Portal:ExRNA/FeaturedPathways

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{| style="margin: 10px; background-color:#efefef"
{| style="margin: 10px; background-color:#efefef"
|width=100px; cell padding=50px|{{#pwImage:Pathway:WP2583|250px||T-Cell Receptor and Co-stimulatory Signaling}}
|width=100px; cell padding=50px|{{#pwImage:Pathway:WP2583|250px||T-Cell Receptor and Co-stimulatory Signaling}}
-
[http://dx.doi.org/10.1002/hep.27043 Takahashi, et al. Long non-coding RNA in liver diseases]
+
[http://dx.doi.org/10.1002/hep.27043 Takahashi et al. Long non-coding RNA in liver diseases]
|width=100px|{{#pwImage:Pathway:WP2865|250px||IL1 and megakaryotyces in obesity}}
|width=100px|{{#pwImage:Pathway:WP2865|250px||IL1 and megakaryotyces in obesity}}
-
[http://dx.doi.org/10.1161/ATVBAHA.113.302700 Beaulieu, et al. Interleukin 1 receptor 1 and interleukin 1beta regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans]
+
[http://dx.doi.org/10.1161/ATVBAHA.113.302700 Beaulieu et al. Interleukin 1 receptor 1 and interleukin 1beta regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans]
-
|width=100px|{{#pwImage:Pathway:WP2805|250px||RNA interference}}
+
|width=100px|{{#pwImage:Pathway:WP2805|250px||miRNA mechanism of action and biogenesis}}
-
[http://dx.doi.org/10.1016/j.addr.2013.12.008 Ozpolat, et al. Liposomal siRNA nanocarriers for cancer therapy]
+
[http://dx.doi.org/10.1016/j.addr.2013.12.008 Ozpolat et al. Liposomal siRNA nanocarriers for cancer therapy]
-
[http://dx.doi.org/10.1016/j.tig.2014.05.003 Thomas, et al. Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways]
+
[http://dx.doi.org/10.1016/j.tig.2014.05.003 Thomas et al. Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways]
|width=100px|{{#pwImage:Pathway:WP2870|250px||Extracellular vesicle-mediated signaling in recipient cells}}
|width=100px|{{#pwImage:Pathway:WP2870|250px||Extracellular vesicle-mediated signaling in recipient cells}}
-
[http://www.mathivananlab.org/publications Gangoda, et al. Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?]
+
[http://www.ncbi.nlm.nih.gov/pubmed/25307053 Gangoda et al. Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?]
|-
|-
|width=100px|{{#pwImage:Pathway:WP2868|250px||TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer}}
|width=100px|{{#pwImage:Pathway:WP2868|250px||TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer}}
-
[http://dx.doi.org/10.1002/msb.20134892 Yang, et al. Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer]
+
[http://dx.doi.org/10.1002/msb.20134892 Yang et al. Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer]
-
|width=100px|{{#pwImage:Pathway:WP2866|250px||mir34a and TGIF2 in osteoclastogenesis}}
+
|width=100px|{{#pwImage:Pathway:WP3674|250px||mir34a and TGIF2 in osteoclastogenesis}}
-
[http://dx.doi.org/10.1038/nature13375 Krzeszinski, et al. miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2]
+
[http://dx.doi.org/10.1038/nature13375 Krzeszinski et al. miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2]
|width=100px|{{#pwImage:Pathway:WP2811|250px||mir219 in Oligodendrocyte Differentiation and Myelination}}
|width=100px|{{#pwImage:Pathway:WP2811|250px||mir219 in Oligodendrocyte Differentiation and Myelination}}
-
[http://dx.doi.org/10.1002/glia.22606 Pusic, et al. Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination]
+
[http://dx.doi.org/10.1002/glia.22606 Pusic et al. Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination]
|width=100px|{{#pwImage:Pathway:WP2864|250px||Apoptosis-related network due to altered Notch3 in ovarian cancer}}
|width=100px|{{#pwImage:Pathway:WP2864|250px||Apoptosis-related network due to altered Notch3 in ovarian cancer}}
-
