Hallmark of cancer: sustaining proliferative signaling (Homo sapiens)

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Width="90.0" Height="25.0" ZOrder="34292" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000109320"/> </DataNode> <DataNode TextLabel="NFKBIE" GraphId="ab7ed" Type="GeneProduct" GroupRef="ce0b8"> <Graphics CenterX="1602.3068308044153" CenterY="1470.9727668236544" Width="90.0" Height="25.0" ZOrder="34293" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000146232"/> </DataNode> <DataNode TextLabel="CHUK" GraphId="ce464" Type="GeneProduct" GroupRef="daa1c"> <Comment Source="OCR">IKKa</Comment> <Graphics CenterX="1069.891884631078" CenterY="1568.6992326407826" Width="90.0" Height="25.00000000000001" ZOrder="34294" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000213341"/> </DataNode> <DataNode TextLabel="IKBKB" GraphId="c802b" Type="GeneProduct" GroupRef="daa1c"> <Graphics CenterX="1069.891884631078" CenterY="1593.6992326407824" Width="90.0" Height="25.0" ZOrder="34295" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000104365"/> </DataNode> <DataNode TextLabel="IKBKG" GraphId="c8bd5" Type="GeneProduct" GroupRef="daa1c"> <Comment Source="OCR">IKKy</Comment> <Graphics CenterX="1069.891884631078" CenterY="1543.6992326407824" Width="90.0" Height="25.00000000000001" ZOrder="34296" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000269335"/> </DataNode> <DataNode TextLabel="RELA" Type="GeneProduct" GroupRef="c48ee"> <Comment Source="OCR">RelA</Comment> <Graphics CenterX="1567.7180438491218" CenterY="970.8346839616617" Width="89.99999999999997" Height="25.00000000000001" ZOrder="34300" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000173039"/> </DataNode> <DataNode TextLabel="REL" Type="GeneProduct" GroupRef="c48ee"> <Comment Source="OCR">c-Rel</Comment> <Graphics CenterX="1567.7180438491218" CenterY="995.8346839616615" Width="89.99999999999997" Height="25.00000000000001" ZOrder="34301" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000162924"/> </DataNode> <DataNode TextLabel="NFKB1" GraphId="c97dc" Type="GeneProduct" GroupRef="c48ee"> <Graphics CenterX="1659.15711040055" CenterY="979.689480850165" Width="90.0" Height="25.0" ZOrder="34302" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000109320"/> </DataNode> <DataNode TextLabel="RELA" Type="GeneProduct" GroupRef="f295b"> <Comment Source="OCR">RelA</Comment> <Graphics CenterX="1251.1663516166118" CenterY="1496.0781922422616" Width="89.99999999999997" Height="25.00000000000001" ZOrder="34303" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000173039"/> </DataNode> <DataNode TextLabel="NFKBIA" GraphId="be1e4" Type="GeneProduct" GroupRef="f295b"> <Graphics CenterX="1289.0185555924127" CenterY="1445.2959969095039" Width="90.0" Height="25.0" ZOrder="34304" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000100906"/> </DataNode> <DataNode TextLabel="REL" GraphId="b4be2" Type="GeneProduct" GroupRef="f295b"> <Comment Source="OCR">c-Rel</Comment> <Graphics CenterX="1251.1663516166116" CenterY="1521.0781922422614" Width="89.99999999999997" Height="25.00000000000001" ZOrder="34305" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000162924"/> </DataNode> <DataNode TextLabel="NFKB1" GraphId="dbf3f" Type="GeneProduct" GroupRef="f295b"> <Graphics CenterX="1342.6054181680386" CenterY="1504.932989130765" Width="90.0" Height="25.0" ZOrder="34306" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000109320"/> </DataNode> <DataNode TextLabel="NFKBIE" GraphId="f28fc" Type="GeneProduct" GroupRef="f295b"> <Graphics CenterX="1289.0185555924124" CenterY="1470.295996909504" Width="90.0" Height="25.0" ZOrder="34307" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000146232"/> </DataNode> <DataNode TextLabel="Junction plakoglobin" GraphId="ea6b5" Type="Protein" GroupRef="bc28b"> <Graphics CenterX="2473.4863129731275" CenterY="655.1685719746513" Width="106.0" Height="20.0" ZOrder="34338" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P14923"/> </DataNode> <DataNode TextLabel="c-MYC" GraphId="f1560" Type="GeneProduct"> <Graphics CenterX="2287.938373022704" CenterY="795.1542604335207" Width="80.0" Height="20.0" ZOrder="34339" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000136997"/> </DataNode> <DataNode