COPII-mediated vesicle transport (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="COPII-mediated vesicle transport" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">COPII components (known as Sec13p, Sec23p, Sec24p, Sec31p, and Sar1p in yeast) traffic cargo from the endoplasmic reticulum to the ER-Golgi intermediate compartment (ERGIC). COPII-coated vesicles were originally discovered in the yeast Saccharomyces cerevisiae using genetic approaches coupled with a cell-free assay. The mammalian counterpart of this pathway is represented here. Newly synthesized proteins destined for secretion are sorted into COPII-coated vesicles at specialized regions of the ER. These vesicles leave the ER, become uncoated and subsequently fuse with the ERGIC membrane. View original pathway at [http://www.reactome.org/PathwayBrowser/#DIAGRAM=204005 Reactome].</Comment> <Comment Source="Reactome-Converter">Pathway is converted from Reactome ID: 204005</Comment> <Comment Source="Reactome-version">Reactome version: 75</Comment> <Comment Source="Reactome Author">Reactome Author: Gillespie, Marc E</Comment> <BiopaxRef>fb3</BiopaxRef> <BiopaxRef>a22</BiopaxRef> <Attribute Key="reactome_id" Value="204005" /> <Graphics BoardWidth="1937.0" BoardHeight="3363.0" /> <DataNode TextLabel="Factor VIII precursor " GraphId="a01bf" Type="Protein" GroupRef="a62cd"> <Attribute Key="cellular_location" Value="COPII-coated ER to Golgi transport vesicle" /> <Attribute Key="complex_id" Value="R-HSA-5694329" /> <Attribute Key="copies_num" Value="29" /> <Graphics CenterX="100.0" CenterY="2523.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P00451" /> </DataNode> <DataNode TextLabel="RAB1A " GraphId="a074e" Type="Protein" GroupRef="d374f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-5694332" /> <Attribute Key="copies_num" Value="69" /> <Graphics CenterX="520.0" CenterY="3143.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P62820" /> </DataNode> <DataNode TextLabel="SEC22A " GraphId="a0825" Type="Protein" GroupRef="b25ba"> <Attribute Key="cellular_location" Value="ER to Golgi transport vesicle membrane" /> <Attribute Key="complex_id" Value="R-HSA-5694326" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="940.0" CenterY="1623.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96IW7" /> </DataNode> <DataNode TextLabel="RAB1B " GraphId="a0967" Type="Protein" GroupRef="c7619"> <Attribute Key="cellular_location" Value="endoplasmic reticulum-Golgi intermediate compartment membrane" /> <Attribute Key="complex_id" Value="R-HSA-6814832" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1780.0" CenterY="1743.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9H0U4" /> </DataNode> <DataNode TextLabel="LMAN2L " GraphId="a0e6f" Type="Protein" GroupRef="fe279"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-5694523" /> <Attribute Key="copies_num" Value="51" /> <Graphics CenterX="1640.0" CenterY="2483.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9H0V9" /> </DataNode> <DataNode TextLabel="COL7A1 " GraphId="a13e6" Type="Protein" GroupRef="fe279"> <Attribute Key="cellular_location" Value="endoplasmic reticulum lumen" /> <Attribute Key="complex_id" Value="R-HSA-5694523" /> <Attribute Key="copies_num" Value="25" /> <Graphics CenterX="1640.0" CenterY="2123.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q02388" /> </DataNode> <DataNode TextLabel="3x4Hyp-GlcGalHyl-COL7A1 " GraphId="a1406" Type="Protein" GroupRef="b25ba"> <Attribute Key="cellular_location" Value="COPII-coated ER to Golgi transport vesicle" /> <Attribute Key="complex_id" Value="R-HSA-5694326" /> <Attribute Key="copies_num" Value="30" /> <Graphics CenterX="940.0" CenterY="2023.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q02388" /> </DataNode> <DataNode TextLabel="SEC24B " GraphId="a14bb" Type="Protein" GroupRef="d8b08"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-203975" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="1683.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O95487" /> </DataNode> <DataNode TextLabel="TGFA precursor " GraphId="a14d9" Type="Protein" GroupRef="d12bc"> <Attribute Key="cellular_location" Value="endoplasmic reticulum-Golgi intermediate compartment membrane" /> <Attribute Key="complex_id" Value="R-HSA-5694253" /> <Attribute Key="copies_num" Value="43" /> <Graphics CenterX="1360.0" CenterY="2563.