Sphingolipid metabolism overview (Homo sapiens)

From WikiPathways

You do not have permission to edit pages, for the following reasons:

• You do not have permission to edit pages in the Pathway namespace.
• You are not allowed to execute the action you have requested.

You can view and copy the source of this page:

<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Sphingolipid metabolism overview" Version="20180908" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">This pathway is inspired by the Lipidmaps&gt;Sphingolipids pathway [https://lipidmaps.org/pathway/pathways_maps]. Sphingolipids are a class of lipids, which act as signal transduction and cell recognition molecules. This pathway provides an overview of the different tail lengths (on the right), which are used to convert sphinganine to DH-ceramide. All products are annotated with a lipid-class identifier. The integrated pathway can be found [https://www.wikipathways.org/index.php/Pathway:WP4690 here].</Comment> <Comment Source="HomologyMapper">This pathway was inferred from Mus musculus pathway [WP4344_107206.gpml] with a 92.0% conversion rate.</Comment> <Comment Source="WikiPathways-description">New PW, homology converted</Comment> <BiopaxRef>fc1</BiopaxRef> <Graphics BoardWidth="1421.0930551543727" BoardHeight="831.0226147461126" /> <DataNode TextLabel="ATP" GraphId="a01f7" Type="Metabolite"> <Graphics CenterX="355.3947368421049" CenterY="512.6315789473686" Width="59.73684210526337" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:30616" /> </DataNode> <DataNode TextLabel="3-keto-sphinganine" GraphId="a3300" Type="Metabolite"> <BiopaxRef>b6c</BiopaxRef> <Graphics CenterX="260.52538196607225" CenterY="333.75" Width="117.5" Height="46.5" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP01020002" /> </DataNode> <DataNode TextLabel="Ppap2a" GraphId="a9de8" Type="Protein" GroupRef="e29dc"> <Comment Source="HomologyMapper">No homologues found for original id L:19012</Comment> <Graphics CenterX="899.1484758460344" CenterY="545.4711673699013" Width="63.0" Height="23.5" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="CERK" GraphId="ac40d" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:223753</Comment> <Graphics CenterX="465.9159724830165" CenterY="363.12483631601896" Width="82.5" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8TCT0" /> </DataNode> <DataNode TextLabel="SGPP1" GraphId="b2311" Type="GeneProduct" GroupRef="ba605"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9JI99</Comment> <Graphics CenterX="118.9473684210526" CenterY="532.6315789473686" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BX95" /> </DataNode> <DataNode TextLabel="ASAH1" GraphId="b614f" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9WV54</Comment> <Graphics CenterX="693.6228077728985" CenterY="470.25879043600634" Width="73.13642756680707" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13510" /> </DataNode> <DataNode TextLabel="Palmitoyl-CoA" GraphId="b7caa" Type="Metabolite"> <Comment>aka CoA(16:0)</Comment> <BiopaxRef>b6c</BiopaxRef> <Graphics CenterX="260.0253819660725" CenterY="109.75" Width="98.5" Height="34.5" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMFA07050360" /> </DataNode> <DataNode TextLabel="SGMS1" GraphId="b96e1" Type="GeneProduct" GroupRef="d945f"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208449</Comment> <Graphics CenterX="1150.09566059728" CenterY="299.6802218777807" Width="79.5" Height="21.5" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q86VZ5" /> </DataNode> <DataNode TextLabel="SPHK2" GraphId="b9b00" Type="GeneProduct" GroupRef="e505a"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9JIA7</Comment> <Graphics CenterX="516.0102901920261" CenterY="552.7694559707356" Width="90.0" Height="20.791338582677554" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NRA0" /> </DataNode> <DataNode TextLabel="SGPL1" GraphId="bd74a" Type="Protein"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20397</Comment> <Graphics CenterX="514.603820431126" CenterY="667.9746835443043" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000166224" /> </DataNode> <DataNode TextLabel="UGCG" GraphId="c268f" Type="Protein"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22234</Comment> <Graphics CenterX="520.2012611034355" CenterY="314.9253731343285" Width="64.5" Height="23.880597014925385" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q16739" /> </DataNode> <DataNode TextLabel="Serine" GraphId="c3e72" Type="Metabolite"> <BiopaxRef>b6c</BiopaxRef> <Graphics CenterX="398.02538196606986" CenterY="113.58333333333334" Width="110.5" Height="33.49999999999999" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="PubChem-compound" ID="5951" /> </DataNode> <DataNode TextLabel="GBA1" GraphId="ca787" Type="GeneProduct" GroupRef="e6298"> <Graphics CenterX="547.1141124586545" CenterY="393.4192392502757" Width="46.102535832415015" Height="18.012679162072715" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P04062" /> </DataNode> <DataNode TextLabel="Hexadecanal" GraphId="d0961" Type="Metabolite"> <Graphics CenterX="257.8689122051721" CenterY="732.755274261604" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMFA06000088" /> </DataNode> <DataNode TextLabel="SPTLC1" GraphId="d5e45" Type="GeneProduct" GroupRef="bb5bd"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:268656</Comment> <BiopaxRef>e62</BiopaxRef> <Graphics CenterX="116.64553700483151" CenterY="187.0503875968994" Width="112.75000000000001" Height="26.333333333333712" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15269" /> </DataNode> <DataNode TextLabel="SPHK1" GraphId="d6dbc" Type="GeneProduct" GroupRef="e505a"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8CI15</Comment> <Graphics CenterX="516.0102901920261" CenterY="531.7445215875338" Width="90.0" Height="21.25853018372678" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NYA1" /> </DataNode> <DataNode TextLabel="DEGS1" GraphId="d7335" Type="GeneProduct" GroupRef="c0c64"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13244</Comment> <Graphics CenterX="699.9210465305932" CenterY="296.80000982049467" Width="62.5" Height="18.5" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15121" /> </DataNode> <DataNode TextLabel="KDSR" GraphId="de6f3" Type="Protein"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q6GV12</Comment> <Graphics CenterX="115.6455370048315" CenterY="399.08333333333337" Width="102.5" Height="23.833333333333307" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q06136" /> </DataNode> <DataNode TextLabel="SPTLC2" GraphId="e40f3" Type="GeneProduct" GroupRef="bb5bd"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P97363</Comment> <BiopaxRef>e62</BiopaxRef> <Graphics CenterX="116.64553700483151" CenterY="212.8003875968989" Width="112.75000000000003" Height="25.166666666665265" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15270" /> </DataNode> <DataNode TextLabel="Ethanolamine-phosphate" GraphId="f4ce4" Type="Metabolite"> <Graphics CenterX="515.512911340217" CenterY="732.7552742616041" Width="151.