TextLabel="AML1" GraphId="ad45e" Type="GeneProduct" GroupRef="b9df8"> <Graphics CenterX="2669.9567888425045" CenterY="578.168571974651" Width="80.0" Height="20.0" ZOrder="34340" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="LRG_482"/> </DataNode> <DataNode TextLabel="TCF" GraphId="a50ef" Type="GeneProduct" GroupRef="abc47"> <Comment>TCF Not Specified</Comment> <Graphics CenterX="2017.4889671055082" CenterY="793.5681642374276" Width="80.0" Height="20.0" ZOrder="34341" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000071564"/> </DataNode> <DataNode TextLabel="LEF" GraphId="e1375" Type="GeneProduct" GroupRef="abc47"> <Comment>LEF Not Specified</Comment> <Graphics CenterX="2017.4889671055082" CenterY="813.568164237427" Width="80.0" Height="20.0" ZOrder="34343" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000138795"/> </DataNode> <DataNode TextLabel="PPARD" GraphId="d9858" Type="GeneProduct"> <Graphics CenterX="2287.938373022704" CenterY="815.15426043352" Width="80.0" Height="20.0" ZOrder="34344" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000112033"/> </DataNode> <DataNode TextLabel="GSK3B" GraphId="bd91f" Type="GeneProduct" GroupRef="c8bdb"> <Graphics CenterX="2473.4863129731266" CenterY="532.1685719746511" Width="80.0" Height="20.0" ZOrder="34345" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000082701"/> </DataNode> <DataNode TextLabel="Frizzled" GraphId="d5653" Type="Protein" GroupRef="a763b"> <Comment>Frizzled Not Specified</Comment> <Graphics CenterX="2473.486312973126" CenterY="344.7560998540544" Width="80.0" Height="20.0" ZOrder="34346" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="E5RGK8"/> </DataNode> <DataNode TextLabel="WNT" GraphId="f8a24" Type="GeneProduct" GroupRef="a763b"> <Comment>Wnt Not Specified</Comment> <Graphics CenterX="2473.486312973126" CenterY="324.75609985405424" Width="80.0" Height="20.0" ZOrder="34347" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000125084"/> </DataNode> <DataNode TextLabel="RARA" GraphId="d4134" Type="GeneProduct" GroupRef="e15f8"> <Graphics CenterX="2669.9567888425045" CenterY="670.1685719746521" Width="80.0" Height="20.0" ZOrder="34348" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000131759"/> </DataNode> <DataNode TextLabel="PLZF" GraphId="d0d8d" Type="GeneProduct" GroupRef="cee4d"> <Graphics CenterX="2669.9567888425045" CenterY="722.1685719746515" Width="80.0" Height="20.0" ZOrder="34349" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000109906"/> </DataNode> <DataNode TextLabel="cyclin-D1" GraphId="d58ee" Type="Protein"> <Graphics CenterX="2287.938373022704" CenterY="775.1542604335207" Width="80.0" Height="20.0" ZOrder="34350" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P24385"/> </DataNode> <DataNode TextLabel="BCL9" GraphId="c1586" Type="GeneProduct" GroupRef="dd7e6"> <Graphics CenterX="1999.4889671055068" CenterY="697.5681642374267" Width="80.0" Height="20.0" ZOrder="34351" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000116128"/> </DataNode> <DataNode TextLabel="RUNX1T1" GraphId="a13f4" Type="GeneProduct" GroupRef="b9df8"> <Graphics CenterX="2669.9567888425045" CenterY="598.1685719746514" Width="80.0" Height="20.0" ZOrder="34352" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000079102"/> </DataNode> <DataNode TextLabel="PML" GraphId="ab5ca" Type="GeneProduct" GroupRef="e15f8"> <Graphics CenterX="2669.9567888425045" CenterY="650.1685719746512" Width="80.0" Height="20.0" ZOrder="34353" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000140464"/> </DataNode> <DataNode TextLabel="Catenin beta-1" GraphId="c0911" Type="Protein"> <Graphics CenterX="2340.5514010200673" CenterY="403.48039990683424" Width="80.0" Height="20.0" ZOrder="34355" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="B4DGU4"/> </DataNode> <DataNode TextLabel="RARA" GraphId="c82bd" Type="GeneProduct" GroupRef="cee4d"> <Graphics CenterX="2669.9567888425045" CenterY="742.1685719746516" Width="80.0" Height="20.0" ZOrder="34356" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000131759"/> </DataNode> <DataNode TextLabel="Phosphate" GraphId="a75d0" Type="Metabolite" GroupRef="c8bdb"> <Graphics