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P01135" /> </DataNode> <DataNode TextLabel="NAPA " GraphId="a1a85" Type="Protein" GroupRef="af10d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-5694312" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1220.0" CenterY="1843.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P54920" /> </DataNode> <DataNode TextLabel="3x4Hyp-5Hyl-COL7A1 " GraphId="a1e01" Type="Protein" GroupRef="b25ba"> <Attribute Key="cellular_location" Value="COPII-coated ER to Golgi transport vesicle" /> <Attribute Key="complex_id" Value="R-HSA-5694326" /> <Attribute Key="copies_num" Value="24" /> <Graphics CenterX="940.0" CenterY="1923.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q02388" /> </DataNode> <DataNode TextLabel="GORASP1 " GraphId="a265f" Type="Protein" GroupRef="b25ba"> <Attribute Key="cellular_location" Value="endoplasmic reticulum-Golgi intermediate compartment membrane" /> <Attribute Key="complex_id" Value="R-HSA-5694326" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="1563.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BQQ3" /> </DataNode> <DataNode TextLabel="SEC24D " GraphId="a2c9f" Type="Protein" GroupRef="d8b08"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-203975" /> <Attribute Key="copies_num" 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Database="Uniprot-TrEMBL" ID="Q02388" /> </DataNode> <DataNode TextLabel="TRAPPC5 " GraphId="a334f" Type="Protein" GroupRef="d374f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-5694332" /> <Attribute Key="copies_num" Value="69" /> <Graphics CenterX="520.0" CenterY="3063.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8IUR0" /> </DataNode> <DataNode TextLabel="SEC23A " GraphId="a354d" Type="Protein" GroupRef="c45f5"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-5694339" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="660.0" CenterY="1883.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15436" /> </DataNode> <DataNode TextLabel="TRAPPC9 " GraphId="a3c75" Type="Protein" GroupRef="fac2f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-5694315" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1683.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96Q05" /> </DataNode> <DataNode TextLabel="TRAPPC2 " GraphId="a3d70" Type="Protein" GroupRef="fe802"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-5694330" /> <Attribute Key="copies_num" Value="61" /> <Graphics CenterX="380.0" CenterY="2783.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0DI81" /> </DataNode> <DataNode TextLabel="TRAPPC3 " GraphId="a3fd6" Type="Protein" GroupRef="d776f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-5694334" /> <Attribute Key="copies_num" Value="57" /> <Graphics CenterX="240.0" CenterY="3223.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O43617" /> </DataNode> <DataNode TextLabel="GlcGalHyl-COL7A1 " GraphId="a41ad" Type="Protein" GroupRef="ad9c8"> <Attribute Key="cellular_location" Value="endoplasmic reticulum lumen" /> <Attribute Key="complex_id" Value="R-HSA-5694244" /> <Attribute Key="copies_num" Value="25" /> <Graphics CenterX="1500.0" CenterY="2163.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q02388" /> </DataNode> <DataNode TextLabel="TMED2 " GraphId="a41fb" Type="Protein" GroupRef="fe279"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-5694523" /> <Attribute Key="copies_num" Value="45" /> <Graphics CenterX="1640.0" CenterY="2403.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15363" /> </DataNode> <DataNode TextLabel="RAB1A " GraphId="a4385" Type="Protein" GroupRef="c7619"> <Attribute Key="cellular_location" Value="endoplasmic reticulum-Golgi intermediate compartment membrane" /> <Attribute Key="complex_id" Value="R-HSA-6814832" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1780.0" CenterY="1763.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P62820" /> </DataNode> <DataNode TextLabel="LMAN2L " GraphId="a43fd" Type="Protein" GroupRef="ad9c8"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-5694244" /> <Attribute Key="copies_num" Value="47" /> <Graphics CenterX="1500.0" CenterY="2503.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9H0V9" /> </DataNode> <DataNode TextLabel="TRAPPC4 " GraphId="a460b" Type="Protein" GroupRef="d776f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-5694334" /> <Attribute Key="copies_num" Value="57" /> <Graphics CenterX="240.0" CenterY="3243.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y296" /> </DataNode> <DataNode TextLabel="TRAPPC2L " GraphId="a463b" Type="Protein" GroupRef="d374f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-5694332" /> <Attribute Key="copies_num" Value="69" /> <Graphics CenterX="520.0" CenterY="3003.