaction GraphId="cab82"> <Comment Source="Reactome">RHEB:GTP interacts with mTORC1 and activates the kinase activity of mTORC1 (Long et al. 2005, Tee et al. 2005, Long et al. 2007, Yang et al. 2017). RHEB binds the catalytic domain of the MTOR subunit of the mTORC1 complex (Long et al. 2005, Yang et al. 2017). The interaction of RHEB with mTORC1 is independent of the guanyl nucleotide bound by RHEB while the activation of MTOR is dependent on GTP bound to RHEB (Long et al. 2005). The binding of MTOR to RHEB is dependent on amino acid sufficiency (Long et al. 2005) due to association of mTORC1 with the Rag heterodimer at the lysosomal membrane.</Comment> <BiopaxRef>dc9</BiopaxRef> <BiopaxRef>bcd</BiopaxRef> <BiopaxRef>f24</BiopaxRef> <BiopaxRef>f86</BiopaxRef> <BiopaxRef>dfa</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="697.0" Y="950.0" /> <Point X="550.0" Y="1081.0" /> <Anchor Position="0.0" Shape="None" GraphId="e5c38" /> <Anchor Position="0.99" Shape="None" GraphId="c5487" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9646468" /> </Interaction> <Interaction GraphId="cc3b6"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="662.0" Y="135.0" GraphRef="afdab" RelX="1.8400000000000318" RelY="0.5199999999999818" /> <Point X="822.0" Y="138.0" GraphRef="a8486" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9645598" /> </Interaction> <Interaction GraphId="ce112"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="705.0" Y="706.0" GraphRef="c7be0" RelX="0.0" RelY="0.6100000000000136" /> <Point X="694.0" Y="737.0" GraphRef="fe68e" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640168" /> </Interaction> <Interaction GraphId="d15b0"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="402.0" Y="79.0" GraphRef="f962d" RelX="-0.003076923076923077" RelY="0.92" /> <Point X="669.0" Y="107.0" GraphRef="ae97d" RelX="99.0" RelY="-2.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9645598" /> </Interaction> <Interaction GraphId="d1abb"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="217.0" Y="752.0" GraphRef="fc6c5" RelX="0.05000000000001137" RelY="-1.6200000000000045" /> <Point X="206.0" Y="667.0" GraphRef="addd8" RelX="-1.0" RelY="-0.034482758620689655" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9657619" /> </Interaction> <Interaction GraphId="d1bec"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="252.0" Y="851.0" GraphRef="c8c89" RelX="-1.0" RelY="0.0" /> <Point X="212.0" Y="914.0" GraphRef="d1a31" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9657619" /> </Interaction> <Interaction GraphId="d2397"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="700.0" Y="394.0" GraphRef="dc00a" RelX="-0.01999999999998181" RelY="0.8000000000000114" /> <Point X="699.0" Y="397.0" GraphRef="c35b7" RelX="-0.004405286343612335" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640175" /> </Interaction> <Interaction GraphId="d7b89"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="604.0" Y="50.0" GraphRef="fceec" RelX="-0.023255813953488372" RelY="1.0" /> <Point X="613.0" Y="106.0" GraphRef="d6855" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9639286" /> </Interaction> <Interaction GraphId="da52f"> <Comment Source="Reactome">The Ragulator complex acts as an unconventional guanyl nucleotide exchange factor (GEF) that ejects GTP from RRAGC and, by inference, RRAGD (Shen and Sabatini 2018). (Other known GEFs cause ejection of GDP rather than GTP from their targets.) The GDP-bound form of RRAGC,D is the active form that recruits mTORC1 to the lysosomal membrane.</Comment> <BiopaxRef>c44</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="613.0" Y="106.0" /> <Point X="645.0" Y="155.0" /> <Anchor Position="0.0" Shape="None" GraphId="d6855" /> <Anchor Position="0.99" Shape="None" GraphId="de399" /> <Anchor Position="0.5" Shape="None" GraphId="f113d" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9639286" /> </Interaction> <Interaction GraphId="db4d0"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="254.0" Y="931.0" GraphRef="b8b78" RelX="-1.0" RelY="-0.02702702702702703" /> <Point X="224.0" Y="922.0" GraphRef="a5a29" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640237" /> </Interaction> <Interaction GraphId="dd0e4"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="564.0" Y="67.0" GraphRef="f962d" RelX="0.9938461538461538" RelY="-0.04" /> <Point X="629.0" Y="125.0" GraphRef="f113d" RelX="0.0" RelY="-5.