G alpha (q) signaling events (Homo sapiens)

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362186, 244, 13, 15, 25, 28232, 301, 26109, 14, 33155, 11cytosolGDP NPSR1 DAG P2RY11 PROKR2 GNGT1 ADP RGS21 OXTR G-protein alpha(q):GRK2BDKRB1 BUT G-protein alpha(q/11):PI3K alphathrombin light chain GTP AGTR1 GNA14 GNA14 GNB1 UTP HTR2A GNB4 Photon 5HT LTC4 PROKR1 TRHR GNB2 P2RY6 GNA11 QRFP GHSR TAC3 GTP ANXA1 LTB4R2 TAC1(58-68) L-Glu GNRHR EDNRA PTGER1 RGS19 HCRTR2 GNRHR2 F2RL2(22-374) GNA14 TRH(135-137) Cysteinyl leukotrienes GNA15 O-octanoyl-L-serine-GHRL-1(24-51) 5HT CASR pH sensing receptors UDP GTPLPAR3 TACR1 NMS TBXA2R GTP GNG11 CH3COO- OXTR P2RY10 ALA LTB4R GPRC6A XCL1 FFAR4 SAA1(19-122) OPN4 PLCB4 GNAQ RGS3 GDP GNA11 LTC4 11,14,17-eicosatrienoic acid GRP(24-50) 11,14,17-eicosatrienoic acid BDKRB1 BDKRB1 RGZ TAC1(58-68) GPRC6A LPA GHSR NPFF(69-76) GNA11 GNA15 G-protein alpha(q/11):GDPGCGR 8,11,14-Eicosatrienoic acid PROKR2 ADRA1D CHRM1 GNG4 PIK3CA LTB4 UDP GNB1 APP(672-713) GCGR PLCB4 ATP GNB5 NTSR2 GNB4 GNGT2 AVPR1A NPFF(69-76) NMB(47-56) TRH(227-229) Endothelin GNA14 P2RY10 GRK5NPFFR1 CHRM5 TRH(227-229) GNA15 PTAFR ADRA1B EDN3(97-117) ADR AGTR1 FFAR4 GNA15 DDCX FFAR4 ligands PROKR1,PROKR2 XCL1 Hist PLCB3 HCRTR1 GAST(76-92) G-protein beta-gammacomplexTRIO GPR17 GNB2 Bombesin-like peptide MLNR OPN4 GNA15 8,11,14-Eicosatrienoic acid GPR39 F2RL3(18-385) Zn2+ EDN1 GNA14 GRM1 LTB4R HTR2B CYSLTR2 SAA1(19-122) RGS2 AVP(20-28) HeterotrimericG-protein Gq/11(inactive)TACR3 GNG10 TXA2 DecS-GHRL-1(24-51) F2RL1(37-397) TAC3 KISS1(68-121) GPR68 PIK3R3 P2RY10 FFAR3 CASR Bombesin-like receptor NTS(151-163) AVP(20-28) MCHR2 EDN2 TRH(114-116) NPFFR1 TACR2 LXA4 Pmoa GNG3 DTTA CCKAR CCK LPAR3 CYSLTR1 DTTA MT-RNR2 GNRH2(24-33) CYSLTR1 HCRTR1 LPAR4 PTGER1 NMS L-Dopa GNA15 PROKR1 L-Glu NPFFR2 P2RY2 FPR2 FFAR3 CASR GCGR PMCH(147-165) GPR68 UTS2B NPSR1 F2RL3(18-385) GNA14 AcCho G-protein alpha(q/11): GTPFPR2 O-octanoyl-L-serine-GHRL-1(24-50) LTD4 PGF2a OLEA GRM1,GRM5 NMB(47-56) GNB1 EtCOO- or C2H5COO- P2RY11 GNGT2 P2RY6 OXT(20-28) GNG13 XCR1 CHRM1, 3, 5 TRH NMUR1 all-cis-icosa-pentaenoic acid GNB5 DHA EDN1 GNAQ TRIO family RhoGEFsGNA11 GNG7 NPFF(69-76) LTB4R,LTB4R2 HCRT(34-66) PTGER1 PGF2a PLCB3 ADRA1D GNAQ TRH(152-154) MCHR1,MCHR2 GNGT1 FPR2 GNRH1(24-33) Valerate Basic L-amino acids HCRT(34-66) NMS LXA4 EDNRB GPRC6A TRH(186-188) LTB4R2 H+ CYSLTR1 Ca2+ GRP(24-50) GPR17 PMCH(147-165) GLA GNG12 AcCho PALM ADRA1A HCOOH GNGT2 GHSR PROK1,PROK2 PGF2a DHA PLC-beta:G-alpha(q/11):DAG:IP3LTB4 CCKAR Photon TRIO FFAR1 G-protein alpha(q):GRK5GRK2 PAF APP(672-713) EtCOO- or C2H5COO- GNG8 AVPR1A,B GNB4 QRFPR CCL23-2 TRHR GNG5 ADR DecS-GHRL-1(24-50) Photon HRH1 AGT(34-41) PLCB2 NTS(151-163) QRFP FFAR3 PMCH(147-165) PGE2 HRH1 GAST(76-92) UTS2B GNB3 BDKRB2 DDCX PTGFR GPR132 P2RY11 L-Dopa OLEA TXA2 ARHGEF25 GNAQ LPAR6 thrombin light chain AGT(34-41) PMCH(147-165) GNRHR2 TBXA2R Bradykinin GNG4 OXT(20-28) GCGR GCG(53-81) GTP thrombin heavy chain PIK3R3 GRM5 O-octanoyl-L-serine-GHRL-1(24-50) Zn2+ TACR3 GNG2 XCR1 Effects of PIP2hydrolysisHTR2A GRPR GRM5 LPAR2 AVP(20-28) GHSR KISS1R GNG13 ADRA1A ALA DecS-GHRL-1(24-51) Bradykinin LTE4 LTE4 all-cis-icosa-pentaenoic acid Hist NMUR1 GNGT2 AGT(34-41) GNG10 EDNRB NAd MLNR Pmoa TAC3 CYSLTR2 CHRM1 ADP CCKBR GNB2 GNRH1(24-33) STEA GTP ELDA NMUR2 Bradykinin FFAR2 GNA11 HXA NPFFR2 NTS(151-163) FPR2 ligands TXA2 CCKBR PTGER1 LTD4 GNA11 HCRT(70-97) GNA14 GNG13 LXA4 KISS1R STEA GAST(76-92) CCKBR GNRHR NMBR PLCB2 PLCB3 GPR39 ELDA MCHR1 BDKRB2 PGE2 HCRT(34-66) DHA TBXA2R TAC1(58-68) ANXA1 GNA15 PALM GNA11 P2RY1 ADRA1B thrombin heavy chain LPAR1,2,3,5 ANXA1 NPS UDP PLCB1 F2R(27-425) LPAR4 AVP(20-28) GNB3 MYSA HCOOH HTR2C CCKBR GNG4 ARHGEF25 NMU GRK5 PIK3R1 P2RY6 QRFPR GLA XCL1,XCL2 TRH(186-188) CYSLTR2 TAC1(98-107) NPSR1 