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UL33" /> </DataNode> <DataNode TextLabel="GOSR2" GraphId="a4bec" Type="Protein"> <Attribute Key="cellular_location" Value="endoplasmic reticulum-Golgi intermediate compartment membrane" /> <Graphics CenterX="1560.0" CenterY="466.5" Width="74.0" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O14653" /> </DataNode> <DataNode TextLabel="LMAN1 " GraphId="a52bb" Type="Protein" GroupRef="d776f"> <Attribute Key="cellular_location" Value="ER to Golgi transport vesicle membrane" /> <Attribute Key="complex_id" Value="R-HSA-5694334" /> <Attribute Key="copies_num" Value="46" /> <Graphics CenterX="240.0" CenterY="2683.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P49257" /> </DataNode> <DataNode TextLabel="SEC22A " GraphId="a5362" Type="Protein" GroupRef="cccdf"> <Attribute Key="cellular_location" Value="endoplasmic reticulum-Golgi intermediate compartment membrane" /> <Attribute Key="complex_id" Value="R-HSA-5694306" /> <Attribute Key="copies_num" Value="5" /> <Graphics CenterX="1500.0" CenterY="1583.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96IW7" /> </DataNode> <DataNode TextLabel="USO1 " GraphId="a55d4" Type="Protein" GroupRef="d374f"> <Attribute Key="cellular_location" Value="ER to Golgi transport vesicle membrane" /> <Attribute Key="complex_id" Value="R-HSA-5694332" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="520.0" CenterY="1723.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O60763" /> </DataNode> <DataNode TextLabel="GPI-CD59 " GraphId="a5616" Type="Protein" GroupRef="d776f"> <Attribute Key="cellular_location" Value="ER to Golgi transport vesicle membrane" /> <Attribute Key="complex_id" Value="R-HSA-5694334" /> <Attribute Key="copies_num" Value="55" /> <Graphics CenterX="240.0" CenterY="3063.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P13987" /> </DataNode> <DataNode TextLabel="CNIH3 " GraphId="a5813" Type="Protein" GroupRef="c45f5"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-5694339" 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<Attribute Key="complex_id" Value="R-HSA-5694329" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="100.0" CenterY="1903.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O94979" /> </DataNode> <DataNode TextLabel="3x4Hyp-GlcGalHyl-COL7A1 " GraphId="a682b" Type="Protein" GroupRef="fe279"> <Attribute Key="cellular_location" Value="endoplasmic reticulum lumen" /> <Attribute Key="complex_id" Value="R-HSA-5694523" /> <Attribute Key="copies_num" Value="17" /> <Graphics CenterX="1640.0" CenterY="2043.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q02388" /> </DataNode> <DataNode TextLabel="GOSR2 " GraphId="a68b0" Type="Protein" GroupRef="ad9c8"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-5694244" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" 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ID="Q6PI25" /> </DataNode> <DataNode TextLabel="TMED2 " GraphId="a741f" Type="Protein" GroupRef="d374f"> <Attribute Key="cellular_location" Value="ER to Golgi transport vesicle membrane" /> <Attribute Key="complex_id" Value="R-HSA-5694332" /> <Attribute Key="copies_num" Value="69" /> <Graphics CenterX="520.0" CenterY="2923.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15363" /> </DataNode> <DataNode TextLabel="MCFD2 " GraphId="a7724" Type="Protein" GroupRef="fe802"> <Attribute Key="cellular_location" Value="ER to Golgi transport vesicle membrane" /> <Attribute Key="complex_id" Value="R-HSA-5694330" /> <Attribute Key="copies_num" Value="51" /> <Graphics CenterX="380.0" CenterY="2303.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NI22" /> </DataNode> <DataNode TextLabel="SEC31A " GraphId="a7769" Type="Protein" GroupRef="afacf"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-5694316" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="1080.0" CenterY="2003.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O94979" /> </DataNode> <DataNode TextLabel="RAB1B " GraphId="a7854" Type="Protein" GroupRef="fe802"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-5694330" /> <Attribute Key="copies_num" Value="65" /> <Graphics CenterX="380.0" CenterY="2963.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9H0U4" /> </DataNode> <DataNode TextLabel="TRAPPC5 " GraphId="a7867" Type="Protein" GroupRef="fe802"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-5694330" /> <Attribute Key="copies_num" Value="61" /> <Graphics CenterX="380.0" CenterY="2863.0" 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<Graphics CenterX="380.0" CenterY="2203.