Portal:CPTAC/Hallmark/Growth
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(Added WP4204) |
Current revision (20:19, 14 June 2022) (view source) (removed "needs work" pathway) |
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| + | In addition to inducing and sustaining positively acting growth-stimulatory signals, cancer cells must also circumvent powerful programs that negatively regulate cell proliferation. | ||
| + | Often these are tumor suppressor genes, that are often mutated in cancer cells. Two examples of this are RB and TP53. (Adapted from [https://www.ncbi.nlm.nih.gov/pubmed/21376230 Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011]) | ||
*[[Pathway:WP2446]] Retinoblastoma (RB) in Cancer | *[[Pathway:WP2446]] Retinoblastoma (RB) in Cancer | ||
*[[Pathway:WP179]] Cell Cycle | *[[Pathway:WP179]] Cell Cycle | ||
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*[[Pathway:WP366]] TGF-beta Signaling Pathway | *[[Pathway:WP366]] TGF-beta Signaling Pathway | ||
*[[Pathway:WP4204]] Tumor suppressor activity of SMARCB1 | *[[Pathway:WP4204]] Tumor suppressor activity of SMARCB1 | ||
| + | *[[Pathway:WP4284]] Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer | ||
Current revision
In addition to inducing and sustaining positively acting growth-stimulatory signals, cancer cells must also circumvent powerful programs that negatively regulate cell proliferation. Often these are tumor suppressor genes, that are often mutated in cancer cells. Two examples of this are RB and TP53. (Adapted from Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011)
- Pathway:WP2446 Retinoblastoma (RB) in Cancer
- Pathway:WP179 Cell Cycle
- Pathway:WP45 G1 toS cell cycle control
- Pathway:WP560 TGF-beta Receptor Signaling
- Pathway:WP366 TGF-beta Signaling Pathway
- Pathway:WP4204 Tumor suppressor activity of SMARCB1
- Pathway:WP4284 Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer
