COVID-19 structural coverage map (Homo sapiens)

From WikiPathways

You do not have permission to edit pages, for the following reasons:

• You do not have permission to edit pages in the Pathway namespace.
• You are not allowed to execute the action you have requested.

You can view and copy the source of this page:

<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="COVID-19 structural coverage map" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">This pathway summarizes the structural relationships (mimicking or hijacking) between COVID-19 (SARS-CoV-2) viral proteins and human proteins.</Comment> <BiopaxRef>c73</BiopaxRef> <Graphics BoardWidth="1071.5945220993653" BoardHeight="682.9641313742426" /> <DataNode TextLabel="ISG15" GraphId="a05b4" Type="Protein"> <Graphics CenterX="660.3151024224042" CenterY="188.5107859724437" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P05161" /> </DataNode> <DataNode TextLabel="nsp13" GraphId="a0dad" Type="Protein"> <Graphics CenterX="906.5945220993653" CenterY="279.26620570440764" Width="80.0" Height="20.0" ZOrder="32768" FillColor="ffcccc" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="NCBI Protein" ID="YP_009725308" /> </DataNode> <DataNode TextLabel="APOA1" GraphId="a0f33" Type="Protein"> <Graphics CenterX="654.7363872082973" CenterY="578.2342264477084" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02647" /> </DataNode> <DataNode TextLabel="E" GraphId="a525d" Type="Protein"> <Graphics CenterX="814.637640449438" CenterY="479.26620570440764" Width="90.0" Height="25.0" ZOrder="32768" FillColor="ffcccc" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="Uniprot-TrEMBL" ID="P0DTC4" /> </DataNode> <DataNode TextLabel="PARP14" GraphId="af6b3" Type="Protein"> <Graphics CenterX="443.96316158097113" CenterY="222.8930792132483" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q460N5" /> </DataNode> <DataNode TextLabel="UBA52" GraphId="b75f1" Type="Protein"> <Graphics CenterX="726.0022242893032" CenterY="222.89307921324826" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P62987" /> </DataNode> <DataNode TextLabel="Spike" GraphId="b9c1c" Type="Protein"> <Graphics CenterX="411.86689714779584" CenterY="479.26620570440764" Width="90.0" Height="25.0" ZOrder="32768" FillColor="ffcccc" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="Uniprot-TrEMBL" ID="P0DTC2" /> </DataNode> <DataNode TextLabel="UBB" GraphId="bd5ee" Type="Protein"> <Graphics CenterX="785.6392165105647" CenterY="188.51078597244373" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0CG47" /> </DataNode> <DataNode TextLabel="PAIP1" GraphId="bfffb" Type="Protein"> <Graphics CenterX="568.674469456807" CenterY="222.89307921324826" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9H074" /> </DataNode> <DataNode TextLabel="PARP9" GraphId="c043f" Type="Protein"> <Graphics CenterX="387.7833863000731" CenterY="188.5107859724437" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8IXQ6" /> </DataNode> <DataNode TextLabel="nsp3" GraphId="c15a8" Type="Protein"> <Graphics CenterX="464.09365701082567" CenterY="76.38291481505222" Width="80.0" Height="20.0" ZOrder="32768" FillColor="ffcccc" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="NCBI Protein" ID="YP_009725299" /> </DataNode> <DataNode TextLabel="CMTR1" GraphId="c5903" Type="Protein"> <Graphics CenterX="113.14261019878984" CenterY="572.1227312013824" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N1G2" /> </DataNode> <DataNode TextLabel="NRP1" GraphId="c73ef" Type="Protein"> <Graphics CenterX="479.71974935177184" CenterY="578.2342264477084" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O14786" /> </DataNode> <DataNode TextLabel="ACE2" GraphId="ca2d6" Type="Protein"> <Graphics CenterX="352.9170267934312" CenterY="578.2342264477084" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BYF1" /> </DataNode> <DataNode TextLabel="orf9b" GraphId="cc2bc" Type="Protein"> <Graphics CenterX="972.6231633535006" CenterY="479.26620570440764" Width="90.0" Height="25.0" ZOrder="32768" FillColor="ffcccc" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="Uniprot-TrEMBL" ID="P0DTD2" /> </DataNode> <DataNode TextLabel="SLC6A19" GraphId="cf12b" Type="Protein"> <Graphics CenterX="352.9170267934312" CenterY="640.4641313742426" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q695T7" /> </DataNode> <DataNode TextLabel="MPP5" GraphId="d8b0f" Type="Protein"> <Graphics CenterX="814.637640449438" CenterY="578.2342264477084" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N3R9" /> </DataNode> <DataNode TextLabel="MRM2" GraphId="d913d" Type="Protein"> <Graphics CenterX="223.77355229040597" CenterY="572.1227312013824" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UI43" /> </DataNode> <DataNode TextLabel="43S" GraphId="da2ee" Type="Complex"> <Graphics