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q02388" /> </DataNode> <DataNode TextLabel="cis-SNARE" GraphId="c5654" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum-Golgi intermediate compartment membrane" /> <Graphics CenterX="1050.0" CenterY="458.5" Width="70.0" Height="29.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-5694303" /> </DataNode> <DataNode TextLabel="GTP " GraphId="c5674" Type="Metabolite" GroupRef="d374f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-5694332" /> <Attribute Key="copies_num" Value="74" /> <Graphics CenterX="520.0" CenterY="3183.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15996" /> </DataNode> <DataNode TextLabel="Pi" GraphId="c594f" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1715.5" CenterY="364.0" Width="55.0" Height="32.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:43474" /> </DataNode> <DataNode TextLabel="SEC22A " GraphId="c59f9" Type="Protein" GroupRef="fe802"> <Attribute Key="cellular_location" Value="ER to Golgi transport vesicle membrane" /> <Attribute Key="complex_id" Value="R-HSA-5694330" /> <Attribute Key="copies_num" Value="7" /> <Graphics CenterX="380.0" CenterY="1723.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96IW7" /> </DataNode> <DataNode TextLabel="RAB1A " GraphId="c5ddb" Type="Protein" GroupRef="fe802"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-5694330" /> <Attribute Key="copies_num" Value="61" /> <Graphics CenterX="380.0" CenterY="2943.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P62820" /> </DataNode> <DataNode TextLabel="Cargo concentration&#xA;in the ER" GraphId="c6099" Type="Pathway"> <Comment Source="Reactome">Computational analysis suggests that ~25% of the proteome may be exported from the ER in human cells (Kanapin et al, 2003). These cargo need to be recognized and concentrated into COPII vesicles, which range in size from 60-90 nm, and which move cargo from the ER to the ERGIC in mammalian cells (reviewed in Lord et al, 2013; Szul and Sztul, 2011). Recognition of transmembrane cargo is mediated by interaction with one of the 4 isoforms of SEC24, a component of the inner COPII coat (Miller et al, 2002; Miller et al, 2003; Mossessova et al, 2003; Mancias and Goldberg, 2008). Soluble cargo in the ER lumen is concentrated into COPII vesicles through interaction with a receptor of the ERGIC-53 family, the p24 family or the ERV family. Each of these families of transmembrane receptors interact with cargo through their lumenal domains and with components of the COPII coat with their cytoplasmic domains and are packaged into the COPII vesicle along with the cargo. The receptors are subsequently recycled to the ER in COPI vesicles through retrograde traffic (reviewed in Dancourt and Barlowe, 2010). Packaging of large cargo such as fibrillar collagen depends on the transmembrane accessory factors MIA3 (also known as TANGO1) and CTAGE5. Like the ERGIC, p24 and ERV cargo receptors, MIA3 and MIA2 (also known as CTAGE5) interact both with the collagen cargo and with components of the COPII coat. Unlike the other cargo receptors, however, MIA3 and MIA2 are not loaded into the vesicle but remain in the ER membrane (reviewed in Malhotra and Erlmann, 2011; Malhotra et al, 2015).</Comment> <BiopaxRef>de3</BiopaxRef> <BiopaxRef>ea7</BiopaxRef> <BiopaxRef>b13</BiopaxRef> <BiopaxRef>f99</BiopaxRef> <BiopaxRef>faf</BiopaxRef> <BiopaxRef>b71</BiopaxRef> <BiopaxRef>f2c</BiopaxRef> <BiopaxRef>ccd</BiopaxRef> <BiopaxRef>a41</BiopaxRef> <BiopaxRef>dd4</BiopaxRef> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="843.5" CenterY="1285.0" Width="161.0" Height="56.0" ZOrder="32768" FontSize="10" Valign="Middle" LineThickness="0.0" Color="14961e" /> <Xref Database="Reactome" ID="R-HSA-5694530" /> </DataNode> <DataNode TextLabel="Glycoproteins with Man8 N-glycans " GraphId="c62b7" GroupRef="fe279"> <Attribute Key="cellular_location" Value="endoplasmic reticulum lumen" /> <Attribute Key="complex_id" Value="R-HSA-5694523" /> <Attribute Key="copies_num" 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/> </Interaction> <Interaction GraphId="afb56"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="590.0" Y="950.0" GraphRef="deea9" RelX="0.0" RelY="0.9591836734693877" /> <Point X="551.0" Y="1116.0" GraphRef="fb67c" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-204008" /> </Interaction> <Interaction GraphId="b14d1"> <Comment Source="Reactome">Once loaded the vesicles become fully sculpted, pinch off from the ER and bud into the cytosol. Budding depends on SAR1:GTPase activity and likely releases the SEC16 complex. SAR1:GTPase activity may result in partial uncoating of the emerging vesicle, allowing SEC23 to be exposed for subsequent TRAPPCII binding.