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9639286" /> </Interaction> <Interaction GraphId="dd777"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="700.0" Y="873.0" GraphRef="fc3cf" RelX="-0.03999999999996362" RelY="0.6000000000000227" /> <Point X="700.0" Y="876.0" GraphRef="cbf19" RelX="-0.004484304932735426" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9645608" /> </Interaction> <Interaction GraphId="dd9b5"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="705.0" Y="641.0" GraphRef="accd3" RelX="-0.004524886877828055" RelY="0.9534883720930233" /> <Point X="705.0" Y="645.0" GraphRef="ad064" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640168" /> </Interaction> <Interaction GraphId="deeb5"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="636.0" Y="27.0" GraphRef="ef2ec" RelX="-1.0" RelY="-0.047619047619047616" /> <Point X="669.0" Y="107.0" GraphRef="f3f68" RelX="99.0" RelY="-2.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9645598" /> </Interaction> <Interaction GraphId="e2f81"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="700.0" Y="914.0" GraphRef="cbf19" RelX="-0.004484304932735426" RelY="0.9487179487179487" /> <Point X="697.0" Y="950.0" GraphRef="e5c38" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9646468" /> </Interaction> <Interaction GraphId="e4ac0"> <Comment Source="Reactome">SESN2 (Sestrin2) and SESN1 (Sestrin1) each interact with the GATOR2 complex in the absence of leucine and, upon binding leucine, dissociate from the GATOR2 complex (Chantranupong et al. 2014, Parmigiani et al. 2014, Kim et al. 2015, Wolfson et al. 2016, Saxton et al. 2016). (SESN3 constitutively binds GATOR2 in the presence and absence of leucine.) When bound to GATOR2, the Sestrins appear to prevent GATOR2 from inhibiting GATOR1, a GTPase activator which negatively regulates mTORC1 activation by increasing the rate of hydrolysis of RRAGA,B:GTP to RRAGA,B:GDP. SESN1,2 complexed with GATOR2 therefore allows GATOR1 to maintain mTORC1 in the inactive state (Chantranupong et al. 2014, Parmigiani et al. 2014, Kim et al. 2015). L-leucine binds SESN1,2 and causes SESN1,2 to dissociate from GATOR2, allowing GATOR2 to inhibit GATOR1 and thereby maintain RRAGA,B in the active (GTP-bound) state (Wolfson et al. 2016, Saxton et al. 2016). GATOR1 is recruited to the lysosomal membrane by the KICSTOR complex (Wolfson et al. 2017, Peng et al. 2017).&lt;br&gt;Sestrins also appear to interact with the Rag heterodimer (Peng et al. 2014) though the interaction may be indirect (Budanov 2015).</Comment> <BiopaxRef>ebc</BiopaxRef> <BiopaxRef>a83</BiopaxRef> <BiopaxRef>a07</BiopaxRef> <BiopaxRef>e94</BiopaxRef> <BiopaxRef>b58</BiopaxRef> <BiopaxRef>ecc</BiopaxRef> <BiopaxRef>d39</BiopaxRef> <BiopaxRef>f41</BiopaxRef> <BiopaxRef>aba</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="187.0" Y="600.0" /> <Point X="190.0" Y="644.0" /> <Anchor Position="0.0" Shape="None" GraphId="b74de" /> <Anchor Position="0.99" Shape="None" GraphId="d9838" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9639287" /> </Interaction> <Interaction GraphId="e4cae"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="705.0" Y="706.0" GraphRef="c7be0" RelX="0.0" RelY="0.6100000000000136" /> <Point X="633.0" Y="319.0" GraphRef="bca9e" RelX="1.0" RelY="-0.04" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640168" /> </Interaction> <Interaction GraphId="e6d20"> <Comment Source="Reactome">The N-terminal domain of SLC38A9 bound to L-arginine interacts indirectly with the Ragulator complex via the Rag GTPases RRAGA and RRAGC (Wang et al. 2015, Rebsamen et al. 2015, Wyant et al. 2017, Shen and Sabatini 2018).</Comment> <BiopaxRef>c44</BiopaxRef> <BiopaxRef>cf9</BiopaxRef> <BiopaxRef>a9c</BiopaxRef> <BiopaxRef>d85</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="702.0" Y="314.0" /> <Point X="700.0" Y="394.0" /> <Anchor Position="0.0" Shape="None" GraphId="a7af6" /> <Anchor Position="0.99" Shape="None" GraphId="dc00a" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640175" /> </Interaction> <Interaction GraphId="eb14e"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="645.0" Y="155.0" GraphRef="de399" RelX="0.32000000000005" RelY="0.4900000000000091" /> <Point X="647.0" Y="201.0" GraphRef="be66c" RelX="-0.0030581039755351682" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9639286" /> </Interaction> <Interaction GraphId="eb9f7"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="131.0" Y="595.0" GraphRef="f7094" RelX="0.9622641509433962" RelY="0.0" /> <Point X="187.0" Y="600.0" GraphRef="b74de" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9639287" /> </Interaction> <Interaction