[http://dx.doi.org/10.1158/0008-5472.CAN-13-2066 Hu, et al. Notch3 pathway alterations in ovarian cancer]
+
[http://dx.doi.org/10.1158/0008-5472.CAN-13-2066 Hu et al. Notch3 pathway alterations in ovarian cancer]
 +
|-
 +
|width=100px|{{#pwimage:Pathway:WP2928|250px||miR-222 in Exercise-Induced Cardiac Growth}}
 +
[http://dx.doi.org/10.1016/j.cmet.2015.02.014 Liu et al. miR-222 Is Necessary for Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling]
 +
|width=100px|{{#pwimage:Pathway:WP2943|250px||Hypoxia-mediated EMT and Stemness}}
 +
[http://dx.doi.org/10.1038/ncomms6203 van den Beucken et al. Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER]
 +
|width=100px|{{#pwimage:Pathway:WP2942|250px||DDX1 as a regulatory component of the Drosha microprocessor}}
 +
[http://dx.doi.org/10.1016/j.celrep.2014.07.058 Han et al. The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression]
 +
|width=100px|{{#pwimage:Pathway:WP3297|250px||EV release from cardiac cells and their functional effects}}
 +
[http://dx.doi.org/10.5772/58390 Danielson and Das, Extracellular Vesicles in Heart Disease: Excitement for the Future?]
 +
|-
 +
|width=100px|{{#pwimage:Pathway:WP3303|250px||Rac1/Pak1/p38/MMP-2 pathway}}
 +
[http://www.ncbi.nlm.nih.gov/pubmed/25595279 Gonzalez-Villasana et al. Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer]
 +
|width=100px|{{#pwimage:Pathway:WP3302|250px||eIF5A regulation in response to inhibition of the nuclear export system}}
 +
[http://www.ncbi.nlm.nih.gov/pubmed/25878333 Miyake et al. XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A]
 +
|width=100px|{{#pwimage:Pathway:WP3301|250px||MFAP5-mediated ovarian cancer cell motility and invasiveness}}
 +
[http://www.ncbi.nlm.nih.gov/pubmed/25277212 Leung et al. Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential]
 +
|width=100px|{{#pwImage:Pathway:WP3672|250px||LncRNA-mediated mechanisms of therapeutic resistance}}
 +
[http://www.ncbi.nlm.nih.gov/pubmed/27013343 Parasramka et al. Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma]
 +
|-
 +
|width=100px|{{#pwimage:Pathway:WP3926|250px||ApoE and miR-146 in inflammation and atherosclerosis}}
 +
[http://www.ncbi.nlm.nih.gov/pubmed/25904598 Li et al. Apolipoprotein E enhances microRNA-146a in monocytes and macrophages to suppress nuclear factor-κB-driven inflammation and atherosclerosis]
 +
|width=100px|{{#pwimage:Pathway:WP3593|250px||miR-148a/miR-31/FIH1/HIF1α-Notch signaling in glioblastoma}}
 +
[http://www.ncbi.nlm.nih.gov/pubmed/25903473 Wong et al. The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma]
 +
|width=100px|{{#pwimage:Pathway:WP3595|250px||mir-124 predicted interactions with cell cycle and differentiation}}
 +
[http://www.ncbi.nlm.nih.gov/pubmed/26655797 Shields et al. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression]
 +
|width=100px|{{#pwimage:Pathway:WP3596|250px||miR-517 relationship with ARCN1 and USP1}}
 +
[http://www.ncbi.nlm.nih.gov/pubmed/26655797 Shields et al. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression]
 +
|-
 +
|width=100px|{{#pwimage:Pathway:WP3967|250px||miR-509-3p alteration of YAP1/ECM axis}}
 +
[https://www.ncbi.nlm.nih.gov/pubmed/27036018 Pan et al. miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer]
 +
|width=100px|{{#pwimage:Pathway:WP3969|250px||H19 action Rb-E2F1 signaling and CDK-β-catenin activity}}
 +
[https://www.ncbi.nlm.nih.gov/pubmed/27789274 Ohtsuka et al. H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer]
 +
|width=100px|{{#pwimage:Pathway:WP3979|250px||mir-193a and MVP in colon cancer metastasis}}
 +
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321731 Teng et al. H19 MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression]
 +
|width=100px|{{#pwImage:Pathway:WP3982|250px||miRNA regulation of p53 pathway in prostate cancer}}