</Comment> <BiopaxRef>cbb</BiopaxRef> <BiopaxRef>c85</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="366.0" Y="1129.0" /> <Point X="370.0" Y="1070.0" /> <Anchor Position="0.0" Shape="None" GraphId="fac87" /> <Anchor Position="0.99" Shape="None" GraphId="bf56c" /> <Anchor Position="0.5" Shape="None" GraphId="be414" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-203973" /> </Interaction> <Interaction GraphId="b2a61"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="370.0" Y="1070.0" GraphRef="bf56c" RelX="0.040000000000020464" RelY="-0.5899999999999181" /> <Point X="852.0" Y="1088.0" GraphRef="dda29" RelX="-1.0" RelY="-0.02564102564102564" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-203973" /> </Interaction> <Interaction GraphId="b2f2e"> <Comment Source="Reactome">The multimeric SEC16 complex marks sites of ER exit (ERES) and helps to localize nascent COPII coat complexes through interaction with SEC23 and SAR1 (Battacharyya et al, 2007; Watson et al, 2006; Hughes et al, 2009; Yorimitsu and Sato, 2012; reviewed in Sprangers and Rabouille, 2015). SEC16 may help to prevent premature dissociation of the COPII coats after activation of SEC13 GTPase (Supek et al, 2002; Kung et al, 2012). SEC16 functions with hexameric TFG1, which is recruited to the ERES through direct interaction with SEC16 and is required for cargo traffic out of the ER and for organization of the ER-to-ERGIC boundary (Witte et al, 2001; Beetz et al, 2012; Johnson et al, 2015).</Comment> <BiopaxRef>db4</BiopaxRef> <BiopaxRef>dcf</BiopaxRef> <BiopaxRef>e02</BiopaxRef> <BiopaxRef>bc9</BiopaxRef> <BiopaxRef>e27</BiopaxRef> <BiopaxRef>ceb</BiopaxRef> <BiopaxRef>c7a</BiopaxRef> <BiopaxRef>d3b</BiopaxRef> <BiopaxRef>f41</BiopaxRef> <BiopaxRef>c9e</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="782.0" Y="1177.0" /> <Point X="700.0" Y="1174.0" /> <Anchor Position="0.0" Shape="None" GraphId="c67b8" /> <Anchor Position="0.99" Shape="None" GraphId="e9f44" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694417" /> </Interaction> <Interaction GraphId="b4425"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="551.0" Y="685.0" GraphRef="fa65d" RelX="0.6900000000000546" RelY="2.1399999999999864" /> <Point X="590.0" Y="902.0" GraphRef="deea9" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694441" /> </Interaction> <Interaction GraphId="b46b8"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="305.0" Y="915.0" GraphRef="fa5f4" RelX="0.0" RelY="-1.0" /> <Point X="376.0" Y="886.0" GraphRef="b99e0" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694439" /> </Interaction> <Interaction GraphId="b5a3f"> <Comment Source="Reactome">PP6 dephosphorylates released coat proteins including SEC24, SEC31 and SEC23, allowing them to recycle for further rounds of vesicle budding from the ER (Lord et al, 2011; Bhandari et al, 2013).</Comment> <BiopaxRef>e40</BiopaxRef> <BiopaxRef>a81</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="811.0" Y="622.0" /> <Point X="917.0" Y="623.0" /> <Anchor Position="0.0" Shape="None" GraphId="a0ae9" /> <Anchor Position="0.99" Shape="None" GraphId="f84b9" /> <Anchor Position="0.5" Shape="None" GraphId="c12ed" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694421" /> </Interaction> <Interaction GraphId="b5b06"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="415.0" Y="939.0" GraphRef="de189" RelX="-1.0" RelY="0.0" /> <Point X="376.0" Y="886.0" GraphRef="b99e0" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694439" /> </Interaction> <Interaction GraphId="b7091"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1180.0" Y="1172.0" GraphRef="e3b7d" RelX="-1.2300000000000182" RelY="0.009999999999990905" /> <Point X="1153.0" Y="1177.0" GraphRef="f520b" RelX="1.0" RelY="-0.03225806451612903" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-203977" /> </Interaction> <Interaction GraphId="b7736"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="551.0" Y="685.0" GraphRef="fa65d" RelX="0.6900000000000546" RelY="2.1399999999999864" /> <Point X="506.0" Y="723.0" GraphRef="d9959" RelX="0.9512195121951219" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694441" /> </Interaction> <Interaction GraphId="b88c3"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1227.0" Y="1238.0" GraphRef="b8461" RelX="0.9692307692307692" RelY="0.0" /> <Point X="1257.0" Y="1176.0" GraphRef="f4fab" RelX="15.5" RelY="4.