GraphId="ec019"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="694.0" Y="777.0" GraphRef="fe68e" RelX="0.0" RelY="1.0" /> <Point X="704.0" Y="813.0" GraphRef="d3139" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9645608" /> </Interaction> <Interaction GraphId="ed1b4"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="720.0" Y="941.0" GraphRef="a52a6" RelX="-1.0" RelY="0.0" /> <Point X="697.0" Y="950.0" GraphRef="e5c38" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9646468" /> </Interaction> <Interaction GraphId="edb59"> <Comment Source="Reactome">CASTOR1 in a heterodimer with CASTOR2 interacts with the GATOR2 complex via the MIOS subunit of GATOR2 (Chantranupong et al. 2016, Gai et al. 2016). The ACT domains of the CASTOR1 subunit bind L-arginine (Chantranupong et al. 2016, Saxton et al. 2016, Xia et al. 2016, Gai et al. 2016) and CASTOR1:arginine dissociates from GATOR2, which then prevents GATOR1 from activating the GTPase of RRAGA,B (Chantranupong et al. 2016). GATOR1 is recruited to the lysosomal membrane by the KICSTOR complex (Wolfson et al. 2017).</Comment> <BiopaxRef>eea</BiopaxRef> <BiopaxRef>bb7</BiopaxRef> <BiopaxRef>f58</BiopaxRef> <BiopaxRef>f3c</BiopaxRef> <BiopaxRef>ecc</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="224.0" Y="922.0" /> <Point X="224.0" Y="807.0" /> <Anchor Position="0.0" Shape="None" GraphId="a5a29" /> <Anchor Position="0.99" Shape="None" GraphId="daf01" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640237" /> </Interaction> <Interaction GraphId="f0f36"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="699.0" Y="441.0" GraphRef="c35b7" RelX="-0.004405286343612335" RelY="1.0" /> <Point X="713.0" Y="482.0" GraphRef="d6cc1" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640167" /> </Interaction> <Interaction GraphId="f1e8e"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="521.0" Y="1084.0" GraphRef="b1555" RelX="-0.004016064257028112" RelY="-1.0" /> <Point X="441.0" Y="584.0" GraphRef="c1381" RelX="23.0" RelY="-119.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640195" /> </Interaction> <Interaction GraphId="f2215"> <Comment Source="Reactome">The heterodimer comprising RRAGA,B:GTP and RRAGC,D:GDP (RagA:GTP or RagB:GTP complexed with RagC:GDP or RagD:GDP) forms the active conformation of the Rag complex that recruits the mTORC1 complex from the cytosol to the lysosomal membrane (Kim et al. 2008, Sancak et al. 2008, Sancak et al. 2010) where RHEB activates the protein kinase activity of mTORC1. Hydrolysis of ATP by the v-ATPase complex is also required for recruitment of mTORC1 (Zoncu et al. 2011). The active state of the RRAGA,B:RRAGC,D heterodimer is less stably associated with the Ragulator complex and appears to cycle with mTORC1 between the lysosomal membrane and the cytosol (Lawrence et al. 2018). The cycling may provide a mechanism for attenuating mTORC1 signaling.</Comment> <BiopaxRef>c91</BiopaxRef> <BiopaxRef>dda</BiopaxRef> <BiopaxRef>a31</BiopaxRef> <BiopaxRef>e8c</BiopaxRef> <BiopaxRef>cb9</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="704.0" Y="813.0" /> <Point X="700.0" Y="873.0" /> <Anchor Position="0.0" Shape="None" GraphId="d3139" /> <Anchor Position="0.99" Shape="None" GraphId="fc3cf" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9645608" /> </Interaction> <Interaction GraphId="f25ec"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="190.0" Y="644.0" GraphRef="d9838" RelX="0.030000000000001137" RelY="0.44000000000005457" /> <Point X="206.0" Y="667.0" GraphRef="addd8" RelX="-1.0" RelY="-0.034482758620689655" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9639287" /> </Interaction> <Interaction GraphId="f3226"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="163.0" Y="453.0" GraphRef="abb47" RelX="-0.030000000000001137" RelY="-0.410000000000025" /> <Point X="214.0" Y="444.0" GraphRef="c023d" RelX="-1.0" RelY="-0.04" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640254" /> </Interaction> <Interaction GraphId="f33f9"> <Comment Source="Reactome">The GTPase activity of RRAGA,B hydrolyzes GTP to GDP (Bar-Peled et al. 2013). RRAGA and RRAGB lack detectable GTPase activity in the absence of a GTPase activating protein (Schurmann et al. 1995). The NPRL2 subunit of the GATOR1 complex acts as a GTPase activator of RRAGA,B and thereby controls the guanyl nucleotide bound to RRAGA,B (Bar-Peled et al. 2013, Shen et al. 2019). GATOR2 antagonizes GATOR1 (Bar-Peled et al. 2013). During amino acid deficiency, Sestrins (SESN1 and SESN2) (Chantranupong et al. 2014, Parmigiani et al. 2014, Peng et al. 2014, Kim et al. 2015, Wolfson et al. 2016, Saxton et al. 2016) and CASTOR1 (Chantranupong et al. 2016, Saxton et al. 2016, Gai et al. 2016, Xia et al. 2016) bound to GATOR2 prevent GATOR2 from antagonizing GATOR1 (Bar-Peled et al. 2013). BMT2 (SAMTOR) bound to GATOR1 enhances inhibition of mTORC1 activation by GATOR1 (Gu et al. 2017).