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="PubChem-compound" ID="1015" /> </DataNode> <DataNode TextLabel="H2O" GraphId="f7997" Type="Metabolite"> <Graphics CenterX="123.28947368421055" CenterY="597.8947368421047" Width="54.4736842105263" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="Sphingosine" GraphId="f88b3" Type="Metabolite"> <Graphics CenterX="760.0531875197355" CenterY="510.78938115330516" Width="160.66666666666657" Height="24.999999999999968" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP01010001" /> </DataNode> <DataNode TextLabel="Sphinganine" GraphId="ed964" Type="Metabolite"> <BiopaxRef>b6c</BiopaxRef> <Graphics CenterX="259.45224553850534" CenterY="477.03410689170175" Width="160.66666666666663" Height="28.49999999999999" ZOrder="32769" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP01020001" /> </DataNode> <DataNode TextLabel="Sphinganine-1-phosphate" GraphId="f368e" Type="Metabolite"> <Graphics CenterX="259.2753819660722" CenterY="614.4644866385379" Width="160.66666666666663" Height="31.833333333333485" ZOrder="32770" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP01050002" /> </DataNode> <DataNode TextLabel="DH-Ceramide" GraphId="c997e" Type="Metabolite"> <BiopaxRef>b6c</BiopaxRef> <Graphics CenterX="761.4596572806357" CenterY="214.56293952180025" Width="117.5" Height="28.5" ZOrder="32771" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP02020000" /> </DataNode> <DataNode TextLabel="CERS4" GraphId="f4e24" Type="Protein" GroupRef="d4bdd"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67260</Comment> <Graphics CenterX="1231.4917804137633" CenterY="294.50166442479895" Width="52.95614268548025" Height="25.0" ZOrder="32772" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000090661" /> </DataNode> <DataNode TextLabel="CERS4" GraphId="c24ce" Type="Protein" GroupRef="fa178"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67260</Comment> <Graphics CenterX="1225.1737236809508" CenterY="115.90094220193114" Width="52.95614268548025" Height="25.0" ZOrder="32773" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000090661" /> </DataNode> <DataNode TextLabel="CERS6" GraphId="e4848" Type="Protein" GroupRef="fa178"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:241447</Comment> <Graphics CenterX="1225.1737236809508" CenterY="140.90094220193134" Width="52.95614268548025" Height="25.0" ZOrder="32774" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000172292" /> </DataNode> <DataNode TextLabel="Ceramide" GraphId="bf530" Type="Metabolite"> <BiopaxRef>b6c</BiopaxRef> <Graphics CenterX="761.4596572806357" CenterY="396.75" Width="117.5" Height="28.5" ZOrder="32775" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP02010000" /> </DataNode> <DataNode TextLabel="Cer-1-P" GraphId="dea07" Type="Metabolite"> <Graphics CenterX="605.4406013383634" CenterY="485.8342733197027" Width="87.99702178113748" Height="28.500000000000032" ZOrder="32776" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP02050000" /> </DataNode> <DataNode TextLabel="DH-Cer-1-P" GraphId="cc25d" Type="Metabolite"> <Graphics CenterX="602.4406013383634" CenterY="179.4629629629628" Width="87.99702178113748" Height="28.500000000000007" ZOrder="32777" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP020500A0" /> </DataNode> <DataNode TextLabel="SM" GraphId="e9d8d" Type="Metabolite"> <Graphics CenterX="1046.5971396997593" CenterY="396.75" Width="117.5" Height="28.5" ZOrder="32778" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP0301" /> </DataNode> <DataNode TextLabel="Glc-Cer" GraphId="d60ba" Type="Metabolite"> <Graphics CenterX="605.4406013383634" CenterY="352.6465376849662" Width="87.99702178113748" Height="28.499999999999982" ZOrder="32779" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP0501AA00" /> </DataNode> <DataNode TextLabel="DH-SM" GraphId="ba26f" Type="Metabolite"> <Graphics CenterX="1044.5971396997593" CenterY="214.56293952180027" Width="117.5" Height="28.5" ZOrder="32780" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP030100A0" /> </DataNode> <DataNode TextLabel="DH-Glc-Cer" GraphId="e6a32" Type="Metabolite"> <Graphics CenterX="594.2465714876168" CenterY="279.1860143725812" Width="87.99702178113742" Height="28.5" ZOrder="32781" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="" /> </DataNode> <DataNode TextLabel="Gal-Cer" GraphId="be1a4" Type="Metabolite"> <Graphics CenterX="843.0526860313873" CenterY="328.5012434039243" Width="117.5" Height="28.5" ZOrder="32782" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP0501AC00" /> </DataNode> <DataNode TextLabel="DH-Gal-Cer" GraphId="c9f6c" Type="Metabolite"> <Graphics CenterX="843.0526860313873" CenterY="295.22933270823546" Width="117.5" Height="28.5" ZOrder="32783" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="" /> </DataNode> <DataNode TextLabel="SMPD1" GraphId="fe827" Type="Protein"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20597</Comment> <Graphics CenterX="1028.3573242198345" CenterY="311.0669014084507" Width="79.5" Height="21.5" ZOrder="32785" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P17405" /> </DataNode> <DataNode TextLabel="DEGS2" GraphId="b3147" Type="GeneProduct" GroupRef="c0c64"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:70059</Comment> <Graphics CenterX="699.9210465305932" CenterY="315.3000098204946" Width="62.5" Height="18.5" ZOrder="32786" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6QHC5" /> </DataNode> <DataNode TextLabel="SGMS2" GraphId="efc57" Type="Protein" GroupRef="d945f"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74442</Comment> <Graphics CenterX="1150.09566059728" CenterY="320.6802218777803" Width="79.5" Height="21.5" ZOrder="32787" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NHU3" /> </DataNode> <DataNode TextLabel="Sphingosine-1-phosphate" GraphId="b32ff" Type="Metabolite"> <Graphics