AMPK regulation of mammary milk protein synthesis (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="AMPK regulation of mammary milk protein synthesis" Version="20241020" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">"AMPK regulates mammary milk protein synthesis: mTORC1 is the master regulator that controls milk protein synthesis in the mammary gland through 4EBP1 and S6K1. AMPK directly inhibits mTORC1 through the phosphorylation of raptor at Ser 792. AMPK also decreases mTOR activity through the phosphorylation of TSC2 (a negative mTORC1 regulator) at Ser1345. The genes encoding as1-casein (CSN1S1), β-casein (CSN2) and κ-casein (CSN3) are also decreased with the activation of AMPK." 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rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Current Evidences and Future Perspectives for AMPK in the Regulation of Milk Production and Mammary Gland Biology.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Front Cell Dev Biol</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2020</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wu Z</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tian M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Heng J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chen J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chen F</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Guan W</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang S</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"><bp:TERM>adenosine monophosphate-activated protein kinase (AMPK) signaling pathway</bp:TERM><bp:ID>PW:0000542</bp:ID><bp:Ontology>Pathway Ontology</bp:Ontology></bp:openControlledVocabulary></Biopax> </Pathway>

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