</Comment> <BiopaxRef>b69</BiopaxRef> <BiopaxRef>bca</BiopaxRef> <BiopaxRef>e1e</BiopaxRef> <BiopaxRef>ebc</BiopaxRef> <BiopaxRef>a83</BiopaxRef> <BiopaxRef>a07</BiopaxRef> <BiopaxRef>e94</BiopaxRef> <BiopaxRef>b58</BiopaxRef> <BiopaxRef>d39</BiopaxRef> <BiopaxRef>eea</BiopaxRef> <BiopaxRef>bb7</BiopaxRef> <BiopaxRef>f58</BiopaxRef> <BiopaxRef>f3c</BiopaxRef> <BiopaxRef>ea1</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="510.0" Y="1081.0" /> <Point X="326.0" Y="325.0" /> <Anchor Position="0.0" Shape="None" GraphId="ccfd5" /> <Anchor Position="0.99" Shape="None" GraphId="e7551" /> <Anchor Position="0.5" Shape="None" GraphId="c1381" /> <Anchor Position="0.5" Shape="None" GraphId="e8218" /> <Anchor Position="0.5" Shape="None" GraphId="f2512" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640195" /> </Interaction> <Interaction GraphId="f439a"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="122.0" Y="958.0" GraphRef="dc248" RelX="1.0" RelY="-0.02564102564102564" /> <Point X="212.0" Y="914.0" GraphRef="d1a31" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9657619" /> </Interaction> <Interaction GraphId="f46fb"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="190.0" Y="644.0" GraphRef="d9838" RelX="0.030000000000001137" RelY="0.44000000000005457" /> <Point X="121.0" Y="646.0" GraphRef="fecc3" RelX="0.9823008849557522" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9639287" /> </Interaction> <Interaction GraphId="f562c"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="699.0" Y="441.0" GraphRef="c35b7" RelX="-0.004405286343612335" RelY="1.0" /> <Point X="703.0" Y="510.0" GraphRef="ba69f" RelX="-6.0" RelY="-4.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640167" /> </Interaction> <Interaction GraphId="f6dd4"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="564.0" Y="67.0" GraphRef="f962d" RelX="0.9938461538461538" RelY="-0.04" /> <Point X="613.0" Y="106.0" GraphRef="d6855" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9639286" /> </Interaction> <Interaction GraphId="f7322"> <Comment Source="Reactome">RRAGC (RagC) and RRAGD (RagD) are guanyl nucleotide-binding proteins that hydrolyze GTP (Tsun et al. 2013, Shen et al. 2017). The GDP-bound form of RRAGC,D is the active form that recruits mTORC1 to the lysosomal membrane (Tsun et al. 2013). RRAGC,D forms a heterodimer with RRAGA,B that has two stable conformations: RRAGA,B:GTP:RRAGC,D:GDP (active) or RRAGA,B:GDP:RRAGC,D:GTP (inactive) (Shen et al. 2017). Folliculin (FLCN) complexed with FNIP1 or FNIP2 interacts with RRAGA (Petit et al. 2013) and acts as a GTPase activator (GAP) for RRAGC:GTP and RRAGD:GTP (Tsun et al. 2013). FLCN is located at the lysosomal membrane during amino acid starvation and in the cytosol during amino acid stimulation (Tsun et al. 2013).</Comment> <BiopaxRef>b17</BiopaxRef> <BiopaxRef>c8b</BiopaxRef> <BiopaxRef>ebd</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="478.0" Y="83.0" /> <Point X="662.0" Y="135.0" /> <Anchor Position="0.0" Shape="None" GraphId="eaf67" /> <Anchor Position="0.99" Shape="None" GraphId="afdab" /> <Anchor Position="0.5" Shape="None" GraphId="ae97d" /> <Anchor Position="0.5" Shape="None" GraphId="f3f68" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9645598" /> </Interaction> <Interaction GraphId="f87fb"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="326.0" Y="325.0" GraphRef="e7551" RelX="-1.8400000000000318" RelY="-7.560000000000059" /> <Point X="172.0" Y="299.0" GraphRef="f2ebb" RelX="0.9428571428571428" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640195" /> </Interaction> <Interaction GraphId="f9bee"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="705.0" Y="547.0" GraphRef="e25db" RelX="-0.08000000000004093" RelY="0.6499999999999773" /> <Point X="847.0" Y="587.0" GraphRef="a93cf" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640167" /> </Interaction> <Interaction GraphId="fa504"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="331.0" Y="592.0" GraphRef="c8c89" RelX="-0.164021164021164" RelY="-14.38888888888889" /> <Point X="441.0" Y="584.0" GraphRef="f2512" RelX="23.0" RelY="-119.