Zn2+ NPS Bradykinin XCR1 MYSA MYSA CH3COO- 5HT TACR1 GNA11 GPR39 GTP UTS2 CHRM5 TRH(114-116) TRH(152-154) GPR132 LPAR3 AVPR1B TACR3 GNRH ligands OXT(20-28) RGZ DPA GNB4 CCK BDKRB2 UTP PALM FFAR4 CHRM3 CHRM5 GNG10 NMU UTS2R Pentadecanoic acid O-octanoyl-L-serine-GHRL-1(24-50) DDCX TACR1 GNG7 AGTR1 CASR GNB5 MT-RNR2 PAF 5HT NMUR1,NMUR2 EtCOO- or C2H5COO- GNB5 GNA15 F2R(27-425) PTAFR GPR17 GPR143 HCRT(70-97) L-Glu PLCB1 CCKAR HTR2A GNB3 MCHR1 HCRT(70-97) Pmoa SAA1(19-122) RGS18 GNA14 HCRT(34-66) CCK GNRH2(24-33) PGF2a F2RL1(37-397) P2RY2 GNB3 TAC1(58-68) LPAR1 NPFF(69-76) NPFFR1 LPAR2 TRH(84-86) GNG3 thrombin light chain PTAFR Acyl Ghrelin P2RY11 XCR1 GNA15 Pentadecanoic acid P2RY10 UTS2,UTS2B GTP GPR68 Ligand:GPCRcomplexes thatactivate Gq/11CHRM3 H+ ADRA1B F2RL3(18-385) KALRN UTS2 O-octanoyl-L-serine-GHRL-1(24-51) H+ P2RY1 GNAQ AVPR1B GPR143 BRS3 FFAR4 NMBR TBXA2R GPR65 GNA15 Bradykinin receptor BUT KISS1R ATP KISS1(68-121) GNA14 HTR2A-C EDNRB GNG12 MLN(26-47) FFAR3 ligands GNA14 GNG5 8,11,14-Eicosatrienoic acid GNAQ NTSR1 GNAQ AVPR1B TAC1(98-107) all-cis-icosa-pentaenoic acid TRH(135-137) Ca2+ GCG(53-81) F2R(27-425) KISS1(68-121) GNAQ UTS2R Hist GNRH2(24-33) LPA NMUR2 UDP FFAR1 HCRTR2 MLN(26-47) PIK3R2 GNB1 Zn2+ ADRA1A LPAR5 GLA GNG10 LPAR5 NMB(47-56) GNGT1 PGE2 BRS3 GNG7 EDN2 PLCB2 G-protein beta:gammasignallingADP Valerate GPR4 PROK2 GPR132 MT-RNR2 HTR2B EDN1 LTD4 UTS2R NTSR1 OXT(20-28) NMS TACR1 MCHR1 EDNRA NPSR1 GNG2 L-Dopa DecS-GHRL-1(24-51) PAF PROK1 GPR143 GDPPTGFR PROK1 KISS1(68-121) GnRH receptor ATP BRS3 OLEA NMBR LPAR6 GPR65 GPR4 UTP Ligands of GPCRsthat activate Gq/11FPR2 HXA Ca2+ HRH1 FFAR3 GPCRs that activateGq/11HCOOH LPAR2 GNG13 LTB4R TRH(186-188) PI3K alphathrombin heavy chain LPAR6 FFAR1 EDN2 Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (active)XCL1 GNG3 TAC1(98-107) GNG11 PI(4,5)P2 GNG2 LTB4R2 FFAR1 ligands PIK3R2 HCRTR2 LTC4 P2RY6 NPFFR1,NPFFR2 GNRHR ATP Basic L-amino acids P2RY2 NTSR1,NTSR2 OPN4 MLNR GNAQ RGSL1 HCRT(70-97) AGTR1 G-protein alpha(q/11):Trio familyRhoGEFsNMU CCKAR,CCKBR KALRN GNG11 DecS-GHRL-1(24-50) GNG3 I(1,4,5)P3 PROK2 ADR, NAd GRM1 GDP GNRHR2 LPAR4 P2RY1 Photon ADRA1A,B,D NPS GNG5 HRH1 FFAR2 XCL2 GNA11 ADP FFAR2 XCL2 GNA11 CCL23-2 GTP ELDA ADR GNG8 KISS1R QRFPR GPR143 GNG12 PLCB3 TACR3 PTAFR MLN(26-47) GAST(76-92) NTSR2 GNA11 GNAQ TACR2 PLCB1 HTR2B P2RY2 CH3COO- Proteinase-activated receptors UTS2B TRH(114-116) HCRTR2 thrombin heavy chain AcCho GNG12 PTGFR GPRC6A L-Glu PTGFR 11,14,17-eicosatrienoic acid LPA UTS2R Hist STEA PLC-betaPROK2 LPA LTB4 CCK TACR2 GNA15 TRH(135-137) NTSR1 FFAR1 LTE4 CHRM1 GNG2 DPA GNG8 RGS proteins activefor G alpha (q)AGT(34-41) GNG4 P2RY1 PLC-beta:G-alpha(q/11):PIP2F2RL2(22-374) GNG11 GNB2 TAC3 DPA DecS-GHRL-1(24-50) PROKR1 NMUR2 F2RL1(37-397) NAd thrombin light chain TAC1(98-107) OPN4 FFAR2 GPR65 TRH(84-86) HTR2C O-octanoyl-L-serine-GHRL-1(24-51) PIK3R1 MCHR2 LPAR4 I(1,4,5)P3NMUR1 Gastrin-CREBsignalling pathwayvia PKC and MAPKAcCho GNG7 LPAR1 GPR39 HTR2C GRK2LPAR1 NPFFR2 DAGGNGT1 GTP OXTR XCL2 GNAQ PLCB1 Valerate MLN(26-47) FFAR2 ligands TRHR PAF CCL23-2 GNAQ PLCB4 TXA2 LPAR6 F2RL2(22-374) GCG(53-81) EDNRA ADRA1D BUT PIK3CA HCRTR1 Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (inactive)QRFPR TRH(152-154) MCHR2 AVPR1A Pentadecanoic acid QRFP GNG5 NMU CHRM3 QRFP HCRTR1 GCG(53-81) GRM5 Ca2+ GRPR H+ TRH(227-229) HXA CYSLTR1,CYSLTR2 NTS(151-163) GRP(24-50) GPR4 PGE2 NMUR2 GPR17 RGZ MLNR EDN3(97-117) UTS2 NPS ALA GNA14 GNG8 NTSR2 GNA11 EDNRA,EDNRB GRPR DTTA PROKR2 TACR2 AVPR1A Basic L-amino acids EDN3(97-117) GNA14 GRM1 PLCB4 OXTR PLCB2 PROK1 TRHR GNRH1(24-33) GNA15 PLC beta:G alpha(q/11)TRH(84-86) GPRC6A ligands APP(672-713) LPAR5 L-Dopa LTB4 NAd 203, 373, 37227, 17, 18, 3512, 3416, 19, 3127, 323, 373, 37223, 373, 37293, 373, 37


