Portal:ExRNA/FeaturedPathways
From WikiPathways
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Current revision (21:17, 13 May 2019) (view source) (removed deleted pathway) |
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{| style="margin: 10px; background-color:#efefef" | {| style="margin: 10px; background-color:#efefef" | ||
|width=100px; cell padding=50px|{{#pwImage:Pathway:WP2583|250px||T-Cell Receptor and Co-stimulatory Signaling}} | |width=100px; cell padding=50px|{{#pwImage:Pathway:WP2583|250px||T-Cell Receptor and Co-stimulatory Signaling}} | ||
- | [http://dx.doi.org/10.1002/hep.27043 Takahashi | + | [http://dx.doi.org/10.1002/hep.27043 Takahashi et al. Long non-coding RNA in liver diseases] |
|width=100px|{{#pwImage:Pathway:WP2865|250px||IL1 and megakaryotyces in obesity}} | |width=100px|{{#pwImage:Pathway:WP2865|250px||IL1 and megakaryotyces in obesity}} | ||
- | [http://dx.doi.org/10.1161/ATVBAHA.113.302700 Beaulieu | + | [http://dx.doi.org/10.1161/ATVBAHA.113.302700 Beaulieu et al. Interleukin 1 receptor 1 and interleukin 1beta regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans] |
- | |width=100px|{{#pwImage:Pathway:WP2805|250px|| | + | |width=100px|{{#pwImage:Pathway:WP2805|250px||miRNA mechanism of action and biogenesis}} |
- | [http://dx.doi.org/10.1016/j.addr.2013.12.008 Ozpolat | + | [http://dx.doi.org/10.1016/j.addr.2013.12.008 Ozpolat et al. Liposomal siRNA nanocarriers for cancer therapy] |
- | [http://dx.doi.org/10.1016/j.tig.2014.05.003 Thomas | + | [http://dx.doi.org/10.1016/j.tig.2014.05.003 Thomas et al. Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways] |
|width=100px|{{#pwImage:Pathway:WP2870|250px||Extracellular vesicle-mediated signaling in recipient cells}} | |width=100px|{{#pwImage:Pathway:WP2870|250px||Extracellular vesicle-mediated signaling in recipient cells}} | ||
- | [http://www.ncbi.nlm.nih.gov/pubmed/25307053 Gangoda | + | [http://www.ncbi.nlm.nih.gov/pubmed/25307053 Gangoda et al. Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?] |
|- | |- | ||
|width=100px|{{#pwImage:Pathway:WP2868|250px||TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer}} | |width=100px|{{#pwImage:Pathway:WP2868|250px||TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer}} | ||
- | [http://dx.doi.org/10.1002/msb.20134892 Yang | + | [http://dx.doi.org/10.1002/msb.20134892 Yang et al. Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer] |
- | |width=100px|{{#pwImage:Pathway: | + | |width=100px|{{#pwImage:Pathway:WP3674|250px||mir34a and TGIF2 in osteoclastogenesis}} |
- | [http://dx.doi.org/10.1038/nature13375 Krzeszinski | + | [http://dx.doi.org/10.1038/nature13375 Krzeszinski et al. miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2] |
|width=100px|{{#pwImage:Pathway:WP2811|250px||mir219 in Oligodendrocyte Differentiation and Myelination}} | |width=100px|{{#pwImage:Pathway:WP2811|250px||mir219 in Oligodendrocyte Differentiation and Myelination}} | ||
- | [http://dx.doi.org/10.1002/glia.22606 Pusic | + | [http://dx.doi.org/10.1002/glia.22606 Pusic et al. Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination] |
|width=100px|{{#pwImage:Pathway:WP2864|250px||Apoptosis-related network due to altered Notch3 in ovarian cancer}} | |width=100px|{{#pwImage:Pathway:WP2864|250px||Apoptosis-related network due to altered Notch3 in ovarian cancer}} | ||
- | [http://dx.doi.org/10.1158/0008-5472.CAN-13-2066 Hu | + | [http://dx.doi.org/10.1158/0008-5472.CAN-13-2066 Hu et al. Notch3 pathway alterations in ovarian cancer] |
+ | |- | ||
+ | |width=100px|{{#pwimage:Pathway:WP2928|250px||miR-222 in Exercise-Induced Cardiac Growth}} | ||
+ | [http://dx.doi.org/10.1016/j.cmet.2015.02.014 Liu et al. miR-222 Is Necessary for Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling] | ||
+ | |width=100px|{{#pwimage:Pathway:WP2943|250px||Hypoxia-mediated EMT and Stemness}} | ||
+ | [http://dx.doi.org/10.1038/ncomms6203 van den Beucken et al. Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER] | ||
+ | |width=100px|{{#pwimage:Pathway:WP2942|250px||DDX1 as a regulatory component of the Drosha microprocessor}} | ||
+ | [http://dx.doi.org/10.1016/j.celrep.2014.07.058 Han et al. The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression] | ||
+ | |width=100px|{{#pwimage:Pathway:WP3297|250px||EV release from cardiac cells and their functional effects}} | ||
+ | [http://dx.doi.org/10.5772/58390 Danielson and Das, Extracellular Vesicles in Heart Disease: Excitement for the Future?] | ||
+ | |- | ||
+ | |width=100px|{{#pwimage:Pathway:WP3303|250px||Rac1/Pak1/p38/MMP-2 pathway}} | ||
+ | [http://www.ncbi.nlm.nih.gov/pubmed/25595279 Gonzalez-Villasana et al. Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer] | ||
+ | |width=100px|{{#pwimage:Pathway:WP3302|250px||eIF5A regulation in response to inhibition of the nuclear export system}} | ||
+ | [http://www.ncbi.nlm.nih.gov/pubmed/25878333 Miyake et al. XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A] | ||
+ | |width=100px|{{#pwimage:Pathway:WP3301|250px||MFAP5-mediated ovarian cancer cell motility and invasiveness}} | ||
+ | [http://www.ncbi.nlm.nih.gov/pubmed/25277212 Leung et al. Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential] | ||
+ | |width=100px|{{#pwImage:Pathway:WP3672|250px||LncRNA-mediated mechanisms of therapeutic resistance}} | ||
+ | [http://www.ncbi.nlm.nih.gov/pubmed/27013343 Parasramka et al. Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma] | ||
+ | |- | ||
+ | |width=100px|{{#pwimage:Pathway:WP3926|250px||ApoE and miR-146 in inflammation and atherosclerosis}} | ||
+ | [http://www.ncbi.nlm.nih.gov/pubmed/25904598 Li et al. Apolipoprotein E enhances microRNA-146a in monocytes and macrophages to suppress nuclear factor-κB-driven inflammation and atherosclerosis] | ||
+ | |width=100px|{{#pwimage:Pathway:WP3593|250px||miR-148a/miR-31/FIH1/HIF1α-Notch signaling in glioblastoma}} | ||
+ | [http://www.ncbi.nlm.nih.gov/pubmed/25903473 Wong et al. The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma] | ||
+ | |width=100px|{{#pwimage:Pathway:WP3595|250px||mir-124 predicted interactions with cell cycle and differentiation}} | ||
+ | [http://www.ncbi.nlm.nih.gov/pubmed/26655797 Shields et al. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression] | ||
+ | |width=100px|{{#pwimage:Pathway:WP3596|250px||miR-517 relationship with ARCN1 and USP1}} | ||
+ | [http://www.ncbi.nlm.nih.gov/pubmed/26655797 Shields et al. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression] | ||
+ | |- | ||
+ | |width=100px|{{#pwimage:Pathway:WP3967|250px||miR-509-3p alteration of YAP1/ECM axis}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pubmed/27036018 Pan et al. miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer] | ||
+ | |width=100px|{{#pwimage:Pathway:WP3969|250px||H19 action Rb-E2F1 signaling and CDK-β-catenin activity}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pubmed/27789274 Ohtsuka et al. H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer] | ||
+ | |width=100px|{{#pwimage:Pathway:WP3979|250px||mir-193a and MVP in colon cancer metastasis}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321731 Teng et al. H19 MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression] | ||
+ | |width=100px|{{#pwImage:Pathway:WP3982|250px||miRNA regulation of p53 pathway in prostate cancer}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pubmed/27903835 Moustafa et al. Identification of microRNA signature and potential pathway targets in prostate cancer] | ||
+ | |- | ||
+ | |width=100px|{{#pwImage:Pathway:WP3981|250px||miRNA regulation of prostate cancer signaling pathways}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pubmed/27903835 Moustafa et al. Identification of microRNA signature and potential pathway targets in prostate cancer] | ||
+ | |width=100px|{{#pwImage:Pathway:WP4258|250px||LncRNA involvement in canonical Wnt signaling and colorectal cancer}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618652/ Shen et al. To Wnt or Lose: The Missing Non-Coding Linc in Colorectal Cancer] | ||
+ | |width=100px|{{#pwImage:Pathway:WP4284|250px||Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703849/ Vannini et al. Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs] | ||
+ | |width=100px|{{#pwimage:Pathway:WP4300|250px||Extracellular vesicles in the crosstalk of cardiac cells}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pubmed/29158817 Bei et al. Extracellular Vesicles in Cardiovascular Theranostics.] | ||
