Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Regulation of mRNA stability by proteins that bind AU-rich elements" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">RNA elements rich in adenine and uracil residues (AU-rich elements) bind specific proteins which either target the RNA for degradation or, more rarely, stabilize the RNA. The activity of the AU-element binding proteins is regulated, usually by phosphorylation but also by subcellular localization. View original pathway at:[http://www.reactome.org/PathwayBrowser/#DIAGRAM=450531 Reactome].</Comment> <Comment Source="Reactome-Converter">Pathway is converted from Reactome ID: 450531</Comment> <Comment Source="Reactome-version">Reactome version: 62</Comment> <Comment Source="Reactome Author">Reactome Author: May, Bruce</Comment> <BiopaxRef>f3e</BiopaxRef> <BiopaxRef>e1a</BiopaxRef> <BiopaxRef>c7c</BiopaxRef> <BiopaxRef>e5a</BiopaxRef> <Attribute Key="reactome_id" Value="450531" /> <Graphics BoardWidth="1831.0" BoardHeight="2115.0" /> <DataNode TextLabel="HuR&#xA;with&#xA;phosphoserine221&#xA;and&#xA;phosphoserine158:mRNA Complex" GraphId="a0b32" Type="Complex"> <BiopaxRef>d25</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1477.0" CenterY="331.5" Width="126.0" Height="75.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-517672" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by Tristetraproline " GraphId="a103b" GroupRef="c6e9b"> <Comment Source="Reactome">Tristetraproline binds AU-rich elements in the following mRNAs: Tumor necrosis factor alpha (TNFA), Granulocyte-macrophage colony stimulating factor (CSF2, GM-CSF), Interleukin-2 (IL-2), and Proto-oncogene C-FOS (FOS, c-fos).</Comment> <BiopaxRef>eb2</BiopaxRef> <BiopaxRef>cd8</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450420" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1185.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450597" /> </DataNode> <DataNode TextLabel="AUF1 Dimer (isoform&#xA;p37 or p40)" GraphId="a18e4" Type="Complex"> <Comment Source="Reactome">Phosphorylated isoform p40 of AUF1 destabilizes mRNA. Isoform p37 (phosphorylation unknown) also destabilizes mRNA.</Comment> <BiopaxRef>c50</BiopaxRef> <BiopaxRef>fb7</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="213.5" CenterY="79.0" Width="95.0" Height="48.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-450391" /> </DataNode> <DataNode TextLabel="XRN1 " GraphId="a2936" Type="Protein" GroupRef="c4507"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450436" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1905.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8IZH2" /> </DataNode> <DataNode TextLabel="ENPP2 mRNA 001 " GraphId="a2af3" Type="Protein" GroupRef="cce59"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-517713" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1045.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENST00000427067" /> </DataNode> <DataNode TextLabel="PSMB2 " GraphId="a3206" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1365.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P49721" /> </DataNode> <DataNode TextLabel="NUP214 " GraphId="a331f" Type="Protein" GroupRef="c642c"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-450537" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1845.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P35658" /> </DataNode> <DataNode TextLabel="EXOSC2 " GraphId="a3a1f" Type="Protein" GroupRef="fadd9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450430" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1585.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13868" /> </DataNode> <DataNode TextLabel="PSMD12 " GraphId="a3dc2" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1705.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O00232" /> </DataNode> <DataNode TextLabel="HNRNPD-4 " GraphId="a41a3" Type="Protein" GroupRef="bb65f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450391" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="100.0" CenterY="985.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q14103-4" /> </DataNode> <DataNode TextLabel="Phosphorylated KSRP&#xA;(Ser193):14-3-3zeta&#xA;Complex" GraphId="a486b" Type="Complex"> <BiopaxRef>f5d</BiopaxRef> <BiopaxRef>c7b</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1157.0" CenterY="90.5" Width="108.0" Height="71.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-450446" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by HuR with Unknown Phosphorylation " GraphId="a4992" GroupRef="c642c"> <Comment Source="Reactome">HuR (phosphorylation state unknown) binds AU-rich elements in the following mRNAs: Antigen CD83 (CD83), Cyclin B1 (CCNB1), and proto-oncogene c-Fos (FOS).</Comment> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-450537" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1915.0" Width="100.0" Height="50.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450613" /> </DataNode> <DataNode TextLabel="EXOSC2 " GraphId="a4b7e" Type="Protein" GroupRef="dafbc"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450479" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1605.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13868" /> </DataNode> <DataNode TextLabel="EXOSC6 " GraphId="a53ef" Type="Protein" GroupRef="fadd9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450430" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1425.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5RKV6" /> </DataNode> <DataNode TextLabel="NUP214" GraphId="a653a" Type="Protein"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1728.0" CenterY="303.0" Width="72.0" Height="34.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P35658" /> </DataNode> <DataNode TextLabel="ATP" GraphId="a65a7" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="573.0" CenterY="189.5" Width="48.0" Height="29.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15422" /> </DataNode> <DataNode TextLabel="PSMD3 " GraphId="a69bd" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1765.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O43242" /> </DataNode> <DataNode TextLabel="Phosphorylated BRF1&#xA;(Ser54, Ser92,&#xA;Ser203):mRNA&#xA;Complex" GraphId="a69f9" Type="Complex"> <BiopaxRef>a7f</BiopaxRef> <BiopaxRef>b90</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1054.5" CenterY="707.5" Width="123.0" Height="63.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-450502" /> </DataNode> <DataNode TextLabel="EXOSC4 " GraphId="a6a34" Type="Protein" GroupRef="c25bd"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-429971" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1145.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NPD3" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by HuR with Unknown Phosphorylation " GraphId="a6b16" GroupRef="bb6c4"> <Comment Source="Reactome">HuR (phosphorylation state unknown) binds AU-rich elements in the following mRNAs: Antigen CD83 (CD83), Cyclin B1 (CCNB1), and proto-oncogene c-Fos (FOS).</Comment> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-450395" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1455.0" Width="100.0" Height="50.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450613" /> </DataNode> <DataNode TextLabel="DCP2 " GraphId="a7933" Type="Protein" GroupRef="c4507"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450436" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1945.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8IU60" /> </DataNode> <DataNode TextLabel="EXOSC6 " GraphId="a7960" Type="Protein" GroupRef="c25bd"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-429971" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1125.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5RKV6" /> </DataNode> <DataNode TextLabel="mRNA Transcript&#xA;Targeted by&#xA;AUF1(hnRNP D0)" GraphId="a7c5f"> <Comment Source="Reactome">AUF1 (hnRNP D0) binds AU-rich elements in mRNAs encoding Interleukin-1 beta (IL1B), Tumor Necrosis Factor alpha (TNFA), Cyclin-dependent kinase inhibitor 1 (CDNK1A, p21), Cyclin-D1 (CCND1), Granulocyte-macrophage colony stimulating factor (GM-CSF, CSF2), inducible Nitric oxide synthase (iNOS, NOS2), Proto-oncogene cFos (FOS), Myc proto-oncogene (MYC), Apoptosis regulator Bcl-2 (BCL2).</Comment> <BiopaxRef>a37</BiopaxRef> <BiopaxRef>fc4</BiopaxRef> <BiopaxRef>fc8</BiopaxRef> <BiopaxRef>fb6</BiopaxRef> <BiopaxRef>f80</BiopaxRef> <BiopaxRef>c47</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="91.0" CenterY="76.5" Width="116.0" Height="57.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450444" /> </DataNode> <DataNode TextLabel="SET " GraphId="a805f" Type="Protein" GroupRef="c642c"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-450537" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1865.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q01105" /> </DataNode> <DataNode TextLabel="ADP" GraphId="a8243" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="981.0" CenterY="888.0" Width="40.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16761" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by BRF1 " GraphId="a84c8" GroupRef="fadd9"> <Comment Source="Reactome">BRF1 binds AU-rich elements in the following mRNAs: IL-3, CSF2 (GM-CSF).</Comment> <BiopaxRef>c0b</BiopaxRef> <BiopaxRef>ec8</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450430" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1405.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450523" /> </DataNode> <DataNode TextLabel="XPO1" GraphId="a8892" Type="Protein"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1620.5" CenterY="139.0" Width="53.0" Height="24.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O14980" /> </DataNode> <DataNode TextLabel="Phospho-MAP kinase&#xA;p38 (Mg2+ cofactor)" GraphId="a8ba8" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="658.5" CenterY="65.0" Width="119.0" Height="48.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-170993" /> </DataNode> <DataNode TextLabel="ADP" GraphId="a8d1f" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="726.0" CenterY="185.5" Width="42.0" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16761" /> </DataNode> <DataNode TextLabel="PSMD13 " GraphId="a9184" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1725.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UNM6" /> </DataNode> <DataNode TextLabel="ZFP36L1 " GraphId="a9b38" Type="Protein" GroupRef="fadd9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450430" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1365.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q07352" /> </DataNode> <DataNode TextLabel="PSMD8 " GraphId="ab531" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1865.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P48556" /> </DataNode> <DataNode TextLabel="PSME2 " GraphId="ab6ae" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1925.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UL46" /> </DataNode> <DataNode TextLabel="PARN" GraphId="aba24" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="353.0" CenterY="302.0" Width="58.0" Height="28.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O95453" /> </DataNode> <DataNode TextLabel="PSMA7 " GraphId="abb17" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1305.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O14818" /> </DataNode> <DataNode TextLabel="EXOSC9 " GraphId="ac033" Type="Protein" GroupRef="dafbc"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450479" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1545.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q06265" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by KSRP " GraphId="ac329" GroupRef="dafbc"> <Comment Source="Reactome">KSRP binds AU-rich elements in the following mRNAs: IL-8, LDLR, and NOS2 (iNOS). Binding of KSRP to the mRNA encoding Beta-catenin is inferred from mouse.</Comment> <BiopaxRef>b98</BiopaxRef> <BiopaxRef>c7b</BiopaxRef> <BiopaxRef>bc9</BiopaxRef> <BiopaxRef>a2d</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450479" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1425.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450386" /> </DataNode> <DataNode TextLabel="PSMB1 " GraphId="ac742" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1325.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P20618" /> </DataNode> <DataNode TextLabel="p-T692-KHSRP" GraphId="accdf" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="816.5" CenterY="139.0" Width="113.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q92945" /> </DataNode> <DataNode TextLabel="ADP" GraphId="ae340" Type="Metabolite"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1197.5" CenterY="257.0" Width="39.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16761" /> </DataNode> <DataNode TextLabel="p-S221,S318-ELAVL1 " GraphId="ae4c4" Type="Protein" GroupRef="ae124"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-517615" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1725.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15717" /> </DataNode> <DataNode TextLabel="TNPO1 " GraphId="afb5e" Type="Protein" GroupRef="b68b3"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450541" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1065.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q92973" /> </DataNode> <DataNode TextLabel="PSMD5 " GraphId="b11f2" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1805.