GPR143 in melanocytes and retinal pigment epithelium cells (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="GPR143 in melanocytes and retinal pigment epithelium cells" Version="20200430" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">A model demonstrating the place of the GPR143 gene in the pathogenesis of ocular albinism type 1. The latter shows the interactions between GPR143 and the different genes responsible for melanogenesis as well as growth factors such as SERPINF1 and VEGF in melanocytes or the retinal pigment epithelium. </Comment> <Comment Source="WikiPathways-description">A model demonstrating the place of the GPR143 gene in the pathogenesis of ocular albinism type 1. The latter shows the interactions between GPR143 and the different genes responsible for melanogenesis as well as growth factors such as SERPINF1 and VEGF in melanocytes or the retinal pigment epithelium. </Comment> <Comment Source="WikiPathways-description"> A model demonstrating the potential place of the GPR143 gene in the pathogenesis of ocular albinism type 1. The latter shows the interactions between GPR143 and the different genes responsible for melanogenesis as well as growth factors such as SERPINF1 and VEGF in melanocytes or the retinal pigment epithelium. </Comment> <Comment Source="WikiPathways-description">A disease model demonstrating the potential place of the GPR143 gene in the pathogenesis of ocular albinism type 1. 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GraphRef="f74ec" RelX="-1.0" RelY="0.0" /> <Point X="250.33333333333331" Y="163.19808806582535" /> <Point X="227.84979328038975" Y="115.98380235153991" GraphRef="f6a54" RelX="1.0" RelY="-0.5" ArrowHead="mim-binding" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idbc110e2d"> <BiopaxRef>d64</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="822.1849740276247" Y="522.2345864948254" GraphRef="ea91a" RelX="0.0" RelY="-1.0" /> <Point X="820.7298822131645" Y="432.8281351340107" GraphRef="f9552" RelX="0.0" RelY="1.0" ArrowHead="mim-stimulation" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idbe08daac"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="99.05638853076545" Y="201.31029669404734" GraphRef="f1dc2" RelX="1.0" RelY="0.0" /> <Point X="160.21708342761525" Y="200.97696336071402" GraphRef="a3ed1" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> <Anchor Position="0.4" Shape="None" GraphId="c40b7" /> 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<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="609.7106657160205" Y="357.97409968360313" GraphRef="f67f8" RelX="-0.5" RelY="-1.0" /> <Point X="658.7495656761557" Y="151.33333333333334" /> <Point X="705.7884656362911" Y="183.51319110403261" GraphRef="c2a5a" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> <Anchor Position="0.07214244273154546" Shape="None" GraphId="a9a3c" /> <Anchor Position="0.4214151493514379" Shape="None" GraphId="e1664" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idd1aa4f0a"> <Comment>Spontaneous cyclazation</Comment> <BiopaxRef>e7a</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="792.1568766496096" Y="257.05096501512213" GraphRef="f75f2" RelX="1.0" RelY="0.0" /> <Point X="823.0791782608455" Y="257.71763168178893" GraphRef="ca151" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idd2aeee24"> <BiopaxRef>d64</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="879.7953861072864" Y="422.9551192609948" GraphRef="ab538" RelX="-1.0" RelY="0.0" /> <Point X="850.7298822131645" Y="422.8281351340107" GraphRef="f9552" RelX="1.0" RelY="0.0" ArrowHead="mim-stimulation" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idd3ecaf6b"> <BiopaxRef>f5c</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="732.3790988718312" Y="109.69642857142992" GraphRef="ea984" RelX="-1.0" RelY="0.0" /> <Point X="526.4999515915804" Y="410.11702232396794" GraphRef="f65aa" RelX="-0.5" RelY="-1.0" ArrowHead="mim-inhibition" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idd7be365e"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="368.28082041653073" Y="182.0800693910112" GraphRef="db87e" RelX="0.0" RelY="1.0" /> <Point X="367.725795711335" Y="210.58756074220153" GraphRef="f8a98" RelX="0.0" 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<Point X="688.8761916274118" Y="183.69096888181048" GraphRef="c5975" RelX="1.0" RelY="0.0" /> <Point X="731.15687664961" Y="183.24652443736585" GraphRef="cd6cf" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> <Anchor Position="0.4" Shape="None" GraphId="c2a5a" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idf0c63627"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="909.9223702342708" Y="463.3615706218094" GraphRef="ff370" RelX="0.0" RelY="-1.0" /> <Point X="909.7953861072864" Y="432.9551192609948" GraphRef="ab538" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idf4148a1"> <Comment>Oxidation</Comment> <BiopaxRef>e7a</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="998.0" Y="281.89594769220645" GraphRef="ffe4e" RelX="0.0" RelY="0.0" /> <Point X="956.1974586301286" Y="281.62583296517937" GraphRef="bf2ad" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idf43f54b3"> <BiopaxRef>aee</BiopaxRef> <BiopaxRef>aae</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="560.8596476458677" Y="450.61328382534805" GraphRef="f65aa" RelX="0.5" RelY="1.0" /> <Point X="586.2171524563455" Y="497.43341761147815" GraphRef="a06d2" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idfa42d105"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="162.05638853077022" Y="281.5365703892569" GraphRef="d1baa" RelX="1.0" RelY="0.0" /> <Point X="231.02660723715303" Y="281.2984751511615" GraphRef="e9760" RelX="-1.0" RelY="0.0" ArrowHead="mim-transcription-translation" /> <Anchor Position="0.4" Shape="None" GraphId="bbb11" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idfb78acf8"> <Comment>Oxidation</Comment> <BiopaxRef>e7a</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="609.7106657160205" Y="216.8428302987029" GraphRef="e1664" RelX="0.0" RelY="0.0" /> <Point X="658.8761916274118" Y="216.50330705730204" GraphRef="dae53" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idfbe5aab2"> <BiopaxRef>da4</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="369.07929707689124" Y="505.26991032784747" GraphRef="f1385" RelX="1.0" RelY="-0.5" /> <Point X="352.6428571428555" Y="497.76991032784747" /> <Point X="369.07929707689124" Y="490.26991032784747" GraphRef="b4578" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idff5be9e4"> <BiopaxRef>e7a</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="744.7106657160205" Y="377.97409968360313" GraphRef="d0dd2" RelX="0.0" RelY="1.0" /> <Point X="684.7106657160205" Y="411.8888888888889" /> <Point X="624.7106657160205" Y="377.97409968360313" GraphRef="f67f8" RelX="0.0" RelY="1.0" ArrowHead="mim-stimulation" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="ab265"> <Comment>Spontaneous Decarboxylation</Comment> <BiopaxRef>e7a</BiopaxRef> <Graphics ZOrder="32776" LineThickness="1.0"> <Point X="903.0791782608455" Y="257.71763168178893" GraphRef="ca151" RelX="1.0" RelY="0.0" /> <Point X="926.1974586301287" Y="257.71763168178893" GraphRef="fee5d" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Shape GraphId="d3c8f"> <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell" /> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="521.75" CenterY="342.0" Width="1001.5" Height="524.0" ZOrder="16384" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" LineThickness="3.0" 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rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Interaction between G Protein-Coupled Receptor 143 and Tyrosinase: Implications for Understanding Ocular Albinism Type 1.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Invest Dermatol</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">De Filippo E</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schiedel AC</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Manga P</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f23"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20201954</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE 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