GPR40 role in insulin secretion (Homo sapiens)

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This hydrolyzes membrane phospholipids such as phosphatidylinositol-4-5-biphosphate into second messenger molecules inositol-1-4-5-triphosphate (IP3) and diacylglycerol (DAG). IP3 initiates calcium efflux from endoplasmic reticulum and increase intracellular calcium concentration. Increased intracellular calcium concentration is involved in activating the insulin exocytosis machinery. DAG on the other hand activates PKD1. 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Return to GPR40 role in insulin secretion (Homo sapiens).