+ | |- | ||
+ | |width=100px|{{#pwimage:Pathway:WP4301|250px||Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pubmed/28844715 Datta et al. Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells] | ||
+ | |width=100px|{{#pwimage:Pathway:WP4329|250px||miRNAs in the signaling pathway of the immune response in sepsis}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pubmed/27740627 Giza et al. Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications] | ||
+ | |width=100px|{{#pwimage:Pathway:WP4336|250px||ncRNAs involved in Wnt signaling in hepatocellular carcinoma}} | ||
+ | [http://www.ncbi.nlm.nih.gov/pubmed/28438689 Klingenberg et al. Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets] | ||
+ | |width=100px|{{#pwimage:Pathway:WP4337|250px||ncRNAs involved in STAT3 signaling in hepatocellular carcinoma}} | ||
+ | [http://www.ncbi.nlm.nih.gov/pubmed/28438689 Klingenberg et al. Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets] | ||
+ | |- | ||
+ | |width=100px|{{#pwimage:Pathway:WP4398|250px||PDGFRα and STMN1 cooperate to exacerbate the cytotoxic effects of vinblastine}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pubmed/30082792 Jun et al. A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine] | ||
+ | |width=100px|{{#pwimage:Pathway:WP4397|250px||Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pubmed/29059175 Mitamara et al. Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP)] | ||
+ | |width=100px|{{#pwimage:Pathway:WP4399|250px||MicroRNA network associated with Chronic lymphocytic leukemia}} | ||
+ | [http://www.ncbi.nlm.nih.gov/pubmed/27568792 Ciccone and Calin, MicroRNAs in Chronic Lymphocytic Leukemia: An Old Disease with New Genetic Insights] | ||
+ | |width=100px|{{#pwimage:Pathway:WP4400|250px||FABP4 in ovarian cancer}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pubmed/30050129 Gharpure et al, FABP4 as a key determinant of metastatic potential of ovarian cancer] | ||
+ | |- | ||
+ | |width=100px|{{#pwimage:Pathway:WP4462|250px||Platelet-mediated interactions with vascular and circulating cells}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pubmed/29348254 Koupenova et al, Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis] | ||
+ | |width=100px|{{#pwimage:Pathway:Pathway:WP4474|250px||Circulating monocytes and cardiac macrophages in diastolic dysfunction}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pubmed/29348254 Hulsmans et al, Cardiac macrophages promote diastolic dysfunction] | ||
+ | |width=100px|{{#pwimage:Pathway:Pathway:WP4566|250px||Translational regulation by PDGFRα}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pubmed/30456354 Zhou et al, Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma] | ||
+ | |width=100px|{{#pwimage:Pathway:Pathway:WP4560|250px||MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pubmed/29251630 Leung et al, Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance] | ||
+ | |- | ||
+ | |width=100px|{{#pwimage:Pathway:Pathway:WP4559|250px||Interactions between immune cells and microRNAs in tumor microenvironment}} | ||
+ | [https://www.ncbi.nlm.nih.gov/pubmed/30578699 Cortez et al, Role of miRNAs in immune responses and immunotherapy in cancer] | ||
+ | |width=100px|{{#pwimage:Pathway:WP2059|250px||Alzheimers Disease}} | ||
+ | |width=100px|{{#pwimage:Pathway:WP2371|250px||Parkinsons Disease}} | ||
+ | |width=100px|{{#pwimage:Pathway:WP2904|250px||Mir302-367 Promoting Cardiomyocyte Proliferation}} | ||
+ | |- | ||
+ | |width=100px|{{#pwImage:Pathway:WP1544|250px||MicroRNAs in cardiomyocyte hypertrophy}} | ||
+ | |width=100px|{{#pwimage:Pathway:WP2512|250px||Integrated Lung Cancer Pathway}} | ||
+ | |width=100px|{{#pwimage:Pathway:WP2338|250px||miRNA Biogenesis}} | ||
+ | |width=100px|{{#pwimage:Pathway:WP2911|250px||miRNA targets in ECM and membrane receptors}} | ||
+ | |- | ||
+ | |width=100px|{{#pwimage:Pathway:WP1601|250px||Fluoropyrimidine Activity}} | ||
+ | |width=100px|{{#pwimage:Pathway:WP1545|250px||miRNAs involved in DNA damage response}} | ||
+ | |width=100px|{{#pwImage:Pathway:WP2249|250px||Metastatic Brain Tumor}} | ||