CenterX="222.05162962916512" CenterY="384.0" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="MACROD1" GraphId="dbcfd" Type="Protein"> <Graphics CenterX="155.28554706066012" CenterY="188.5107859724437" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BQ69" /> </DataNode> <DataNode TextLabel="orf3a" GraphId="dc61f" Type="Protein"> <Graphics CenterX="654.7363872082973" CenterY="479.26620570440764" Width="90.0" Height="25.0" ZOrder="32768" FillColor="ffcccc" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="Uniprot-TrEMBL" ID="P0DTC6" /> </DataNode> <DataNode TextLabel="nsp1" GraphId="dcb93" Type="Protein"> <Graphics CenterX="222.05162962916512" CenterY="279.26620570440764" Width="80.0" Height="20.0" ZOrder="32768" FillColor="ffcccc" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="NCBI Protein" ID="YP_009725297" /> </DataNode> <DataNode TextLabel="IGHMBP2" GraphId="e902d" Type="Protein"> <Graphics CenterX="996.5945220993652" CenterY="377.1227312013824" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P38935" /> </DataNode> <DataNode TextLabel="40S" GraphId="eaa16" Type="Complex"> <Graphics CenterX="117.0" CenterY="384.0" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Complex Portal" ID="CPX-5223" /> </DataNode> <DataNode TextLabel="UBC" GraphId="ebcd7" Type="Protein"> <Graphics CenterX="852.1906426125531" CenterY="222.89307921324826" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0CG48" /> </DataNode> <DataNode TextLabel="GDAP2" GraphId="edde0" Type="Protein"> <Graphics CenterX="99.97007601485194" CenterY="222.8930792132483" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NXN4" /> </DataNode> <DataNode TextLabel="MACROD2" GraphId="f112f" Type="Protein"> <Graphics CenterX="213.19393081174107" CenterY="222.8930792132483" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="A1Z1Q3" /> </DataNode> <DataNode TextLabel="TOMM70" GraphId="f1467" Type="Protein"> <Graphics CenterX="972.6231633535004" CenterY="578.2342264477084" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O94826" /> </DataNode> <DataNode TextLabel="nsp16" GraphId="f24ba" Type="Protein"> <Graphics CenterX="168.63526361279196" CenterY="479.26620570440764" Width="90.0" Height="25.0" ZOrder="32768" FillColor="ffcccc" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="NCBI Protein" ID="YP_009725311" /> </DataNode> <DataNode TextLabel="MACROH2A1" GraphId="f570f" Type="Protein"> <Graphics CenterX="272.83092303300293" CenterY="188.5107859724437" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75367" /> </DataNode> <DataNode TextLabel="UPF1" GraphId="fb403" Type="Protein"> <Graphics CenterX="906.5945220993653" CenterY="377.1227312013824" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q92900" /> </DataNode> <DataNode TextLabel="AQR" GraphId="fc62e" Type="Protein"> <Graphics CenterX="816.5945220993653" CenterY="377.1227312013824" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O60306" /> </DataNode> <DataNode TextLabel="PF-07321332 (Pfizer PAXLOVID)" GraphId="fdbb7" Type="Metabolite"> <Graphics CenterX="714.0" CenterY="279.75" Width="212.0" Height="40.5" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="DrugBank" ID="DB16691" /> </DataNode> <DataNode TextLabel="MACROH2A1" GraphId="c85ab" Type="Protein"> <Graphics CenterX="329.5033517279036" CenterY="222.8930792132483" Width="90.0" Height="25.0" ZOrder="32772" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9P0M6" /> </DataNode> <DataNode TextLabel="UPF2" GraphId="bc079" Type="Protein"> <Graphics CenterX="906.5945220993653" CenterY="442.0209519268021" Width="90.0" Height="25.0" ZOrder="32782" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9HAU5" /> </DataNode> <DataNode TextLabel="80S" GraphId="e0700" Type="Complex"> <Graphics CenterX="332.0" CenterY="384.0" Width="90.0" Height="25.0" ZOrder="32783" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="nsp5" GraphId="bd0fb" Type="Protein"> <Graphics CenterX="520.0516296291651" CenterY="279.26620570440764" Width="80.0" Height="20.0" ZOrder="32784" FillColor="ffcccc" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="NCBI Protein" ID="YP_009725301" /> </DataNode> <DataNode TextLabel="TAB1" GraphId="bff6b" Type="Protein"> <Graphics CenterX="459.59452209936535" CenterY="384.1227312013824" Width="90.0" Height="25.0" ZOrder="32785" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15750" /> </DataNode> <DataNode TextLabel="NLRP12" GraphId="ac5b4" Type="Protein"> <Graphics CenterX="576.5945220993653" CenterY="384.1227312013824" Width="90.0" Height="25.0" ZOrder="32786" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P59046" /> </DataNode> <Interaction GraphId="id17c744dd"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="484.09365701082567" Y="86.38291481505222" GraphRef="c15a8" RelX="0.5" RelY="1.0" /> <Point X="785.6392165105647" Y="176.01078597244373" GraphRef="bd5ee" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id1b34dc8"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="222.05162962916512" Y="289.26620570440764" GraphRef="dcb93" RelX="0.0" RelY="1.0" /> <Point X="277.02581481458253" Y="309.0" /> <Point X="332.0" Y="371.5" GraphRef="e0700" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id1b5dcfbc"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="484.09365701082567" Y="86.38291481505222" GraphRef="c15a8" RelX="0.5" RelY="1.0" /> <Point X="726.0022242893032" Y="210.39307921324826" GraphRef="b75f1" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id2ec68abc"> <BiopaxRef>c73</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="654.7363872082973" Y="491.76620570440764" GraphRef="dc61f" RelX="0.0" RelY="1.0" /> <Point X="654.7363872082973" Y="565.7342264477084" GraphRef="a0f33" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id3530b916"> <BiopaxRef>cf9</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="520.0516296291651" Y="289.26620570440764" GraphRef="bd0fb" RelX="0.0" RelY="1.0" /> <Point X="459.59452209936535" Y="371.6227312013824" GraphRef="bff6b" RelX="0.0" RelY="-1.0" ArrowHead="mim-cleavage" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id43ac5041"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="168.63526361279196" Y="491.76620570440764" GraphRef="f24ba" RelX="0.0" RelY="1.0" /> <Point X="201.27355229040597" Y="559.6227312013824" GraphRef="d913d" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id4a6d0ed4"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="411.86689714779584" Y="491.76620570440764" GraphRef="b9c1c" RelX="0.0" RelY="1.0" /> <Point X="352.9170267934312" Y="565.7342264477084" GraphRef="ca2d6" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id4b0190a8"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="444.09365701082567" Y="86.38291481505222" GraphRef="c15a8" RelX="-0.5" RelY="1.0" /> <Point X="329.5033517279036" Y="210.3930792132483" GraphRef="c85ab" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id4e00a894"> <BiopaxRef>c73</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="814.637640449438" Y="491.76620570440764" GraphRef="a525d" RelX="0.0" RelY="1.0" /> <Point X="814.637640449438" Y="565.7342264477084" GraphRef="d8b0f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id58a990df"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="168.63526361279196" Y="491.76620570440764" GraphRef="f24ba" RelX="0.0" RelY="1.0" /> <Point X="135.64261019878984" Y="559.6227312013824" GraphRef="c5903" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id5eee3adf"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="906.5945220993653" Y="289.26620570440764" GraphRef="a0dad" RelX="0.0" RelY="1.0" /> <Point X="951.5945220993653" Y="344.0972695041712" /> <Point X="996.5945220993653" Y="364.6227312013824" GraphRef="e902d" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id6003e92e"> <BiopaxRef>cf9</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="520.0516296291651" Y="289.26620570440764" GraphRef="bd0fb" RelX="0.0" RelY="1.0" /> <Point X="576.5945220993653" Y="371.6227312013824" GraphRef="ac5b4" RelX="0.0" RelY="-1.0" ArrowHead="mim-cleavage" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id66041830"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="906.5945220993653" Y="289.26620570440764" GraphRef="a0dad" RelX="0.0" RelY="1.0" /> <Point X="906.5945220993653" Y="364.6227312013824" GraphRef="fb403" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id6863394"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="444.09365701082567" Y="86.38291481505222" GraphRef="c15a8" RelX="-0.5" RelY="1.0" /> <Point X="387.7833863000731" Y="176.0107859724437" GraphRef="c043f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id6fa171ec"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="444.09365701082567" Y="86.38291481505222" GraphRef="c15a8" RelX="-0.5" RelY="1.0" /> <Point X="444.0284092958984" Y="105.0" /> <Point X="443.96316158097113" Y="210.3930792132483" GraphRef="af6b3" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id8a5ff58f"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="484.09365701082567" Y="86.38291481505222" GraphRef="c15a8" RelX="0.5" RelY="1.0" /> <Point X="660.3151024224042" Y="176.0107859724437" GraphRef="a05b4" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id9a41f5a1"> <Comment>hijacks</Comment> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="464.09365701082567" Y="86.38291481505222" GraphRef="c15a8" RelX="0.0" RelY="1.0" /> <Point X="516.3840632338163" Y="172.30368714521" /> <Point X="568.674469456807" Y="210.39307921324826" GraphRef="bfffb" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id9a703194"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="411.86689714779584" Y="491.76620570440764" GraphRef="b9c1c" RelX="0.0" RelY="1.0" /> <Point