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q16401" /> </DataNode> <DataNode TextLabel="p-S60,S186-ZFP36 " GraphId="b1e60" Type="Protein" GroupRef="c6e9b"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450420" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1225.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P26651" /> </DataNode> <DataNode TextLabel="YWHAB" GraphId="b1fb9" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1162.5" CenterY="780.5" Width="103.0" Height="39.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P31946" /> </DataNode> <DataNode TextLabel="EXOSC4 " GraphId="b27a7" Type="Protein" GroupRef="fadd9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450430" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1445.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NPD3" /> </DataNode> <DataNode TextLabel="KSRP:mRNA&#xA;Degradation Complex" GraphId="b283a" Type="Complex"> <BiopaxRef>d97</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="451.0" CenterY="423.5" Width="88.0" Height="51.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-450479" /> </DataNode> <DataNode TextLabel="EXOSC5 " GraphId="b2f9a" Type="Protein" GroupRef="c25bd"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-429971" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1205.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQT4" /> </DataNode> <DataNode TextLabel="p-S158,S221-ELAVL1 " GraphId="b3036" Type="Protein" GroupRef="cce59"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-517713" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1155.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15717" /> </DataNode> <DataNode TextLabel="p-S92,S203-ZFP36L1 " GraphId="b3613" Type="Protein" GroupRef="e6d09"> <BiopaxRef>a7f</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450378" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1065.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q07352" /> </DataNode> <DataNode TextLabel="p-S158,S221-ELAVL1 " GraphId="b4370" Type="Protein" GroupRef="ae124"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-517615" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1605.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15717" /> </DataNode> <DataNode TextLabel="p-T180,Y182-MAPK11 " GraphId="b499d" Type="Protein" GroupRef="e5f0e"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-170993" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1125.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15759" /> </DataNode> <DataNode TextLabel="PSMB7 " GraphId="b49b4" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1465.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q99436" /> </DataNode> <DataNode TextLabel="PRKCA" GraphId="b5c8d" Type="Protein"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1143.5" CenterY="339.5" Width="65.0" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P17252" /> </DataNode> <DataNode TextLabel="PSMA6 " GraphId="b5d48" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1285.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P60900" /> </DataNode> <DataNode TextLabel="ZFP36L1 " GraphId="b6a1f" Type="Protein" GroupRef="f49cd"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450589" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1025.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q07352" /> </DataNode> <DataNode TextLabel="HNRNPD-4 " GraphId="b6c5b" Type="Protein" GroupRef="cc659"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450598" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="100.0" CenterY="1105.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q14103-4" /> </DataNode> <DataNode TextLabel="p-S83,S87-Ub-HNRNPD-3 " GraphId="b6e86" Type="Protein" GroupRef="e9a83"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450458" /> <Attribute Key="copies_num" Value="7" /> <Graphics CenterX="240.0" CenterY="1105.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q14103-3" /> </DataNode> <DataNode TextLabel="PSMA2 " GraphId="b8b7e" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1205.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P25787" /> </DataNode> <DataNode TextLabel="ATP" GraphId="b940d" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="838.0" CenterY="890.5" Width="38.0" Height="21.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15422" /> </DataNode> <DataNode TextLabel="p-S83,S87-HNRNPD-3 " GraphId="b94e6" Type="Protein" GroupRef="cc659"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450598" /> <Attribute Key="copies_num" Value="7" /> <Graphics CenterX="100.0" CenterY="1125.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q14103-3" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by HuR Phosphorylated on Ser221 and Ser318 " GraphId="ba13a" GroupRef="cce59"> <Comment Source="Reactome">Phosphorylated HuR (phosphoserine221 and phosphoserine318) binds AU-rich elements in the following mRNAs: Cyclooxygenase-2 (COX-2, PTGS2), Cyclin A (CCNA, CCNA2), and Cyclin D1 (CCND1).</Comment> <BiopaxRef>a29</BiopaxRef> <BiopaxRef>b5d</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-517713" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1225.0" Width="100.0" Height="50.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-517560" /> </DataNode> <DataNode TextLabel="EXOSC5 " GraphId="bad57" Type="Protein" GroupRef="fadd9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450430" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1505.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQT4" /> </DataNode> <DataNode TextLabel="PSMB5 " GraphId="bbfbe" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1425.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P28074" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by HuR Phosphorylated on Ser221 and Ser318 " GraphId="bc663" GroupRef="a7322"> <Comment Source="Reactome">Phosphorylated HuR (phosphoserine221 and phosphoserine318) binds AU-rich elements in the following mRNAs: Cyclooxygenase-2 (COX-2, PTGS2), Cyclin A (CCNA, CCNA2), and Cyclin D1 (CCND1).</Comment> <BiopaxRef>a29</BiopaxRef> <BiopaxRef>b5d</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-517751" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1345.0" Width="100.0" Height="50.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-517622" /> </DataNode> <DataNode TextLabel="PSMD4 " GraphId="bc95c" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1785.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P55036" /> </DataNode> <DataNode TextLabel="PSMB4 " GraphId="bce69" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1405.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P28070" /> </DataNode> <DataNode TextLabel="DCP2 " GraphId="bd1d7" Type="Protein" GroupRef="fadd9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450430" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1665.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8IU60" /> </DataNode> <DataNode TextLabel="EXOSC3 " GraphId="bdd20" Type="Protein" GroupRef="c25bd"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-429971" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1265.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQT5" /> </DataNode> <DataNode TextLabel="p-T244-TNFSF13 " GraphId="bde26" Type="Protein" GroupRef="c642c"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-450537" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1785.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75888" /> </DataNode> <DataNode TextLabel="UBC(305-380) " GraphId="bdf16" Type="Protein" GroupRef="dcdab"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-113595" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1585.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0CG48" /> </DataNode> <DataNode TextLabel="SHFM1 " GraphId="be15b" Type="Protein" GroupRef="f9fce"> <BiopaxRef>e26</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="2045.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P60896" /> </DataNode> <DataNode TextLabel="XRN1 " GraphId="be288" Type="Protein" GroupRef="fadd9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450430" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1625.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8IZH2" /> </DataNode> <DataNode TextLabel="mRNA Transcript&#xA;Targeted by HuR&#xA;Phosphorylated on&#xA;Ser158 and Ser318." GraphId="be2a7"> <Comment Source="Reactome">Phosphorylated HuR (phosphoserine158 and phosphoserine318) binds AU-rich elements in the Cyclooxygenase-2 (COX-2, PTGS2) mRNA.</Comment> <BiopaxRef>d25</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1291.0" CenterY="386.0" Width="134.0" Height="70.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450605" /> </DataNode> <DataNode TextLabel="HuR with Unknown&#xA;Phosphorylation:&#xA;mRNA Complex" GraphId="be572" Type="Complex"> <BiopaxRef>b5d</BiopaxRef> <BiopaxRef>d25</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1442.5" CenterY="455.5" Width="137.0" Height="51.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-450395" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. " GraphId="bea52" GroupRef="ae124"> <Comment Source="Reactome">Phosphorylated HuR (phosphoserine158 and phosphoserine318) binds AU-rich elements in the Cyclooxygenase-2 (COX-2, PTGS2) mRNA.</Comment> <BiopaxRef>d25</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-517615" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1655.0" Width="100.0" Height="50.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450605" /> </DataNode> <DataNode TextLabel="p-S221,S318-ELAVL1 " GraphId="bf1da" Type="Protein" GroupRef="cce59"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-517713" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1175.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15717" /> </DataNode> <DataNode TextLabel="TNPO1 " GraphId="bf3f0" Type="Protein" GroupRef="c4507"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450436" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1885.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q92973" /> </DataNode> <DataNode TextLabel="HuR:mRNA complexes" GraphId="c0535" Type="Complex"> <BiopaxRef>d25</BiopaxRef> <BiopaxRef>a29</BiopaxRef> <BiopaxRef>b5d</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1598.5" CenterY="325.0" Width="75.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-517615" /> </DataNode> <DataNode TextLabel="HSPB1 " GraphId="c10ce" Type="Protein" GroupRef="d3e7d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450623" /> <Attribute Key="copies_num" Value="7" /> <Graphics CenterX="100.0" CenterY="1265.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P04792" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by AUF1(hnRNP D0) " GraphId="c1440" GroupRef="cc659"> <Comment Source="Reactome">AUF1 (hnRNP D0) binds AU-rich elements in mRNAs encoding Interleukin-1 beta (IL1B), Tumor Necrosis Factor alpha (TNFA), Cyclin-dependent kinase inhibitor 1 (CDNK1A, p21), Cyclin-D1 (CCND1), Granulocyte-macrophage colony stimulating factor (GM-CSF, CSF2), inducible Nitric oxide synthase (iNOS, NOS2), Proto-oncogene cFos (FOS), Myc proto-oncogene (MYC), Apoptosis regulator Bcl-2 (BCL2).</Comment> <BiopaxRef>a37</BiopaxRef> <BiopaxRef>fc4</BiopaxRef> <BiopaxRef>fc8</BiopaxRef> <BiopaxRef>fb6</BiopaxRef> <BiopaxRef>f80</BiopaxRef> <BiopaxRef>c47</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450598" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1085.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450444" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by HuR Phosphorylated on Ser221 and Ser318 " GraphId="c1f73" GroupRef="c642c"> <Comment Source="Reactome">Phosphorylated HuR (phosphoserine221 and phosphoserine318) binds AU-rich elements in the following mRNAs: Cyclooxygenase-2 (COX-2, PTGS2), Cyclin A (CCNA, CCNA2), and Cyclin D1 (CCND1).</Comment> <BiopaxRef>a29</BiopaxRef> <BiopaxRef>b5d</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-450537" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="2055.0" Width="100.0" Height="50.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-517622" /> </DataNode> <DataNode TextLabel="26S proteasome" GraphId="c1fe2" Type="Complex"> <BiopaxRef>ee4</BiopaxRef> <BiopaxRef>e26</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="244.5" CenterY="567.5" Width="93.0" Height="37.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-68819" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by BRF1 " GraphId="c220f" GroupRef="d3816"> <Comment Source="Reactome">BRF1 binds AU-rich elements in the following mRNAs: IL-3, CSF2 (GM-CSF).</Comment> <BiopaxRef>c0b</BiopaxRef> <BiopaxRef>ec8</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-482787" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1405.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450523" /> </DataNode> <DataNode TextLabel="p-S221,S318-ELAVL1 " GraphId="c3131" Type="Protein" GroupRef="a7322"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-517751" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1365.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15717" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318 " GraphId="c33aa" GroupRef="cce59"> <Comment Source="Reactome">Phosphorylated HuR (phosphoserine158 and phosphoserine318) binds AU-rich elements in the Cyclooxygenase-2 (COX-2, PTGS2) mRNA.