+ | |width=100px|{{#pwimage:Pathway:WP673|250px||ErbB Signaling Pathway}} | ||
+ | |- | ||
+ | |width=100px|{{#pwImage:Pathway:WP2431|250px||Spinal Cord Injury}} | ||
+ | |width=100px|{{#pwImage:Pathway:WP1530|250px||miRNA Regulation of DNA Damage Response}} | ||
+ | |width=100px|{{#pwImage:Pathway:WP3638|250px||Parkinsons Disease Pathway (Mus musculus)}} | ||
+ | |width=100px|{{#pwImage:Pathway:WP3646|250px||Hepatitis C and Hepatocellular Carcinoma}} | ||
+ | |- | ||
+ | |width=100px|{{#pwImage:Pathway:WP2249|250px||Metastatic brain tumor}} | ||
+ | |width=100px|{{#pwImage:Pathway:WP3971|250px||Role of Osx and miRNAs in tooth development}} | ||
+ | |width=100px|{{#pwImage:Pathway:WP3991|250px||miR-127 in mesendoderm differentiation}} | ||
+ | |width=100px|{{#pwimage:Pathway:WP2910|250px||Mecp2 and Associated Rett Syndrome}} | ||
|- | |- | ||
|width=100px|{{#pwimage:Pathway:WP2012|250px||miRs in Muscle Cell Differentiation}} | |width=100px|{{#pwimage:Pathway:WP2012|250px||miRs in Muscle Cell Differentiation}} | ||
+ | |width=100px|{{#pwImage:Pathway:WP2029|250px||Cell Differentiation}} | ||
+ | |width=100px|{{#pwimage:Pathway:WP2261|250px||Signaling Pathways in Glioblastoma}} | ||
|width=100px|{{#pwImage:Pathway:WP2011|250px||REBF and miR33 in cholesterol and lipid homeostasis}} | |width=100px|{{#pwImage:Pathway:WP2011|250px||REBF and miR33 in cholesterol and lipid homeostasis}} | ||
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- | |width=100px|{{#pwImage:Pathway: | + | |width=100px|{{#pwImage:Pathway:WP2004|250px||miR-targeted genes in lymphocytes - TarBase}} |
+ | [http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase] | ||
+ | |width=100px|{{#pwImage:Pathway:WP2005|250px||miR-targeted genes in muscle cell - TarBase}} | ||
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase] | [http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase] | ||
|width=100px|{{#pwImage:Pathway:WP2003|250px||miR-targeted genes in leukocytes - TarBase}} | |width=100px|{{#pwImage:Pathway:WP2003|250px||miR-targeted genes in leukocytes - TarBase}} | ||
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase] | [http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase] | ||
|width=100px|{{#pwImage:Pathway:WP2006|250px||miR-targeted genes in squamous cell - TarBase}} | |width=100px|{{#pwImage:Pathway:WP2006|250px||miR-targeted genes in squamous cell - TarBase}} | ||
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[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase] | [http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase] | ||
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- | |width=100px|{{#pwImage:Pathway: | + | |width=100px|{{#pwImage:Pathway:WP2002|250px||miR-targeted genes in epithelium - TarBase}} |
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase] | [http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase] | ||
- | |width=100px|{{#pwImage:Pathway: | + | |width=100px|{{#pwImage:Pathway:WP1992|250px||TarBasePathway}} |
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase] | [http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase] | ||
|width=100px|{{#pwImage:Pathway:WP2001|250px||miR-targeted genes in adipocytes - TarBase}} | |width=100px|{{#pwImage:Pathway:WP2001|250px||miR-targeted genes in adipocytes - TarBase}} | ||
[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase] | [http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase] | ||
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|width=100px|{{#pwimage:Pathway:WP2858|250px||Ectoderm Differentiation}} | |width=100px|{{#pwimage:Pathway:WP2858|250px||Ectoderm Differentiation}} | ||
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- | |width=100px|{{# | + | |width=100px|{{#pwImage:Pathway:WP2853|250px||Endoderm Differentiation}} |
- | |width=100px|{{#pwimage:Pathway: | + | |width=100px|{{#pwimage:Pathway:WP2857|250px||Mesodermal Commitment Pathway}} |
- | + | |width=100px|{{#pwImage:Pathway:WP1991|250px||SRF and miRs in Smooth Muscle Differentiation and Proliferation}} | |
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Current revision
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