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-203977" /> </Interaction> <Interaction GraphId="b9246"> <Comment Source="Reactome">NSF-dependent hydrolysis of ATP is required to disassociate the cis-SNARE complex, releasing the SNAREs for further rounds of membrane fusion (Mayer et al, 1996; Muller et al, 1999; Muller et al, 2002; Otto et al, 1997; Whiteheart et al, 2004; Yu et al, 1999; Zhao et al, 2012; Shah et al, 2015; reviewed in Sudhof and Rothman, 2009).</Comment> <BiopaxRef>d55</BiopaxRef> <BiopaxRef>abe</BiopaxRef> <BiopaxRef>c13</BiopaxRef> <BiopaxRef>a8a</BiopaxRef> <BiopaxRef>e7b</BiopaxRef> <BiopaxRef>b44</BiopaxRef> <BiopaxRef>ffc</BiopaxRef> <BiopaxRef>b6d</BiopaxRef> <BiopaxRef>f3b</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1310.0" Y="417.0" /> <Point X="1616.0" Y="379.0" /> <Anchor Position="0.0" Shape="None" GraphId="da13e" /> <Anchor Position="0.99" Shape="None" GraphId="e5d85" /> <Anchor Position="0.5" Shape="None" GraphId="ef262" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694425" /> </Interaction> <Interaction GraphId="b9317"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="551.0" Y="685.0" GraphRef="fa65d" RelX="0.6900000000000546" RelY="2.1399999999999864" /> <Point X="578.0" Y="756.0" GraphRef="decc5" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694441" /> </Interaction> <Interaction GraphId="b939f"> <Comment Source="Reactome">Coat release at the ERGIC membrane may be stimulated by CSNK1D-dependent phosphorylation of SEC23 and SEC24 (Lord et al, 2011).</Comment> <BiopaxRef>e40</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="482.0" Y="471.0" /> <Point X="551.0" Y="685.0" /> <Anchor Position="0.0" Shape="None" GraphId="e8d26" /> <Anchor Position="0.99" Shape="None" GraphId="fa65d" /> <Anchor Position="0.5" Shape="None" GraphId="c067a" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694441" /> </Interaction> <Interaction GraphId="b9afb"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="368.0" Y="299.0" GraphRef="d7318" RelX="-0.2300000000000182" RelY="0.30000000000001137" /> <Point X="365.0" Y="313.0" GraphRef="aa21e" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-6814831" /> </Interaction> <Interaction GraphId="b9c5d"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1276.0" Y="524.0" GraphRef="e5384" RelX="-1.0" RelY="0.0" /> <Point X="1085.0" Y="423.0" GraphRef="e9fea" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694423" /> </Interaction> <Interaction GraphId="bad7f"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="898.0" Y="1211.0" GraphRef="a4d79" RelX="-0.4800000000000182" RelY="-0.2899999999999636" /> <Point X="882.0" Y="1207.0" GraphRef="f269a" RelX="-0.007874015748031496" RelY="0.9591836734693877" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694522" /> </Interaction> <Interaction GraphId="bfe9e"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1333.0" Y="1207.0" GraphRef="e7a00" RelX="-1.0" RelY="-0.034482758620689655" /> <Point X="1303.0" Y="1171.0" GraphRef="d5a32" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-203977" /> </Interaction> <Interaction GraphId="c0511"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="551.0" Y="685.0" GraphRef="fa65d" RelX="0.6900000000000546" RelY="2.1399999999999864" /> <Point X="623.0" Y="483.0" GraphRef="ce77d" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694441" /> </Interaction> <Interaction GraphId="c0b0f"> <Comment Source="Reactome">SAR1:GTP recruits the cytoplasmic SEC23:SEC24 complex. SEC24, and to a lesser extent SEC23, also mediate interaction with COPII cargo, concentrating it into the emerging vesicle. 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TBC1D20 is the only GAP that has been identified to block delivery of secretory cargo from the ER to the cell surface (Haas et al, 2007).