</Comment> <BiopaxRef>d25</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-517713" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1135.0" Width="100.0" Height="50.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450425" /> </DataNode> <DataNode TextLabel="PSMD10 " GraphId="c3b02" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1665.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75832" /> </DataNode> <DataNode TextLabel="p-S158,S221-ELAVL1 " GraphId="c3d82" Type="Protein" GroupRef="e4da8"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-517672" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1205.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15717" /> </DataNode> <DataNode TextLabel="ELAVL1 " GraphId="c3e04" Type="Protein" GroupRef="c642c"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-450537" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1935.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15717" /> </DataNode> <DataNode TextLabel="EXOSC9 " GraphId="c443f" Type="Protein" GroupRef="fadd9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450430" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1525.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q06265" /> </DataNode> <DataNode TextLabel="PSMD14 " GraphId="c4dea" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1165.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O00487" /> </DataNode> <DataNode TextLabel="p-S221,S318-ELAVL1 " GraphId="c52dd" Type="Protein" GroupRef="c642c"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-450537" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="2075.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15717" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by HuR Phosphorylated on Ser221 and Ser318 " GraphId="c53bd" GroupRef="ae124"> <Comment Source="Reactome">Phosphorylated HuR (phosphoserine221 and phosphoserine318) binds AU-rich elements in the following mRNAs: Cyclooxygenase-2 (COX-2, PTGS2), Cyclin A (CCNA, CCNA2), and Cyclin D1 (CCND1).</Comment> <BiopaxRef>a29</BiopaxRef> <BiopaxRef>b5d</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-517615" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1705.0" Width="100.0" Height="50.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-517622" /> </DataNode> <DataNode TextLabel="p-S193-KHSRP " GraphId="c5f0d" Type="Protein" GroupRef="b3a08"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-450446" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1045.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q92945" /> </DataNode> <DataNode TextLabel="UBC(153-228) " GraphId="c6532" Type="Protein" GroupRef="dcdab"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-113595" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1545.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0CG48" /> </DataNode> <DataNode TextLabel="p-T180,Y182-MAPK14 " GraphId="c65d8" Type="Protein" GroupRef="e5f0e"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-170993" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1145.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q16539" /> </DataNode> <DataNode TextLabel="XRN1" GraphId="c6829" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="584.5" CenterY="704.0" Width="49.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8IZH2" /> </DataNode> <DataNode TextLabel="PSMD6 " GraphId="c711b" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1825.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15008" /> </DataNode> <DataNode TextLabel="YWHAZ" GraphId="c7615" Type="Protein"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1030.5" CenterY="62.0" Width="83.0" Height="26.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P63104" /> </DataNode> <DataNode TextLabel="EXOSC9 " GraphId="c7d57" Type="Protein" GroupRef="c4507"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450436" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1725.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q06265" /> </DataNode> <DataNode TextLabel="PSMC3 " GraphId="c8d6d" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1565.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P17980" /> </DataNode> <DataNode TextLabel="GPRC5A mRNA 001 " GraphId="c9065" Type="Protein" GroupRef="cce59"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-517713" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1065.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENST00000014914" /> </DataNode> <DataNode TextLabel="HSPA1A " GraphId="c945e" Type="Protein" GroupRef="d3e7d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450623" /> <Attribute Key="copies_num" Value="7" /> <Graphics CenterX="100.0" CenterY="1345.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0DMV8" /> </DataNode> <DataNode TextLabel="EXOSC2 " GraphId="c9d63" Type="Protein" GroupRef="c25bd"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-429971" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1285.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13868" /> </DataNode> <DataNode TextLabel="UBB(1-76) " GraphId="ca343" Type="Protein" GroupRef="dcdab"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-113595" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1445.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0CG47" /> </DataNode> <DataNode TextLabel="EXOSC1 " GraphId="ca50a" Type="Protein" GroupRef="dafbc"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450479" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1625.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y3B2" /> </DataNode> <DataNode TextLabel="p-S221,S318-ELAVL1" GraphId="ca54d" Type="Protein"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1290.0" CenterY="164.0" Width="118.0" Height="38.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15717" /> </DataNode> <DataNode TextLabel="EIF4G1 " GraphId="ca7c6" Type="Protein" GroupRef="d3e7d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450623" /> <Attribute Key="copies_num" Value="7" /> <Graphics CenterX="100.0" CenterY="1325.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q04637" /> </DataNode> <DataNode TextLabel="Phosphorylated&#xA;TTP:mRNA:14-3-3&#xA;Complex" GraphId="caba0" Type="Complex"> <BiopaxRef>ddf</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1337.5" CenterY="847.0" Width="157.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-450420" /> </DataNode> <DataNode TextLabel="RPS27A(1-76) " GraphId="cac54" Type="Protein" GroupRef="dcdab"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-113595" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1405.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P62979" /> </DataNode> <DataNode TextLabel="mRNA Transcript&#xA;Targeted by KSRP" GraphId="cb20c"> <Comment Source="Reactome">KSRP binds AU-rich elements in the following mRNAs: IL-8, LDLR, and NOS2 (iNOS). Binding of KSRP to the mRNA encoding Beta-catenin is inferred from mouse.</Comment> <BiopaxRef>b98</BiopaxRef> <BiopaxRef>c7b</BiopaxRef> <BiopaxRef>bc9</BiopaxRef> <BiopaxRef>a2d</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="364.5" CenterY="178.5" Width="125.0" Height="45.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450386" /> </DataNode> <DataNode TextLabel="p-T222,S272,T334-MAPKAPK2" GraphId="cbe4b" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="906.5" CenterY="777.5" Width="109.0" Height="55.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P49137" /> </DataNode> <DataNode TextLabel="EXOSC7 " GraphId="cc13e" Type="Protein" GroupRef="dafbc"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450479" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1485.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15024" /> </DataNode> <DataNode TextLabel="DCP1A" GraphId="cca91" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="584.5" CenterY="737.0" Width="55.0" Height="28.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NPI6" /> </DataNode> <DataNode TextLabel="EXOSC4 " GraphId="cccb3" Type="Protein" GroupRef="dafbc"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450479" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1465.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NPD3" /> </DataNode> <DataNode TextLabel="p-S193-KHSRP" GraphId="cd89c" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="824.0" CenterY="232.0" Width="102.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q92945" /> </DataNode> <DataNode TextLabel="PSMB9 " GraphId="cdf23" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1505.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P28065" /> </DataNode> <DataNode TextLabel="PSMB6 " GraphId="ce272" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1445.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P28072" /> </DataNode> <DataNode TextLabel="HSPA1A" GraphId="cea36" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="190.5" CenterY="255.0" Width="59.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0DMV8" /> </DataNode> <DataNode TextLabel="PSMC4 " GraphId="cf04f" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1585.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P43686" /> </DataNode> <DataNode TextLabel="TTP:mRNA Degradation&#xA;Complex" GraphId="cf380" Type="Complex"> <BiopaxRef>ec8</BiopaxRef> <BiopaxRef>c11</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="424.0" CenterY="811.5" Width="100.0" Height="49.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-450436" /> </DataNode> <DataNode TextLabel="PSMC5 " GraphId="cf554" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1605.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P62195" /> </DataNode> <DataNode TextLabel="BRF1:mRNA Complex" GraphId="cf6d6" Type="Complex"> <BiopaxRef>c11</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="749.0" CenterY="652.0" Width="84.0" Height="34.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-450589" /> </DataNode> <DataNode TextLabel="EXOSC8 " GraphId="d0213" Type="Protein" GroupRef="fadd9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450430" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1485.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96B26" /> </DataNode> <DataNode TextLabel="HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1" GraphId="d0581" Type="Complex"> <BiopaxRef>a03</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1663.0" CenterY="442.0" Width="110.0" Height="68.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-450537" /> </DataNode> <DataNode TextLabel="SET" GraphId="d05b0" Type="Protein"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1717.5" CenterY="143.0" Width="53.0" Height="32.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q01105" /> </DataNode> <DataNode TextLabel="HuR:mRNA Complex" GraphId="d12ea" Type="Complex"> <BiopaxRef>d25</BiopaxRef> <BiopaxRef>a29</BiopaxRef> <BiopaxRef>b5d</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1703.0" CenterY="603.0" Width="76.0" Height="38.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-517713" /> </DataNode> <DataNode TextLabel="EXOSC1 " GraphId="d15a9" Type="Protein" GroupRef="c4507"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450436" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1805.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y3B2" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by BRF1 " GraphId="d15f7" GroupRef="e8927"> <Comment Source="Reactome">BRF1 binds AU-rich elements in the following mRNAs: IL-3, CSF2 (GM-CSF).</Comment> <BiopaxRef>c0b</BiopaxRef> <BiopaxRef>ec8</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450502" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1145.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450523" /> </DataNode> <DataNode TextLabel="Phosphorylated BRF1&#xA;(Ser92,&#xA;Ser203):mRNA:14-3-3&#xA;Complex" GraphId="d1737" Type="Complex"> <BiopaxRef>a7f</BiopaxRef> <BiopaxRef>b90</BiopaxRef> <BiopaxRef>c0b</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1318.5" CenterY="613.0" Width="155.0" Height="50.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-450585" /> </DataNode> <DataNode TextLabel="mRNA Transcript&#xA;Targeted by HuR&#xA;with Unknown&#xA;Phosphorylation" GraphId="d1e4e"> <Comment Source="Reactome">HuR (phosphorylation state unknown) binds AU-rich elements in the following mRNAs: Antigen CD83 (CD83), Cyclin B1 (CCNB1), and proto-oncogene c-Fos (FOS).</Comment> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1078.5" CenterY="458.0" Width="163.0" Height="64.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450613" /> </DataNode> <DataNode TextLabel="KSRP " GraphId="d2106" Type="Protein" GroupRef="dafbc"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450479" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1385.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q92945" /> </DataNode> <DataNode TextLabel="mRNA Transcript&#xA;Targeted by&#xA;Tristetraproline" GraphId="d28f2"> <Comment Source="Reactome">Tristetraproline binds AU-rich elements in the following mRNAs: Tumor necrosis factor alpha (TNFA), Granulocyte-macrophage colony stimulating factor (CSF2, GM-CSF), Interleukin-2 (IL-2), and Proto-oncogene C-FOS (FOS, c-fos).</Comment> <BiopaxRef>eb2</BiopaxRef> <BiopaxRef>cd8</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="409.0" CenterY="498.5" Width="122.0" Height="51.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450597" /> </DataNode> <DataNode TextLabel="PSMB10 " GraphId="d2b47" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1345.