Description

The classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides a path to calcium-regulated kinases and phosphatases, GEFs, MAP kinase cassettes and other proteins that mediate cellular responses ranging from granule secretion, integrin activation, and aggregation in platelets. Gq participates in many other signalling events including direct interaction with RhoGEFs that stimulate RhoA activity and inhibition of PI3K. Both in vitro and in vivo, the G-protein Gq seems to be the predominant mediator of the activation of platelets. Moreover, G alpha (q) can stimulate the activation of Burton tyrosine kinase (Ma Y C et al. 1998). Regulator of G-protein Signalling (RGS) proteins can regulate the activity of G alpha (z) (Soundararajan M et al. 2008). View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 416476
Reactome-version 
Reactome version: 63
Reactome Author 
Reactome Author: Jupe, Steve

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Bibliography

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History

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CompareRevisionActionTimeUserComment
116409view09:05, 7 May 2021EweitzModified title
113243view11:31, 2 November 2020ReactomeTeamReactome version 74
101713view14:51, 1 November 2018DeSlOntology Term : 'G protein mediated signaling pathway via Galphaq family' added !
101370view11:26, 1 November 2018ReactomeTeamreactome version 66
100908view21:01, 31 October 2018ReactomeTeamreactome version 65
100449view19:35, 31 October 2018ReactomeTeamreactome version 64
100273view16:57, 31 October 2018ReactomeTeamNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
11,14,17-eicosatrienoic acid MetaboliteCHEBI:53460 (ChEBI)
5HT MetaboliteCHEBI:28790 (ChEBI)
8,11,14-Eicosatrienoic acid MetaboliteCHEBI:53486 (ChEBI)
ADP MetaboliteCHEBI:16761 (ChEBI)
ADR MetaboliteCHEBI:28918 (ChEBI)
ADR, NAd R-ALL-390627 (Reactome)
ADRA1A ProteinP35348 (Uniprot-TrEMBL)
ADRA1A,B,D R-HSA-390684 (Reactome)
ADRA1B ProteinP35368 (Uniprot-TrEMBL)
ADRA1D ProteinP25100 (Uniprot-TrEMBL)
AGT(34-41) ProteinP01019 (Uniprot-TrEMBL)
AGTR1 ProteinP30556 (Uniprot-TrEMBL)
ALA MetaboliteCHEBI:27432 (ChEBI)
ANXA1 ProteinP04083 (Uniprot-TrEMBL)
APP(672-713) ProteinP05067 (Uniprot-TrEMBL)
ARHGEF25 ProteinQ86VW2 (Uniprot-TrEMBL)
ATP MetaboliteCHEBI:15422 (ChEBI)
AVP(20-28) ProteinP01185 (Uniprot-TrEMBL)
AVPR1A ProteinP37288 (Uniprot-TrEMBL)
AVPR1A,B R-HSA-388458 (Reactome)
AVPR1B ProteinP47901 (Uniprot-TrEMBL)
AcCho MetaboliteCHEBI:15355 (ChEBI)
Acyl Ghrelin R-HSA-422096 (Reactome)
BDKRB1 ProteinP46663 (Uniprot-TrEMBL)
BDKRB2 ProteinP30411 (Uniprot-TrEMBL)
BRS3 ProteinP32247 (Uniprot-TrEMBL)
BUT MetaboliteCHEBI:30772 (ChEBI)
Basic L-amino acids R-ALL-420746 (Reactome)
Bombesin-like peptide R-HSA-375360 (Reactome)
Bombesin-like receptor R-HSA-375362 (Reactome)
Bradykinin ProteinP01042 (Uniprot-TrEMBL)
Bradykinin receptor R-HSA-374323 (Reactome)
CASR ProteinP41180 (Uniprot-TrEMBL)
CCK ProteinP06307 (Uniprot-TrEMBL)
CCKAR ProteinP32238 (Uniprot-TrEMBL)
CCKAR,CCKBR R-HSA-388518 (Reactome)
CCKBR ProteinP32239 (Uniprot-TrEMBL)
CCL23-2 ProteinP55773-2 (Uniprot-TrEMBL)
CH3COO- MetaboliteCHEBI:15366 (ChEBI)
CHRM1 ProteinP11229 (Uniprot-TrEMBL)
CHRM1, 3, 5 R-HSA-390660 (Reactome)
CHRM3 ProteinP20309 (Uniprot-TrEMBL)
CHRM5 ProteinP08912 (Uniprot-TrEMBL)
CYSLTR1 ProteinQ9Y271 (Uniprot-TrEMBL)
CYSLTR1,CYSLTR2 R-HSA-416385 (Reactome)
CYSLTR2 ProteinQ9NS75 (Uniprot-TrEMBL)
Ca2+ MetaboliteCHEBI:29108 (ChEBI)
Cysteinyl leukotrienes R-ALL-416372 (Reactome)
DAG MetaboliteCHEBI:17815 (ChEBI)
DAGMetaboliteCHEBI:17815 (ChEBI)
DDCX MetaboliteCHEBI:30805 (ChEBI)
DHA MetaboliteCHEBI:28125 (ChEBI)
DPA MetaboliteCHEBI:53488 (ChEBI)
DTTA MetaboliteCHEBI:53487 (ChEBI)
DecS-GHRL-1(24-50) ProteinQ9UBU3-1 (Uniprot-TrEMBL)
DecS-GHRL-1(24-51) ProteinQ9UBU3-1 (Uniprot-TrEMBL)
EDN1 ProteinP05305 (Uniprot-TrEMBL)
EDN2 ProteinP20800 (Uniprot-TrEMBL)
EDN3(97-117) ProteinP14138 (Uniprot-TrEMBL)
EDNRA ProteinP25101 (Uniprot-TrEMBL)
EDNRA,EDNRB R-HSA-388547 (Reactome)
EDNRB ProteinP24530 (Uniprot-TrEMBL)
ELDA MetaboliteCHEBI:27997 (ChEBI)
Effects of PIP2 hydrolysisPathwayR-HSA-114508 (Reactome) Hydrolysis of phosphatidyl inositol-bisphosphate (PIP2) by phospholipase C (PLC) produces diacylglycerol (DAG) and inositol triphosphate (IP3). Both are potent second messengers. IP3 diffuses into the cytosol, but as DAG is a hydrophobic lipid it remains within the plasma membrane. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, while DAG activates the conventional and unconventional protein kinase C (PKC) isoforms, facilitating the translocation of PKC from the cytosol to the plasma membrane. The effects of DAG are mimicked by tumor-promoting phorbol esters. DAG is also a precursor for the biosynthesis of prostaglandins, the endocannabinoid 2-arachidonoylglycerol and an activator of a subfamily of TRP-C (Transient Receptor Potential Canonical) cation channels 3, 6, and 7.
Endothelin R-HSA-388544 (Reactome)
EtCOO- or C2H5COO- MetaboliteCHEBI:30768 (ChEBI)
F2R(27-425) ProteinP25116 (Uniprot-TrEMBL) This is the inactive form of the receptor, before protease activation. Proteinase (protease) activated receptors are activated by the cleavage of an N-terminal extracellular segment by serine proteases, particularly thrombin which activates PAR1, 3 and 4. The cleaved fragment is an activating ligand for the receptor; synthetic peptide mimics of the N-terminal fragment can activate uncleaved receptors.
F2RL1(37-397) ProteinP55085 (Uniprot-TrEMBL) This is the inactive form of the receptor, before protease activation. Proteinase (protease) activated receptors are activated by the cleavage of an N-terminal extracellular segment by serine proteases, particularly thrombin which activates PAR1, 3 and 4. The cleaved fragment is an activating ligand for the receptor; synthetic peptide mimics of the N-terminal fragment can activate uncleaved receptors.
F2RL2(22-374) ProteinO00254 (Uniprot-TrEMBL) This is the inactive form of the receptor, before protease activation. Proteinase (protease) activated receptors are activated by the cleavage of an N-terminal extracellular segment by serine proteases, particularly thrombin which activates PAR1, 3 and 4. The cleaved fragment is an activating ligand for the receptor; synthetic peptide mimics of the N-terminal fragment can activate uncleaved receptors.
F2RL3(18-385) ProteinQ96RI0 (Uniprot-TrEMBL) This is the inactive form of the receptor, before protease activation. Proteinase (protease) activated receptors are activated by the cleavage of an N-terminal extracellular segment by serine proteases, particularly thrombin which activates PAR1, 3 and 4. The cleaved fragment is an activating ligand for the receptor; synthetic peptide mimics of the N-terminal fragment can activate uncleaved receptors.
FFAR1 ProteinO14842 (Uniprot-TrEMBL)
FFAR1 ligands R-ALL-400427 (Reactome)
FFAR2 ProteinO15552 (Uniprot-TrEMBL)
FFAR2 ligands R-ALL-444210 (Reactome)
FFAR3 ProteinO14843 (Uniprot-TrEMBL)
FFAR3 ligands R-ALL-444074 (Reactome)
FFAR4 ProteinQ5NUL3 (Uniprot-TrEMBL)
FFAR4 ligands R-ALL-400551 (Reactome)
FPR2 ProteinP25090 (Uniprot-TrEMBL)
FPR2 ligands R-HSA-444472 (Reactome)
G-protein alpha (q):GRK2ComplexR-HSA-416515 (Reactome)
G-protein alpha (q):GRK5ComplexR-HSA-416517 (Reactome)
G-protein alpha (q/11): GTPComplexR-HSA-114534 (Reactome)
G-protein alpha (q/11):GDPComplexR-HSA-114556 (Reactome)
G-protein alpha (q/11):PI3K alphaComplexR-HSA-416356 (Reactome)
G-protein alpha