</Comment> <BiopaxRef>e71</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="290.0" Y="298.0" /> <Point X="259.0" Y="280.0" /> <Anchor Position="0.0" Shape="None" GraphId="a7cb1" /> <Anchor Position="0.99" Shape="None" GraphId="e615e" /> <Anchor Position="0.5" Shape="None" GraphId="cacd5" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-6814833" /> </Interaction> <Interaction GraphId="ceeee"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1284.0" Y="576.0" GraphRef="b6623" RelX="-1.0" RelY="0.0" /> <Point X="1085.0" Y="423.0" GraphRef="e9fea" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694423" /> </Interaction> <Interaction GraphId="d2be5"> <Comment Source="Reactome">The outer coat proteins SEC13 and SEC31A are thought to exist in a cytosolic heterohexamer with SEC23IP and are recruited to the ER through interaction with pre-bound SEC23-SEC24 complexes (Stephens et al, 2000; Hammond and Glick, 2000; Ong et al, 2010; reviewed in Szul and Sztul, 2011). v-SNAREs such as the SEC22 proteins are also incorporated into the emerging vesicle through interactions with components of the COPII coat (Xu et al, 2000; Mancias and Goldberg, 2008; Gordon et al, 2010; reviewed in Szul and Sztul, 2011; Lord et al, 2013).</Comment> <BiopaxRef>cbb</BiopaxRef> <BiopaxRef>c85</BiopaxRef> <BiopaxRef>ed6</BiopaxRef> <BiopaxRef>aa9</BiopaxRef> <BiopaxRef>f24</BiopaxRef> <BiopaxRef>b13</BiopaxRef> <BiopaxRef>ea7</BiopaxRef> <BiopaxRef>f2c</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="551.0" Y="1116.0" /> <Point X="428.0" Y="1139.0" /> <Anchor Position="0.0" Shape="None" GraphId="fb67c" /> <Anchor Position="0.99" Shape="None" GraphId="fa072" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-204008" /> </Interaction> <Interaction GraphId="d3ae5"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="374.0" Y="734.0" GraphRef="b5628" RelX="-1.0" RelY="-0.034482758620689655" /> <Point X="341.0" Y="732.0" GraphRef="e8447" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694409" /> </Interaction> <Interaction GraphId="d53a6"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="370.0" Y="1070.0" GraphRef="bf56c" RelX="0.040000000000020464" RelY="-0.5899999999999181" /> <Point X="305.0" Y="1009.0" GraphRef="fa5f4" RelX="0.0" RelY="0.9789473684210527" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-203973" /> </Interaction> <Interaction GraphId="d6cd2"> <Comment Source="Reactome">TRAPPC is a multi-subunit tethering complex that facilitates ER-to-Golgi traffic (reviewed in Barrowman et al, 2010; Brunet and Sacher, 2014). 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reviewed in Brunet and Sacher, 2014).</Comment> <BiopaxRef>df4</BiopaxRef> <BiopaxRef>cde</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="341.0" Y="732.0" /> <Point X="341.0" Y="674.0" /> <Anchor Position="0.0" Shape="None" GraphId="e8447" /> <Anchor Position="0.99" Shape="None" GraphId="e7be4" /> <Anchor Position="0.5" Shape="None" GraphId="f03a5" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694409" /> </Interaction> <Interaction GraphId="e596d"> <Comment Source="Reactome">After membrane fusion, the cis-SNARE complex is dissociated in an ATP-dependent fashion by the AAA protein NSF in conjunction with SNAP proteins (Mayer et al, 1996; Sollner et al, 1993; reviewed in Jahn and Scheller, 2006; Sudhof and Rothman, 2009).</Comment> <BiopaxRef>d55</BiopaxRef> <BiopaxRef>b3c</BiopaxRef> <BiopaxRef>f3b</BiopaxRef> <BiopaxRef>e51</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1085.0" Y="423.0" /> <Point X="1146.0" Y="415.0" /> <Anchor Position="0.0" Shape="None" GraphId="e9fea" /> <Anchor Position="0.99" Shape="None" GraphId="cc444" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694423" /> </Interaction> <Interaction GraphId="e5fe6"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="445.0" Y="865.0" GraphRef="c1813" RelX="-1.0" RelY="-0.037037037037037035" /> <Point X="376.0" Y="886.0" GraphRef="b99e0" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694439" /> </Interaction> <Interaction GraphId="e6c48"> <Comment Source="Reactome">SAR1-GDP is recruited to the ER membrane by the transmembrane GEF (Guanine nucleotide exchange factor) PREB (also known as SEC12), where it is converted to SAR1-GTP. PREB itself is recruited to ER exit sites through interaction with MIA2 (also known as CTAGE5).