Matrix metalloproteinases (Rattus norvegicus)

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<?xml version="1.0" encoding="ISO-8859-1"?> <Pathway xmlns="http://genmapp.org/GPML/2007" Name="Matrix Metalloproteinases" Data-Source="GenMAPP 2.0" Version="20041203" Author="Kam Dahlquist" Email="genmapp@gladstone.ucsf.edu" Copyright="2001, Gladstone Institutes" Last-Modified="7/29/2009" Organism="Rattus norvegicus"> <Comment Source="GenMAPP notes">Vu &amp;amp; Werb (2000) Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev 14:2123-2133</Comment> <Comment Source="WikiPathways-category">Molecular Function</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP129&amp;oldid=20953 WP129(r20953)] with a 87% conversion rate.</Comment> <Graphics BoardWidth="14313.75" BoardHeight="9097.0" WindowWidth="13388.0" WindowHeight="9447.0"/> <DataNode TextLabel="Mmp2" Type="GeneProduct" BackpageHead="Mmp2" GraphId="a14" GroupRef="ecc72"> <Graphics Color="000000" CenterX="3950.0" CenterY="1800.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="81686"/> </DataNode> <DataNode TextLabel="Mmp9" Type="GeneProduct" BackpageHead="Mmp9" GraphId="b03" GroupRef="ecc72"> <Graphics Color="000000" CenterX="3950.0" CenterY="2100.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="81687"/> </DataNode> <DataNode TextLabel="Mmp7" Type="GeneProduct" BackpageHead="Mmp7" GraphId="bb1" GroupRef="f9175"> <Graphics Color="000000" CenterX="1450.0" CenterY="3350.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="25335"/> </DataNode> <DataNode TextLabel="Mmp12" Type="GeneProduct" BackpageHead="Mmp12" GraphId="d23" GroupRef="faf96"> <Graphics Color="000000" CenterX="1450.0" CenterY="4600.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="117033"/> </DataNode> <DataNode TextLabel="Mmp20" Type="GeneProduct" BackpageHead="Mmp20" GraphId="d7e" GroupRef="e0ed6"> <Graphics Color="000000" CenterX="3950.0" CenterY="3350.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="300341"/> </DataNode> <DataNode TextLabel="Mmp10" Type="GeneProduct" BackpageHead="Mmp10" GraphId="bbe" GroupRef="e75ce"> <Graphics Color="000000" CenterX="6300.0" CenterY="2100.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="117061"/> </DataNode> <DataNode TextLabel="Mmp3" Type="GeneProduct" BackpageHead="Mmp3" GraphId="b11" GroupRef="e75ce"> <Graphics Color="000000" CenterX="6300.0" CenterY="1800.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="171045"/> </DataNode> <DataNode TextLabel="Mmp11" Type="GeneProduct" BackpageHead="Mmp11" GraphId="a4e" GroupRef="e75ce"> <Graphics Color="000000" CenterX="6300.0" CenterY="2400.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="25481"/> </DataNode> <DataNode TextLabel="Mmp19" Type="GeneProduct" BackpageHead="Mmp19" GraphId="c23" GroupRef="ed0f8"> <Graphics Color="000000" CenterX="6300.0" CenterY="3350.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="304608"/> </DataNode> <DataNode TextLabel="Mmp14" Type="GeneProduct" BackpageHead="Mmp14" GraphId="d30" GroupRef="fdc10"> <Graphics Color="000000" CenterX="9250.0" CenterY="1800.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="81707"/> </DataNode> <DataNode TextLabel="Mmp15" Type="GeneProduct" BackpageHead="Mmp15" GraphId="a77" GroupRef="fdc10"> <Graphics Color="000000" CenterX="9250.0" CenterY="2100.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="291848"/> </DataNode> <DataNode TextLabel="Mmp16" Type="GeneProduct" BackpageHead="Mmp16" GraphId="d25" GroupRef="fdc10"> <Graphics Color="000000" CenterX="9250.0" CenterY="2400.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="65205"/> </DataNode> <DataNode TextLabel="Mmp17" Type="GeneProduct" BackpageHead="Mmp17" GraphId="be5" GroupRef="fdc10"> <Graphics Color="000000" CenterX="9250.0" CenterY="2700.