(q/11):Trio family

RhoGEFs
ComplexR-HSA-400608 (Reactome)
G-protein beta-gamma complexComplexR-HSA-167434 (Reactome)
G-protein beta:gamma signallingPathwayR-HSA-397795 (Reactome) The classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known that Gbeta/gamma subunits can directly modulate many effectors, including some also regulated by G alpha.
GAST(76-92) ProteinP01350 (Uniprot-TrEMBL)
GCG(53-81) ProteinP01275 (Uniprot-TrEMBL)
GCGR ProteinP47871 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GHSR ProteinQ92847 (Uniprot-TrEMBL)
GLA MetaboliteCHEBI:28661 (ChEBI)
GNA11 ProteinP29992 (Uniprot-TrEMBL)
GNA14 ProteinO95837 (Uniprot-TrEMBL)
GNA15 ProteinP30679 (Uniprot-TrEMBL)
GNAQ ProteinP50148 (Uniprot-TrEMBL)
GNB1 ProteinP62873 (Uniprot-TrEMBL)
GNB2 ProteinP62879 (Uniprot-TrEMBL)
GNB3 ProteinP16520 (Uniprot-TrEMBL)
GNB4 ProteinQ9HAV0 (Uniprot-TrEMBL)
GNB5 ProteinO14775 (Uniprot-TrEMBL)
GNG10 ProteinP50151 (Uniprot-TrEMBL)
GNG11 ProteinP61952 (Uniprot-TrEMBL)
GNG12 ProteinQ9UBI6 (Uniprot-TrEMBL)
GNG13 ProteinQ9P2W3 (Uniprot-TrEMBL)
GNG2 ProteinP59768 (Uniprot-TrEMBL)
GNG3 ProteinP63215 (Uniprot-TrEMBL)
GNG4 ProteinP50150 (Uniprot-TrEMBL)
GNG5 ProteinP63218 (Uniprot-TrEMBL)
GNG7 ProteinO60262 (Uniprot-TrEMBL)
GNG8 ProteinQ9UK08 (Uniprot-TrEMBL)
GNGT1 ProteinP63211 (Uniprot-TrEMBL)
GNGT2 ProteinO14610 (Uniprot-TrEMBL)
GNRH ligands R-HSA-873938 (Reactome)
GNRH1(24-33) ProteinP01148 (Uniprot-TrEMBL)
GNRH2(24-33) ProteinO43555 (Uniprot-TrEMBL)
GNRHR ProteinP30968 (Uniprot-TrEMBL)
GNRHR2 ProteinQ96P88 (Uniprot-TrEMBL)
GPCRs that activate Gq/11ComplexR-HSA-791493 (Reactome)
GPR132 ProteinQ9UNW8 (Uniprot-TrEMBL)
GPR143 ProteinP51810 (Uniprot-TrEMBL)
GPR17 ProteinQ13304 (Uniprot-TrEMBL)
GPR39 ProteinO43194 (Uniprot-TrEMBL)
GPR4 ProteinP46093 (Uniprot-TrEMBL)
GPR65 ProteinQ8IYL9 (Uniprot-TrEMBL)
GPR68 ProteinQ15743 (Uniprot-TrEMBL)
GPRC6A ProteinQ5T6X5 (Uniprot-TrEMBL)
GPRC6A ligands R-ALL-420706 (Reactome)
GRK2 ProteinP25098 (Uniprot-TrEMBL)
GRK2ProteinP25098 (Uniprot-TrEMBL)
GRK5 ProteinP34947 (Uniprot-TrEMBL)
GRK5ProteinP34947 (Uniprot-TrEMBL)
GRM1 ProteinQ13255 (Uniprot-TrEMBL)
GRM1,GRM5 R-HSA-420566 (Reactome)
GRM5 ProteinP41594 (Uniprot-TrEMBL)
GRP(24-50) ProteinP07492 (Uniprot-TrEMBL)
GRPR ProteinP30550 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
Gastrin-CREB

signalling pathway

via PKC and MAPK
PathwayR-HSA-881907 (Reactome) Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17.Gastrin gene expression is upregulated in both a number of pre-malignant conditions and in established cancer through a variety of mechanisms. Depending on the tissue where it is expressed and the level of expression, differential processing of the polypeptide product leads to the production of different biologically active peptides. In turn, acting through the classical gastrin cholecystokinin B receptor CCK-BR, its isoforms and alternative receptors, these peptides trigger signalling pathways which influence the expression of downstream genes that affect cell survival, angiogenesis and invasion (Wank 1995, de Weerth et al. 1999, Grabowska & Watson 2007)
GnRH receptor R-HSA-391368 (Reactome)
H+ MetaboliteCHEBI:15378 (ChEBI)
HCOOH MetaboliteCHEBI:30751 (ChEBI)
HCRT(34-66) ProteinO43612 (Uniprot-TrEMBL)
HCRT(70-97) ProteinO43612 (Uniprot-TrEMBL)
HCRTR1 ProteinO43613 (Uniprot-TrEMBL)
HCRTR2 ProteinO43614 (Uniprot-TrEMBL)
HRH1 ProteinP35367 (Uniprot-TrEMBL)
HTR2A ProteinP28223 (Uniprot-TrEMBL)
HTR2A-C R-HSA-391030 (Reactome)
HTR2B ProteinP41595 (Uniprot-TrEMBL)
HTR2C ProteinP28335 (Uniprot-TrEMBL)
HXA MetaboliteCHEBI:17120 (ChEBI)
Heterotrimeric

G-protein Gq/11

(inactive)
ComplexR-HSA-114557 (Reactome)
Hist MetaboliteCHEBI:18295 (ChEBI)
I(1,4,5)P3 MetaboliteCHEBI:16595 (ChEBI)
I(1,4,5)P3MetaboliteCHEBI:16595 (ChEBI)
KALRN ProteinO60229 (Uniprot-TrEMBL)
KISS1(68-121) ProteinQ15726 (Uniprot-TrEMBL)
KISS1R ProteinQ969F8 (Uniprot-TrEMBL)
L-Dopa MetaboliteCHEBI:15765 (ChEBI)
L-Glu MetaboliteCHEBI:29985 (ChEBI)
LPA MetaboliteCHEBI:52288 (ChEBI)
LPAR1 ProteinQ92633 (Uniprot-TrEMBL)
LPAR1,2,3,5 R-HSA-419369 (Reactome)
LPAR2 ProteinQ9HBW0 (Uniprot-TrEMBL)
LPAR3 ProteinQ9UBY5 (Uniprot-TrEMBL)
LPAR4 ProteinQ99677 (Uniprot-TrEMBL)
LPAR5 ProteinQ9H1C0 (Uniprot-TrEMBL)
LPAR6 ProteinP43657 (Uniprot-TrEMBL)
LTB4 MetaboliteCHEBI:15647 (ChEBI)
LTB4R ProteinQ15722 (Uniprot-TrEMBL)
LTB4R,LTB4R2 R-HSA-416401 (Reactome)
LTB4R2 ProteinQ9NPC1 (Uniprot-TrEMBL)
LTC4 MetaboliteCHEBI:16978 (ChEBI)
LTD4 MetaboliteCHEBI:28666 (ChEBI)
LTE4 MetaboliteCHEBI:15650 (ChEBI)
LXA4 MetaboliteCHEBI:6498 (ChEBI)
Ligand:GPCR