X="479.71974935177184" Y="565.7342264477084" GraphRef="c73ef" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id9c4f9726"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="484.09365701082567" Y="86.38291481505222" GraphRef="c15a8" RelX="0.5" RelY="1.0" /> <Point X="852.1906426125531" Y="210.39307921324826" GraphRef="ebcd7" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="ida1fdb6f3"> <BiopaxRef>c73</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="222.05162962916512" Y="289.26620570440764" GraphRef="dcb93" RelX="0.0" RelY="1.0" /> <Point X="222.05162962916512" Y="371.5" GraphRef="da2ee" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idaa627eba"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="444.09365701082567" Y="86.38291481505222" GraphRef="c15a8" RelX="-0.5" RelY="1.0" /> <Point X="155.28554706066012" Y="176.0107859724437" GraphRef="dbcfd" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idb79fa38f"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="906.5945220993653" Y="289.26620570440764" GraphRef="a0dad" RelX="0.0" RelY="1.0" /> <Point X="861.5945220993653" Y="343.9097625594694" /> <Point X="816.5945220993653" Y="364.6227312013824" GraphRef="fc62e" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idbb46518"> <Comment>hijacks</Comment> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="222.05162962916512" Y="289.26620570440764" GraphRef="dcb93" RelX="0.0" RelY="1.0" /> <Point X="117.0" Y="371.5" GraphRef="eaa16" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idc1ddcb8d"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="444.09365701082567" Y="86.38291481505222" GraphRef="c15a8" RelX="-0.5" RelY="1.0" /> <Point X="213.1939308117411" Y="210.3930792132483" GraphRef="f112f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idce4dd064"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="444.09365701082567" Y="86.38291481505222" GraphRef="c15a8" RelX="-0.5" RelY="1.0" /> <Point X="99.97007601485194" Y="210.3930792132483" GraphRef="edde0" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idd3ea562f"> <BiopaxRef>c73</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="444.09365701082567" Y="86.38291481505222" GraphRef="c15a8" RelX="-0.5" RelY="1.0" /> <Point X="272.83092303300293" Y="176.0107859724437" GraphRef="f570f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="iddf395a60"> <BiopaxRef>c73</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="972.6231633535006" Y="491.76620570440764" GraphRef="cc2bc" RelX="0.0" RelY="1.0" /> <Point X="972.6231633535004" Y="565.7342264477084" GraphRef="f1467" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idf18bb31d"> <BiopaxRef>b64</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="608.0" Y="279.75" GraphRef="fdbb7" RelX="-1.0" RelY="0.0" /> <Point X="560.0516296291651" Y="279.26620570440764" GraphRef="bd0fb" RelX="1.0" RelY="0.0" ArrowHead="mim-inhibition" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idfb6970e2"> <BiopaxRef>c73</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="906.5945220993653" Y="389.6227312013824" GraphRef="fb403" RelX="0.0" RelY="1.0" /> <Point X="906.5945220993653" Y="429.5209519268021" GraphRef="bc079" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idfbff0a88"> <BiopaxRef>c73</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="352.9170267934312" Y="590.7342264477084" GraphRef="ca2d6" RelX="0.0" RelY="1.0" /> <Point X="352.9170267934312" Y="627.9641313742426" GraphRef="cf12b" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Label TextLabel="mimics" GraphId="e42df"> <Graphics CenterX="942.2715118865308" CenterY="331.3789732304379" Width="90.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontStyle="Italic" FontSize="12" Valign="Middle" Color="ff6600" /> </Label> <Label TextLabel="mimics" GraphId="a1fc2"> <Graphics CenterX="372.0596756485328" CenterY="91.4232222901157" Width="90.0" Height="25.0" ZOrder="32773" FillColor="ffffff" FontWeight="Bold" FontStyle="Italic" FontSize="12" Valign="Middle" Color="ff6600" /> </Label> <Label TextLabel="hijacks" GraphId="a03ab"> <Graphics CenterX="506.90525882046137" CenterY="158.3137296250302" Width="90.0" Height="25.0" ZOrder="32774" FillColor="ffffff" FontWeight="Bold" FontStyle="Italic" FontSize="12" Valign="Middle" Color="666666" /> </Label> <Label TextLabel="hijacks" GraphId="a66b6"> <Graphics CenterX="555.0310884941694" CenterY="95.50147284497213" Width="90.0" Height="25.0" ZOrder="32775" FillColor="ffffff" FontWeight="Bold" FontStyle="Italic" FontSize="12" Valign="Middle" Color="666666" /> </Label> <Label TextLabel="mimics" GraphId="c0ef5"> <Graphics CenterX="168.4848482175929" CenterY="526.6216111336494" Width="90.0" Height="25.0" ZOrder="32776" FillColor="ffffff" FontWeight="Bold" FontStyle="Italic" FontSize="12" Valign="Middle" Color="ff6600" /> </Label> <Label