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P40306" /> </DataNode> <DataNode TextLabel="PSMC6 " GraphId="d2c3c" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1625.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P62333" /> </DataNode> <DataNode TextLabel="ELAVL1 " GraphId="d33b0" Type="Protein" GroupRef="cce59"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-517713" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1085.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15717" /> </DataNode> <DataNode TextLabel="Phosphorylated BRF1&#xA;(Ser54, Ser92,&#xA;Ser203):mRNA:14-3-3&#xA;Complex" GraphId="d3b92" Type="Complex"> <BiopaxRef>c0b</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1320.5" CenterY="704.0" Width="151.0" Height="64.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-482787" /> </DataNode> <DataNode TextLabel="Phosphorylated BRF1&#xA;(Ser92,&#xA;Ser203):mRNA&#xA;Complex" GraphId="d3e07" Type="Complex"> <BiopaxRef>a7f</BiopaxRef> <BiopaxRef>b90</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1056.5" CenterY="615.5" Width="113.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-450378" /> </DataNode> <DataNode TextLabel="p-T244-TNFSF13" GraphId="d4b3d" Type="Protein"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1563.0" CenterY="99.0" Width="128.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75888" /> </DataNode> <DataNode TextLabel="EXOSC5 " GraphId="d5210" Type="Protein" GroupRef="dafbc"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450479" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1525.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQT4" /> </DataNode> <DataNode TextLabel="p-S54,S92,S203-p-ZFP36L1 " GraphId="d5337" Type="Protein" GroupRef="e8927"> <BiopaxRef>a7f</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450502" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1185.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q07352" /> </DataNode> <DataNode TextLabel="PSMC1 " GraphId="d5fe5" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1525.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P62191" /> </DataNode> <DataNode TextLabel="EXOSC1 " GraphId="d62a7" Type="Protein" GroupRef="c25bd"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-429971" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1305.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y3B2" /> </DataNode> <DataNode TextLabel="EXOSC7 " GraphId="d6361" Type="Protein" GroupRef="fadd9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450430" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1465.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15024" /> </DataNode> <DataNode TextLabel="PSMD2 " GraphId="d6aa4" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1745.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13200" /> </DataNode> <DataNode TextLabel="EXOSC2 " GraphId="d8856" Type="Protein" GroupRef="c4507"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450436" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1785.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13868" /> </DataNode> <DataNode TextLabel="EXOSC6 " GraphId="d8974" Type="Protein" GroupRef="dafbc"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450479" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1445.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5RKV6" /> </DataNode> <DataNode TextLabel="DIS3 " GraphId="d903f" Type="Protein" GroupRef="c4507"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450436" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1745.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y2L1" /> </DataNode> <DataNode TextLabel="PSMB11 " GraphId="d990a" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="2025.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="A5LHX3" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by Tristetraproline " GraphId="dab37" GroupRef="c4507"> <Comment Source="Reactome">Tristetraproline binds AU-rich elements in the following mRNAs: Tumor necrosis factor alpha (TNFA), Granulocyte-macrophage colony stimulating factor (CSF2, GM-CSF), Interleukin-2 (IL-2), and Proto-oncogene C-FOS (FOS, c-fos).</Comment> <BiopaxRef>eb2</BiopaxRef> <BiopaxRef>cd8</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450436" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1865.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450597" /> </DataNode> <DataNode TextLabel="UBA52(1-76) " GraphId="db1ba" Type="Protein" GroupRef="dcdab"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-113595" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1425.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P62987" /> </DataNode> <DataNode TextLabel="EXOSC8 " GraphId="dbd23" Type="Protein" GroupRef="dafbc"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450479" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1505.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96B26" /> </DataNode> <DataNode TextLabel="PSMF1 " GraphId="dbfe6" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1965.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q92530" /> </DataNode> <DataNode TextLabel="p-S92,S203-ZFP36L1 " GraphId="dc075" Type="Protein" GroupRef="da8e0"> <BiopaxRef>a7f</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450585" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1305.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q07352" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by KSRP " GraphId="dc6fb" GroupRef="cc26f"> <Comment Source="Reactome">KSRP binds AU-rich elements in the following mRNAs: IL-8, LDLR, and NOS2 (iNOS). Binding of KSRP to the mRNA encoding Beta-catenin is inferred from mouse.</Comment> <BiopaxRef>b98</BiopaxRef> <BiopaxRef>c7b</BiopaxRef> <BiopaxRef>bc9</BiopaxRef> <BiopaxRef>a2d</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450608" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1325.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450386" /> </DataNode> <DataNode TextLabel="PSMA1 " GraphId="dc966" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1185.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P25786" /> </DataNode> <DataNode TextLabel="HSPA8 " GraphId="dd1ae" Type="Protein" GroupRef="d3e7d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450623" /> <Attribute Key="copies_num" Value="7" /> <Graphics CenterX="100.0" CenterY="1285.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P11142" /> </DataNode> <DataNode TextLabel="p-S83,S87-HNRNPD-3 " GraphId="dd245" Type="Protein" GroupRef="bb65f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450391" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="100.0" CenterY="1005.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q14103-3" /> </DataNode> <DataNode TextLabel="p-S158,S221-ELAVL1" GraphId="dd565" Type="Protein"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1275.0" CenterY="310.5" Width="108.0" Height="39.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15717" /> </DataNode> <DataNode TextLabel="EXOSC3 " GraphId="dd680" Type="Protein" GroupRef="dafbc"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450479" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1585.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQT5" /> </DataNode> <DataNode TextLabel="UBC(1-76) " GraphId="ddca6" Type="Protein" GroupRef="dcdab"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-113595" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1505.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0CG48" /> </DataNode> <DataNode TextLabel="Phosphorylated&#xA;TTP:mRNA Complex" GraphId="dde00" Type="Complex"> <BiopaxRef>ddf</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1058.0" CenterY="851.5" Width="100.0" Height="51.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-450541" /> </DataNode> <DataNode TextLabel="mRNA Transcript&#xA;Targeted by HuR&#xA;Phosphorylated on&#xA;Ser221 and Ser318" GraphId="ddf55"> <Comment Source="Reactome">Phosphorylated HuR (phosphoserine221 and phosphoserine318) binds AU-rich elements in the following mRNAs: Cyclooxygenase-2 (COX-2, PTGS2), Cyclin A (CCNA, CCNA2), and Cyclin D1 (CCND1).</Comment> <BiopaxRef>a29</BiopaxRef> <BiopaxRef>b5d</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1308.5" CenterY="85.0" Width="181.0" Height="50.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-517622" /> </DataNode> <DataNode TextLabel="Mg2+ " GraphId="de46c" Type="Metabolite" GroupRef="e5f0e"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-170993" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1105.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:18420" /> </DataNode> <DataNode TextLabel="PSMC2 " GraphId="de6a3" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1545.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P35998" /> </DataNode> <DataNode TextLabel="DCP2" GraphId="de84b" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="624.5" CenterY="595.5" Width="59.0" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8IU60" /> </DataNode> <DataNode TextLabel="ZFP36 " GraphId="deec6" Type="Protein" GroupRef="c4507"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450436" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1825.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P26651" /> </DataNode> <DataNode TextLabel="ANP32A " GraphId="df0d6" Type="Protein" GroupRef="c642c"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-450537" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1825.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P39687" /> </DataNode> <DataNode TextLabel="AUF1 Tetramer:&#xA;Destabilized mRNA&#xA;Complex" GraphId="df396" Type="Complex"> <BiopaxRef>fb7</BiopaxRef> <BiopaxRef>ce0</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="154.0" CenterY="215.0" Width="108.0" Height="48.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-450598" /> </DataNode> <DataNode TextLabel="PSME4 " GraphId="df687" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1985.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q14997" /> </DataNode> <DataNode TextLabel="ZFP36" GraphId="df85d" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="478.0" CenterY="557.5" Width="100.0" Height="21.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P26651" /> </DataNode> <DataNode TextLabel="EXOSC3 " GraphId="dfd68" Type="Protein" GroupRef="fadd9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450430" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1565.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQT5" /> </DataNode> <DataNode TextLabel="ANP32A" GraphId="e0431" Type="Protein"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1683.5" CenterY="99.5" Width="71.0" Height="27.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P39687" /> </DataNode> <DataNode TextLabel="KSRP " GraphId="e04d3" Type="Protein" GroupRef="cc26f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450608" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1285.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q92945" /> </DataNode> <DataNode TextLabel="PSMB3 " GraphId="e08e3" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1385.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P49720" /> </DataNode> <DataNode TextLabel="ATP" GraphId="e097a" Type="Metabolite"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1103.5" CenterY="260.0" Width="49.0" Height="24.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15422" /> </DataNode> <DataNode TextLabel="EXOSC5 " GraphId="e0e40" Type="Protein" GroupRef="c4507"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450436" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1705.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQT4" /> </DataNode> <DataNode TextLabel="PSMD7 " GraphId="e2223" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1845.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P51665" /> </DataNode> <DataNode TextLabel="p-T308,S473-AKT1" GraphId="e237c" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="922.0" CenterY="553.0" Width="134.0" Height="32.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P31749" /> </DataNode> <DataNode TextLabel="PRKCD(1-676)" GraphId="e2573" Type="Protein"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1140.5" CenterY="177.5" Width="105.0" Height="27.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q05655" /> </DataNode> <DataNode TextLabel="PSMA8 " GraphId="e2575" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="2005.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8TAA3" /> </DataNode> <DataNode TextLabel="DCP2 " GraphId="e2609" Type="Protein" GroupRef="dafbc"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450479" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1665.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8IU60" /> </DataNode> <DataNode TextLabel="HSPA8" GraphId="e2d64" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="201.0" CenterY="280.5" Width="64.0" Height="23.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P11142" /> </DataNode> <DataNode TextLabel="PSMA5 " GraphId="e3046" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1265.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P28066" /> </DataNode> <DataNode TextLabel="TNPO1 " GraphId="e381d" Type="Protein" GroupRef="c6e9b"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450420" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1205.