complexes that activate

Gq/11:Heterotrimeric G-protein Gq (active)
ComplexR-HSA-749447 (Reactome)
Ligand:GPCR

complexes that activate

Gq/11:Heterotrimeric G-protein Gq (inactive)
ComplexR-HSA-749451 (Reactome)
Ligand:GPCR

complexes that

activate Gq/11
ComplexR-HSA-380110 (Reactome)
Ligands of GPCRs that activate Gq/11ComplexR-HSA-791492 (Reactome)
MCHR1 ProteinQ99705 (Uniprot-TrEMBL)
MCHR1,MCHR2 R-HSA-947667 (Reactome)
MCHR2 ProteinQ969V1 (Uniprot-TrEMBL)
MLN(26-47) ProteinP12872 (Uniprot-TrEMBL)
MLNR ProteinO43193 (Uniprot-TrEMBL)
MT-RNR2 ProteinQ8IVG9 (Uniprot-TrEMBL)
MYSA MetaboliteCHEBI:28875 (ChEBI)
NAd MetaboliteCHEBI:18357 (ChEBI)
NMB(47-56) ProteinP08949 (Uniprot-TrEMBL)
NMBR ProteinP28336 (Uniprot-TrEMBL)
NMS ProteinQ5H8A3 (Uniprot-TrEMBL)
NMU ProteinP48645 (Uniprot-TrEMBL)
NMUR1 ProteinQ9HB89 (Uniprot-TrEMBL)
NMUR1,NMUR2 R-HSA-964805 (Reactome)
NMUR2 ProteinQ9GZQ4 (Uniprot-TrEMBL)
NPFF(69-76) ProteinO15130 (Uniprot-TrEMBL)
NPFFR1 ProteinQ9GZQ6 (Uniprot-TrEMBL)
NPFFR1,NPFFR2 R-HSA-389406 (Reactome)
NPFFR2 ProteinQ9Y5X5 (Uniprot-TrEMBL)
NPS ProteinP0C0P6 (Uniprot-TrEMBL)
NPSR1 ProteinQ6W5P4 (Uniprot-TrEMBL)
NTS(151-163) ProteinP30990 (Uniprot-TrEMBL)
NTSR1 ProteinP30989 (Uniprot-TrEMBL)
NTSR1,NTSR2 R-HSA-388917 (Reactome)
NTSR2 ProteinO95665 (Uniprot-TrEMBL)
O-octanoyl-L-serine-GHRL-1(24-50) ProteinQ9UBU3-1 (Uniprot-TrEMBL)
O-octanoyl-L-serine-GHRL-1(24-51) ProteinQ9UBU3-1 (Uniprot-TrEMBL)
OLEA MetaboliteCHEBI:16196 (ChEBI)
OPN4 ProteinQ9UHM6 (Uniprot-TrEMBL)
OXT(20-28) ProteinP01178 (Uniprot-TrEMBL)
OXTR ProteinP30559 (Uniprot-TrEMBL)
P2RY1 ProteinP47900 (Uniprot-TrEMBL)
P2RY10 ProteinO00398 (Uniprot-TrEMBL)
P2RY11 ProteinQ96G91 (Uniprot-TrEMBL)
P2RY2 ProteinP41231 (Uniprot-TrEMBL)
P2RY6 ProteinQ15077 (Uniprot-TrEMBL)
PAF MetaboliteCHEBI:52450 (ChEBI)
PALM MetaboliteCHEBI:15756 (ChEBI)
PGE2 MetaboliteCHEBI:15551 (ChEBI)
PGF2a MetaboliteCHEBI:15553 (ChEBI)
PI(4,5)P2 MetaboliteCHEBI:18348 (ChEBI)
PI3K alphaComplexR-HSA-198379 (Reactome)
PIK3CA ProteinP42336 (Uniprot-TrEMBL)
PIK3R1 ProteinP27986 (Uniprot-TrEMBL)
PIK3R2 ProteinO00459 (Uniprot-TrEMBL)
PIK3R3 ProteinQ92569 (Uniprot-TrEMBL)
PLC beta:G alpha (q/11)ComplexR-HSA-398158 (Reactome)
PLC-beta:G-alpha(q/11):DAG:IP3ComplexR-HSA-8983509 (Reactome)
PLC-beta:G-alpha(q/11):PIP2ComplexR-HSA-8983508 (Reactome)
PLC-betaComplexR-HSA-111854 (Reactome)
PLCB1 ProteinQ9NQ66 (Uniprot-TrEMBL)
PLCB2 ProteinQ00722 (Uniprot-TrEMBL)
PLCB3 ProteinQ01970 (Uniprot-TrEMBL)
PLCB4 ProteinQ15147 (Uniprot-TrEMBL)
PMCH(147-165) ProteinP20382 (Uniprot-TrEMBL)
PROK1 ProteinP58294 (Uniprot-TrEMBL)
PROK1,PROK2 R-HSA-444692 (Reactome)
PROK2 ProteinQ9HC23 (Uniprot-TrEMBL)
PROKR1 ProteinQ8TCW9 (Uniprot-TrEMBL)
PROKR1,PROKR2 R-HSA-444628 (Reactome)
PROKR2 ProteinQ8NFJ6 (Uniprot-TrEMBL)
PTAFR ProteinP25105 (Uniprot-TrEMBL)
