TGF-beta receptor signaling (Bos taurus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="TGF-beta receptor signaling" Last-Modified="2/21/2013" Organism="Bos taurus" License="CC BY 2.0"> <Comment Source="GenMAPP remarks">edited by: Nathan Salomonis</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="WikiPathways-description">The Transforming growth factor beta (TGF&amp;#x3b2;) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGF&amp;#x3b2; signaling pathway regulates, the process is relatively simple. TGF&amp;#x3b2; superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. (source: [http://en.wikipedia.org/wiki/TGF_beta_signaling_pathway WikiPedia]). Also see: [http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=200110&amp;amp;source=NCI-Nature%20curated&amp;amp;what=graphic&amp;amp;gif=on&amp;amp;ppage=1 TGF-beta receptor signaling] at the NCI-Nature pathway interaction database.</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP560_r68944 WP560(68944)] with a 98.0% conversion rate.</Comment> <BiopaxRef>ce9</BiopaxRef> <BiopaxRef>ba4</BiopaxRef> <Graphics BoardWidth="1079.333333333333" BoardHeight="774.0"/> <DataNode TextLabel="TGFB1" GraphId="a29" Type="GeneProduct" GroupRef="ee9e2"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TGFB1 | transforming growth factor beta 1 (Cam..."/> <Graphics CenterX="425.3333333333338" CenterY="77.49999999999999" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000020457"/> </DataNode> <DataNode TextLabel="INHBA" GraphId="e44" Type="GeneProduct" GroupRef="ee9e2"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3624</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="INHBA | inhibin beta A (activin A activin AB ..."/> <Graphics CenterX="425.3333333333338" CenterY="103.33333333333331" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000002912"/> </DataNode> <DataNode TextLabel="BMP4" GraphId="aed" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:652</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="BMP4 | bone morphogenetic protein 4"/> <Graphics CenterX="425.33333333333303" CenterY="133.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000003835"/> </DataNode> <DataNode TextLabel="TGFBR3" GraphId="a06" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7049</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TGFBR3 | transforming growth factor beta recep..."/> <Graphics CenterX="179.3333333333331" CenterY="215.66666666666669" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000024269"/> </DataNode> <DataNode TextLabel="ENG" GraphId="c44" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2022</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENG | endoglin (Osler-Rendu-Weber syndrome 1)"/> <Graphics CenterX="230.33333333333346" CenterY="266.66666666666663" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000008997"/> </DataNode> <DataNode TextLabel="TGFBR2" GraphId="be1" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7048</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TGFBR2 | transforming growth factor beta recep..."/> <Graphics CenterX="343.66666666666697" CenterY="215.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000019832"/> </DataNode> <DataNode TextLabel="TGFBR1" GraphId="fdf" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7046</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TGFBR1 | transforming growth factor beta recep..."/> <Graphics CenterX="283.6666666666664" CenterY="215.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000018035"/> </DataNode> <DataNode TextLabel="FKBP1A" GraphId="b66" Type="GeneProduct" GroupRef="abb43"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2280</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="FKBP1A | FK506 binding protein 1A 12kDa"/> <Graphics CenterX="314.33333333333366" CenterY="292.3333333333331" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000032651"/> </DataNode> <DataNode TextLabel="LTBP1" GraphId="e49" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4052</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LTBP1 | latent transforming growth factor beta ..."/> <Graphics CenterX="542.0000000000005" CenterY="77.5" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000019839"/> </DataNode> <DataNode TextLabel="FST" GraphId="b50" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10468</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="FST | follistatin"/> <Graphics CenterX="542.0000000000005" CenterY="103.33333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000003329"/> </DataNode> <DataNode TextLabel="NOG" GraphId="c13" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9241</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="NOG | noggin"/> <Graphics CenterX="542.0000000000005" CenterY="133.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000040282"/> </DataNode> <DataNode TextLabel="ITGB6" GraphId="fe9" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3694</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ITGB6 | integrin beta 6"/> <Graphics CenterX="572.3333333333337" CenterY="27.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000009080"/> </DataNode> <DataNode TextLabel="THBS1" GraphId="c0d" Type="GeneProduct"> <Comment Source="GenMAPP remarks">there are 5 types of tsp</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7057</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="THBS1 | thrombospondin 1"/> <Graphics CenterX="643.3333333333339" CenterY="77.5" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000002006"/> </DataNode> <DataNode TextLabel="TGFBR2" GraphId="e8d" Type="GeneProduct" GroupRef="b30b6"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7048</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TGFBR2 | transforming growth factor beta recep..."