CenterX="760.0531875197412" CenterY="614.4644866385379" Width="160.66666666666663" Height="31.833333333333485" ZOrder="32788" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP01050001" /> </DataNode> <DataNode TextLabel="(2E)-hexadecenal" GraphId="ba579" Type="Metabolite"> <Graphics CenterX="760.0531875197355" CenterY="732.755274261604" Width="90.0" Height="25.0" ZOrder="32789" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMFA06000089" /> </DataNode> <DataNode TextLabel="PLPP3" GraphId="a5a0a" Type="GeneProduct" GroupRef="e29dc"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67916</Comment> <Graphics CenterX="899.1484758460344" CenterY="568.2211673699013" Width="63.0" Height="23.5" ZOrder="32790" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O14495" /> </DataNode> <DataNode TextLabel="Ppap2c" GraphId="c0dd9" Type="Protein" GroupRef="e29dc"> <Graphics CenterX="899.1484758460344" CenterY="591.7211673699013" Width="63.0" Height="23.5" ZOrder="32791" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="CoA(16:0)" GraphId="f11ea" Type="Metabolite" GroupRef="af21a"> <Graphics CenterX="715.7552118446347" CenterY="36.96117249737806" Width="90.0" Height="25.0" ZOrder="32792" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMFA07050360" /> </DataNode> <DataNode TextLabel="UGT8" GraphId="cbfa3" Type="Protein"> <Comment>EC:2.4.1.47</Comment> <Graphics CenterX="944.6777512536523" CenterY="310.2239903975606" Width="64.5" Height="20.0" ZOrder="32795" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000174607" /> </DataNode> <DataNode TextLabel="CoA(18:0)" GraphId="fe378" Type="Metabolite" GroupRef="af21a"> <Graphics CenterX="805.7552118446346" CenterY="36.96117249737806" Width="90.0" Height="25.0" ZOrder="32796" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15541" /> </DataNode> <DataNode TextLabel="CoA(20:0)" GraphId="efdb4" Type="Metabolite" GroupRef="af21a"> <Graphics CenterX="715.7552118446348" CenterY="61.96117249737808" Width="90.0" Height="25.0" ZOrder="32797" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15527" /> </DataNode> <DataNode TextLabel="CoA(22:0)" GraphId="e18f7" Type="Metabolite" GroupRef="af21a"> <Graphics CenterX="805.7552118446346" CenterY="61.96117249737808" Width="90.0" Height="25.0" ZOrder="32798" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="24330-89-0" /> </DataNode> <DataNode TextLabel="CoA(24:0)" GraphId="a179b" Type="Metabolite" GroupRef="af21a"> <Graphics CenterX="715.7552118446348" CenterY="86.96117249737807" Width="90.0" Height="25.0" ZOrder="32799" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="24305-30-4" /> </DataNode> <DataNode TextLabel="CoA(24:1)" GraphId="c7424" Type="Metabolite" GroupRef="af21a"> <Graphics CenterX="805.7552118446346" CenterY="86.96117249737807" Width="90.0" Height="25.0" ZOrder="32800" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="88362-35-0" /> </DataNode> <DataNode TextLabel="CoA(16:0)" GraphId="abbf5" Type="Metabolite"> <Graphics CenterX="1286.4349529687574" CenterY="82.22446450135992" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32802" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMFA07050360" /> </DataNode> <DataNode TextLabel="CoA(18:0)" GraphId="b07bd" Type="Metabolite"> <Graphics CenterX="1286.9743289659436" CenterY="234.33714055769806" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32803" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15541" /> </DataNode> <DataNode TextLabel="CoA(20:0)" GraphId="f0afd" Type="Metabolite"> <Graphics CenterX="1242.4432824279213" CenterY="387.85826731826194" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32804" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15527" /> </DataNode> <DataNode TextLabel="CoA(22:0)" GraphId="c1c64" Type="Metabolite"> <Comment>AKA "Coenzyme A, S-​docosanoate"</Comment> <Graphics CenterX="1337.3488556082075" CenterY="387.85826731826194" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32805" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="24330-89-0" /> </DataNode> <DataNode TextLabel="CoA(24:0)" GraphId="ef435" Type="Metabolite"> <Comment>AKA "Coenzyme A, S-​(tetracosanoate)​"</Comment> <Graphics CenterX="1244.8643163014908" CenterY="551.2385490084023" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32806" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="24305-30-4" /> </DataNode> <DataNode TextLabel="CoA(24:1)" GraphId="e3f72" Type="Metabolite"> <Comment>AKA "Coenzyme A, S-​(15Z)​-​15-​tetracosenoate"</Comment> <Graphics CenterX="1338.4276076025826" CenterY="551.2385490084023" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32807" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="88362-35-0" /> </DataNode> <DataNode TextLabel="DH-Ceramide" GraphId="f9b34" Type="Metabolite"> <Graphics CenterX="1286.4349529687574" CenterY="178.6634598165359" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32808" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP02020000" /> </DataNode> <DataNode TextLabel="DH-Ceramide" GraphId="f2a27" Type="Metabolite"> <Graphics CenterX="1286.9743289659436" CenterY="330.77613587287453" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32809" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP02020000" /> </DataNode> <DataNode TextLabel="DH-Ceramide" GraphId="cc18d" Type="Metabolite"> <Graphics CenterX="1288.0215013481172" CenterY="484.2972626334377" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32811" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP02020000" /> </DataNode> <DataNode TextLabel="DH-Ceramide" GraphId="aceae" Type="Metabolite"> <Graphics CenterX="1292.8371741197716" CenterY="647.6775443235779" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32813" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP02020000" /> </DataNode> <DataNode TextLabel="CERS1" GraphId="ac8a6" Type="Protein" GroupRef="d4bdd"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P27545</Comment> <Graphics CenterX="1231.4917804137635" CenterY="269.5016644247988" Width="52.95614268548025" Height="25.0" ZOrder="32820" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000223802" /> </DataNode> <DataNode TextLabel="CERS4" GraphId="fc613" Type="Protein"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67260</Comment> <Graphics CenterX="1288.5314754569397" CenterY="419.34880964260884" Width="52.95614268548025" Height="25.0" ZOrder="32824" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000090661" /> </DataNode> <DataNode