PTGER1 ProteinP34995 (Uniprot-TrEMBL)
PTGFR ProteinP43088 (Uniprot-TrEMBL)
Pentadecanoic acid MetaboliteCHEBI:42504 (ChEBI)
Photon R-ALL-419777 (Reactome)
Pmoa MetaboliteCHEBI:28716 (ChEBI)
Proteinase-activated receptors R-HSA-389458 (Reactome)
QRFP ProteinP83859 (Uniprot-TrEMBL)
QRFPR ProteinQ96P65 (Uniprot-TrEMBL)
RGS proteins active for G alpha (q)ComplexR-HSA-921123 (Reactome)
RGS18 ProteinQ9NS28 (Uniprot-TrEMBL)
RGS19 ProteinP49795 (Uniprot-TrEMBL)
RGS2 ProteinP41220 (Uniprot-TrEMBL)
RGS21 ProteinQ2M5E4 (Uniprot-TrEMBL)
RGS3 ProteinP49796 (Uniprot-TrEMBL)
RGSL1 ProteinA5PLK6 (Uniprot-TrEMBL)
RGZ MetaboliteCHEBI:50122 (ChEBI)
SAA1(19-122) ProteinP0DJI8 (Uniprot-TrEMBL)
STEA MetaboliteCHEBI:9254 (ChEBI)
TAC1(58-68) ProteinP20366 (Uniprot-TrEMBL)
TAC1(98-107) ProteinP20366 (Uniprot-TrEMBL)
TAC3 ProteinQ9UHF0 (Uniprot-TrEMBL)
TACR1 ProteinP25103 (Uniprot-TrEMBL)
TACR2 ProteinP21452 (Uniprot-TrEMBL)
TACR3 ProteinP29371 (Uniprot-TrEMBL)
TBXA2R ProteinP21731 (Uniprot-TrEMBL)
TRH R-HSA-444529 (Reactome)
TRH(114-116) ProteinP20396 (Uniprot-TrEMBL)
TRH(135-137) ProteinP20396 (Uniprot-TrEMBL)
TRH(152-154) ProteinP20396 (Uniprot-TrEMBL)
TRH(186-188) ProteinP20396 (Uniprot-TrEMBL)
TRH(227-229) ProteinP20396 (Uniprot-TrEMBL)
TRH(84-86) ProteinP20396 (Uniprot-TrEMBL)
TRHR ProteinP34981 (Uniprot-TrEMBL)
TRIO ProteinO75962 (Uniprot-TrEMBL)
TRIO family RhoGEFsComplexR-HSA-399963 (Reactome)
TXA2 MetaboliteCHEBI:15627 (ChEBI)
UDP MetaboliteCHEBI:17659 (ChEBI)
UTP MetaboliteCHEBI:15713 (ChEBI)
UTS2 ProteinO95399 (Uniprot-TrEMBL)
UTS2,UTS2B R-HSA-445115 (Reactome)
UTS2B ProteinQ765I0 (Uniprot-TrEMBL)
UTS2R ProteinQ9UKP6 (Uniprot-TrEMBL)
Valerate MetaboliteCHEBI:31011 (ChEBI)
XCL1 ProteinP47992 (Uniprot-TrEMBL)
XCL1,XCL2 R-HSA-373356 (Reactome)
XCL2 ProteinQ9UBD3 (Uniprot-TrEMBL)
XCR1 ProteinP46094 (Uniprot-TrEMBL)
Zn2+ MetaboliteCHEBI:29105 (ChEBI)
all-cis-icosa-pentaenoic acid MetaboliteCHEBI:28364 (ChEBI)
pH sensing receptors R-HSA-444736 (Reactome)
thrombin heavy chain ProteinP00734 (Uniprot-TrEMBL)
thrombin light chain ProteinP00734 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
G-protein alpha (q):GRK2ArrowR-HSA-416516 (Reactome)
G-protein alpha (q):GRK5ArrowR-HSA-416510 (Reactome)
G-protein alpha (q/11): GTPArrowR-HSA-749452 (Reactome)
G-protein alpha (q/11): GTPR-HSA-398188 (Reactome)
G-protein alpha (q/11): GTPR-HSA-400586 (Reactome)
G-protein alpha (q/11): GTPR-HSA-416358 (Reactome)
G-protein alpha (q/11): GTPR-HSA-416510 (Reactome)
G-protein alpha (q/11): GTPR-HSA-416516 (Reactome)
G-protein alpha (q/11): GTPR-HSA-418582 (Reactome)
G-protein alpha (q/11): GTPmim-catalysisR-HSA-418582 (Reactome)
G-protein alpha (q/11):GDPArrowR-HSA-418582 (Reactome)
G-protein alpha (q/11):GDPR-HSA-750993 (Reactome)
G-protein alpha (q/11):PI3K alphaArrowR-HSA-416358 (Reactome)
G-protein alpha