</Comment> <BiopaxRef>cbb</BiopaxRef> <BiopaxRef>c85</BiopaxRef> <BiopaxRef>ef1</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1303.0" Y="1171.0" /> <Point X="1180.0" Y="1172.0" /> <Anchor Position="0.0" Shape="None" GraphId="d5a32" /> <Anchor Position="0.99" Shape="None" GraphId="e3b7d" /> <Anchor Position="0.5" Shape="None" GraphId="f4fab" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-203977" /> </Interaction> <Interaction GraphId="e71a5"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="293.0" Y="313.0" GraphRef="aa21e" RelX="-1.0" RelY="0.0" /> <Point X="290.0" Y="298.0" GraphRef="a7cb1" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-6814833" /> </Interaction> <Interaction GraphId="e72c8"> <Comment Source="Reactome">Protein protein interactions involving activated RAB1:GTP help dock the ER-derived vesicle on the cis-Golgi membrane (reviewed in Lord et al, 2013) . Independently, RAB:GTP interacts with both the USO1 homodimer (a long coiled coil tethering factor also known as p115) and the GOLGA2 component of the GOLGA2:GORASP1 complex on the cis-Golgi membrane (Allan et al, 2000; Moyer et al, 2001; Weide et al, 2001). USO1 also contacts GOLGA2 directly (Nakamura et al, 1997; Seeman et al, 2000). t-SNARES such as STX5, GOSR1and GOSR2 also participate in this complex on the cis-ERGIC membrane (Brandon et al, 2006; Shorter et al, 2002; reviewed in Brandizzi and Barlowe, 2013).</Comment> <BiopaxRef>ea7</BiopaxRef> <BiopaxRef>cc1</BiopaxRef> <BiopaxRef>d21</BiopaxRef> <BiopaxRef>e2e</BiopaxRef> <BiopaxRef>a71</BiopaxRef> <BiopaxRef>a0b</BiopaxRef> <BiopaxRef>c16</BiopaxRef> <BiopaxRef>e0c</BiopaxRef> <BiopaxRef>bc1</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="405.0" Y="500.0" /> <Point X="362.0" Y="480.0" /> <Anchor Position="0.0" Shape="None" GraphId="a6428" /> <Anchor Position="0.99" Shape="None" GraphId="b5660" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694418" /> </Interaction> <Interaction GraphId="e9537"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="700.0" Y="1174.0" GraphRef="e9f44" 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Source="Reactome">After displacement of the COPII coat, a tetrameric SNAREpin forms between the v-SNARE and the three t-SNARE proteins (Hay et al, 1997; Hay et al, 1998; Hui et al, 1997; Bentley et al, 2006; reviewed in Hong and Lev 2014). This interaction is promoted by the tethering factor USO1 and by the STX5-interacting protein SCFD1 (Wang et al, 2014; Dascher and Balch, 1996; Cao and Barlowe 2000; Flanagan and Barlowe, 2006; reviewed in Lord et al, 2013). 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rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang T, Grabski R, Sztul E, Hay JC.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a17"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">9094723</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hay JC, Chao DS, Kuo CS, Scheller RH.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e27"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25619252</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SEC16 in COPII coat dynamics at ER exit sites.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sprangers J, Rabouille C.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="db9"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8663406</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mammalian Sly1 regulates syntaxin 5 function in endoplasmic reticulum to Golgi transport.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dascher C, Balch WE.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref 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rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sequential interactions with Sec23 control the direction of vesicle traffic.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lord C, Bhandari D, Menon S, Ghassemian M, Nycz D, Hay J, Ghosh P, Ferro-Novick S.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e0c"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11927603</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ed6"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20679433</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">p125A exists as part of the mammalian Sec13/Sec31 COPII subcomplex to facilitate ER-Golgi transport.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ong YS, Tang BL, Loo LS, Hong W.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a0b"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10679020</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The role of the tethering proteins p115 and GM130 in transport through the Golgi apparatus in vivo.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Seemann J, Jokitalo EJ, Warren G.</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">transport pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000103</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> </Biopax> </Pathway>

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