TextLabel="CERS2" GraphId="fed26" Type="Protein"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:76893</Comment> <Graphics CenterX="1291.3851990924109" CenterY="581.2343230218369" Width="52.956142685480245" Height="25.0" ZOrder="32827" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000143418" /> </DataNode> <DataNode TextLabel="CoA(26:0)" GraphId="ae76f" Type="Metabolite"> <Comment>AKA "Coenzyme A, S-​hexacosanoate"</Comment> <Graphics CenterX="1248.8261385293467" CenterY="692.083619430937" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32829" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="99313-57-2" /> </DataNode> <DataNode TextLabel="CoA(26:1)" GraphId="b6b95" Type="Metabolite"> <Graphics CenterX="1343.6402685642295" CenterY="692.1907917310195" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32830" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="DH-Ceramide" GraphId="d3fb3" Type="Metabolite"> <Graphics CenterX="1300.3834306931892" CenterY="788.5226147461126" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32832" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMSP02020000" /> </DataNode> <DataNode TextLabel="CERS3" GraphId="f166f" Type="Protein"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q1A3B0</Comment> <Graphics CenterX="1298.7931485147683" CenterY="724.3215459107397" Width="52.956142685480245" Height="25.0" ZOrder="32837" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000154227" /> </DataNode> <DataNode TextLabel="CoA(26:0)" GraphId="f9a59" Type="Metabolite" GroupRef="af21a"> <Graphics CenterX="715.7552118446348" CenterY="111.96117249737856" Width="89.99999999999996" Height="25.000000000000014" ZOrder="32839" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="99313-57-2" /> </DataNode> <DataNode TextLabel="CoA(26:1)" GraphId="b12b3" Type="Metabolite" GroupRef="af21a"> <Graphics CenterX="805.7552118446346" CenterY="111.9611724973781" Width="89.99999999999996" Height="25.0" ZOrder="32840" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="ADP" GraphId="aeba0" Type="Metabolite"> <Graphics CenterX="359.0789473684206" CenterY="581.578947368421" Width="59.73684210526337" Height="25.0" ZOrder="32841" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:456216" /> </DataNode> <DataNode TextLabel="SGPP2" GraphId="a9f9a" Type="GeneProduct" GroupRef="ba605"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q810K3</Comment> <Graphics CenterX="118.9473684210526" CenterY="557.6315789473686" Width="90.0" Height="25.0" ZOrder="32843" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8IWX5" /> </DataNode> <DataNode TextLabel="GBA2" GraphId="d55a6" Type="GeneProduct" GroupRef="e6298"> <Graphics CenterX="547.1141124586545" CenterY="411.4319184123485" Width="46.102535832414986" Height="18.012679162072743" ZOrder="33043" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9HCG7" /> </DataNode> <DataNode TextLabel="GBA3" GraphId="c88e2" Type="GeneProduct" GroupRef="e6298"> <Graphics CenterX="547.1141124586545" CenterY="429.4445975744212" Width="46.102535832414986" Height="18.012679162072743" ZOrder="33044" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9H227" /> </DataNode> <Interaction> <Comment>EC:3.2.1.45</Comment> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="583.4413458930791" Y="366.8965376849662" GraphRef="d60ba" RelX="-0.5" RelY="1.0" /> <Point X="702.7096572806357" Y="396.75" GraphRef="bf530" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4" Shape="None" GraphId="bd8ca" /> </Graphics> <Xref Database="Rhea" ID="13270" /> </Interaction> <Interaction> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="578.165380374862" Y="411.43191841234847" GraphRef="cdf83" RelX="1.0" RelY="0.0" /> <Point X="631.1486704481017" Y="378.8379226109797" GraphRef="bd8ca" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id11c71881"> <Comment>EC:1.1.1.102</Comment> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="260.52538196607225" Y="357.0" GraphRef="a3300" RelX="0.0" RelY="1.0" /> <Point X="259.45224553850534" Y="462.78410689170175" GraphRef="ed964" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4" Shape="None" GraphId="a8460" /> </Graphics> <Xref Database="Rhea" ID="22642" /> </Interaction> <Interaction GraphId="id1472a2e3"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="258.68942108158626" Y="667.8243468042979" GraphRef="c54f2" RelX="0.0" RelY="0.0" /> <Point X="515.512911340217" Y="720.2552742616041" GraphRef="f4ce4" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id1aec68d4"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="166.8955370048315" Y="399.08333333333337" GraphRef="de6f3" RelX="1.0" RelY="0.0" /> <Point X="260.09612739504547" Y="399.3136427566807" GraphRef="a8460" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id204b067"> <Comment>EC2.7.8.27</Comment> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="820.2096572806357" Y="403.875" GraphRef="bf530" RelX="1.0" RelY="0.5" /> <Point X="987.8471396997593" Y="403.875" GraphRef="e9d8d" RelX="-1.0" RelY="0.5" ArrowHead="mim-conversion" /> <Anchor Position="0.629218832916282" Shape="None" GraphId="abc88" /> </Graphics> <Xref Database="Rhea" ID="18766" /> </Interaction> <Interaction GraphId="id20e811f3"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="859.6484758460344" Y="568.5961673699013" GraphRef="feaff" RelX="-1.0" RelY="0.0" /> <Point X="800.2198541864055" Y="568.4444444444448" GraphRef="b29de" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id29679d60"> <Comment>EC:2.3.1.24</Comment> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="339.78557887183865" Y="477.03410689170175" GraphRef="ed964" RelX="1.0" RelY="0.0" /> <Point X="417.67353011421966" Y="315.74737697772764" /> <Point X="760.983613110104" Y="154.46064706375353" GraphRef="afbb2" RelX="0.