CenterX="2473.4863129731266" CenterY="552.1685719746511" Width="80.0" Height="20.0" ZOrder="34357" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="HMDB" ID="HMDB0001429"/> </DataNode> <DataNode TextLabel="LRP6" GraphId="ec4bb" Type="GeneProduct" GroupRef="a763b"> <Graphics CenterX="2473.486312973126" CenterY="304.7560998540543" Width="80.0" Height="20.0" ZOrder="34358" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000070018"/> </DataNode> <DataNode TextLabel="APC" GraphId="f61ba" Type="GeneProduct" GroupRef="c8bdb"> <Graphics CenterX="2473.4863129731266" CenterY="492.1685719746516" Width="80.0" Height="20.0" ZOrder="34359" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000134982"/> </DataNode> <DataNode TextLabel="CK1" GraphId="fc880" Type="GeneProduct" GroupRef="c8bdb"> <Graphics CenterX="2473.4863129731266" CenterY="512.1685719746511" Width="80.0" Height="20.0" ZOrder="34360" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000113712"/> </DataNode> <DataNode TextLabel="LRP5" GraphId="c4938" Type="GeneProduct" GroupRef="a763b"> <Graphics CenterX="2473.486312973126" CenterY="284.75609985405424" Width="80.0" Height="20.0" ZOrder="34361" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000162337"/> </DataNode> <DataNode TextLabel="AXIN" GraphId="fd108" Type="GeneProduct" GroupRef="c8bdb"> <Graphics CenterX="2473.4863129731266" CenterY="472.16857197465197" Width="80.0" Height="20.0" ZOrder="34362" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000168646"/> </DataNode> <DataNode TextLabel="SALL4" GraphId="a7f32" Type="GeneProduct"> <Graphics CenterX="2287.938373022704" CenterY="755.1542604335202" Width="80.0" Height="20.0" ZOrder="34363" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000101115"/> </DataNode> <DataNode TextLabel="Catenin beta-1" GraphId="c9a63" Type="Protein" GroupRef="bc28b"> <Graphics CenterX="2473.4863129731275" CenterY="635.1685719746514" Width="80.0" Height="20.0" ZOrder="34364" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="B4DGU4"/> </DataNode> <DataNode TextLabel="PYGO" GraphId="f3179" Type="GeneProduct" GroupRef="dd7e6"> <Comment>PYGO Not Specified</Comment> <Graphics CenterX="1999.4889671055068" CenterY="717.5681642374266" Width="80.0" Height="20.0" ZOrder="34365" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000171016"/> </DataNode> <DataNode TextLabel="KSR1" GraphId="ac66a" Type="GeneProduct"> <BiopaxRef>f7f</BiopaxRef> <Graphics CenterX="1783.1391731581448" CenterY="1446.0330715390733" Width="90.0" Height="43.0" ZOrder="34372" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000141068"/> </DataNode> <DataNode TextLabel="MAP2K2" GraphId="bf01f" Type="GeneProduct" GroupRef="b495f"> <Graphics CenterX="1902.0486937739015" CenterY="1229.4657629254853" Width="90.0" Height="43.0" ZOrder="34375" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000126934"/> </DataNode> <DataNode TextLabel="ELK1" Type="GeneProduct" GroupRef="bcf1e"> <Graphics CenterX="2184.762596236297" CenterY="992.2962059007968" Width="80.0" Height="20.0" ZOrder="34389" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000126767"/> </DataNode> <DataNode TextLabel="c-FOS" Type="GeneProduct" GroupRef="bcf1e"> <Graphics CenterX="2184.762596236297" CenterY="932.2962059007966" Width="80.0" Height="20.000000000000075" ZOrder="34390" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000170345"/> </DataNode> <DataNode TextLabel="c-MYC" Type="GeneProduct" GroupRef="bcf1e"> <Graphics CenterX="2184.762596236297" CenterY="972.2962059007968" Width="80.0" Height="20.0" ZOrder="34391" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000136997"/> </DataNode> <DataNode TextLabel="c-JUN" Type="GeneProduct" GroupRef="bcf1e"> <Graphics CenterX="2184.762596236297" CenterY="952.296205900797" Width="80.0" Height="20.0" ZOrder="34392" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000177606"/> </DataNode> <DataNode TextLabel="CRAF&#10;" GraphId="d6672" Type="GeneProduct" GroupRef="b6169"> <Graphics CenterX="1996.4196177303404" CenterY="1329.128876527735" Width="90.0" Height="43.0" ZOrder="34393" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000132155"/> </DataNode> <DataNode