/> <Graphics CenterX="517.9415295549354" CenterY="220.46941305443193" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000019832"/> </DataNode> <DataNode TextLabel="TGFBR1" GraphId="d6f" Type="GeneProduct" GroupRef="b30b6"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7046</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TGFBR1 | transforming growth factor beta recep..."/> <Graphics CenterX="517.9415295549354" CenterY="200.4694130544319" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000018035"/> </DataNode> <DataNode TextLabel="ZFYVE9" GraphId="ead" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9372</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ZFYVE9 | zinc finger FYVE domain containing 9"/> <Graphics CenterX="433.2605659683927" CenterY="255.79492833517105" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000014289"/> </DataNode> <DataNode TextLabel="SMAD1" GraphId="a7d" Type="GeneProduct" GroupRef="a193c"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4086</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SMAD1 | SMAD mothers against DPP homolog 1 (Dr..."/> <Graphics CenterX="488.3333333333342" CenterY="304.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000002835"/> </DataNode> <DataNode TextLabel="SMAD5" GraphId="fe1" Type="GeneProduct" GroupRef="a193c"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4090</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SMAD5 | SMAD mothers against DPP homolog 5 (Dr..."/> <Graphics CenterX="488.3333333333342" CenterY="324.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000021772"/> </DataNode> <DataNode TextLabel="SMAD9" GraphId="a44" Type="GeneProduct" GroupRef="a193c"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4093</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SMAD9 | SMAD mothers against DPP homolog 9 (Dr..."/> <Graphics CenterX="488.3333333333342" CenterY="344.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000007589"/> </DataNode> <DataNode TextLabel="SMAD2" GraphId="e54" Type="GeneProduct" GroupRef="a193c"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4087</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SMAD2 | SMAD mothers against DPP homolog 2 (Dr..."/> <Graphics CenterX="548.666666666668" CenterY="304.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000039916"/> </DataNode> <DataNode TextLabel="SMAD3" GraphId="d96" Type="GeneProduct" GroupRef="a193c"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4088</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SMAD3 | SMAD mothers against DPP homolog 3 (Dr..."/> <Graphics CenterX="548.666666666668" CenterY="320.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000012599"/> </DataNode> <DataNode TextLabel="SMAD4" GraphId="ae4" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4089</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SMAD4 | SMAD mothers against DPP homolog 4 (Dr..."/> <Graphics CenterX="614.0000000000007" CenterY="391.33333333333314" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000006919"/> </DataNode> <DataNode TextLabel="IFNG" GraphId="eaf" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNG | interferon gamma"/> <Graphics CenterX="160.00000000000034" CenterY="493.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000012529"/> </DataNode> <DataNode TextLabel="TGFB1" GraphId="ebc" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TGFB1 | transforming growth factor beta 1 (Cam..."/> <Graphics CenterX="160.00000000000034" CenterY="516.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000020457"/> </DataNode> <DataNode TextLabel="BMP4" GraphId="c61" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:652</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="BMP4 | bone morphogenetic protein 4"/> <Graphics CenterX="160.00000000000034" CenterY="540.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000003835"/> </DataNode> <DataNode TextLabel="TNF" GraphId="b39" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TNF | tumor necrosis factor (TNF superfamily m..."/> <Graphics CenterX="160.00000000000034" CenterY="566.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000025471"/> </DataNode> <DataNode TextLabel="EGF" GraphId="f6a" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="EGF | epidermal growth factor (beta-urogastrone..."/> <Graphics CenterX="379.3333333333337" CenterY="618.6666666666678" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="STAT1" GraphId="f8c" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1 | signal transducer and activator of tran..."/> <Graphics CenterX="253.99999999999977" CenterY="493.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000007867"/> </DataNode> <DataNode TextLabel="SMAD2" GraphId="ec1" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4087</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SMAD2 | SMAD mothers against DPP homolog 2 (Dr..."/> <Graphics CenterX="253.99999999999977" CenterY="516.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000039916"/> </DataNode> <DataNode TextLabel="SMAD1" GraphId="e0b" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4086</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SMAD1 | SMAD mothers against DPP homolog 1 (Dr..."/> <Graphics CenterX="253.99999999999977" CenterY="540.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000002835"/> </DataNode> <DataNode TextLabel="NFKB1" GraphId="d70" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="NFKB1 | nuclear factor of kappa light polypepti..."