TextLabel="hijacks" GraphId="e958d"> <Graphics CenterX="411.83748434550967" CenterY="545.8186724992496" Width="90.0" Height="25.0" ZOrder="32777" FillColor="ffffff" FontWeight="Bold" FontStyle="Italic" FontSize="12" Valign="Middle" Color="666666" /> </Label> <Label TextLabel="?" GraphId="f9033"> <Graphics CenterX="665.5712786411017" CenterY="539.3275713050989" Width="90.0" Height="25.0" ZOrder="32778" FillColor="ffffff" FontWeight="Bold" FontStyle="Italic" FontSize="12" Valign="Middle" Color="cc0033" /> </Label> <Label TextLabel="hijacks" GraphId="a878a"> <Graphics CenterX="839.2964298943419" CenterY="539.3275713050989" Width="90.0" Height="24.99999999999996" ZOrder="32779" FillColor="ffffff" FontWeight="Bold" FontStyle="Italic" FontSize="12" Valign="Middle" Color="666666" /> </Label> <Label TextLabel="hijacks" GraphId="ee57c"> <Graphics CenterX="996.2281498597695" CenterY="539.3275713050989" Width="90.00000000000009" Height="24.99999999999996" ZOrder="32780" FillColor="ffffff" FontWeight="Bold" FontStyle="Italic" FontSize="12" Valign="Middle" Color="666666" /> </Label> <Label TextLabel="hijacks" GraphId="df35a"> <Graphics CenterX="191.6015292893299" CenterY="323.6069179616533" Width="90.0" Height="25.0" ZOrder="32781" FillColor="ffffff" FontWeight="Bold" FontStyle="Italic" FontSize="12" Valign="Middle" Color="666666" /> </Label> <InfoBox CenterX="0.0" CenterY="0.0" /> <Biopax> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">infectious disease pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0001028</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cf9"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">33372854</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Emerg Microbes Infect</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2021</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Moustaqil M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ollivier E</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chiu HP</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Van Tol S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rudolffi-Soto P</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stevens C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bhumkar A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hunter DJB</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Freiberg AN</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jacques D</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lee B</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sierecki E</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gambin Y</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b64"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">34502033</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Exploring the Binding Mechanism of PF-07321332 SARS-CoV-2 Protease Inhibitor through Molecular Dynamics and Binding Free Energy Simulations.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Int J Mol Sci</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2021</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ahmad B</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Batool M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ain QU</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim MS</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Choi S</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">COVID-19</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0080600</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c73"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">34519429</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SARS-CoV-2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mol Syst Biol</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2021</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">O'Donoghue SI</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schafferhans A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sikta N</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stolte C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kaur S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ho BK</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Anderson S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Procter JB</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dallago C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bordin N</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Adcock M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rost B</bp:AUTHORS> </bp:PublicationXref> </Biopax> </Pathway>

• Template:AuthorInfo
• Template:CheckAvailable (protected)
• Template:Help:LiteratureReferences (protected)
• Template:PathwayPage:History
• Template:PathwayPage:Xrefs

Return to COVID-19 structural coverage map (Homo sapiens).