(q/11):Trio family

RhoGEFs
ArrowR-HSA-400586 (Reactome)
G-protein beta-gamma complexArrowR-HSA-749452 (Reactome)
G-protein beta-gamma complexR-HSA-750993 (Reactome)
GDPArrowR-HSA-379048 (Reactome)
GPCRs that activate Gq/11ArrowR-HSA-749452 (Reactome)
GRK2R-HSA-416516 (Reactome)
GRK5R-HSA-416510 (Reactome)
GTPR-HSA-379048 (Reactome)
Heterotrimeric

G-protein Gq/11

(inactive)
ArrowR-HSA-750993 (Reactome)
Heterotrimeric

G-protein Gq/11

(inactive)
R-HSA-749448 (Reactome)
Ligand:GPCR

complexes that activate

Gq/11:Heterotrimeric G-protein Gq (active)
ArrowR-HSA-379048 (Reactome)
Ligand:GPCR

complexes that activate

Gq/11:Heterotrimeric G-protein Gq (active)
R-HSA-749452 (Reactome)
Ligand:GPCR

complexes that activate

Gq/11:Heterotrimeric G-protein Gq (inactive)
ArrowR-HSA-749448 (Reactome)
Ligand:GPCR

complexes that activate

Gq/11:Heterotrimeric G-protein Gq (inactive)
R-HSA-379048 (Reactome)
Ligand:GPCR

complexes that activate

Gq/11:Heterotrimeric G-protein Gq (inactive)
mim-catalysisR-HSA-379048 (Reactome)
Ligand:GPCR

