Portal:ExRNA/FeaturedPathways

T-Cell Receptor and Co-stimulatory Signaling

Takahashi et al. Long non-coding RNA in liver diseases

IL1 and megakaryotyces in obesity

Beaulieu et al. Interleukin 1 receptor 1 and interleukin 1beta regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans

miRNA mechanism of action and biogenesis

Ozpolat et al. Liposomal siRNA nanocarriers for cancer therapy Thomas et al. Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways

Extracellular vesicle-mediated signaling in recipient cells

Gangoda et al. Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?

TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer

Yang et al. Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer

mir34a and TGIF2 in osteoclastogenesis

Krzeszinski et al. miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2

mir219 in Oligodendrocyte Differentiation and Myelination

Pusic et al. Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination

Apoptosis-related network due to altered Notch3 in ovarian cancer

Hu et al. Notch3 pathway alterations in ovarian cancer

miR-222 in Exercise-Induced Cardiac Growth

Liu et al. miR-222 Is Necessary for Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling

Hypoxia-mediated EMT and Stemness

van den Beucken et al. Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

DDX1 as a regulatory component of the Drosha microprocessor

Han et al. The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression

EV release from cardiac cells and their functional effects

Danielson and Das, Extracellular Vesicles in Heart Disease: Excitement for the Future?

Rac1/Pak1/p38/MMP-2 pathway

Gonzalez-Villasana et al. Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer

eIF5A regulation in response to inhibition of the nuclear export system

Miyake et al. XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A

MFAP5-mediated ovarian cancer cell motility and invasiveness

Leung et al. Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential

LncRNA-mediated mechanisms of therapeutic resistance

Parasramka et al. Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma

ApoE and miR-146 in inflammation and atherosclerosis

Li et al. Apolipoprotein E enhances microRNA-146a in monocytes and macrophages to suppress nuclear factor-κB-driven inflammation and atherosclerosis

miR-148a/miR-31/FIH1/HIF1α-Notch signaling in glioblastoma

Wong et al. The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma

mir-124 predicted interactions with cell cycle and differentiation

Shields et al. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression

miR-517 relationship with ARCN1 and USP1

Shields et al. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression

miR-509-3p alteration of YAP1/ECM axis

Pan et al. miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer

H19 action Rb-E2F1 signaling and CDK-β-catenin activity

Ohtsuka et al. H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer

mir-193a and MVP in colon cancer metastasis

Teng et al. H19 MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression

miRNA regulation of p53 pathway in prostate cancer

Moustafa et al. Identification of microRNA signature and potential pathway targets in prostate cancer

miRNA regulation of prostate cancer signaling pathways

Moustafa et al. Identification of microRNA signature and potential pathway targets in prostate cancer

LncRNA involvement in canonical Wnt signaling and colorectal cancer

Shen et al. To Wnt or Lose: The Missing Non-Coding Linc in Colorectal Cancer

Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer

Vannini et al. Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs

Extracellular vesicles in the crosstalk of cardiac cells

Bei et al. Extracellular Vesicles in Cardiovascular Theranostics.

Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells

Datta et al. Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells

miRNAs in the signaling pathway of the immune response in sepsis

Giza et al. Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications

ncRNAs involved in Wnt signaling in hepatocellular carcinoma

Klingenberg et al. Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

ncRNAs involved in STAT3 signaling in hepatocellular carcinoma

Klingenberg et al. Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

PDGFRα and STMN1 cooperate to exacerbate the cytotoxic effects of vinblastine

Jun et al. A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors

Mitamara et al. Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP)

MicroRNA network associated with Chronic lymphocytic leukemia

Ciccone and Calin, MicroRNAs in Chronic Lymphocytic Leukemia: An Old Disease with New Genetic Insights

FABP4 in ovarian cancer

Gharpure et al, FABP4 as a key determinant of metastatic potential of ovarian cancer

Platelet-mediated interactions with vascular and circulating cells

Koupenova et al, Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis

Circulating monocytes and cardiac macrophages in diastolic dysfunction

Hulsmans et al, Cardiac macrophages promote diastolic dysfunction

Translational regulation by PDGFRα

Zhou et al, Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma

MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement

Leung et al, Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance

Interactions between immune cells and microRNAs in tumor microenvironment

Cortez et al, Role of miRNAs in immune responses and immunotherapy in cancer

Status:1
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miR-targeted genes in lymphocytes - TarBase

TarBase

miR-targeted genes in muscle cell - TarBase

TarBase

miR-targeted genes in leukocytes - TarBase

TarBase

miR-targeted genes in squamous cell - TarBase

TarBase

miR-targeted genes in epithelium - TarBase

TarBase

TarBasePathway

TarBase

miR-targeted genes in adipocytes - TarBase

TarBase