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="Rhea" ID="34736" /> </Interaction> <Interaction GraphId="id2cf5a716"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="552.4512611034355" Y="308.9552238805972" GraphRef="c268f" RelX="1.0" RelY="-0.5" /> <Point X="571.7049924467191" Y="308.2089552238807" /> <Point X="616.7701510080417" Y="307.46268656716416" /> <Point X="661.8353095693644" Y="247.22310846018314" GraphRef="ca6bf" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id2fa1d96b"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="739.1710465305932" Y="306.05000982049467" GraphRef="fb07d" RelX="1.0" RelY="0.0" /> <Point X="761.4596572806357" Y="305.4263565891473" GraphRef="b938a" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id3752d4e4"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="944.6777512536523" Y="320.2239903975606" GraphRef="cbfa3" RelX="0.0" RelY="1.0" /> <Point X="811.7218687809363" Y="366.60049736156975" GraphRef="acb81" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Rhea" ID="13094" /> </Interaction> <Interaction GraphId="id45ffb504"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="465.9159724830165" Y="373.12483631601896" GraphRef="ac40d" RelX="0.0" RelY="1.0" /> <Point X="637.818994042946" Y="449.04557979533706" GraphRef="c3008" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id46848a70"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="732.0846572806357" Y="200.31293952180025" GraphRef="c997e" RelX="-0.5" RelY="-1.0" /> <Point X="646.4391122289321" Y="179.4629629629628" GraphRef="cc25d" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> <Anchor Position="0.4" Shape="None" GraphId="ab0aa" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id6cf838b"> <Comment>EC:2.3.1.50</Comment> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="260.0253819660725" Y="127.0" GraphRef="b7caa" RelX="0.0" RelY="1.0" /> <Point X="260.52538196607225" Y="310.5" GraphRef="a3300" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4004838636372226" Shape="None" GraphId="aa5ea" /> </Graphics> <Xref Database="Rhea" ID="14762" /> </Interaction> <Interaction GraphId="id6dd64cb8"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1286.4349529687574" Y="94.72446450135992" GraphRef="abbf5" RelX="0.0" RelY="1.0" /> <Point X="1286.4349529687574" Y="166.1634598165359" GraphRef="f9b34" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.47556324386737214" Shape="None" GraphId="cb42d" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id7451d8ea"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="790.8346572806357" Y="228.81293952180025" GraphRef="c997e" RelX="0.5" RelY="1.0" /> <Point X="843.0526860313873" Y="280.97933270823546" GraphRef="c9f6c" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4" Shape="None" GraphId="e5204" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id765f7ea9"> <BiopaxRef>b39</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="171.9473684210526" Y="545.1315789473686" GraphRef="e9f31" RelX="1.0" RelY="0.0" /> <Point X="219.19658251621775" Y="545.2583618678739" GraphRef="e0038" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id79689790"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="732.0846572806357" Y="228.81293952180025" GraphRef="c997e" RelX="-0.5" RelY="1.0" /> <Point X="594.2465714876168" Y="264.9360143725812" GraphRef="e6a32" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.5096512136475798" Shape="None" GraphId="ca6bf" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id7a708c67"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="944.6777512536523" Y="300.2239903975606" GraphRef="cbfa3" RelX="0.0" RelY="-1.0" /> <Point X="811.7218687809363" Y="249.67949679637434" GraphRef="e5204" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id82b82715"> <Comment>EC:2.7.1.91</Comment> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="299.618912205172" Y="491.28410689170175" GraphRef="ed964" RelX="0.5" RelY="1.0" /> <Point X="299.4420486327389" Y="598.5478199718711" GraphRef="f368e" RelX="0.5" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.48366739822863825" Shape="None" GraphId="a78e1" /> </Graphics> <Xref Database="Rhea" ID="15466" /> </Interaction> <Interaction GraphId="id874d313b"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="552.4512611034355" Y="320.8955223880599" GraphRef="c268f" RelX="1.0" RelY="0.5" /> <Point X="663.8020349037268" Y="380.5336150739865" GraphRef="b20a1" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id924ac751"> <Comment>EC:3.5.1.23</Comment> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="761.4596572806357" Y="411.0" GraphRef="bf530" RelX="0.0" RelY="1.0" /> <Point X="760.0531875197355" Y="498.28938115330516" GraphRef="f88b3" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.6891235390038983" Shape="None" GraphId="cc60b" /> </Graphics> <Xref Database="Rhea" ID="20857" /> </Interaction> <Interaction GraphId="id9535ea46"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="325.52631578947324" Y="512.6315789473686" GraphRef="a01f7" RelX="-1.0" RelY="0.0" /> <Point X="299.53336906125185" Y="543.1640679215304" GraphRef="a78e1" RelX="0.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="Rhea" ID="15466" /> </Interaction> <Interaction GraphId="id96290d76"> <Comment>EC:4.1.2.27</Comment> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="760.0531875197412" Y="630.3811533052046" GraphRef="b32ff" RelX="0.0" RelY="1.0" /> <Point X="760.0531875197355" Y="720.255274261604" GraphRef="ba579" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.403737059960402" Shape="None" GraphId="e70e1" /> </Graphics> <Xref Database="Rhea" ID="33508" /> </Interaction> <Interaction GraphId="id981fc8c8"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="398.02538196606986" Y="130.33333333333334" GraphRef="c3e72" RelX="0.0" RelY="1.0" /> <Point X="260.225623897891" Y="200.48878897743035" GraphRef="aa5ea" RelX="0.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id9884255a"> <Comment>EC:2.4.1.80</Comment> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="702.7096572806357" Y="389.625" GraphRef="bf530" RelX="-1.0" RelY="-0.5" /> <Point X="605.4406013383634" Y="366.8965376849662" GraphRef="d60ba" RelX="0.0" RelY="1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4" Shape="None" GraphId="b20a1" /> </Graphics> <Xref Database="Rhea" ID="12089" /> </Interaction> <Interaction GraphId="id9d280dab"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="985.8471396997593" Y="221.68793952180027" GraphRef="ba26f" RelX="-1.0" RelY="0.5" /> <Point X="820.2096572806357" Y="221.68793952180025" GraphRef="c997e" RelX="1.0" RelY="0.5" ArrowHead="mim-conversion" /> <Anchor Position="0.14454685887107652" Shape="None" GraphId="f2bba" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="ida1231f2e"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1028.3573242198345" Y="300.3169014084507" GraphRef="fe827" RelX="0.0" RelY="-1.0" /> <Point