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640195" /> </Interaction> <Interaction GraphId="facd3"> <Comment Source="Reactome">The CASTOR1 homodimer interacts with the GATOR2 complex via the MIOS subunit of GATOR2 (Chantranupong et al. 2016, Gai et al. 2016). The ACT domains of CASTOR1 bind L-arginine (Chantranupong et al. 2016, Saxton et al. 2016, Xia et al. 2016, Gai et al. 2016) and CASTOR1:arginine dissociates from GATOR2, which then prevents GATOR1 from activating the GTPase of RRAGA,B (Chantranupong et al. 2016). GATOR1 is recruited to the lysosomal membrane by the KICSTOR complex (Wolfson et al. 2017).</Comment> <BiopaxRef>eea</BiopaxRef> <BiopaxRef>bb7</BiopaxRef> <BiopaxRef>f58</BiopaxRef> <BiopaxRef>f3c</BiopaxRef> <BiopaxRef>ecc</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="212.0" Y="914.0" /> <Point X="217.0" Y="752.0" /> <Anchor Position="0.0" Shape="None" GraphId="d1a31" /> <Anchor Position="0.99" Shape="None" GraphId="fc6c5" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9657619" /> </Interaction> <Interaction GraphId="fb1f6"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="331.0" Y="592.0" GraphRef="f1525" RelX="1.0" RelY="-0.02564102564102564" /> <Point X="441.0" Y="584.0" GraphRef="f2512" RelX="23.0" RelY="-119.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640195" /> </Interaction> <Interaction GraphId="fe164"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="394.0" Y="667.0" GraphRef="addd8" RelX="1.0" RelY="-0.034482758620689655" /> <Point X="441.0" Y="584.0" GraphRef="e8218" RelX="23.0" RelY="-119.0" ArrowHead="TBar" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640195" /> </Interaction> <Interaction GraphId="ff0ec"> <Comment Source="Reactome">Upon binding L-arginine, SLC38A9 acts as a guanyl nucleotide exchange factor (GEF) that enhances the conversion of RRAGA:GDP (RagA:GDP, and by inference RRAGB:GDP, RagB:GDP) to RRAGA:GTP, the active form (Shen and Sabatini 2018). The Ragulator complex also shows GEF activity for RRAGA,B (Bar-Peled et al. 2012). SH3BP4 inhibits loading of GTP onto RRAGB during amino acid starvation (Kim et al. 2012). The binding of GTP by RRAGA,B appears to inhibit binding of GTP by RRAGC,D (Shen et al. 2017).</Comment> <BiopaxRef>b2c</BiopaxRef> <BiopaxRef>c44</BiopaxRef> <BiopaxRef>ebd</BiopaxRef> <BiopaxRef>ace</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="713.0" Y="482.0" /> <Point X="705.0" Y="547.0" /> <Anchor Position="0.0" Shape="None" GraphId="d6cc1" /> <Anchor Position="0.99" Shape="None" GraphId="e25db" /> <Anchor Position="0.5" Shape="None" GraphId="ba69f" /> <Anchor Position="0.5" Shape="None" GraphId="f5779" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9640167" /> </Interaction> <Label TextLabel="lysosomal membrane" GraphId="a8ad0" GroupRef="b1de8"> <Graphics CenterX="277.0" CenterY="1108.5" Width="152.0" Height="33.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" /> </Label> <Shape GraphId="b765f" GroupRef="b1de8"> <Graphics CenterX="505.0" CenterY="599.0" Width="614.0" Height="1092.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" /> </Shape> <Group GroupId="af541" GraphId="a01a6" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9639281" /> </Group> <Group GroupId="ed054" GraphId="a274f" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9657634" /> </Group> <Group GroupId="f15a9" GraphId="a88dc" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9640226" /> </Group> <Group GroupId="d0ad9" GraphId="a8f11" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9646465" /> </Group> <Group GroupId="e0c00" GraphId="ac45e" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9640231" /> </Group> <Group GroupId="fa9e3" GraphId="ad344" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9657636" /> </Group> <Group GroupId="fb14d" GraphId="b46e8" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9639283" /> </Group> <Group GroupId="dbc52" GraphId="b6fe7" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-377400" /> </Group> <Group GroupId="c939f" GraphId="b9e4a" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9646467" /> </Group> <Group GroupId="e8fef" GraphId="be904" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9640192" /> </Group> <Group GroupId="b1de8" GraphId="c6b51" Style="Group" /> <Group GroupId="d3800" GraphId="cf2a0" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9639274" /> </Group> <Group