complexes that

activate Gq/11
R-HSA-749448 (Reactome)
Ligands of GPCRs that activate Gq/11ArrowR-HSA-749452 (Reactome)
PI3K alphaR-HSA-416358 (Reactome)
PLC beta:G alpha (q/11)ArrowR-HSA-398188 (Reactome)
PLC beta:G alpha (q/11)mim-catalysisR-HSA-114688 (Reactome)
PLC-beta:G-alpha(q/11):DAG:IP3ArrowR-HSA-114688 (Reactome)
PLC-beta:G-alpha(q/11):PIP2R-HSA-114688 (Reactome)
PLC-betaR-HSA-398188 (Reactome)
R-HSA-114688 (Reactome) Phospholipase C (PLC) isozymes are a group of related proteins that cleave the polar head group from inositol phospholipids, typically in response to signals from cell surface receptors. They hydrolyze the highly phosphorylated lipid phosphatidylinositol 4,5-bisphosphate (PIP2) generating two products: inositol 1,4,5-trisphosphate (IP3), a universal calcium-mobilizing second messenger, and diacylglycerol (DAG), an activator of protein kinase C. PLC-beta isoforms are regulated by heterotrimeric GTP-binding proteins. PLC-beta 1 and 3 are widely expressed, with the highest concentrations found in (differing) specific regions of the brain. PLC-beta 2 is expressed at highest levels in cells of hematopoeitic origin; it is involved in leukocyte signaling and host defense. PLC-beta 4 is highly concentrated in cerebellar Purkinje and granule cells, the median geniculate body, whose axons terminate in the auditory cortex, and the lateral geniculate nucleus, where most retinal axons terminate in a visuotopic representation of each half of the visual field.
R-HSA-379048 (Reactome) G alpha q protein (or Gq/11) consists of four family members (G-alpha 11, -alpha 14, -alpha 15 and -alpha q). It activates phospholipase C (PLC) (Dowal L et al, 2006). PLC hydrolyzes phosphatidylinositol (PIP2) to diacyl glycerol (DAG) and inositol triphosphate (IP3). DAG acts as a second messenger that activates protein kinase C (PKC) and IP3 can bind to IP3 receptors, particular calcium channels in the endoplasmic reticulum (ER). Calcium flow causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.
R-HSA-398188 (Reactome) The active form of G protein alpha subunit q (Gq-alpha) was found to activate phospholipase C beta-1 (PLC-beta1), in investigations using bovine membranes. Subsequently, all 4 human isoforms have been shown to be activated by Gq, though activation of PLCbeta-4 is limited. In recombinant assays, several activated rat G alpha q family members were found to stimulate human PLC-beta isoforms with the same rank order of decreasing potency. PLC-beta1 stimulation was slightly more than for PLC-beta3; PLC-beta3 stimulation was 10-fold greater than for beta-2. PLC-beta2 is expressed specifically in hematopoietic cells. PLC-beta acts directly on Gq to accelerate hydrolysis of bound GTP, thus PLC-betas are GTPase activating proteins (GAPs). The crystal structure of the C-terminal region from Turkey PLC-beta, revealed a novel fold composed almost entirely of three long helices forming a coiled-coil that dimerizes along its long axis in an antiparallel orientation. The extent of the dimer interface and gel exclusion chromatography data suggest that PLC-betas are functionally dimeric.
R-HSA-400586 (Reactome) The Trio family of RhoA guanine nucleotide exchange factors (RhoGEFs) are directly activated by G alpha (q), possibly within a Gq:Trio:RhoA signalling complex, thereby linking Gq to RhoA-mediated processes such as cell migration, proliferation, and contraction. Like most other RhoGEFs, they have a tandem motif consisting of a Dbl homology (DH) and a pleckstrin homology (PH) domain. Trio and Duet have a number of other domains including an immunoglobin domains that may be involved in interacting with Rho, but the considerably smaller GEFT (p63RhoGEF) does not have any identifiable additional domains yet appears to be sufficient to mediate the activation of RhoA by G alpha (q). The structure represented by GEFT is proposed to represent the core of an ancient signal transduction pathway.
R-HSA-416358 (Reactome) Phospholipase C activation is the classical signalling route for G alpha (q) but an additional mechanism is an inhibitory interaction between G alpha (q) and phosphatidylinositol 3-kinase alpha (PI3K alpha). There are several PI3K subtypes but only the p85 alpha/p110 alpha subtype (PI3K alpha) is a G alpha (q) effector (PMID: 18515384). Activated G alpha (q) inhibits PI3K alpha directly, in a GTP-dependent manner. G alpha(q) binding of PI3K competes with Ras, a PI3K activator (PMID: 16268778).
R-HSA-416510 (Reactome) GRKs are serine/threonine kinases that phosphorylate GPCRs leading to receptor desensitization. GRK5 appears to be the predominant regulator of PAR1 desensitization in endothelial cells.
R-HSA-416516 (Reactome) GRK2 can inhibit GPCR signaling via phosphorylation-independent sequestration of Gq/11/14 subunits utilising its RGS homology (RH) domain. GRK2 may be an effector of activated Gq, initiating signalling cascades other than the classical PLC beta signalling associated with Gq.
R-HSA-418582 (Reactome) When a ligand activates a G protein-coupled receptor, it induces a conformational change in the receptor (a change in shape) that allows the receptor to function as a guanine nucleotide exchange factor (GEF), stimulating the exchange of GDP for GTP on the G alpha subunit. In the traditional view of heterotrimeric protein activation, this exchange triggers the dissociation of the now active G alpha subunit from the beta:gamma dimer, initiating downstream signalling events. The G alpha subunit has intrinsic GTPase activity and will eventually hydrolyze the attached GTP to GDP, allowing reassociation with G beta:gamma. Additional GTPase-activating proteins (GAPs) stimulate the GTPase activity of G alpha, leading to more rapid termination of the transduced signal. In some cases the downstream effector may have GAP activity, helping to deactivate the pathway. This is the case for phospholipase C beta, which possesses GAP activity within its C-terminal region (Kleuss et al. 1994).
R-HSA-749448 (Reactome) Numerous functionally unrelated GPCRs couple with the Gq G-protein subtype.
R-HSA-749452 (Reactome) The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (q) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).
R-HSA-750993 (Reactome) The classical model of G-protein signaling suggests that the G-protein dissociates upon GPCR activation. The active G alpha (q) subunit then participates in signaling, until its intrinsic GTPase activity degrades the bound GTP to GDP. The inactive G alpha (q):GDP complex has much higher affinity for the G beta:gamma complex and consequently reassociates.
RGS proteins active for G alpha (q)ArrowR-HSA-418582 (Reactome)
TRIO family RhoGEFsR-HSA-400586 (Reactome)
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