X="961.9047619047618" Y="221.68793952180027" GraphRef="f2bba" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idaad03b91"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="760.7552118446347" Y="132.46117249737856" GraphRef="bfe17" RelX="0.0" RelY="1.0" /> <Point X="761.4596572806357" Y="200.31293952180025" GraphRef="c997e" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.32422846936995403" Shape="None" GraphId="afbb2" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idae7f7f89"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="559.603820431126" Y="667.9746835443043" GraphRef="bd74a" RelX="1.0" RelY="0.0" /> <Point X="760.0531875197389" Y="666.6666666666669" GraphRef="e70e1" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idaf973609"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="469.603820431126" Y="667.9746835443043" GraphRef="bd74a" RelX="-1.0" RelY="0.0" /> <Point X="258.68942108158626" Y="667.8243468042979" GraphRef="c54f2" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idb39e1f3c"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="181.0205370048315" Y="199.63372093023204" GraphRef="a7438" RelX="1.0" RelY="0.0" /> <Point X="260.225623897891" Y="200.48878897743035" GraphRef="aa5ea" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idb9579e0d"> <Comment>EC:2.4.1.47</Comment> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="790.8346572806357" Y="382.5" GraphRef="bf530" RelX="0.5" RelY="-1.0" /> <Point X="843.0526860313873" Y="342.7512434039243" GraphRef="be1a4" RelX="0.0" RelY="1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4" Shape="None" GraphId="acb81" /> </Graphics> <Xref Database="Rhea" ID="13094" /> </Interaction> <Interaction GraphId="idbb8ae26"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="219.10871529940553" Y="598.5478199718711" GraphRef="f368e" RelX="-0.5" RelY="-1.0" /> <Point X="219.28557887183868" Y="491.28410689170175" GraphRef="ed964" RelX="-0.5" RelY="1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4968078819364429" Shape="None" GraphId="e0038" /> </Graphics> <Xref Database="Rhea" ID="27515" /> </Interaction> <Interaction GraphId="idbdf2f556"> <Comment>EC:2.7.1.91</Comment> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="719.8865208530689" Y="523.2893811533052" GraphRef="f88b3" RelX="-0.5" RelY="1.0" /> <Point X="719.8865208530746" Y="598.5478199718711" GraphRef="b32ff" RelX="-0.5" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.2640037967228627" Shape="None" GraphId="a5e51" /> </Graphics> <Xref Database="Rhea" ID="35848" /> </Interaction> <Interaction GraphId="idc2904d49"> <Comment>EC:4.1.2.27</Comment> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="259.2753819660722" Y="630.3811533052046" GraphRef="f368e" RelX="0.0" RelY="1.0" /> <Point X="257.8689122051721" Y="720.255274261604" GraphRef="d0961" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.41661818886949686" Shape="None" GraphId="c54f2" /> </Graphics> <Xref Database="Rhea" ID="18594" /> </Interaction> <Interaction GraphId="idc444fee0"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="820.2096572806357" Y="207.43793952180025" GraphRef="c997e" RelX="1.0" RelY="-0.5" /> <Point X="985.8471396997593" Y="207.43793952180027" GraphRef="ba26f" RelX="-1.0" RelY="-0.5" ArrowHead="mim-conversion" /> <Anchor Position="0.4" Shape="None" GraphId="f7a25" /> </Graphics> <Xref Database="Rhea" ID="44621" /> </Interaction> <Interaction GraphId="idc931ada7"> <Comment>3.1.4.12</Comment> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="987.8471396997593" Y="389.625" GraphRef="e9d8d" RelX="-1.0" RelY="-0.5" /> <Point X="820.2096572806357" Y="389.625" GraphRef="bf530" RelX="1.0" RelY="-0.5" ArrowHead="mim-conversion" /> <Anchor Position="0.16611523448041574" Shape="None" GraphId="ae05e" /> </Graphics> <Xref Database="Rhea" ID="19254" /> </Interaction> <Interaction GraphId="idca8136b2"> <Comment>EC:1.14.19.17</Comment> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="761.4596572806357" Y="228.81293952180025" GraphRef="c997e" RelX="0.0" RelY="1.0" /> <Point X="761.4596572806357" Y="382.5" GraphRef="bf530" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.49850271603193647" Shape="None" GraphId="b938a" /> </Graphics> <Xref Database="Rhea" ID="46545" /> </Interaction> <Interaction GraphId="idd65a3387"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="465.9159724830165" Y="353.12483631601896" GraphRef="ac40d" RelX="0.0" RelY="-1.0" /> <Point X="573.6715036933717" Y="214.15607985480943" /> <Point X="697.8264392599543" Y="191.97294889826526" GraphRef="ab0aa" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="iddbfe9fa1"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="1150.09566059728" Y="339.43022187778024" GraphRef="a8e79" RelX="0.0" RelY="1.0" /> <Point X="1037.8929894593502" Y="445.8509142053446" /> <Point X="925.6903183214204" Y="403.875" GraphRef="abc88" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="iddcdb3ebd"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1028.3573242198345" Y="321.8169014084507" GraphRef="fe827" RelX="0.0" RelY="1.0" /> <Point X="960.0" Y="389.625" GraphRef="ae05e" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="ide0bbc0c3"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="800.2198541864078" Y="598.5478199718711" GraphRef="b32ff" RelX="0.5" RelY="-1.0" /> <Point X="800.2198541864021" Y="523.2893811533052" GraphRef="f88b3" RelX="0.5" RelY="1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4" Shape="None" GraphId="b29de" /> </Graphics> <Xref Database="Rhea" ID="27519" /> </Interaction> <Interaction GraphId="idf29bfd2c"> <Comment>EC:2.7.1.138</Comment> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="702.7096572806357" Y="403.875" GraphRef="bf530" RelX="-1.0" RelY="0.5" /> <Point X="605.4406013383634" Y="471.5842733197027" GraphRef="dea07" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.667125455357574" Shape="None" GraphId="c3008" /> </Graphics> <Xref Database="Rhea" ID="17930" /> </Interaction> <Interaction GraphId="idf3d315c9"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="1150.09566059728" Y="280.9302218777807" GraphRef="a8e79" RelX="0.0" RelY="-1.0" /> <Point X="1018.2801554227825" Y="168.77637130801688" /> <Point X="886.4646502482851" Y="207.43793952180025" GraphRef="f7a25" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idf779ba24"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="760.0531875197389" Y="666.6666666666669" GraphRef="e70e1" RelX="0.0" RelY="0.0" /> <Point