TextLabel="&#10;RAS&#10;" GraphId="c8f63" Type="Protein" GroupRef="f5f82"> <Comment>RAS protein has three isoforms ( K,N and H RAS). the isoforms differ in ability of activating RAF protein, the isoform which is responsable the most of activating of Raf protein is Kras&gt; also, HRAS has the ability of activating the RAF proteins but less efficiently than KRAS. (PMID: 9727023)</Comment> <BiopaxRef>fb4</BiopaxRef> <BiopaxRef>b2b</BiopaxRef> <BiopaxRef>e37</BiopaxRef> <BiopaxRef>d95</BiopaxRef> <BiopaxRef>c70</BiopaxRef> <BiopaxRef>de3</BiopaxRef> <BiopaxRef>f77</BiopaxRef> <BiopaxRef>f6a</BiopaxRef> <BiopaxRef>e0d</BiopaxRef> <BiopaxRef>be4</BiopaxRef> <BiopaxRef>c2b</BiopaxRef> <BiopaxRef>c8a</BiopaxRef> <BiopaxRef>e23</BiopaxRef> <Graphics CenterX="1902.0486937739015" CenterY="1644.924307845802" Width="90.0" Height="43.0" ZOrder="34394" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000133703"/> </DataNode> <DataNode TextLabel="GTP" GraphId="f3acb" Type="Metabolite" GroupRef="f5f82"> <Graphics CenterX="1849.2760739278424" CenterY="1607.8968015381147" Width="47.0" Height="24.5" ZOrder="34395" FontSize="12" Valign="Middle" Color="0066cc"/> <Xref Database="ChEBI" ID="CHEBI:15996"/> </DataNode> <DataNode TextLabel="MAP2K1" GraphId="f1b1a" Type="GeneProduct" GroupRef="b495f"> <BiopaxRef>cb0</BiopaxRef> <Graphics CenterX="1902.0486937739015" CenterY="1185.4657629254853" Width="90.0" Height="43.0" ZOrder="34396" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000169032"/> </DataNode> <DataNode TextLabel="SOS2" GraphId="d8a52" Type="GeneProduct" GroupRef="b8284"> <BiopaxRef>a6e</BiopaxRef> <Graphics CenterX="1989.8584251781945" CenterY="1574.126129889175" Width="80.5" Height="22.5" ZOrder="34397" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000100485"/> </DataNode> <DataNode TextLabel="MAPK3" GraphId="daf87" Type="GeneProduct"> <Comment>Also known as ERK</Comment> <Comment>Type your comment here</Comment> <BiopaxRef>cff</BiopaxRef> <BiopaxRef>cb0</BiopaxRef> <Graphics CenterX="2120.681801946764" CenterY="1180.0826228149808" Width="90.0" Height="43.0" ZOrder="34398" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000102882"/> </DataNode> <DataNode TextLabel="GDP" GraphId="cf715" Type="Metabolite" GroupRef="f5f82"> <Graphics CenterX="1849.2760739278422" CenterY="1510.7342069228037" Width="50.0" Height="28.5" ZOrder="34399" FontSize="12" Valign="Middle" Color="0066ff"/> <Xref Database="ChEBI" ID="CHEBI:17552"/> </DataNode> <DataNode TextLabel="MAPK3&#10;&#10;" GraphId="c19b2" Type="GeneProduct"> <Comment>Also known as ERK</Comment> <BiopaxRef>cff</BiopaxRef> <BiopaxRef>cb0</BiopaxRef> <Graphics CenterX="2051.540102543985" CenterY="936.6295392341303" Width="90.0" Height="43.0" ZOrder="34400" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000102882"/> </DataNode> <DataNode TextLabel="SHC1" GraphId="becc8" Type="GeneProduct"> <BiopaxRef>a0b</BiopaxRef> <Graphics CenterX="2209.874905976888" CenterY="1549.5986235814878" Width="90.0" Height="43.0" ZOrder="34401" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000160691"/> </DataNode> <DataNode TextLabel="BRAF" GraphId="a72fb" Type="GeneProduct" GroupRef="b6169"> <BiopaxRef>f00</BiopaxRef> <BiopaxRef>cff</BiopaxRef> <BiopaxRef>aee</BiopaxRef> <BiopaxRef>b30</BiopaxRef> <BiopaxRef>cb0</BiopaxRef> <BiopaxRef>d6b</BiopaxRef> <Graphics CenterX="1902.0486937739015" CenterY="1375.842339847335" Width="90.0" Height="43.0" ZOrder="34402" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000157764"/> </DataNode> <DataNode TextLabel="SOS1" GraphId="d13df" Type="GeneProduct" GroupRef="b8284"> <BiopaxRef>a6e</BiopaxRef> <Graphics CenterX="1989.8584251781945" CenterY="1549.5986235814876" Width="80.5" Height="22.5" ZOrder="34403" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000115904"/> </DataNode> <DataNode TextLabel="GRB2" GraphId="b8f71" Type="Protein"> <BiopaxRef>a0b</BiopaxRef> <Graphics CenterX="2123.9253265866637" CenterY="1549.5986235814873" Width="90.0" Height="43.0" ZOrder="34404" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q75VX8"/> </DataNode> <State GraphRef="e42b5" TextLabel="P" GraphId="a873e"> <Graphics RelX="0.9510000000000004" 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