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q92973" /> </DataNode> <DataNode TextLabel="Ub" GraphId="e3e36" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="250.5" CenterY="407.0" Width="61.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-113595" /> </DataNode> <DataNode TextLabel="PABPC1 " GraphId="e460a" Type="Protein" GroupRef="d3e7d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450623" /> <Attribute Key="copies_num" Value="7" /> <Graphics CenterX="100.0" CenterY="1305.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P11940" /> </DataNode> <DataNode TextLabel="p-S54,S92,S203-p-ZFP36L1 " GraphId="e4b81" Type="Protein" GroupRef="d3816"> <BiopaxRef>a7f</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-482787" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1445.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q07352" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by HuR with Unknown Phosphorylation " GraphId="e5086" GroupRef="ae124"> <Comment Source="Reactome">HuR (phosphorylation state unknown) binds AU-rich elements in the following mRNAs: Antigen CD83 (CD83), Cyclin B1 (CCNB1), and proto-oncogene c-Fos (FOS).</Comment> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-517615" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1565.0" Width="100.0" Height="50.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450613" /> </DataNode> <DataNode TextLabel="PSMD1 " GraphId="e694e" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1645.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q99460" /> </DataNode> <DataNode TextLabel="p-S158,S221-ELAVL1 " GraphId="e6f25" Type="Protein" GroupRef="c642c"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-450537" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1955.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15717" /> </DataNode> <DataNode TextLabel="DCP1A " GraphId="e76c8" Type="Protein" GroupRef="c4507"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450436" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1925.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NPI6" /> </DataNode> <DataNode TextLabel="ELAVL1" GraphId="e77e7" Type="Protein"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1022.5" CenterY="271.5" Width="63.0" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15717" /> </DataNode> <DataNode TextLabel="UBC(229-304) " GraphId="e82cf" Type="Protein" GroupRef="dcdab"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-113595" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1565.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0CG48" /> </DataNode> <DataNode TextLabel="TTP:mRNA Complex" GraphId="e85b8" Type="Complex"> <BiopaxRef>d53</BiopaxRef> <BiopaxRef>ffe</BiopaxRef> <BiopaxRef>c99</BiopaxRef> <BiopaxRef>a2b</BiopaxRef> <BiopaxRef>d1f</BiopaxRef> <BiopaxRef>eb4</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="413.0" CenterY="663.0" Width="76.0" Height="42.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-450365" /> </DataNode> <DataNode TextLabel="HNRNPD-4 " GraphId="e8c3c" Type="Protein" GroupRef="d3e7d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450623" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="100.0" CenterY="1225.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q14103-4" /> </DataNode> <DataNode TextLabel="EXOSC9 " GraphId="e9003" Type="Protein" GroupRef="c25bd"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-429971" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1225.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q06265" /> </DataNode> <DataNode TextLabel="PSMD11 " GraphId="e914b" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1685.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O00231" /> </DataNode> <DataNode TextLabel="AUF1 Complexed with&#xA;Translation and&#xA;Heat Shock Proteins" GraphId="e924e" Type="Complex"> <BiopaxRef>d0c</BiopaxRef> <BiopaxRef>fb7</BiopaxRef> <BiopaxRef>e32</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="153.5" CenterY="367.5" Width="113.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-450623" /> </DataNode> <DataNode TextLabel="CD83 mRNA 001 " GraphId="e995f" GroupRef="cce59"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-517713" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1025.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-HSA-450486" /> </DataNode> <DataNode TextLabel="UBC(381-456) " GraphId="ea538" Type="Protein" GroupRef="dcdab"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-113595" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1605.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0CG48" /> </DataNode> <DataNode TextLabel="ADP" GraphId="eabad" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="968.0" CenterY="652.0" Width="46.0" Height="26.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16761" /> </DataNode> <DataNode TextLabel="ATP" GraphId="eadf7" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="838.0" CenterY="655.5" Width="40.0" Height="23.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15422" /> </DataNode> <DataNode TextLabel="p-S60,S186-ZFP36 " GraphId="eb076" Type="Protein" GroupRef="b68b3"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450541" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1085.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P26651" /> </DataNode> <DataNode TextLabel="PSMA3 " GraphId="eba20" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1225.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P25788" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by BRF1 " GraphId="ebaee" GroupRef="e6d09"> <Comment Source="Reactome">BRF1 binds AU-rich elements in the following mRNAs: IL-3, CSF2 (GM-CSF).</Comment> <BiopaxRef>c0b</BiopaxRef> <BiopaxRef>ec8</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450378" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1045.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450523" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. " GraphId="ebca7" GroupRef="c642c"> <Comment Source="Reactome">Phosphorylated HuR (phosphoserine158 and phosphoserine318) binds AU-rich elements in the Cyclooxygenase-2 (COX-2, PTGS2) mRNA.</Comment> <BiopaxRef>d25</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-450537" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="2005.0" Width="100.0" Height="50.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450605" /> </DataNode> <DataNode TextLabel="EIF4G1" GraphId="ebde5" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="66.0" CenterY="251.0" Width="58.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q04637" /> </DataNode> <DataNode TextLabel="XPO1 " GraphId="ec02d" Type="Protein" GroupRef="c642c"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-450537" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1805.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O14980" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by Tristetraproline " GraphId="ec903" GroupRef="b68b3"> <Comment Source="Reactome">Tristetraproline binds AU-rich elements in the following mRNAs: Tumor necrosis factor alpha (TNFA), Granulocyte-macrophage colony stimulating factor (CSF2, GM-CSF), Interleukin-2 (IL-2), and Proto-oncogene C-FOS (FOS, c-fos).</Comment> <BiopaxRef>eb2</BiopaxRef> <BiopaxRef>cd8</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450541" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="1045.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450597" /> </DataNode> <DataNode TextLabel="UBB(77-152) " GraphId="ed036" Type="Protein" GroupRef="dcdab"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-113595" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1465.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0CG47" /> </DataNode> <DataNode TextLabel="p-T244-TNFSF13" GraphId="ed3ed" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1588.0" CenterY="595.5" Width="120.0" Height="33.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75888" /> </DataNode> <DataNode TextLabel="HuR&#xA;with&#xA;phosphoserine221&#xA;and&#xA;phosphoserine318:mRNA Complex" GraphId="edfef" Type="Complex"> <BiopaxRef>a29</BiopaxRef> <BiopaxRef>b5d</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1489.5" CenterY="181.0" Width="119.0" Height="82.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-517751" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by AUF1(hnRNP D0) " GraphId="ee8f4" GroupRef="e9a83"> <Comment Source="Reactome">AUF1 (hnRNP D0) binds AU-rich elements in mRNAs encoding Interleukin-1 beta (IL1B), Tumor Necrosis Factor alpha (TNFA), Cyclin-dependent kinase inhibitor 1 (CDNK1A, p21), Cyclin-D1 (CCND1), Granulocyte-macrophage colony stimulating factor (GM-CSF, CSF2), inducible Nitric oxide synthase (iNOS, NOS2), Proto-oncogene cFos (FOS), Myc proto-oncogene (MYC), Apoptosis regulator Bcl-2 (BCL2).</Comment> <BiopaxRef>a37</BiopaxRef> <BiopaxRef>fc4</BiopaxRef> <BiopaxRef>fc8</BiopaxRef> <BiopaxRef>fb6</BiopaxRef> <BiopaxRef>f80</BiopaxRef> <BiopaxRef>c47</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450458" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1045.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450444" /> </DataNode> <DataNode TextLabel="DIS3 " GraphId="ef4ee" Type="Protein" GroupRef="fadd9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450430" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1545.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y2L1" /> </DataNode> <DataNode TextLabel="EXOSC8 " GraphId="ef555" Type="Protein" GroupRef="c4507"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450436" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1685.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96B26" /> </DataNode> <DataNode TextLabel="YWHAB " GraphId="f0001" Type="Protein" GroupRef="d3816"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-482787" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1365.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P31946" /> </DataNode> <DataNode TextLabel="ZFP36L1" GraphId="f011c" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="801.0" CenterY="540.0" Width="76.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q07352" /> </DataNode> <DataNode TextLabel="PSMA4 " GraphId="f0607" Type="Protein" GroupRef="f9fce"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-68819" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1245.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P25789" /> </DataNode> <DataNode TextLabel="KSRP:mRNA Complex" GraphId="f0e76" Type="Complex"> <BiopaxRef>c7b</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="451.5" CenterY="292.0" Width="83.0" Height="38.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-450608" /> </DataNode> <DataNode TextLabel="ZFP36 " GraphId="f11ca" Type="Protein" GroupRef="b291c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450365" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1505.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P26651" /> </DataNode> <DataNode TextLabel="EXOSC4 " GraphId="f1275" Type="Protein" GroupRef="c4507"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450436" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1645.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NPD3" /> </DataNode> <DataNode TextLabel="DIS3 " GraphId="f16b0" Type="Protein" GroupRef="c25bd"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-429971" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1245.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y2L1" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by Tristetraproline " GraphId="f1ac1" GroupRef="b291c"> <Comment Source="Reactome">Tristetraproline binds AU-rich elements in the following mRNAs: Tumor necrosis factor alpha (TNFA), Granulocyte-macrophage colony stimulating factor (CSF2, GM-CSF), Interleukin-2 (IL-2), and Proto-oncogene C-FOS (FOS, c-fos).</Comment> <BiopaxRef>eb2</BiopaxRef> <BiopaxRef>cd8</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450365" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1545.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450597" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by BRF1 " GraphId="f1caf" GroupRef="da8e0"> <Comment Source="Reactome">BRF1 binds AU-rich elements in the following mRNAs: IL-3, CSF2 (GM-CSF).</Comment> <BiopaxRef>c0b</BiopaxRef> <BiopaxRef>ec8</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450585" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1285.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450523" /> </DataNode> <DataNode TextLabel="ELAVL1 " GraphId="f1d23" Type="Protein" GroupRef="bb6c4"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-450395" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1475.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15717" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by BRF1 " GraphId="f1db6" GroupRef="f49cd"> <Comment Source="Reactome">BRF1 binds AU-rich elements in the following mRNAs: IL-3, CSF2 (GM-CSF).</Comment> <BiopaxRef>c0b</BiopaxRef> <BiopaxRef>ec8</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450589" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1065.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450523" /> </DataNode> <DataNode TextLabel="EXOSC6 " GraphId="f2336" Type="Protein" GroupRef="c4507"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450436" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1625.