Portal:ExRNA/FeaturedPathways

From WikiPathways

(Difference between revisions)

Current revision

Image does not exist T-Cell Receptor and Co-stimulatory Signaling Takahashi et al. Long non-coding RNA in liver diseases	Image does not exist IL1 and megakaryotyces in obesity Beaulieu et al. Interleukin 1 receptor 1 and interleukin 1beta regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans	Image does not exist miRNA mechanism of action and biogenesis Ozpolat et al. Liposomal siRNA nanocarriers for cancer therapy Thomas et al. Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways	Image does not exist Extracellular vesicle-mediated signaling in recipient cells Gangoda et al. Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?
Image does not exist TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer Yang et al. Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer	Image does not exist mir34a and TGIF2 in osteoclastogenesis Krzeszinski et al. miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2	Image does not exist mir219 in Oligodendrocyte Differentiation and Myelination Pusic et al. Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination	Image does not exist Apoptosis-related network due to altered Notch3 in ovarian cancer Hu et al. Notch3 pathway alterations in ovarian cancer
Image does not exist miR-222 in Exercise-Induced Cardiac Growth Liu et al. miR-222 Is Necessary for Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling	Image does not exist Hypoxia-mediated EMT and Stemness van den Beucken et al. Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER	Image does not exist DDX1 as a regulatory component of the Drosha microprocessor Han et al. The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression	Image does not exist EV release from cardiac cells and their functional effects Danielson and Das, Extracellular Vesicles in Heart Disease: Excitement for the Future?
Image does not exist Rac1/Pak1/p38/MMP-2 pathway Gonzalez-Villasana et al. Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer	Image does not exist eIF5A regulation in response to inhibition of the nuclear export system Miyake et al. XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A	Image does not exist MFAP5-mediated ovarian cancer cell motility and invasiveness Leung et al. Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential	Image does not exist LncRNA-mediated mechanisms of therapeutic resistance Parasramka et al. Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma
Image does not exist ApoE and miR-146 in inflammation and atherosclerosis Li et al. Apolipoprotein E enhances microRNA-146a in monocytes and macrophages to suppress nuclear factor-κB-driven inflammation and atherosclerosis	Image does not exist miR-148a/miR-31/FIH1/HIF1α-Notch signaling in glioblastoma Wong et al. The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma	Image does not exist mir-124 predicted interactions with cell cycle and differentiation Shields et al. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression	Image does not exist miR-517 relationship with ARCN1 and USP1 Shields et al. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression
Image does not exist miR-509-3p alteration of YAP1/ECM axis Pan et al. miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer	Image does not exist H19 action Rb-E2F1 signaling and CDK-β-catenin activity Ohtsuka et al. H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer	Image does not exist mir-193a and MVP in colon cancer metastasis Teng et al. H19 MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression	Image does not exist miRNA regulation of p53 pathway in prostate cancer Moustafa et al. Identification of microRNA signature and potential pathway targets in prostate cancer
Image does not exist miRNA regulation of prostate cancer signaling pathways Moustafa et al. Identification of microRNA signature and potential pathway targets in prostate cancer	Image does not exist LncRNA involvement in canonical Wnt signaling and colorectal cancer Shen et al. To Wnt or Lose: The Missing Non-Coding Linc in Colorectal Cancer	Image does not exist Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer Vannini et al. Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs	Image does not exist Extracellular vesicles in the crosstalk of cardiac cells Bei et al. Extracellular Vesicles in Cardiovascular Theranostics.
Image does not exist Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells Datta et al. Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells	Image does not exist miRNAs in the signaling pathway of the immune response in sepsis Giza et al. Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications	Image does not exist ncRNAs involved in Wnt signaling in hepatocellular carcinoma Klingenberg et al. Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets	Image does not exist ncRNAs involved in STAT3 signaling in hepatocellular carcinoma Klingenberg et al. Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets
Image does not exist PDGFRα and STMN1 cooperate to exacerbate the cytotoxic effects of vinblastine Jun et al. A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine	Image does not exist Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors Mitamara et al. Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP)	Image does not exist MicroRNA network associated with Chronic lymphocytic leukemia Ciccone and Calin, MicroRNAs in Chronic Lymphocytic Leukemia: An Old Disease with New Genetic Insights	Image does not exist FABP4 in ovarian cancer Gharpure et al, FABP4 as a key determinant of metastatic potential of ovarian cancer
Image does not exist Platelet-mediated interactions with vascular and circulating cells Koupenova et al, Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis	Image does not exist Circulating monocytes and cardiac macrophages in diastolic dysfunction Hulsmans et al, Cardiac macrophages promote diastolic dysfunction	Image does not exist Translational regulation by PDGFRα Zhou et al, Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma	Image does not exist MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement Leung et al, Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance
Image does not exist Interactions between immune cells and microRNAs in tumor microenvironment Cortez et al, Role of miRNAs in immune responses and immunotherapy in cancer	Image does not exist Alzheimers Disease	Image does not exist Parkinsons Disease	Image does not exist Mir302-367 Promoting Cardiomyocyte Proliferation
Image does not exist MicroRNAs in cardiomyocyte hypertrophy	Image does not exist Integrated Lung Cancer Pathway	Image does not exist miRNA Biogenesis	Image does not exist miRNA targets in ECM and membrane receptors
Image does not exist Fluoropyrimidine Activity	Image does not exist miRNAs involved in DNA damage response	Image does not exist Metastatic Brain Tumor	Image does not exist ErbB Signaling Pathway
Image does not exist Spinal Cord Injury	Image does not exist miRNA Regulation of DNA Damage Response	Image does not exist Parkinsons Disease Pathway (Mus musculus)	Image does not exist Hepatitis C and Hepatocellular Carcinoma
Image does not exist Metastatic brain tumor	Image does not exist Role of Osx and miRNAs in tooth development	Image does not exist miR-127 in mesendoderm differentiation	Image does not exist Mecp2 and Associated Rett Syndrome
Image does not exist miRs in Muscle Cell Differentiation	Image does not exist Cell Differentiation	Image does not exist Signaling Pathways in Glioblastoma	Image does not exist REBF and miR33 in cholesterol and lipid homeostasis
Image does not exist miR-targeted genes in lymphocytes - TarBase TarBase	Image does not exist miR-targeted genes in muscle cell - TarBase TarBase	Image does not exist miR-targeted genes in leukocytes - TarBase TarBase	Image does not exist miR-targeted genes in squamous cell - TarBase TarBase
Image does not exist miR-targeted genes in epithelium - TarBase TarBase	Image does not exist TarBasePathway TarBase	Image does not exist miR-targeted genes in adipocytes - TarBase TarBase	Image does not exist Ectoderm Differentiation
Image does not exist Endoderm Differentiation	Image does not exist Mesodermal Commitment Pathway	Image does not exist SRF and miRs in Smooth Muscle Differentiation and Proliferation