/> <Graphics CenterX="253.99999999999977" CenterY="566.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000020270"/> </DataNode> <DataNode TextLabel="SMAD7" GraphId="ecf" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4092</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SMAD7 | SMAD mothers against DPP homolog 7 (Dr..."/> <Graphics CenterX="404.00000000000045" CenterY="436.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000012441"/> </DataNode> <DataNode TextLabel="SMAD6" GraphId="c48" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4091</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SMAD6 | SMAD mothers against DPP homolog 6 (Dr..."/> <Graphics CenterX="339.666666666667" CenterY="398.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000000625"/> </DataNode> <DataNode TextLabel="MAPK3" GraphId="d0b" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK3 | mitogen-activated protein kinase 3"/> <Graphics CenterX="517.3333333333339" CenterY="503.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000016156"/> </DataNode> <DataNode TextLabel="HRAS" GraphId="ef6" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="HRAS | v-Ha-ras Harvey rat sarcoma viral oncoge..."/> <Graphics CenterX="517.3333333333339" CenterY="556.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000046644"/> </DataNode> <DataNode TextLabel="WNT1" GraphId="bd0" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7471</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="WNT1 | wingless-type MMTV integration site fami..."/> <Graphics CenterX="698.9999999999999" CenterY="349.9999999999999" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000015364"/> </DataNode> <DataNode TextLabel="TNF" GraphId="f21" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TNF | tumor necrosis factor (TNF superfamily m..."/> <Graphics CenterX="698.9999999999999" CenterY="403.33333333333326" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000025471"/> </DataNode> <DataNode TextLabel="CTNNB1" GraphId="ef9" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CTNNB1 | catenin (cadherin-associated protein)..."/> <Graphics CenterX="785.9999999999999" CenterY="349.9999999999999" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000016420"/> </DataNode> <DataNode TextLabel="JAK1" GraphId="a4d" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK1 | Janus kinase 1 (a protein tyrosine kinas..."/> <Graphics CenterX="785.9999999999999" CenterY="376.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000003147"/> </DataNode> <DataNode TextLabel="MAPK9" GraphId="a75" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK9 | mitogen-activated protein kinase 9"/> <Graphics CenterX="785.9999999999999" CenterY="403.33333333333326" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000004709"/> </DataNode> <DataNode TextLabel="SPP1" GraphId="b6c" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6696</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SPP1 | secreted phosphoprotein 1 (osteopontin ..."/> <Graphics CenterX="873.3333333333331" CenterY="236.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000005260"/> </DataNode> <DataNode TextLabel="ZEB2" GraphId="a0d" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9839</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ZFHX1B | zinc finger homeobox 1b"/> <Graphics CenterX="873.3333333333331" CenterY="256.66666666666674" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000012615"/> </DataNode> <DataNode TextLabel="RUNX2" GraphId="a9d" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:860</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RUNX2 | runt-related transcription factor 2"/> <Graphics CenterX="873.3333333333331" CenterY="296.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000004104"/> </DataNode> <DataNode TextLabel="RUNX3" GraphId="d5c" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:864</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RUNX3 | runt-related transcription factor 3"/> <Graphics CenterX="873.3333333333331" CenterY="323.33333333333326" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000019800"/> </DataNode> <DataNode TextLabel="LEF1" GraphId="c42" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51176</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LEF1 | lymphoid enhancer-binding factor 1"/> <Graphics CenterX="873.3333333333331" CenterY="349.9999999999999" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000006844"/> </DataNode> <DataNode TextLabel="STAT3" GraphId="e55" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT3 | signal transducer and activator of tran..."/> <Graphics CenterX="873.3333333333331" CenterY="376.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000021523"/> </DataNode> <DataNode TextLabel="JUN" GraphId="ec0" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JUN | v-jun sarcoma virus 17 oncogene homolog (..."/> <Graphics CenterX="873.3333333333331" CenterY="403.33333333333326" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000004037"/> </DataNode> <DataNode TextLabel="TFE3" GraphId="f61" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7030</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TFE3 | transcription factor binding to IGHM enh..."/> <Graphics CenterX="873.3333333333331" CenterY="429.9999999999999" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000008523"/> </DataNode> <DataNode TextLabel="FOXH1" GraphId="eeb" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8928</Comment> <Attribute 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