GroupId="ce8c2" GraphId="d655d" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9639277" /> </Group> <Group GroupId="c48b6" GraphId="e1a99" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9640172" /> </Group> <Group GroupId="ab427" GraphId="e9d1d" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9640285" /> </Group> <Group GroupId="fbe47" GraphId="ef6ee" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9639275" /> </Group> <Group GroupId="c8dac" GraphId="f4f36" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9640184" /> </Group> <Group GroupId="fd29d" GraphId="f6395" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9640224" /> </Group> <Group GroupId="e8e7d" GraphId="f7e29" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9640252" /> </Group> <Group GroupId="db9de" GraphId="f7fb0" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9640174" /> </Group> <Group GroupId="f4a43" GraphId="fb6da" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-165189" /> </Group> <Group GroupId="d0c75" GraphId="fbf7b" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9639290" /> </Group> <Group GroupId="d562c" GraphId="fc23f" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-9645607" /> </Group> <InfoBox CenterX="0.0" CenterY="0.0" /> <Biopax> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f85"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">24529380</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Demetriades C, Doumpas N, Teleman AA.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c91"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18497260</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bcd"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">15878852</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Long X, Ortiz-Vega S, Lin Y, Avruch J.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b69"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">30651352</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shen K, Valenstein ML, Gu X, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f41"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">27308486</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SESTRINs regulate mTORC1 via RRAGs: The riddle of GATOR.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Budanov AV.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="dff"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">29107538</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Su MY, Morris KL, Kim DJ, Fu Y, Lawrence R, Stjepanovic G, Zoncu R, Hurley JH.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f3c"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">26972053</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chantranupong L, Scaria SM, Saxton RA, Gygi MP, Shen K, Wyant GA, Wang T, Harper JW, Gygi SP, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c8b"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">24081491</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Petit CS, Roczniak-Ferguson A, Ferguson SM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bca"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">23723238</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, Spear ED, Carter SL, Meyerson M, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="aba"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28199315</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SZT2 dictates GATOR control of mTORC1 signalling.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Peng M, Yin N, Li MO.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="eea"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28066558</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gai Z, Wang Q, Yang C, Wang L, Deng W, Wu G.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cb9"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22053050</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bb7"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">27487210</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Saxton RA, Chantranupong L, Knockenhauer KE, Schwartz TU, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f24"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16098514</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tee AR, Blenis J, Proud CG.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c15"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">29123114</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang T, Wang R, Wang Z, Wang X, Wang F, Ding J.