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5RKV6" /> </DataNode> <DataNode TextLabel="ELAVL1 " GraphId="f2b41" Type="Protein" GroupRef="ae124"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-517615" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1585.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15717" /> </DataNode> <DataNode TextLabel="Ub-HNRNPD-4 " GraphId="f3c82" Type="Protein" GroupRef="e9a83"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450458" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="240.0" CenterY="1065.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q14103-4" /> </DataNode> <DataNode TextLabel="UBC(457-532) " GraphId="f3ee5" Type="Protein" GroupRef="dcdab"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-113595" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1625.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0CG48" /> </DataNode> <DataNode TextLabel="EXOSC7 " GraphId="f3f0d" Type="Protein" GroupRef="c25bd"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-429971" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="1165.0" Width="100.0" Height="20.0" ZOrder="32768" 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The ring contains EXOSC2, EXOSC7, EXOSC8, EXOSC9, EXOSC5, and EXOSC6. The subunits EXOSC1, EXOSC2, EXOSC3, and RRP44 bind the ring. The catalytic ribonuclease site is located in RRP44, which yields ribonucleotides having 5'-monophosphates.</Comment> <BiopaxRef>ec8</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="575.0" CenterY="668.5" Width="70.0" Height="35.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-429971" /> </DataNode> <DataNode TextLabel="mRNA Transcript&#xA;Targeted by BRF1" GraphId="f642c"> <Comment Source="Reactome">BRF1 binds AU-rich elements in the following mRNAs: IL-3, CSF2 (GM-CSF).</Comment> <BiopaxRef>c0b</BiopaxRef> <BiopaxRef>ec8</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="683.0" CenterY="534.0" Width="120.0" Height="44.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-ALL-450523" /> </DataNode> <DataNode TextLabel="UBC(533-608) " GraphId="f6c01" Type="Protein" GroupRef="dcdab"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-113595" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1645.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0CG48" /> </DataNode> <DataNode TextLabel="YWHAZ " GraphId="f70d0" Type="Protein" GroupRef="b3a08"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-450446" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="1025.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P63104" /> </DataNode> <DataNode TextLabel="EXOSC3 " GraphId="f7331" Type="Protein" GroupRef="c4507"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-450436" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="1765.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQT5" /> </DataNode> <DataNode TextLabel="mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. 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TTP also recruits PARN deadenylase, however a direct interaction between TTP and PARN has not been demonstrated.</Comment> <BiopaxRef>ec8</BiopaxRef> <BiopaxRef>f2b</BiopaxRef> <BiopaxRef>c11</BiopaxRef> <BiopaxRef>cd8</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="413.0" Y="725.0" /> <Point X="419.0" Y="784.0" /> <Anchor Position="0.0" Shape="None" GraphId="e8948" /> <Anchor Position="0.99" Shape="None" GraphId="be8ec" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450431" /> </Interaction> <Interaction GraphId="addcd"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1176.0" Y="300.0" GraphRef="f87ef" RelX="0.6099999999999" RelY="-0.009999999999990905" /> <Point X="1221.0" Y="310.0" GraphRef="dd565" RelX="-1.0" RelY="-0.02564102564102564" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450550" /> </Interaction> <Interaction GraphId="aeee8"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="153.0" Y="332.0" GraphRef="c7ba5" RelX="0.28000000000000114" RelY="0.4900000000000091" /> <Point X="153.0" Y="335.0" GraphRef="e924e" RelX="-0.008849557522123894" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450551" /> </Interaction> <Interaction GraphId="af16a"> <Comment Source="Reactome">Activated MAPK p38 alpha and beta phosphorylate KSRP at threonine692. The phosphorylation interferes with the ability of KSRP to bind and destabilize RNA. 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Phosphorylation does not prevent KSRP from binding RNA.</Comment> <BiopaxRef>c7b</BiopaxRef> <BiopaxRef>f5d</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="597.0" Y="238.0" /> <Point X="691.0" Y="238.0" /> <Anchor Position="0.0" Shape="None" GraphId="ca7b5" /> <Anchor Position="0.99" Shape="None" GraphId="cea02" /> <Anchor Position="0.5" Shape="None" GraphId="d0f3b" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450499" /> </Interaction> <Interaction GraphId="b1a97"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="694.0" Y="131.0" GraphRef="c9832" RelX="0.9400000000000546" RelY="-0.009999999999990905" /> <Point X="726.0" Y="170.0" GraphRef="a8d1f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-451152" /> </Interaction> <Interaction GraphId="b2c56"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1256.0" Y="851.0" GraphRef="eabb3" RelX="0.4900000000000091" RelY="-0.009999999999990905" /> <Point X="1259.0" Y="847.0" GraphRef="caba0" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450394" /> </Interaction> <Interaction GraphId="b2cc8"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="855.0" Y="553.0" GraphRef="e237c" RelX="-1.0" RelY="0.0" /> <Point X="651.0" Y="238.0" GraphRef="d0f3b" RelX="7.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450499" /> </Interaction> <Interaction GraphId="b31e5"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="166.0" Y="79.0" GraphRef="a18e4" RelX="-1.0" RelY="0.0" /> <Point X="154.0" Y="140.0" GraphRef="c2467" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450434" /> </Interaction> <Interaction GraphId="b450d"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="413.0" Y="684.0" GraphRef="e85b8" RelX="0.0" RelY="1.0" /> <Point X="413.0" Y="725.0" GraphRef="e8948" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450431" /> </Interaction> <Interaction GraphId="b5bf0"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="924.0" Y="616.0" GraphRef="b7db2" RelX="0.6000000000000227" RelY="0.0" /> <Point X="945.0" Y="652.0" GraphRef="eabad" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450490" /> </Interaction> <Interaction GraphId="b8392"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="924.0" Y="616.0" GraphRef="b7db2" RelX="0.6000000000000227" RelY="0.0" /> <Point X="1000.0" Y="615.0" GraphRef="d3e07" RelX="-1.0" RelY="-0.015384615384615385" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450490" /> </Interaction> <Interaction GraphId="b8e51"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1692.0" Y="303.0" GraphRef="a653a" RelX="-1.0" RelY="0.0" /> <Point X="1661.0" Y="327.0" GraphRef="eeeb5" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450387" /> </Interaction> <Interaction GraphId="b9c7e"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="949.0" Y="850.0" GraphRef="c9fe7" RelX="0.7999999999999545" RelY="0.0" /> <Point X="1008.0" Y="851.0" GraphRef="dde00" RelX="-1.0" RelY="-0.0196078431372549" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450463" /> </Interaction> <Interaction GraphId="b9e54"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1620.0" Y="151.0" GraphRef="a8892" RelX="-0.018867924528301886" RelY="1.0" /> <Point X="1661.0" Y="327.0" GraphRef="eeeb5" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450387" /> </Interaction> <Interaction GraphId="bb21d"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1053.0" Y="271.0" GraphRef="e77e7" RelX="0.9682539682539683" RelY="-0.03225806451612903" /> <Point X="1115.0" Y="301.0" GraphRef="bf486" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450550" /> </Interaction> <Interaction GraphId="bd3bc"> <Comment Source="Reactome">mRNA bound to HuR is exported from the nucleus by a mechanism that requires the shuttle protein APRIL but not pp32. Phosphorylation of APRIL determines its subcellular localization: APRIL phosphorylated at threonine244 is found in both the nucleus and cytoplasm while APRIL that is not phosphorylated at threonine244 is cytoplasmic.&lt;br&gt;HuR bound to mRNAs in the cytoplasm acts to stabilize the mRNAs by an unknown mechanism.</Comment> <BiopaxRef>acd</BiopaxRef> <BiopaxRef>fb6</BiopaxRef> <BiopaxRef>f85</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1662.0" Y="479.0" /> <Point X="1663.0" Y="559.0" /> <Anchor Position="0.0" Shape="None" GraphId="d8b4f" /> <Anchor Position="0.99" Shape="None" GraphId="dab5d" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450595" /> </Interaction> <Interaction GraphId="bd59d"> <Comment Source="Reactome">HuR phosphorylated on ser221 and ser318 binds AU-rich regions of mRNAs. Phosphorylation on ser318 appears to affect RNA binding and phosphorylation of ser221 affects nucleocytoplasmic shuttling.</Comment> <BiopaxRef>a29</BiopaxRef> <BiopaxRef>b5d</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1374.0" Y="143.0" /> <Point X="1427.0" Y="154.0" /> <Anchor Position="0.0" Shape="None" GraphId="aa29c" /> <Anchor Position="0.99" Shape="None" GraphId="f9382" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-517705" /> </Interaction> <Interaction GraphId="bd912"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="451.0" Y="270.0" GraphRef="aa636" RelX="0.009999999999990905" RelY="0.5299999999999727" /> <Point X="451.0" Y="273.0" GraphRef="f0e76" RelX="-0.012048192771084338" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450592" /> </Interaction> <Interaction GraphId="bd99d"> <Comment Source="Reactome">KSRP phosphorylated at serine193 binds 14-3-3zeta (YWHAZ) which impairs the ability of KSRP to destabilize RNA. Thus the RNAs become stabilized. KSRP is able to shuttle between the nucleus and the cytoplasm. 14-3-3zeta is nucleoplasmic. Binding of KSRP to 14-3-3zeta causes KSRP to be retained in the nucleus.</Comment> <BiopaxRef>f5d</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1041.0" Y="90.0" /> <Point X="1100.0" Y="90.0" /> <Anchor Position="0.0" Shape="None" GraphId="b4889" /> <Anchor Position="0.99" Shape="None" GraphId="ab31c" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450620" /> </Interaction> <Interaction GraphId="bedf0"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1162.0" Y="761.0" GraphRef="b1fb9" RelX="-0.009708737864077669" RelY="-1.0" /> <Point X="1195.0" Y="615.0" GraphRef="e861a" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450406" /> </Interaction> <Interaction GraphId="bf2a4"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1112.0" Y="615.0" GraphRef="d3e07" RelX="0.9823008849557522" RelY="-0.015384615384615385" /> <Point X="1195.0" Y="615.0" GraphRef="e861a" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450406" /> </Interaction> <Interaction GraphId="bfe27"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1663.0" Y="476.0" GraphRef="d0581" RelX="0.0" RelY="1.0" /> <Point X="1662.0" Y="479.0" GraphRef="d8b4f" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450595" /> </Interaction> <Interaction GraphId="c1dcd"> <Comment Source="Reactome">Ubiquitin-dependent proteolysis of AUF1 and nuclease-dependent destruction of AUF1-bound mRNA are coupled in an unknown way. It is possible that ubiquitinated AUF1 targets other members of the AUF1 and signal transduction regulated complex (ASTRC), such as polyA-binding protein, for degradation and this renders the mRNA susceptible to nucleases.</Comment> <BiopaxRef>fb6</BiopaxRef> <BiopaxRef>b61</BiopaxRef> <BiopaxRef>e31</BiopaxRef> <BiopaxRef>e32</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="152.0" Y="543.0" /> <Point X="152.0" Y="597.0" /> <Anchor Position="0.0" Shape="None" GraphId="df2d4" /> <Anchor Position="0.99" Shape="None" /> <Anchor Position="0.5" Shape="None" GraphId="e35a8" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450466" /> </Interaction> <Interaction GraphId="c20eb"> <Comment Source="Reactome">Phosphorylated tristetraproline (TTP) binds 14-3-3, which inhibits the ability of TTP to destabilize RNA. Thus RNAs bound by TTP become stabilized. The binding of 14-3-3 causes TTP to be excluded from stress granules.</Comment> <BiopaxRef>cdb</BiopaxRef> <BiopaxRef>db2</BiopaxRef> <BiopaxRef>aaf</BiopaxRef> <BiopaxRef>ddf</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1207.0" Y="852.0" /> <Point X="1256.0" Y="851.0" /> <Anchor Position="0.0" Shape="None" GraphId="f9fb6" /> <Anchor Position="0.99" Shape="None" GraphId="eabb3" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450394" /> </Interaction> <Interaction GraphId="c4703"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="161.0" Y="255.0" GraphRef="cea36" RelX="-1.0" RelY="0.0" /> <Point X="125.0" Y="283.0" GraphRef="cef69" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450551" /> </Interaction> <Interaction GraphId="c5d87"> <Comment Source="Reactome">KSRP (KHSRP) binds AU-rich regions of target RNAs via its four K-homology (KH) domains.