 +
[https://www.ncbi.nlm.nih.gov/pubmed/27903835 Moustafa et al. Identification of microRNA signature and potential pathway targets in prostate cancer]
 +
|-
 +
|width=100px|{{#pwImage:Pathway:WP3981|250px||miRNA regulation of prostate cancer signaling pathways}}
 +
[https://www.ncbi.nlm.nih.gov/pubmed/27903835 Moustafa et al. Identification of microRNA signature and potential pathway targets in prostate cancer]
 +
|width=100px|{{#pwImage:Pathway:WP4258|250px||LncRNA involvement in canonical Wnt signaling and colorectal cancer}}
 +
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618652/ Shen et al. To Wnt or Lose: The Missing Non-Coding Linc in Colorectal Cancer]
 +
|width=100px|{{#pwImage:Pathway:WP4284|250px||Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer}}
 +
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703849/ Vannini et al. Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs]
 +
|width=100px|{{#pwimage:Pathway:WP4300|250px||Extracellular vesicles in the crosstalk of cardiac cells}}
 +
[https://www.ncbi.nlm.nih.gov/pubmed/29158817 Bei et al. Extracellular Vesicles in Cardiovascular Theranostics.]
 +
|-
 +
|width=100px|{{#pwimage:Pathway:WP4301|250px||Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells}}
 +
[https://www.ncbi.nlm.nih.gov/pubmed/28844715 Datta et al. Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells]
 +
|width=100px|{{#pwimage:Pathway:WP4329|250px||miRNAs in the signaling pathway of the immune response in sepsis}}
 +
[https://www.ncbi.nlm.nih.gov/pubmed/27740627 Giza et al. Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications]
 +
|width=100px|{{#pwimage:Pathway:WP4336|250px||ncRNAs involved in Wnt signaling in hepatocellular carcinoma}}
 +
[http://www.ncbi.nlm.nih.gov/pubmed/28438689 Klingenberg et al. Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets]
 +
|width=100px|{{#pwimage:Pathway:WP4337|250px||ncRNAs involved in STAT3 signaling in hepatocellular carcinoma}}
 +
[http://www.ncbi.nlm.nih.gov/pubmed/28438689 Klingenberg et al. Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets]
 +
|-
 +
|width=100px|{{#pwimage:Pathway:WP4398|250px||PDGFRα and STMN1 cooperate to exacerbate the cytotoxic effects of vinblastine}}
 +
[https://www.ncbi.nlm.nih.gov/pubmed/30082792 Jun et al. A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine]
 +
|width=100px|{{#pwimage:Pathway:WP4397|250px||Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors}}
 +
[https://www.ncbi.nlm.nih.gov/pubmed/29059175 Mitamara et al. Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP)]
 +
|width=100px|{{#pwimage:Pathway:WP4399|250px||MicroRNA network associated with Chronic lymphocytic leukemia}}
 +
[http://www.ncbi.nlm.nih.gov/pubmed/27568792 Ciccone and Calin, MicroRNAs in Chronic Lymphocytic Leukemia: An Old Disease with New Genetic Insights]
 +
|width=100px|{{#pwimage:Pathway:WP4400|250px||FABP4 in ovarian cancer}}
 +
[https://www.ncbi.nlm.nih.gov/pubmed/30050129 Gharpure et al, FABP4 as a key determinant of metastatic potential of ovarian cancer]
 +
|-
 +
|width=100px|{{#pwimage:Pathway:WP4462|250px||Platelet-mediated interactions with vascular and circulating cells}}
 +
[https://www.ncbi.nlm.nih.gov/pubmed/29348254 Koupenova et al, Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis]
 +
|width=100px|{{#pwimage:Pathway:Pathway:WP4474|250px||Circulating monocytes and cardiac macrophages in diastolic dysfunction}}
 +
[https://www.ncbi.nlm.nih.gov/pubmed/29348254 Hulsmans et al, Cardiac macrophages promote diastolic dysfunction]
 +
|width=100px|{{#pwimage:Pathway:Pathway:WP4566|250px||Translational regulation by PDGFRα}}
 +
[https://www.ncbi.nlm.nih.gov/pubmed/30456354 Zhou et al, Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma]