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f86"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17470430</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Long X, Lin Y, Ortiz-Vega S, Busch S, Avruch J.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d39"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25259925</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Peng M, Yin N, Li MO.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b7c"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">30844724</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Recent advances in understanding of amino acid signaling to mTORC1 activation.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhuang Y, Wang XX, He J, He S, Yin Y.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ecc"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28199306</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d63"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">26378229</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stransky LA, Forgac M.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e8c"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18604198</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Regulation of TORC1 by Rag GTPases in nutrient response.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan KL.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ed0"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28935770</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">de Araujo MEG, Naschberger A, Fürnrohr BG, Stasyk T, Dunzendorfer-Matt T, Lechner S, Welti S, Kremser L, Shivalingaiah G, Offterdinger M, Lindner HH, Huber LA, Scheffzek K.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ebc"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">26449471</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sestrin2 is a leucine sensor for the mTORC1 pathway.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="dda"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20381137</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b72"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28686218</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yao Y, Jones E, Inoki K.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c44"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">30181260</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shen K, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fca"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18663353</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Takagi Y, Kobayashi T, Shiono M, Wang L, Piao X, Sun G, Zhang D, Abe M, Hagiwara Y, Takahashi K, Hino O.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d72"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28768171</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wolfson RL, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cf9"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25567906</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b17"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">24095279</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tsun ZY, Bar-Peled L, Chantranupong L, Zoncu R, Wang T, Kim C, Spooner E, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b2c"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22575674</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim YM, Stone M, Hwang TH, Kim YG, Dunlevy JR, Griffin TJ, Kim DH.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cd9"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25567907</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Metabolism. Differential regulation of mTORC1 by leucine and glutamine.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jewell JL, Kim YC, Russell RC, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan KL.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="dcb"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">29311260</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mTOR signaling in stem and progenitor cells.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Meng D, Frank AR, Jewell JL.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a33"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17028174</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Baba M, Hong SB, Sharma N, Warren MB, Nickerson ML, Iwamatsu A, Esposito D, Gillette WK, Hopkins RF, Hartley JL, Furihata M, Oishi S, Zhen W, Burke TR, Linehan WM, Schmidt LS, Zbar B.