X="515.512911340217" Y="720.2552742616041" GraphRef="f4ce4" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idf9bd034"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="730.1910215563021" Y="470.25879043600634" GraphRef="b614f" RelX="1.0" RelY="0.0" /> <Point X="760.4904258615022" Y="471.1531672578258" GraphRef="cc60b" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idfd30c455"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="463.0102901920261" Y="542.1401908788723" GraphRef="ce853" RelX="-1.0" RelY="0.0" /> <Point X="299.53336906125185" Y="543.1640679215304" GraphRef="a78e1" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idfee96b1a"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="569.0102901920261" Y="542.1401908788723" GraphRef="ce853" RelX="1.0" RelY="0.0" /> <Point X="719.8865208530704" Y="543.1578947368419" GraphRef="a5e51" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="efb40"> <Graphics ZOrder="32814" LineThickness="1.0"> <Point X="1286.9743289659436" Y="246.83714055769806" GraphRef="b07bd" RelX="0.0" RelY="1.0" /> <Point X="1286.9743289659436" Y="318.27613587287453" GraphRef="f2a27" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4781258250072417" Shape="None" GraphId="a8f13" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="cba2e"> <Graphics ZOrder="32815" LineThickness="1.0"> <Point X="1242.4432824279215" Y="400.35826731826194" GraphRef="f0afd" RelX="0.0" RelY="1.0" /> <Point X="1264.2951080530459" Y="471.7972626334377" GraphRef="cc18d" RelX="-0.5" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.6463920682111056" Shape="None" GraphId="e8fc0" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="b5996"> <Graphics ZOrder="32816" LineThickness="1.0"> <Point X="1337.3488556082075" Y="400.35826731826194" GraphRef="c1c64" RelX="0.0" RelY="1.0" /> <Point X="1311.747894643189" Y="471.7972626334377" GraphRef="cc18d" RelX="0.5" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.6735613865368164" Shape="None" GraphId="d16aa" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="af2e4"> <Graphics ZOrder="32817" LineThickness="1.0"> <Point X="1244.8643163014908" Y="563.7385490084023" GraphRef="ef435" RelX="0.0" RelY="1.0" /> <Point X="1269.1107808247" Y="635.1775443235779" GraphRef="aceae" RelX="-0.5" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.6754355571891035" Shape="None" GraphId="c5b91" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="e27f1"> <Graphics ZOrder="32818" LineThickness="1.0"> <Point X="1338.4276076025826" Y="563.7385490084023" GraphRef="e3f72" RelX="0.0" RelY="1.0" /> <Point X="1316.5635674148432" Y="635.1775443235779" GraphRef="aceae" RelX="0.5" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.659531446958284" Shape="None" GraphId="dc646" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="b36ce"> <Graphics ZOrder="32819" LineThickness="1.0"> <Point X="1259.651795023691" Y="128.40094220193123" GraphRef="c7a3b" RelX="1.0" RelY="0.0" /> <Point X="1286.4349529687574" Y="128.698224852071" GraphRef="cb42d" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="aa321"> <Graphics ZOrder="32821" LineThickness="1.0"> <Point X="1265.9698517565039" Y="282.00166442479883" GraphRef="da538" RelX="1.0" RelY="0.0" /> <Point X="1286.9743289659436" Y="280.9939691304553" GraphRef="a8f13" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="e7095"> <Graphics ZOrder="32823" LineThickness="1.0"> <Point X="1275.2924397855695" Y="431.84880964260884" GraphRef="fc613" RelX="-0.5" RelY="1.0" /> <Point X="1256.5681291879341" Y="446.53586725096187" GraphRef="e8fc0" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="d54e4"> <Graphics ZOrder="32825" LineThickness="1.0"> <Point X="1301.7705111283099" Y="431.84880964260884" GraphRef="fc613" RelX="0.5" RelY="1.0" /> <Point X="1320.1050368439348" Y="448.47681605554885" GraphRef="d16aa" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="bde74"> <Graphics ZOrder="32826" LineThickness="1.0"> <Point X="1278.146163421041" Y="593.7343230218369" GraphRef="fed26" RelX="-0.5" RelY="1.0" /> <Point X="1261.2412405765904" Y="611.9909866141377" GraphRef="c5b91" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="c9b6b"> <Graphics ZOrder="32828" LineThickness="1.0"> <Point X="1304.6242347637808" Y="593.7343230218369" GraphRef="fed26" RelX="0.5" RelY="1.0" /> <Point X="1324.0075855412088" Y="610.8548129578661" GraphRef="dc646" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="ca493"> <Graphics ZOrder="32833" LineThickness="1.0"> <Point X="1248.8261385293467" Y="704.583619430937" GraphRef="ae76f" RelX="0.0" RelY="1.0" /> <Point X="1276.6570373981178" Y="776.0226147461126" GraphRef="d3fb3" RelX="-0.5" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.6930899883380343" Shape="None" GraphId="b0e5b" /> <Anchor Position="0.4" Shape="None" GraphId="ec86d" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="aa3b3"> <Graphics ZOrder="32834" LineThickness="1.0"> <Point X="1343.6402685642297" Y="704.6907917310195" GraphRef="b6b95" RelX="0.0" RelY="1.0" /> <Point X="1324.109823988261" Y="776.0226147461126" GraphRef="d3fb3" RelX="0.5" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.7118275756247109" Shape="None" GraphId="aa5cc" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="db3cb"> <Graphics ZOrder="32836" LineThickness="1.0"> <Point X="1285.5541128433983" Y="736.8215459107397" GraphRef="f166f" RelX="-0.5" RelY="1.0" /> <Point X="1268.1154559017402" Y="754.097271860813" GraphRef="b0e5b" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="fdd42"> <Graphics ZOrder="32838" LineThickness="1.0"> <Point X="1312.0321841861382" Y="736.8215459107397" GraphRef="f166f" RelX="0.5" RelY="1.0" /> <Point X="1329.737959550845" Y="755.4667503727442" GraphRef="aa5cc" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="dd0d4"> <Graphics ZOrder="32842" LineThickness="1.0"> <Point X="299.53336906125185" Y="543.1640679215304" GraphRef="a78e1" RelX="0.0" RelY="0.0" /> <Point X="329.2105263157889" Y="581.578947368421" GraphRef="aeba0" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="Rhea" ID="15466" /> </Interaction> <Interaction GraphId="fa914"> <Graphics ZOrder="32844" LineThickness="1.0"> <Point X="150.5263157894737" Y="597.8947368421047" GraphRef="f7997" RelX="1.0" RelY="0.0" /> <Point X="219.19658251621775" Y="545.2583618678739" GraphRef="e0038" RelX="0.