@@ Line 4: / Line 4: @@
 |width=100px|{{#pwImage:Pathway:WP2865|250px||IL1 and megakaryotyces in obesity}}
 [http://dx.doi.org/10.1161/ATVBAHA.113.302700 Beaulieu et al. Interleukin 1 receptor 1 and interleukin 1beta regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans]
-|width=100px|{{#pwImage:Pathway:WP2805|250px||RNA interference}}
+|width=100px|{{#pwImage:Pathway:WP2805|250px||miRNA mechanism of action and biogenesis}}
 [http://dx.doi.org/10.1016/j.addr.2013.12.008 Ozpolat et al. Liposomal siRNA nanocarriers for cancer therapy]
 [http://dx.doi.org/10.1016/j.tig.2014.05.003 Thomas et al. Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways]
@@ Line 12: / Line 12: @@
 |width=100px|{{#pwImage:Pathway:WP2868|250px||TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer}}
 [http://dx.doi.org/10.1002/msb.20134892 Yang et al. Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer]
-|width=100px|{{#pwImage:Pathway:WP2866|250px||mir34a and TGIF2 in osteoclastogenesis}}
+|width=100px|{{#pwImage:Pathway:WP3674|250px||mir34a and TGIF2 in osteoclastogenesis}}
 [http://dx.doi.org/10.1038/nature13375 Krzeszinski et al. miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2]
 |width=100px|{{#pwImage:Pathway:WP2811|250px||mir219 in Oligodendrocyte Differentiation and Myelination}}
@@ Line 37: / Line 37: @@
 [http://www.ncbi.nlm.nih.gov/pubmed/27013343 Parasramka et al. Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma]
 |-
-|width=100px|{{#pwimage:Pathway:WP3592|250px||ApoE and miR-146 in inflammation and atherosclerosis}}
+|width=100px|{{#pwimage:Pathway:WP3926|250px||ApoE and miR-146 in inflammation and atherosclerosis}}
 [http://www.ncbi.nlm.nih.gov/pubmed/25904598 Li et al. Apolipoprotein E enhances microRNA-146a in monocytes and macrophages to suppress nuclear factor-κB-driven inflammation and atherosclerosis]
 |width=100px|{{#pwimage:Pathway:WP3593|250px||miR-148a/miR-31/FIH1/HIF1α-Notch signaling in glioblastoma}}
@@ Line 52: / Line 52: @@
 |width=100px|{{#pwimage:Pathway:WP3979|250px||mir-193a and MVP in colon cancer metastasis}}
 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321731 Teng et al. H19 MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression]
-|width=100px|{{#pwimage:Pathway:WP2261|250px||Signaling Pathways in Glioblastoma}}
+|width=100px|{{#pwImage:Pathway:WP3982|250px||miRNA regulation of p53 pathway in prostate cancer}}
+[https://www.ncbi.nlm.nih.gov/pubmed/27903835 Moustafa et al. Identification of microRNA signature and potential pathway targets in prostate cancer]
 |-
-|width=100px|{{#pwimage:Pathway:WP2012|250px||miRs in Muscle Cell Differentiation}}
+|width=100px|{{#pwImage:Pathway:WP3981|250px||miRNA regulation of prostate cancer signaling pathways}}
-|width=100px|{{#pwImage:Pathway:WP2011|250px||REBF and miR33 in cholesterol and lipid homeostasis}}
+[https://www.ncbi.nlm.nih.gov/pubmed/27903835 Moustafa et al. Identification of microRNA signature and potential pathway targets in prostate cancer]
-|width=100px|{{#pwImage:Pathway:WP1991|250px||SRF and miRs in Smooth Muscle Differentiation and Proliferation}}
+|width=100px|{{#pwImage:Pathway:WP4258|250px||LncRNA involvement in canonical Wnt signaling and colorectal cancer}}
-|width=100px|{{#pwimage:Pathway:WP2910|250px||Mecp2 and Associated Rett Syndrome}}
+[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618652/ Shen et al. To Wnt or Lose: The Missing Non-Coding Linc in Colorectal Cancer]