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a83"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">26586190</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Saxton RA, Knockenhauer KE, Wolfson RL, Chantranupong L, Pacold ME, Wang T, Schwartz TU, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="dfa"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">29236692</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yang H, Jiang X, Li B, Yang HJ, Miller M, Yang A, Dhar A, Pavletich NP.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a9c"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">29053970</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wyant GA, Abu-Remaileh M, Wolfson RL, Chen WW, Freinkman E, Danai LV, Vander Heiden MG, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a07"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25819761</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Lee JH.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e1e"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7499430</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schürmann A, Brauers A, Massmann S, Becker W, Joost HG.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b58"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25263562</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chantranupong L, Wolfson RL, Orozco JM, Saxton RA, Scaria SM, Bar-Peled L, Spooner E, Isasa M, Gygi SP, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ace"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22980980</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b4d"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">30602761</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mTOR as a central hub of nutrient signalling and cell growth.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim J, Guan KL.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d85"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25561175</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rebsamen M, Pochini L, Stasyk T, de Araújo ME, Galluccio M, Kandasamy RK, Snijder B, Fauster A, Rudashevskaya EL, Bruckner M, Scorzoni S, Filipek PA, Huber KV, Bigenzahn JW, Heinz LX, Kraft C, Bennett KL, Indiveri C, Huber LA, Superti-Furga G.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bb5"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">29078414</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Twenty-five years of mTOR: Uncovering the link from nutrients to growth.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f58"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">27648300</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Xia J, Wang R, Zhang T, Ding J.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ebd"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">29056322</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shen K, Choe A, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ea1"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">29123071</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gu X, Orozco JM, Saxton RA, Condon KJ, Liu GY, Krawczyk PA, Scaria SM, Harper JW, Gygi SP, Sabatini DM.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a31"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">30061680</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lawrence RE, Cho KF, Rappold R, Thrun A, Tofaute M, Kim DJ, Moldavski O, Hurley JH, Zoncu R.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ffe"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">29158492</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Structural basis for the assembly of the Ragulator-Rag GTPase complex.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yonehara R, Nada S, Nakai T, Nakai M, Kitamura A, Ogawa A, Nakatsumi H, Nakayama KI, Li S, Standley DM, Yamashita E, Nakagawa A, Okada M.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="dc9"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">15854902</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rheb binds and regulates the mTOR kinase.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e94"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25457612</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sestrins inhibit mTORC1 kinase activation through the GATOR complex.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, Budanov AV.</bp:AUTHORS> </bp:PublicationXref> </Biopax> </Pathway>

Return to Amino acids regulate mTORC1 (Homo sapiens).