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="Rhea" ID="27515" /> </Interaction> <GraphicalLine GraphId="e8959"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="961.9047619047618" Y="221.68793952180027" GraphRef="f2bba" RelX="0.0" RelY="0.0" /> <Point X="1041.369449942553" Y="268.94650907102744" GraphRef="b59c1" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="aa1a6"> <Graphics ConnectorType="Elbow" ZOrder="33042" LineStyle="Broken" LineThickness="1.0"> <Point X="960.0" Y="389.625" GraphRef="ae05e" RelX="0.0" RelY="0.0" /> <Point X="1086.369449942553" Y="281.44650907102744" GraphRef="b59c1" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> </Graphics> </GraphicalLine> <Label TextLabel="N-acyl chains:" GraphId="b8214"> <Graphics CenterX="1285.553691275168" CenterY="38.92617449664429" Width="183.25503355704723" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="22" Valign="Middle" Color="404040" /> </Label> <Label TextLabel="NP Type B" GraphId="b59c1" Href="https://omim.org/entry/607616"> <Comment>NIEMANN-PICK DISEASE, TYPE B</Comment> <Comment>results from mutation in SMPD1 gene</Comment> <Graphics CenterX="1086.369449942553" CenterY="268.94650907102744" Width="90.0" Height="25.0" ZOrder="33041" FillColor="ffcccc" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Group GroupId="c13d0" GraphId="a6c1c" Style="Group" /> <Group GroupId="bb5bd" GraphId="a7438" Style="Group" /> <Group GroupId="d945f" GraphId="a8e79" Style="Group" /> <Group GroupId="af21a" GraphId="bfe17" Style="Group" /> <Group GroupId="fa178" GraphId="c7a3b" Style="Group" /> <Group GroupId="e6298" GraphId="cdf83" Style="Group" /> <Group GroupId="e505a" GraphId="ce853" Style="Group" /> <Group GroupId="d4bdd" GraphId="da538" Style="Group" /> <Group GroupId="ba605" GraphId="e9f31" Style="Group" /> <Group GroupId="c0c64" GraphId="fb07d" Style="Group" /> <Group GroupId="e29dc" GraphId="feaff" Style="Group" /> <InfoBox CenterX="0.0" CenterY="0.0" /> <Biopax> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b39"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11756451</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Characterization of murine sphingosine-1-phosphate phosphohydrolase.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2002</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Le Stunff H</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Peterson C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Thornton R</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Milstien S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mandala SM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Spiegel S</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e62"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">19416851</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Identification of small subunits of mammalian serinepalmitoyltransferase that confer distinct acyl-CoA substrate specificities.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Proc Natl Acad Sci U S A</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Han G</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gupta SD</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gable K</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Niranjanakumari S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Moitra P</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Eichler F</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brown RH Jr</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Harmon JM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dunn TM</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">sphingomyelin metabolic pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000745</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b6c"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">12011104</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2002</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Merrill AH Jr</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fc1"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20923771</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:YEAR> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20923771</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mouse macrophage lipidome.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dennis EA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Deems RA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Harkewicz R</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Quehenberger O</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brown HA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Milne SB</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Myers DS</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Glass CK</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hardiman G</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reichart D</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Merrill AH Jr</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sullards MC</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang E</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Murphy RC</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Raetz CR</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Garrett TA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Guan Z</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ryan AC</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Russell DW</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">McDonald JG</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Thompson BM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shaw WA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sud M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhao Y</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gupta S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Maurya MR</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fahy E</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Subramaniam S</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">sphingolipid biosynthetic pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000162</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">sphingolipid metabolic pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000197</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> </Biopax> </Pathway>

• Template:AuthorInfo
• Template:CheckAvailable (protected)
• Template:Help:LiteratureReferences (protected)
• Template:PathwayPage:History
• Template:PathwayPage:Xrefs

Return to Sphingolipid metabolism overview (Homo sapiens).