+|width=100px|{{#pwImage:Pathway:WP4284|250px||Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer}}
+[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703849/ Vannini et al. Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs]
+|width=100px|{{#pwimage:Pathway:WP4300|250px||Extracellular vesicles in the crosstalk of cardiac cells}}
+[https://www.ncbi.nlm.nih.gov/pubmed/29158817 Bei et al. Extracellular Vesicles in Cardiovascular Theranostics.]
 |-
-|width=100px|{{#pwImage:Pathway:WP2029|250px||Cell Differentiation}}
+|width=100px|{{#pwimage:Pathway:WP4301|250px||Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells}}
-|width=100px|{{#pwImage:Pathway:WP2853|250px||Endoderm Differentiation}}
+[https://www.ncbi.nlm.nih.gov/pubmed/28844715 Datta et al. Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells]
-|width=100px|{{#pwimage:Pathway:WP2858|250px||Ectoderm Differentiation}}
+|width=100px|{{#pwimage:Pathway:WP4329|250px||miRNAs in the signaling pathway of the immune response in sepsis}}
-|width=100px|{{#pwimage:Pathway:WP2857|250px||Mesodermal Commitment Pathway}}
+[https://www.ncbi.nlm.nih.gov/pubmed/27740627 Giza et al. Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications]
+|width=100px|{{#pwimage:Pathway:WP4336|250px||ncRNAs involved in Wnt signaling in hepatocellular carcinoma}}
+[http://www.ncbi.nlm.nih.gov/pubmed/28438689 Klingenberg et al. Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets]
+|width=100px|{{#pwimage:Pathway:WP4337|250px||ncRNAs involved in STAT3 signaling in hepatocellular carcinoma}}
+[http://www.ncbi.nlm.nih.gov/pubmed/28438689 Klingenberg et al. Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets]
 |-
-|width=100px|{{#pwimage:Pathway:WP673|250px||ErbB Signaling Pathway}}
+|width=100px|{{#pwimage:Pathway:WP4398|250px||PDGFRα and STMN1 cooperate to exacerbate the cytotoxic effects of vinblastine}}
-|width=100px|{{#pwimage:Pathway:WP2904|250px||Mir302-367 Promoting Cardiomyocyte Proliferation}}
+[https://www.ncbi.nlm.nih.gov/pubmed/30082792 Jun et al. A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine]
+|width=100px|{{#pwimage:Pathway:WP4397|250px||Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors}}
+[https://www.ncbi.nlm.nih.gov/pubmed/29059175 Mitamara et al. Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP)]
+|width=100px|{{#pwimage:Pathway:WP4399|250px||MicroRNA network associated with Chronic lymphocytic leukemia}}
+[http://www.ncbi.nlm.nih.gov/pubmed/27568792 Ciccone and Calin, MicroRNAs in Chronic Lymphocytic Leukemia: An Old Disease with New Genetic Insights]
+|width=100px|{{#pwimage:Pathway:WP4400|250px||FABP4 in ovarian cancer}}
+[https://www.ncbi.nlm.nih.gov/pubmed/30050129 Gharpure et al, FABP4 as a key determinant of metastatic potential of ovarian cancer]
+|-
+|width=100px|{{#pwimage:Pathway:WP4462|250px||Platelet-mediated interactions with vascular and circulating cells}}
+[https://www.ncbi.nlm.nih.gov/pubmed/29348254 Koupenova et al, Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis]
+|width=100px|{{#pwimage:Pathway:Pathway:WP4474|250px||Circulating monocytes and cardiac macrophages in diastolic dysfunction}}
+[https://www.ncbi.nlm.nih.gov/pubmed/29348254 Hulsmans et al, Cardiac macrophages promote diastolic dysfunction]
+|width=100px|{{#pwimage:Pathway:Pathway:WP4566|250px||Translational regulation by PDGFRα}}