 +
|width=100px|{{#pwimage:Pathway:Pathway:WP4560|250px||MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement}}
 +
[https://www.ncbi.nlm.nih.gov/pubmed/29251630 Leung et al, Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance]
 +
|-
 +
|width=100px|{{#pwimage:Pathway:Pathway:WP4559|250px||Interactions between immune cells and microRNAs in tumor microenvironment}}
 +
[https://www.ncbi.nlm.nih.gov/pubmed/30578699 Cortez et al, Role of miRNAs in immune responses and immunotherapy in cancer]
 +
|width=100px|{{#pwimage:Pathway:WP2059|250px||Alzheimers Disease}}
 +
|width=100px|{{#pwimage:Pathway:WP2371|250px||Parkinsons Disease}}
 +
|width=100px|{{#pwimage:Pathway:WP2904|250px||Mir302-367 Promoting Cardiomyocyte Proliferation}}
|-
|-
|width=100px|{{#pwImage:Pathway:WP1544|250px||MicroRNAs in cardiomyocyte hypertrophy}}
|width=100px|{{#pwImage:Pathway:WP1544|250px||MicroRNAs in cardiomyocyte hypertrophy}}
-
|width=100px|{{#pwImage:Pathway:WP2011|250px||REBF and miR33 in cholesterol and lipid homeostasis}}
+
|width=100px|{{#pwimage:Pathway:WP2512|250px||Integrated Lung Cancer Pathway}}
-
|width=100px|{{#pwImage:Pathway:WP1991|250px||SRF and miRs in Smooth Muscle Differentiation and Proliferation}}
+
|width=100px|{{#pwimage:Pathway:WP2338|250px||miRNA Biogenesis}}
 +
|width=100px|{{#pwimage:Pathway:WP2911|250px||miRNA targets in ECM and membrane receptors}}
 +
|-
 +
|width=100px|{{#pwimage:Pathway:WP1601|250px||Fluoropyrimidine Activity}}
 +
|width=100px|{{#pwimage:Pathway:WP1545|250px||miRNAs involved in DNA damage response}}
 +
|width=100px|{{#pwImage:Pathway:WP2249|250px||Metastatic Brain Tumor}}
 +
|width=100px|{{#pwimage:Pathway:WP673|250px||ErbB Signaling Pathway}}
 +
|-
 +
|width=100px|{{#pwImage:Pathway:WP2431|250px||Spinal Cord Injury}}
|width=100px|{{#pwImage:Pathway:WP1530|250px||miRNA Regulation of DNA Damage Response}}
|width=100px|{{#pwImage:Pathway:WP1530|250px||miRNA Regulation of DNA Damage Response}}
 +
|width=100px|{{#pwImage:Pathway:WP3638|250px||Parkinsons Disease Pathway (Mus musculus)}}
 +
|width=100px|{{#pwImage:Pathway:WP3646|250px||Hepatitis C and Hepatocellular Carcinoma}}
|-
|-
-
|width=100px|{{#pwImage:Pathway:WP2002|250px||miR-targeted genes in epithelium - TarBase}}
+
|width=100px|{{#pwImage:Pathway:WP2249|250px||Metastatic brain tumor}}
 +
|width=100px|{{#pwImage:Pathway:WP3971|250px||Role of Osx and miRNAs in tooth development}}
 +
|width=100px|{{#pwImage:Pathway:WP3991|250px||miR-127 in mesendoderm differentiation}}
 +
|width=100px|{{#pwimage:Pathway:WP2910|250px||Mecp2 and Associated Rett Syndrome}}
 +
|-
 +
|width=100px|{{#pwimage:Pathway:WP2012|250px||miRs in Muscle Cell Differentiation}}
 +
|width=100px|{{#pwImage:Pathway:WP2029|250px||Cell Differentiation}}
 +
|width=100px|{{#pwimage:Pathway:WP2261|250px||Signaling Pathways in Glioblastoma}}
 +
|width=100px|{{#pwImage:Pathway:WP2011|250px||REBF and miR33 in cholesterol and lipid homeostasis}}
 +
|-
 +
|width=100px|{{#pwImage:Pathway:WP2004|250px||miR-targeted genes in lymphocytes - TarBase}}
 +
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
 +
|width=100px|{{#pwImage:Pathway:WP2005|250px||miR-targeted genes in muscle cell - TarBase}}
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
|width=100px|{{#pwImage:Pathway:WP2003|250px||miR-targeted genes in leukocytes - TarBase}}
|width=100px|{{#pwImage:Pathway:WP2003|250px||miR-targeted genes in leukocytes - TarBase}}
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
|width=100px|{{#pwImage:Pathway:WP2006|250px||miR-targeted genes in squamous cell - TarBase}}
|width=100px|{{#pwImage:Pathway:WP2006|250px||miR-targeted genes in squamous cell - TarBase}}
-
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
 