</Comment> <BiopaxRef>e78</BiopaxRef> <BiopaxRef>b98</BiopaxRef> <BiopaxRef>bc9</BiopaxRef> <BiopaxRef>a2d</BiopaxRef> <BiopaxRef>c7b</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="450.0" Y="217.0" /> <Point X="451.0" Y="270.0" /> <Anchor Position="0.0" Shape="None" GraphId="c61e4" /> <Anchor Position="0.99" Shape="None" GraphId="aa636" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450592" /> </Interaction> <Interaction GraphId="c6028"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1411.0" Y="332.0" GraphRef="f664c" RelX="0.4500000000000455" RelY="-0.009999999999990905" /> <Point X="1414.0" Y="331.0" GraphRef="a0b32" RelX="-1.0" RelY="-0.013333333333333334" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-517674" /> </Interaction> <Interaction GraphId="c6112"> <Comment Source="Reactome">HuR binds AU-rich elements of mRNAs. Bound HuR can form oligomers on longer AU-rich elements. Phosphorylated HuR binds mRNA more tightly than unphosphorylated HuR does.</Comment> <BiopaxRef>efc</BiopaxRef> <BiopaxRef>e44</BiopaxRef> <BiopaxRef>e54</BiopaxRef> <BiopaxRef>a03</BiopaxRef> <BiopaxRef>cf8</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1109.0" Y="405.0" /> <Point X="1371.0" Y="454.0" /> <Anchor Position="0.0" Shape="None" GraphId="e6ae8" /> <Anchor Position="0.99" Shape="None" GraphId="d182f" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450494" /> </Interaction> <Interaction GraphId="c7b35"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1683.0" Y="112.0" GraphRef="e0431" RelX="-0.014084507042253521" RelY="0.9259259259259259" /> <Point X="1661.0" Y="327.0" GraphRef="eeeb5" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450387" /> </Interaction> <Interaction GraphId="c80b1"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="573.0" Y="175.0" GraphRef="a65a7" RelX="0.0" RelY="-1.0" /> <Point X="600.0" Y="132.0" GraphRef="c3d5e" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-451152" /> </Interaction> <Interaction GraphId="c851a"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1663.0" Y="559.0" GraphRef="dab5d" RelX="0.009999999999990905" RelY="0.7999999999999545" /> <Point X="1665.0" Y="603.0" GraphRef="d12ea" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450595" /> </Interaction> <Interaction GraphId="c89cc"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="540.0" Y="668.0" GraphRef="f5ed5" RelX="-1.0" RelY="-0.02857142857142857" /> <Point X="413.0" Y="725.0" GraphRef="e8948" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450431" /> </Interaction> <Interaction GraphId="c8b5c"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="154.0" Y="239.0" GraphRef="df396" RelX="0.0" RelY="1.0" /> <Point X="125.0" Y="283.0" GraphRef="cef69" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450551" /> </Interaction> <Interaction GraphId="ca27a"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="608.0" Y="704.0" GraphRef="c6829" RelX="0.9591836734693877" RelY="0.0" /> <Point X="746.0" Y="715.0" GraphRef="d6d12" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450488" /> </Interaction> <Interaction GraphId="cb4e5"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1053.0" Y="271.0" GraphRef="e77e7" RelX="0.9682539682539683" RelY="-0.03225806451612903" /> <Point X="1107.0" Y="221.0" GraphRef="bb1fa" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450533" /> </Interaction> <Interaction GraphId="cc599"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="409.0" Y="523.0" GraphRef="d28f2" RelX="0.0" RelY="0.9607843137254902" /> <Point X="414.0" Y="592.0" GraphRef="e97f4" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450400" /> </Interaction> <Interaction GraphId="cc872"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="791.0" Y="652.0" GraphRef="cf6d6" RelX="1.0" RelY="0.0" /> <Point X="864.0" Y="616.0" GraphRef="a5faf" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450490" /> </Interaction> <Interaction GraphId="cd233"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="198.0" Y="567.0" GraphRef="c1fe2" RelX="-1.0" RelY="-0.02702702702702703" /> <Point X="152.0" Y="569.0" GraphRef="e35a8" RelX="0.0" RelY="-1.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450466" /> </Interaction> <Interaction GraphId="ce6f9"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="471.0" Y="194.0" GraphRef="fb5dc" RelX="-1.0" RelY="-0.05263157894736842" /> <Point X="450.0" Y="217.0" GraphRef="c61e4" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450592" /> </Interaction> <Interaction GraphId="ce70b"> <Comment Source="Reactome">AUF1 monomers form dimers which bind the U-rich sequences in AU-rich elements of mRNAs. Binding of the mRNA causes the dimers of AUF1 to form tetramers. Nonphosphorylated AUF1 isoform p40 causes the mRNA to form a rigid structure whereas p40 that is phosphorylated at serines 83 and 87 does not. This difference may cause nonphosphorylated p40 to fail to destabilize the bound mRNA.</Comment> <BiopaxRef>ce0</BiopaxRef> <BiopaxRef>fb7</BiopaxRef> <BiopaxRef>d0c</BiopaxRef> <BiopaxRef>c8b</BiopaxRef> <BiopaxRef>d4c</BiopaxRef> <BiopaxRef>bd5</BiopaxRef> <BiopaxRef>a37</BiopaxRef> <BiopaxRef>fc4</BiopaxRef> <BiopaxRef>fc8</BiopaxRef> <BiopaxRef>fb6</BiopaxRef> <BiopaxRef>f80</BiopaxRef> <BiopaxRef>b47</BiopaxRef> <BiopaxRef>c50</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="154.0" Y="140.0" /> <Point X="153.0" Y="188.0" /> <Anchor Position="0.0" Shape="None" GraphId="c2467" /> <Anchor Position="0.99" Shape="None" GraphId="fd989" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450434" /> </Interaction> <Interaction GraphId="ce8ef"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="906.0" Y="750.0" GraphRef="cbe4b" RelX="-0.009174311926605505" RelY="-1.0" /> <Point X="904.0" Y="707.0" GraphRef="ec2ca" RelX="4.0" RelY="1.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450474" /> </Interaction> <Interaction GraphId="ce956"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1635.0" Y="325.0" GraphRef="c0535" RelX="0.9733333333333334" RelY="0.0" /> <Point X="1661.0" Y="327.0" GraphRef="eeeb5" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450387" /> </Interaction> <Interaction GraphId="ce9f8"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="413.0" Y="639.0" GraphRef="fa957" RelX="-0.009999999999990905" RelY="0.4700000000000273" /> <Point X="413.0" Y="642.0" GraphRef="e85b8" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450400" /> </Interaction> <Interaction GraphId="cf7f4"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1329.0" Y="310.0" GraphRef="dd565" RelX="1.0" RelY="-0.02564102564102564" /> <Point X="1366.0" Y="333.0" GraphRef="f1f31" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-517674" /> </Interaction> <Interaction GraphId="d0a36"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1242.0" Y="705.0" GraphRef="f75fa" RelX="0.4500000000000455" RelY="-0.009999999999990905" /> <Point X="1245.0" Y="704.0" GraphRef="d3b92" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-482788" /> </Interaction> <Interaction GraphId="d0f75"> <Comment Source="Reactome">BRF1 recruits RNA degradation activities to hydrolyze the RNA bound to BRF1. Coimmunoprecipitation has shown BRF1 interacts with the exosome (3' to 5' nuclease), XRN1 (5' to 3' nuclease), and DCP1a and DCP2 (decapping). BRF1 localizes RNAs to processing bodies, sites of translation repression and possible sites of RNA degradation.</Comment> <BiopaxRef>c11</BiopaxRef> <BiopaxRef>ec8</BiopaxRef> <BiopaxRef>eb2</BiopaxRef> <BiopaxRef>d4c</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="746.0" Y="715.0" /> <Point X="746.0" Y="764.0" /> <Anchor Position="0.0" Shape="None" GraphId="d6d12" /> <Anchor Position="0.99" Shape="None" GraphId="d5d33" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450488" /> </Interaction> <Interaction GraphId="d1026"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1108.0" Y="851.0" GraphRef="dde00" RelX="1.0" RelY="-0.0196078431372549" /> <Point X="1207.0" Y="852.0" GraphRef="f9fb6" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450394" /> </Interaction> <Interaction GraphId="d10d9"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1103.0" Y="272.0" GraphRef="e097a" RelX="-0.02040816326530612" RelY="1.0" /> <Point X="1115.0" Y="301.0" GraphRef="bf486" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450550" /> </Interaction> <Interaction GraphId="d16f5"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="857.0" Y="890.0" GraphRef="b940d" RelX="1.0" RelY="-0.047619047619047616" /> <Point X="869.0" Y="850.0" GraphRef="dc9e3" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450463" /> </Interaction> <Interaction GraphId="d25ab"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="153.0" Y="399.0" GraphRef="e924e" RelX="-0.008849557522123894" RelY="0.9692307692307692" /> <Point X="152.0" Y="428.0" GraphRef="e81d0" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450580" /> </Interaction> <Interaction GraphId="d3418"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="691.0" Y="238.0" GraphRef="cea02" RelX="0.9400000000000546" RelY="0.0" /> <Point X="773.0" Y="232.0" GraphRef="cd89c" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450499" /> </Interaction> <Interaction GraphId="d35a9"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="906.0" Y="804.0" GraphRef="cbe4b" RelX="-0.009174311926605505" RelY="0.9636363636363636" /> <Point X="905.0" Y="849.0" GraphRef="ed102" RelX="-4.0" RelY="-1.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450463" /> </Interaction> <Interaction GraphId="d3b6c"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="949.0" Y="850.0" GraphRef="c9fe7" RelX="0.7999999999999545" RelY="0.0" /> <Point X="961.0" Y="888.0" GraphRef="a8243" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450463" /> </Interaction> <Interaction GraphId="d594b"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="517.0" Y="194.0" GraphRef="fb5dc" RelX="1.0" RelY="-0.05263157894736842" /> <Point X="600.0" Y="132.0" GraphRef="c3d5e" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-451152" /> </Interaction> <Interaction GraphId="d6ea9"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="838.0" Y="644.0" GraphRef="eadf7" RelX="0.0" RelY="-1.0" /> <Point X="864.0" Y="616.0" GraphRef="a5faf" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450490" /> </Interaction> <Interaction GraphId="d712a"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="653.0" Y="595.0" GraphRef="de84b" RelX="0.9661016949152542" RelY="-0.04" /> <Point X="746.0" Y="715.0" GraphRef="d6d12" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450488" /> </Interaction> <Interaction GraphId="d8555"> <Comment Source="Reactome">Protein kinase C delta (PKCdelta) phosphorylates HuR (ELAVL1) at serine 221 and serine 318.</Comment> <BiopaxRef>b5d</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1107.0" Y="221.0" /> <Point X="1178.0" Y="221.0" /> <Anchor Position="0.0" Shape="None" GraphId="bb1fa" /> <Anchor Position="0.99" Shape="None" GraphId="a89cf" /> <Anchor Position="0.5" Shape="None" GraphId="cebb7" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450533" /> </Interaction> <Interaction GraphId="d8f9e"> <Comment Source="Reactome">Tetrameric AUF1 bound to RNA forms a complex with other proteins, including elongation factor eIF4G, polyA-binding protein PABP, Hsp, Hsc70, and Hsp27. AUF1 also directly interacts with polyadenylate.</Comment> <BiopaxRef>d0c</BiopaxRef> <BiopaxRef>fb7</BiopaxRef> <BiopaxRef>e32</BiopaxRef> <BiopaxRef>b8b</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="125.0" Y="283.0" /> <Point X="153.0" Y="332.0" /> <Anchor Position="0.0" Shape="None" GraphId="cef69" /> <Anchor Position="0.99" Shape="None" GraphId="c7ba5" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450551" /> </Interaction> <Interaction GraphId="d8fad"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1162.0" Y="799.0" GraphRef="b1fb9" RelX="-0.009708737864077669" RelY="0.9487179487179487" /> <Point X="1207.0" Y="852.0" GraphRef="f9fb6" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450394" /> </Interaction> <Interaction GraphId="d9358"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="855.0" Y="553.0" GraphRef="e237c" RelX="-1.0" RelY="0.0" /> <Point X="903.0" Y="615.0" GraphRef="b794b" RelX="9.0" RelY="-1.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450490" /> </Interaction> <Interaction GraphId="da6f1"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1053.0" Y="271.0" GraphRef="e77e7" RelX="0.9682539682539683" RelY="-0.03225806451612903" /> <Point X="1109.0" Y="405.0" GraphRef="e6ae8" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450494" /> </Interaction> <Interaction GraphId="db4a1"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="743.0" Y="534.0" GraphRef="f642c" RelX="1.0" RelY="0.0" /> <Point X="747.0" Y="584.0" GraphRef="af383" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450517" /> </Interaction> <Interaction GraphId="db4bd"> <Comment Source="Reactome">Tristetraprolin (TTP) binds UUAUUUAUU motifs in the AU-rich elements of mRNAs. TTP binds Transportin-1 (Importin beta-2) which plays a role in shuttling TTP between P-bodies and stress granules.