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="288626"/> </DataNode> <DataNode TextLabel="MMP24" Type="GeneProduct" BackpageHead="" GraphId="e85" GroupRef="fdc10"> <Graphics Color="000000" CenterX="9250.0" CenterY="3000.0" Width="900.0" Height="300.0"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Timp2" Type="GeneProduct" BackpageHead="Timp2" GraphId="b9e" GroupRef="fb39f"> <Graphics Color="000000" CenterX="3950.0" CenterY="6300.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="29543"/> </DataNode> <DataNode TextLabel="Timp3" Type="GeneProduct" BackpageHead="Timp3" GraphId="e00" GroupRef="fb39f"> <Graphics Color="000000" CenterX="3950.0" CenterY="6600.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="25358"/> </DataNode> <DataNode TextLabel="Timp4" Type="GeneProduct" BackpageHead="Timp4" GraphId="ff7" GroupRef="fb39f"> <Graphics Color="000000" CenterX="3950.0" CenterY="6900.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="680130"/> </DataNode> <DataNode TextLabel="Bsg" Type="GeneProduct" BackpageHead="Bsg" GraphId="c49" GroupRef="ef37f"> <Graphics Color="000000" CenterX="7750.0" CenterY="6000.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="25246"/> </DataNode> <DataNode TextLabel="Tnf" Type="GeneProduct" BackpageHead="Tnf" GraphId="eb0" GroupRef="ef37f"> <Graphics Color="000000" CenterX="7750.0" CenterY="6700.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="24835"/> </DataNode> <DataNode TextLabel="MMP26" Type="GeneProduct" BackpageHead="" GraphId="fc8" GroupRef="f9175"> <Graphics Color="000000" CenterX="1450.0" CenterY="3650.0" Width="900.0" Height="300.0"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Mmp28" Type="GeneProduct" BackpageHead="Mmp28" GraphId="b8a" GroupRef="ed0f8"> <Graphics Color="000000" CenterX="6300.0" CenterY="4850.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="303384"/> </DataNode> <DataNode TextLabel="MMP23A" Type="GeneProduct" BackpageHead="" GraphId="efd" GroupRef="ed0f8"> <Graphics Color="000000" CenterX="6300.0" CenterY="3950.0" Width="900.0" Height="300.0"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="MMP25" Type="GeneProduct" BackpageHead="" GraphId="b00" GroupRef="fdc10"> <Graphics Color="000000" CenterX="9250.0" CenterY="3300.0" Width="900.0" Height="300.0"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Mmp27" Type="GeneProduct" BackpageHead="Mmp27" GraphId="a12" GroupRef="ed0f8"> <Graphics Color="000000" CenterX="6300.0" CenterY="4550.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="300340"/> </DataNode> <DataNode TextLabel="Tcf20" Type="GeneProduct" BackpageHead="Tcf20" GraphId="d26" GroupRef="ef37f"> <Graphics Color="000000" CenterX="7750.0" CenterY="6350.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="366964"/> </DataNode> <DataNode TextLabel="Mmp21" Type="GeneProduct" BackpageHead="Mmp21" GraphId="d77" GroupRef="ed0f8"> <Graphics Color="000000" CenterX="6300.0" CenterY="3650.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="293573"/> </DataNode> <DataNode TextLabel="Mmp1a" Type="GeneProduct" BackpageHead="Mmp1a" GraphId="ee0" GroupRef="b2044"> <Graphics Color="000000" CenterX="1450.0" CenterY="1800.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="300339"/> </DataNode> <DataNode TextLabel="Mmp8" Type="GeneProduct" BackpageHead="Mmp8" GraphId="dca" GroupRef="b2044"> <Graphics Color="000000" CenterX="1450.0" CenterY="2100.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="63849"/> </DataNode> <DataNode TextLabel="Mmp13" Type="GeneProduct" BackpageHead="Mmp13" GraphId="de9" GroupRef="b2044"> <Graphics Color="000000" CenterX="1450.0" CenterY="2400.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="171052"/> </DataNode> <DataNode TextLabel="Timp1" Type="GeneProduct" BackpageHead="Timp1" GraphId="dbd" GroupRef="fb39f"> <Graphics Color="000000" CenterX="3950.0" CenterY="6000.