-
|width=100px|{{#pwImage:Pathway:WP1992|250px||TarBasePathway}}
 
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
|-
|-
-
|width=100px|{{#pwImage:Pathway:WP2005|250px||miR-targeted genes in muscle cell - TarBase}}
+
|width=100px|{{#pwImage:Pathway:WP2002|250px||miR-targeted genes in epithelium - TarBase}}
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
-
|width=100px|{{#pwImage:Pathway:WP2004|250px||miR-targeted genes in lymphocytes - TarBase}}
+
|width=100px|{{#pwImage:Pathway:WP1992|250px||TarBasePathway}}
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
|width=100px|{{#pwImage:Pathway:WP2001|250px||miR-targeted genes in adipocytes - TarBase}}
|width=100px|{{#pwImage:Pathway:WP2001|250px||miR-targeted genes in adipocytes - TarBase}}
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
 +
|width=100px|{{#pwimage:Pathway:WP2858|250px||Ectoderm Differentiation}}
 +
|-
 +
|width=100px|{{#pwImage:Pathway:WP2853|250px||Endoderm Differentiation}}
 +
|width=100px|{{#pwimage:Pathway:WP2857|250px||Mesodermal Commitment Pathway}}
 +
|width=100px|{{#pwImage:Pathway:WP1991|250px||SRF and miRs in Smooth Muscle Differentiation and Proliferation}}
|}
|}

Current revision

Image does not exist
T-Cell Receptor and Co-stimulatory Signaling

Takahashi et al. Long non-coding RNA in liver diseases

Image does not exist
IL1 and megakaryotyces in obesity

Beaulieu et al. Interleukin 1 receptor 1 and interleukin 1beta regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans

Image does not exist
miRNA mechanism of action and biogenesis

Ozpolat et al. Liposomal siRNA nanocarriers for cancer therapy Thomas et al. Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways

Image does not exist
Extracellular vesicle-mediated signaling in recipient cells

Gangoda et al. Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?

Image does not exist
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer

Yang et al. Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer

Image does not exist
mir34a and TGIF2 in osteoclastogenesis

Krzeszinski et al. miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2

Image does not exist
mir219 in Oligodendrocyte Differentiation and Myelination

Pusic et al. Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination

Image does not exist
Apoptosis-related network due to altered Notch3 in ovarian cancer

Hu et al. Notch3 pathway alterations in ovarian cancer

Image does not exist
miR-222 in Exercise-Induced Cardiac Growth

Liu et al. miR-222 Is Necessary for Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling

Image does not exist
Hypoxia-mediated EMT and Stemness

van den Beucken et al. Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

Image does not exist
DDX1 as a regulatory component of the Drosha microprocessor

Han et al. The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression

Image does not exist
EV release from cardiac cells and their functional effects

Danielson and Das, Extracellular Vesicles in Heart Disease: Excitement for the Future?

Image does not exist
Rac1/Pak1/p38/MMP-2 pathway

Gonzalez-Villasana et al. Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer

Image does not exist
eIF5A regulation in response to inhibition of the nuclear export system

Miyake et al. XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A

Image does not exist
MFAP5-mediated ovarian cancer cell motility and invasiveness

Leung et al. Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential

Image does not exist
LncRNA-mediated mechanisms of therapeutic resistance

Parasramka et al. Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma

Image does not exist
ApoE and miR-146 in inflammation and atherosclerosis

Li et al. Apolipoprotein E enhances microRNA-146a in monocytes and macrophages to suppress nuclear factor-κB-driven inflammation and atherosclerosis

