Portal:Disease/COVIDPathways

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Lipid metabolism alternations that are related to infection by the corona virus.
Lipid metabolism alternations that are related to infection by the corona virus.
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== More about ACE2 ==
== More about ACE2 ==

Revision as of 19:04, 29 May 2020


Welcome to the COVID-19 Pathway Collection

This special subset of disease pathways is being highlighted during the current COVID-19 crisis. This content is released under a CC0 waiver to be freely used, reused and distributed. Let us know if you add a new pathway or want to recommend one for this collection.

The current list of authors and contributors of content of this portal: Friederike Ehrhart, Alex Pico, Kristina Hanspers, Amber Koning, Rex D A B, Penny Nymark, Denise Slenter, Caroline Thorn, the Reactome project, Chris Evelo, Lauren Dupuis, Matthew Conroy, Martina Kutmon, Marvin Martens, and many more.

We also thank the authors of all the cited articles (recursively).


SARS-CoV-2 Pathways

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SARS-CoV-2 and COVID-19 Pathway

Collaborative project for curation biological processes involved in the COVID-19 disease after SARS-Cov-2 infection.

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Hijack of Ubiquitination by SARS-CoV-2

SARS-CoV-2 includes a novel Orf10 that interacts with muliple members of the Cullin 2 ubiquitin ligase complex.

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Integrative stress response in SARS-CoV-2 infection
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Type I Interferon Induction and Signaling During SARS-CoV-2 Infection

The induction and signaling of type I interferon with specific SARS-CoV-2 protein and relevant drug.

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Activation of NLRP3 Inflammasome by SARS-CoV-2

Orf3a from SARS-CoV has been shown to bind TRAF3 and activate the NLRP3 inflammasome.

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SARS-CoV-2 and Angiotensin-converting enzyme 2 (ACE2) receptor : Molecular mechanisms and potential therapeutic target
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COVID-19 AOP

Experimental pathway to investigate overlap of virus-host interaction and adverse outcome pathways

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nsp9/nsp10-mediated SARS-CoV-2 pathogenesis

Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

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LDLRAD4 pathway in COVID-19
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COVID-19, thrombosis and anticoagulation

Other coronaviruses: MERS, SARS-CoV-2, etc

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Coronavirus lipid metabolism

Lipid metabolism alternations that are related to infection by the corona virus.

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Host-pathogen interaction of human corona viruses - autophagy
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Host-pathogen interaction of human corona viruses - apoptosis
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SARS coronavirus and innate immunity
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Host-pathogen interaction of human corona viruses - ER stress
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Downregulation of ACE2 expression by SARS-CoV infection and SARS-CoV Spike protein
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Host-pathogen interaction of human corona viruses - MAPK signaling
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Host-pathogen interaction of human corona viruses - Interferon induction

More about ACE2

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ACE Inhibitor Pathway
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Metabolism of Angiotensinogen to Angiotensins (Reactome)
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