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="116510"/> </DataNode> <DataNode TextLabel="Mmp23" Type="GeneProduct" BackpageHead="Mmp23" GraphId="a11" GroupRef="ed0f8"> <Graphics Color="000000" CenterX="6300.0" CenterY="4250.0" Width="900.0" Height="300.0"/> <Xref Database="Entrez Gene" ID="94339"/> </DataNode> <Label TextLabel="Gelatinases" GraphId="b07" GroupRef="ecc72"> <Graphics FontWeight="Bold" FontSize="180" Color="000000" CenterX="3950.0" CenterY="1400.0" Width="1415.0" Height="285.0"/> </Label> <Label TextLabel="Collagenases" GraphId="b2a" GroupRef="b2044"> <Graphics FontWeight="Bold" FontSize="180" Color="000000" CenterX="1450.0" CenterY="1400.0" Width="1640.0" Height="285.0"/> </Label> <Label TextLabel="Stromelysins" GraphId="c64" GroupRef="e75ce"> <Graphics FontWeight="Bold" FontSize="180" Color="000000" CenterX="6300.0" CenterY="1400.0" Width="1580.0" Height="285.0"/> </Label> <Label TextLabel="Membrane-type MMPs" GraphId="e5c" GroupRef="fdc10"> <Graphics FontWeight="Bold" FontSize="180" Color="000000" CenterX="9250.0" CenterY="1400.0" Width="2600.0" Height="285.0"/> </Label> <Label TextLabel="Matrilysin" GraphId="eb5" GroupRef="f9175"> <Graphics FontWeight="Bold" FontSize="180" Color="000000" CenterX="1450.0" CenterY="2950.0" Width="1175.0" Height="285.0"/> </Label> <Label TextLabel="Inhibitors" GraphId="ca7" GroupRef="fb39f"> <Graphics FontWeight="Bold" FontSize="180" Color="000000" CenterX="3950.0" CenterY="5650.0" Width="1160.0" Height="285.0"/> </Label> <Label TextLabel="Enamelysin" GraphId="ee4" GroupRef="e0ed6"> <Graphics FontWeight="Bold" FontSize="180" Color="000000" CenterX="3950.0" CenterY="2950.0" Width="1415.0" Height="285.0"/> </Label> <Label TextLabel="Other" GraphId="f8b" GroupRef="ed0f8"> <Graphics FontWeight="Bold" FontSize="180" Color="000000" CenterX="6300.0" CenterY="2950.0" Width="710.0" Height="285.0"/> </Label> <Label TextLabel="Potential Inducers of Transcription" GraphId="ecd" GroupRef="ef37f"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="7750.0" CenterY="5650.0" Width="3350.0" Height="240.0"/> </Label> <Label TextLabel="Metalloelastase" GraphId="d0f" GroupRef="faf96"> <Graphics FontWeight="Bold" FontSize="180" Color="000000" CenterX="1450.0" CenterY="4200.0" Width="1835.0" Height="285.0"/> </Label> <Label TextLabel="Based on Vu &amp;amp; Werb (2000)" GraphId="e28"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="10600.0" CenterY="7400.0" Width="2645.0" Height="240.0"/> </Label> <Label TextLabel="Matrix metalloproteinases: effectors of" GraphId="cf0"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="11150.0" CenterY="7650.0" Width="3725.0" Height="240.0"/> </Label> <Label TextLabel="development and normal physiology." GraphId="f1c"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="11100.0" CenterY="7900.0" Width="3620.0" Height="240.0"/> </Label> <Label TextLabel="Genes Dev 14:2123-2133" GraphId="db4"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="10450.0" CenterY="8150.0" Width="2330.0" Height="240.0"/> </Label> <Group GroupId="b2044" Style="None" TextLabel="new group"/> <Group GroupId="ecc72" Style="None" TextLabel="new group"/> <Group GroupId="e75ce" Style="None" TextLabel="new group"/> <Group GroupId="fdc10" Style="None" TextLabel="new group"/> <Group GroupId="ed0f8" Style="None" TextLabel="new group"/> <Group GroupId="e0ed6" Style="None" TextLabel="new group"/> <Group GroupId="f9175" Style="None" TextLabel="new group"/> <Group GroupId="faf96" Style="None" TextLabel="new group"/> <Group GroupId="fb39f" Style="None" TextLabel="new group"/> <Group GroupId="ef37f" Style="None" TextLabel="new group"/> <InfoBox CenterX="0.0" CenterY="7417.5"/> <Legend CenterX="10210.5" CenterY="4778.0"/> </Pathway>

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