Image does not exist
miR-148a/miR-31/FIH1/HIF1α-Notch signaling in glioblastoma

Wong et al. The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma

Image does not exist
mir-124 predicted interactions with cell cycle and differentiation

Shields et al. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression

Image does not exist
miR-517 relationship with ARCN1 and USP1

Shields et al. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression

Image does not exist
miR-509-3p alteration of YAP1/ECM axis

Pan et al. miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer

Image does not exist
H19 action Rb-E2F1 signaling and CDK-β-catenin activity

Ohtsuka et al. H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer

Image does not exist
mir-193a and MVP in colon cancer metastasis

Teng et al. H19 MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression

Image does not exist
miRNA regulation of p53 pathway in prostate cancer

Moustafa et al. Identification of microRNA signature and potential pathway targets in prostate cancer

Image does not exist
miRNA regulation of prostate cancer signaling pathways

Moustafa et al. Identification of microRNA signature and potential pathway targets in prostate cancer

Image does not exist
LncRNA involvement in canonical Wnt signaling and colorectal cancer

Shen et al. To Wnt or Lose: The Missing Non-Coding Linc in Colorectal Cancer

Image does not exist
Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer

Vannini et al. Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs

Image does not exist
Extracellular vesicles in the crosstalk of cardiac cells

Bei et al. Extracellular Vesicles in Cardiovascular Theranostics.

Image does not exist
Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells

Datta et al. Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells

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miRNAs in the signaling pathway of the immune response in sepsis

Giza et al. Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications

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ncRNAs involved in Wnt signaling in hepatocellular carcinoma

Klingenberg et al. Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

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ncRNAs involved in STAT3 signaling in hepatocellular carcinoma

Klingenberg et al. Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

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PDGFRα and STMN1 cooperate to exacerbate the cytotoxic effects of vinblastine

Jun et al. A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

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Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors

Mitamara et al. Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP)

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MicroRNA network associated with Chronic lymphocytic leukemia

Ciccone and Calin, MicroRNAs in Chronic Lymphocytic Leukemia: An Old Disease with New Genetic Insights

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FABP4 in ovarian cancer

Gharpure et al, FABP4 as a key determinant of metastatic potential of ovarian cancer

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Platelet-mediated interactions with vascular and circulating cells

Koupenova et al, Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis

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Circulating monocytes and cardiac macrophages in diastolic dysfunction

Hulsmans et al, Cardiac macrophages promote diastolic dysfunction

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Translational regulation by PDGFRα

Zhou et al, Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma

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MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement

Leung et al, Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance

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Interactions between immune cells and microRNAs in tumor microenvironment

Cortez et al, Role of miRNAs in immune responses and immunotherapy in cancer

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Alzheimers Disease
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Parkinsons Disease
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Mir302-367 Promoting Cardiomyocyte Proliferation
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MicroRNAs in cardiomyocyte hypertrophy
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Integrated Lung Cancer Pathway
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miRNA Biogenesis
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miRNA targets in ECM and membrane receptors
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Fluoropyrimidine Activity
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miRNAs involved in DNA damage response
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Metastatic Brain Tumor
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ErbB Signaling Pathway
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Spinal Cord Injury
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miRNA Regulation of DNA Damage Response
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Parkinsons Disease Pathway (Mus musculus)
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Hepatitis C and Hepatocellular Carcinoma
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Metastatic brain tumor
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Role of Osx and miRNAs in tooth development
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miR-127 in mesendoderm differentiation
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Mecp2 and Associated Rett Syndrome
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miRs in Muscle Cell Differentiation
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Cell Differentiation
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Signaling Pathways in Glioblastoma
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REBF and miR33 in cholesterol and lipid homeostasis
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miR-targeted genes in lymphocytes - TarBase

TarBase

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miR-targeted genes in muscle cell - TarBase

TarBase

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miR-targeted genes in leukocytes - TarBase

TarBase

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miR-targeted genes in squamous cell - TarBase

TarBase

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miR-targeted genes in epithelium - TarBase

TarBase

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TarBasePathway

TarBase

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miR-targeted genes in adipocytes - TarBase

TarBase

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Ectoderm Differentiation
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Endoderm Differentiation
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Mesodermal Commitment Pathway
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SRF and miRs in Smooth Muscle Differentiation and Proliferation
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