+[https://www.ncbi.nlm.nih.gov/pubmed/30456354 Zhou et al, Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma]
+|width=100px|{{#pwimage:Pathway:Pathway:WP4560|250px||MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement}}
+[https://www.ncbi.nlm.nih.gov/pubmed/29251630 Leung et al, Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance]
+|-
+|width=100px|{{#pwimage:Pathway:Pathway:WP4559|250px||Interactions between immune cells and microRNAs in tumor microenvironment}}
+[https://www.ncbi.nlm.nih.gov/pubmed/30578699 Cortez et al, Role of miRNAs in immune responses and immunotherapy in cancer]
 |width=100px|{{#pwimage:Pathway:WP2059|250px||Alzheimers Disease}}
 |width=100px|{{#pwimage:Pathway:WP2371|250px||Parkinsons Disease}}
+|width=100px|{{#pwimage:Pathway:WP2904|250px||Mir302-367 Promoting Cardiomyocyte Proliferation}}
 |-
 |width=100px|{{#pwImage:Pathway:WP1544|250px||MicroRNAs in cardiomyocyte hypertrophy}}
@@ Line 77: / Line 105: @@
 |width=100px|{{#pwimage:Pathway:WP1545|250px||miRNAs involved in DNA damage response}}
 |width=100px|{{#pwImage:Pathway:WP2249|250px||Metastatic Brain Tumor}}
-|width=100px|{{#pwimage:Pathway:WP1901|250px||Regulatory RNA pathways}}
+|width=100px|{{#pwimage:Pathway:WP673|250px||ErbB Signaling Pathway}}
 |-
 |width=100px|{{#pwImage:Pathway:WP2431|250px||Spinal Cord Injury}}
@@ Line 86: / Line 114: @@
 |width=100px|{{#pwImage:Pathway:WP2249|250px||Metastatic brain tumor}}
 |width=100px|{{#pwImage:Pathway:WP3971|250px||Role of Osx and miRNAs in tooth development}}
-|width=100px|{{#pwImage:Pathway:WP2002|250px||miR-targeted genes in epithelium - TarBase}}
+|width=100px|{{#pwImage:Pathway:WP3991|250px||miR-127 in mesendoderm differentiation}}
-[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
+|width=100px|{{#pwimage:Pathway:WP2910|250px||Mecp2 and Associated Rett Syndrome}}
-|width=100px|{{#pwImage:Pathway:WP2001|250px||miR-targeted genes in adipocytes - TarBase}}
+|-
-[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
+|width=100px|{{#pwimage:Pathway:WP2012|250px||miRs in Muscle Cell Differentiation}}
+|width=100px|{{#pwImage:Pathway:WP2029|250px||Cell Differentiation}}
+|width=100px|{{#pwimage:Pathway:WP2261|250px||Signaling Pathways in Glioblastoma}}
+|width=100px|{{#pwImage:Pathway:WP2011|250px||REBF and miR33 in cholesterol and lipid homeostasis}}
 |-
 |width=100px|{{#pwImage:Pathway:WP2004|250px||miR-targeted genes in lymphocytes - TarBase}}
@@ Line 100: / Line 131: @@
 [http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
 |-
+|width=100px|{{#pwImage:Pathway:WP2002|250px||miR-targeted genes in epithelium - TarBase}}
+[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
 |width=100px|{{#pwImage:Pathway:WP1992|250px||TarBasePathway}}
 [http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
+|width=100px|{{#pwImage:Pathway:WP2001|250px||miR-targeted genes in adipocytes - TarBase}}
+[http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index TarBase]
+|width=100px|{{#pwimage:Pathway:WP2858|250px||Ectoderm Differentiation}}
+|-
+|width=100px|{{#pwImage:Pathway:WP2853|250px||Endoderm Differentiation}}
+|width=100px|{{#pwimage:Pathway:WP2857|250px||Mesodermal Commitment Pathway}}
+|width=100px|{{#pwImage:Pathway:WP1991|250px||SRF and miRs in Smooth Muscle Differentiation and Proliferation}}
 |}

Portal:ExRNA/FeaturedPathways

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