</Comment> <BiopaxRef>eb2</BiopaxRef> <BiopaxRef>c7f</BiopaxRef> <BiopaxRef>c99</BiopaxRef> <BiopaxRef>cd8</BiopaxRef> <BiopaxRef>d1f</BiopaxRef> <BiopaxRef>eb4</BiopaxRef> <BiopaxRef>bf3</BiopaxRef> <BiopaxRef>d53</BiopaxRef> <BiopaxRef>a2b</BiopaxRef> <BiopaxRef>ffe</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="414.0" Y="592.0" /> <Point X="413.0" Y="639.0" /> <Anchor Position="0.0" Shape="None" GraphId="e97f4" /> <Anchor Position="0.99" Shape="None" GraphId="fa957" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450400" /> </Interaction> <Interaction GraphId="db875"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="763.0" Y="540.0" GraphRef="f011c" RelX="-1.0" RelY="0.0" /> <Point X="747.0" Y="584.0" GraphRef="af383" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450517" /> </Interaction> <Interaction GraphId="dc9b7"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1078.0" Y="426.0" GraphRef="d1e4e" RelX="-0.006134969325153374" RelY="-1.0" /> <Point X="1109.0" Y="405.0" GraphRef="e6ae8" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450494" /> </Interaction> <Interaction GraphId="dde62"> <Comment Source="Reactome">Protein kinase C alpha (PKCalpha) phosphorylates HuR (ELAVL1) on serine221 and serine 158.</Comment> <BiopaxRef>d25</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1115.0" Y="301.0" /> <Point X="1176.0" Y="300.0" /> <Anchor Position="0.0" Shape="None" GraphId="bf486" /> <Anchor Position="0.99" Shape="None" GraphId="f87ef" /> <Anchor Position="0.5" Shape="None" GraphId="d580f" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450550" /> </Interaction> <Interaction GraphId="de95d"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="153.0" Y="472.0" GraphRef="cd993" RelX="0.009999999999990905" RelY="0.4399999999999977" /> <Point X="154.0" Y="475.0" GraphRef="fcd1e" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450580" /> </Interaction> <Interaction GraphId="e0a35"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="936.0" Y="706.0" GraphRef="fab27" RelX="0.7200000000000273" RelY="0.0" /> <Point X="993.0" Y="707.0" GraphRef="a69f9" RelX="-1.0" RelY="-0.015873015873015872" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450474" /> </Interaction> <Interaction GraphId="e1a89"> <Comment Source="Reactome">HuR interacts with SETalpha (Template activating factor 1), SETbeta (CAN/Nup214), APRIL, pp32, and the nuclear export factor CRM1.</Comment> <BiopaxRef>acd</BiopaxRef> <BiopaxRef>a03</BiopaxRef> <BiopaxRef>f85</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" 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serine158 binds COX-2 mRNA in the nucleus. 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The number of ubiquitin molecules conjugated to AUF1 and their linkage is unknown. Ubiquitination is required for subsequent degradation of both AUF1 and the mRNA bound by AUF1. It is uncertain if AUF1 is in a larger complex when it is ubiquitinated.</Comment> <BiopaxRef>e31</BiopaxRef> <BiopaxRef>e32</BiopaxRef> <BiopaxRef>b61</BiopaxRef> <BiopaxRef>ce0</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="152.0" Y="428.0" /> <Point X="153.0" Y="472.0" /> <Anchor Position="0.0" Shape="None" GraphId="e81d0" /> <Anchor Position="0.99" Shape="None" GraphId="cd993" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450580" /> </Interaction> <Interaction GraphId="edf20"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1349.0" Y="164.0" GraphRef="ca54d" RelX="1.0" RelY="0.0" /> <Point X="1374.0" Y="143.0" GraphRef="aa29c" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-517705" /> </Interaction> <Interaction GraphId="ef7c0"> <Comment Source="Reactome">Butyrate response factor 1 (BRF1) binds AU-rich elements in the 3' untranslated region of mRNAs.</Comment> <BiopaxRef>c0b</BiopaxRef> <BiopaxRef>a92</BiopaxRef> <BiopaxRef>a7f</BiopaxRef> <BiopaxRef>b90</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="747.0" Y="584.0" /> <Point X="748.0" Y="632.0" /> <Anchor Position="0.0" Shape="None" GraphId="af383" /> <Anchor Position="0.99" Shape="None" GraphId="a190b" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450517" /> </Interaction> <Interaction GraphId="f0692"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="575.0" Y="651.0" GraphRef="f5ed5" RelX="0.0" RelY="-1.0" /> <Point X="450.0" Y="344.0" GraphRef="f5410" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450422" /> </Interaction> <Interaction GraphId="f08a4"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="748.0" Y="632.0" GraphRef="a190b" RelX="0.009999999999990905" RelY="0.4800000000000182" /> <Point X="749.0" Y="635.0" GraphRef="cf6d6" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450517" /> </Interaction> <Interaction GraphId="f1ef4"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="426.0" Y="178.0" GraphRef="cb20c" RelX="0.984" RelY="-0.022222222222222223" /> <Point X="450.0" Y="217.0" GraphRef="c61e4" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450592" /> </Interaction> <Interaction GraphId="f2bfd"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="573.0" Y="203.0" GraphRef="a65a7" RelX="0.0" RelY="0.9310344827586207" /> <Point X="597.0" Y="238.0" GraphRef="ca7b5" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450499" /> </Interaction> <Interaction GraphId="f2ddc"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="419.0" Y="784.0" GraphRef="be8ec" RelX="0.060000000000002274" RelY="0.5900000000000318" /> <Point X="424.0" Y="787.0" GraphRef="cf380" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450431" /> </Interaction> <Interaction GraphId="f301d"> <Comment Source="Reactome">BRF1 is phosphorylated at Serine92 and Serine203 by Protein kinase B/AKT. Protein kinase B is activated by phosphatidylinositol 3-kinase. Phosphorylation of BRF1 does not interfere with the ability of BRF1 to bind RNA or interact with enzymes that catalyze RNA degradation therefore larger complexes may contain phosphorylated BRF1.</Comment> <BiopaxRef>a7f</BiopaxRef> <BiopaxRef>b90</BiopaxRef> <BiopaxRef>a92</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="864.0" Y="616.0" /> <Point X="924.0" Y="616.0" /> <Anchor Position="0.0" Shape="None" GraphId="a5faf" /> <Anchor Position="0.99" Shape="None" GraphId="b7db2" /> <Anchor Position="0.5" Shape="None" GraphId="b794b" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450490" /> </Interaction> <Interaction GraphId="f34bd"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1661.0" Y="405.0" GraphRef="b1c7e" RelX="0.0" RelY="0.7799999999999727" /> <Point X="1663.0" Y="408.0" GraphRef="d0581" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450387" /> </Interaction> <Interaction GraphId="f52af"> <Comment Source="Reactome">TTP is phosphorylated by MK2 at serines 60 and 186.</Comment> <BiopaxRef>db2</BiopaxRef> <BiopaxRef>cdb</BiopaxRef> <BiopaxRef>a99</BiopaxRef> <BiopaxRef>aaf</BiopaxRef> <BiopaxRef>ddf</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="869.0" Y="850.0" /> <Point X="949.0" Y="850.0" /> <Anchor Position="0.0" Shape="None" GraphId="dc9e3" /> <Anchor Position="0.99" Shape="None" GraphId="c9fe7" /> <Anchor Position="0.5" Shape="None" GraphId="ed102" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450463" /> </Interaction> <Interaction GraphId="f53eb"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1103.0" Y="248.0" GraphRef="e097a" RelX="-0.02040816326530612" RelY="-1.0" /> <Point X="1107.0" Y="221.0" GraphRef="bb1fa" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450533" /> </Interaction> <Interaction GraphId="f5b55"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1358.0" Y="386.0" GraphRef="be2a7" RelX="1.0" RelY="0.0" /> <Point X="1366.0" Y="333.0" GraphRef="f1f31" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-517674" /> </Interaction> <Interaction GraphId="f821f"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="691.0" Y="238.0" GraphRef="cea02" RelX="0.9400000000000546" RelY="0.0" /> <Point X="726.0" Y="200.0" GraphRef="a8d1f" RelX="0.0" RelY="0.9354838709677419" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450499" /> </Interaction> <Interaction GraphId="f94c7"> <Comment Source="Reactome">Phosphorylated BRF1 interacts with 14-3-3, becomes localized to the cytoskeleton, and no longer promotes RNA degradation. Phosphorylated BRF1 is, however, still able to bind RNA.</Comment> <BiopaxRef>a7f</BiopaxRef> <BiopaxRef>b90</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1195.0" Y="615.0" /> <Point X="1238.0" Y="615.0" /> <Anchor Position="0.0" Shape="None" GraphId="e861a" /> <Anchor Position="0.99" Shape="None" GraphId="bed8d" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450406" /> </Interaction> <Interaction GraphId="f9bd1"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="610.0" Y="668.0" GraphRef="f5ed5" RelX="1.0" RelY="-0.02857142857142857" /> <Point X="746.0" Y="715.0" GraphRef="d6d12" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450488" /> </Interaction> <Interaction GraphId="fa16e"> <Comment Source="Reactome">Phosphorylated BRF1 interacts with 14-3-3, becomes localized to the cytoskeleton, and no longer promotes RNA degradation. Phosphorylated BRF1 is, however, still able to bind RNA.</Comment> <BiopaxRef>c0b</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1197.0" Y="706.0" /> <Point X="1242.0" Y="705.0" /> <Anchor Position="0.0" Shape="None" GraphId="f0b21" /> <Anchor Position="0.99" Shape="None" GraphId="f75fa" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-482788" /> </Interaction> <Interaction GraphId="fc41d"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="560.0" Y="704.0" GraphRef="c6829" RelX="-1.0" RelY="0.0" /> <Point X="413.0" Y="725.0" GraphRef="e8948" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450431" /> </Interaction> <Interaction GraphId="fe7c3"> <Comment Source="Reactome">MAPK-activated protein kinase 2 (MK2) phosphorylates BRF1 at serine 54, serine 92, serine 203, and an unknown site in the C terminus. Phosphorylation inhibits the ability of BRF1 to cause degradation of RNA. It is unknown if tetraphosphorylated BRF1 binds 14-3-3 in the same way as diphosphorylated BRF1 does.</Comment> <BiopaxRef>c0b</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="864.0" Y="706.0" /> <Point X="936.0" Y="706.0" /> <Anchor Position="0.0" Shape="None" GraphId="a9cc8" /> <Anchor Position="0.99" Shape="None" GraphId="fab27" /> <Anchor Position="0.5" Shape="None" GraphId="ec2ca" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450474" /> </Interaction> <Interaction GraphId="ff79f"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="451.0" Y="311.0" GraphRef="f0e76" RelX="-0.012048192771084338" RelY="1.0" /> <Point X="450.0" Y="344.0" GraphRef="f5410" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-450422" /> </Interaction> <Label TextLabel="nucleoplasm" GraphId="abe57" GroupRef="f23da"> <Graphics CenterX="1732.0" CenterY="485.5" Width="92.0" Height="33.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" /> </Label> <Label TextLabel="cytosol" GraphId="f9d31" GroupRef="ba627"> <Graphics CenterX="1755.5" CenterY="924.5" Width="59.0" Height="33.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" /> </Label> <Shape GraphId="ae91b" GroupRef="ba627"> <Graphics CenterX="902.5" CenterY="481.0" Width="1797.0" Height="952.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" /> </Shape> <Shape GraphId="da892" GroupRef="f23da"> <Graphics CenterX="1379.5" CenterY="272.5" Width="823.0" Height="485.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" /> </Shape> <Group GroupId="d3e7d" GraphId="aa9a9" Style="Complex"> <Attribute Key="complex_id" Value="R-HSA-450623" /> </Group> <Group GroupId="f23da" GraphId="ac079" Style="Group" /> <Group GroupId="cce59" GraphId="ace78"> <Attribute 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<bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18240226</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">AUF1, the regulator of tumor necrosis factor alpha messenger RNA decay, is targeted by autoantibodies of patients with systemic rheumatic diseases.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Skriner K, Hueber W, Süleymanoglu E, Höfler E, Krenn V, Smolen J, Steiner G.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e54"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">14981256</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Identification of a target RNA motif for RNA-binding protein HuR.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">López de Silanes I, Zhan M, Lal A, Yang X, Gorospe M.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cf8"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11834731</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Goldberg-Cohen I, Furneauxb H, Levy AP.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a2d"> <bp:ID 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xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cdb"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">14688255</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chrestensen CA, Schroeder MJ, Shabanowitz J, Hunt DF, Pelo JW, Worthington MT, Sturgill TW.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b5d"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18285462</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Doller A, Akool el-S, Huwiler A, Müller R, Radeke HH, Pfeilschifter J, Eberhardt W.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a99"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16262601</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cao H, Deterding LJ, Venable JD, Kennington EA, Yates JR, Tomer KB, Blackshear PJ.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e44"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16484227</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Prechtel AT, Chemnitz J, Schirmer S, Ehlers C, Langbein-Detsch I, Stülke J, Dabauvalle MC, Kehlenbach RH, Hauber J.</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM 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