G alpha (q) signaling events (Homo sapiens)

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102, 22306, 20, 367, 162125, 3211, 31125, 8, 17, 33, 353515cytosolTRIO LPAR2 ADRA1A,B,D LPAR4 O-octanoyl-L-serine-GHRL-1(24-51) TRH(135-137) FFAR4 P2RY6 LPAR1,2,3,5 Zn2+ 8,11,14-Eicosatrienoic acid GCG(53-81) NPFF(69-76) LPAR5 NPFFR2 GNG2 MLNR PMCH(147-165) TBXA2R MCHR2 Pmoa GPR39 GNG11 GAST(76-92) PLCB1 MLN(26-47) GNA15 EPA G-protein alpha(q):GRK5HTR2B Ca2+ LPAR1 QRFP GPR143 UTS2,UTS2B NPS GNA14 NMB(47-56) GRPR PROKR1 PLCB1 UTS2 TACR3 MYSA GNG8 GNA14 AVPR1A PGE2 EDN2 GNG8 PROKR1,PROKR2 L-Glu DDCX GPR4 PROK1 MCHR2 GLA GRM1,GRM5 MLNR GNA15 GRK5 GNB1 GNG13 OXTR AcCho F2RL2(22-374) KALRN AVPR1A GPR65 RGS proteins activefor G alpha (q)FFAR3 ligands NMB(47-56) QRFP GRK2 GNA15 ADRA1D NPFF(69-76) PLCB3 GAST(76-92) TXA2 OPN4 GNGT1 Endothelin UDP TRH(227-229) EPA Basic L-amino acids CASR PLCB4 XCL1 LTC4 PAF EtCOO- or C2H5COO- KISS1(68-121) NMUR2 EtCOO- or C2H5COO- F2RL3(18-385) Pmoa CCKBR DecS-GHRL-1(24-51) NMUR1,NMUR2 GNGT1 CYSLTR2 LXA4 GHSR HCOOH AGT(34-41) GNAQ PLCB2 LTC4 ADRA1A RGS2 NAd PALM OXT(20-28) GCG(53-81) PTGER1 FFAR1 TBXA2R GNG5 P2RY2 GNG2 GPR17 NMU LTB4R EDN3(97-117) CCL23-2 PLCB1 GNRHR2 ARHGEF25 GNG5 AVP(20-28) LTE4 MYSA PIK3R3 HRH1 TRH(84-86) GNA14 EDNRA LXA4 PROK2 Bradykinin receptor MYSA TRH(114-116) CHRM5 TAC1(58-68) TXA2 KISS1R NPS GNRH2(24-33) EDN3(97-117) GTP TACR3 GLA PIK3R1 AcCho FFAR2 ligands HTR2A LPAR1 NPS TAC3 TACR1 5HT GNG7 ATP LPAR4 P2RY2 PI(4,5)P2 HTR2C GNAQ MCHR2 AVPR1A,B NMUR1 GNB4 GNG11 CHRM3 NAd P2RY1 PROKR2 GNA15 DecS-GHRL-1(24-50) L-Dopa TRH(114-116) Valerate FPR2 F2RL1(37-397) NMUR2 NTSR2 AGTR1 TRH(186-188) DTTA GNG13 FPR2 GNG10 LTB4R GDPPROK1,PROK2 Ca2+ RGZ GNRH2(24-33) GNB4 AVP(20-28) GRPR PALM ADR Ligand:GPCRcomplexes thatactivate Gq/11DPA TAC3 GNRH ligands GCGR NMS GNB5 CCKBR LTB4R2 BUT GNA11 F2RL2(22-374) MCHR1,MCHR2 P2RY10 NPFFR1 GnRH receptor GPR17 FFAR3 NPFFR2 PROK1 GNB3 GNG7 Ca2+ PLCB3 OLEA HCRT(34-66) LTB4R2 PTAFR NMUR1 CHRM3 Hist TRH(186-188) GNG2 PROKR1 AVPR1A Valerate PIK3R2 FFAR4 SAA1(19-122) O-octanoyl-L-serine-GHRL-1(24-51) CCKAR,CCKBR CHRM5 CYSLTR1 ELDA DPA AGT(34-41) GPR4 HCRTR2 8,11,14-Eicosatrienoic acid KISS1R GPR143 GNAQ NMUR2 MCHR1 NMS GHSR GHSR CH3COO- HRH1 GNB1 GAST(76-92) TACR1 LTB4R,LTB4R2 TAC3 GPR143 11,14,17-eicosatrienoic acid PLC-beta:G-alpha(q/11):DAG:IP3P2RY11 GNG8 BDKRB1 F2RL2(22-374) ATP LTB4 MLN(26-47) GNB2 Cysteinyl leukotrienes F2RL1(37-397) GNAQ FFAR2 ADR NPSR1 AVP(20-28) CCKAR GCGR O-octanoyl-L-serine-GHRL-1(24-50) TRH(84-86) EDNRA,EDNRB ADRA1D RGSL1 H+ AGTR1 Acyl Ghrelin O-octanoyl-L-serine-GHRL-1(24-50) GAST(76-92) GNA11 P2RY1 LPA OPN4 Basic L-amino acids ADP HeterotrimericG-protein Gq/11(inactive)O-octanoyl-L-serine-GHRL-1(24-50) UTS2 GNA15 GPRC6A QRFP Hist TRH(135-137) P2RY6 TRH(152-154) CASR ATP Basic L-amino acids HCRTR2 ALA PLCB4 KISS1(68-121) XCL1 GPR39 PTGFR LPAR2 ADP UTP AGTR1 OPN4 PAF GNG12 PAF Photon GNA14 NPSR1 LPAR5 PGE2 AGTR1 BRS3 ANXA1 HCRTR2 L-Dopa GNRHR GNA15 HTR2C DDCX FFAR3 LTB4R GNB4 HRH1 CCKBR GNGT2 GPR143 NTSR1 GNA14 DHA NPS GNA11 TRIO family RhoGEFsLPAR4 NMU AGT(34-41) Pmoa PIK3CA TRH(114-116) PGF2a GNRHR2 GNA11 DHA MLNR UDP GNG12 OXT(20-28) MCHR1 CHRM5 NTS(151-163) LPA Ligands of GPCRsthat activate Gq/11TACR1 GNB3 TXA2 CHRM1 GRM5 GNAQ GNG8 thrombin heavy chain GNG10 F2R(27-425) P2RY10 TRH AVPR1B TAC1(58-68) UTS2R FFAR2 MT-RNR2 PI3K alphaNMB(47-56) thrombin light chain Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (inactive)PGF2a TRH(152-154) GNRH1(24-33) Hist H+ NPSR1 STEA MT-RNR2 NTS(151-163) GNA15 GNGT1 EDNRA LPAR4 TRH(135-137) GNAQ KALRN NMUR2 GPR17 NPFF(69-76) GNAQ HCRT(34-66) CCK RGZ CCKBR Pentadecanoic acid GNA14 PTAFR NMUR1 Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (active)FFAR1 Pentadecanoic acid ALA DTTA LTB4R2 KISS1R NPFFR1,NPFFR2 CYSLTR1 GNA11 HTR2A GDP ANXA1 LPAR6 FFAR1 CCKAR GNRHR LTE4 PLCB2 GNG13 PTGER1 G-protein alpha(q):GRK2Photon EDN1 GCGR PTGFR GRM5 DecS-GHRL-1(24-50) GNG3 GNG2 TRH(227-229) PROK1 TRHR DecS-GHRL-1(24-51) L-Dopa UTS2B P2RY10 STEA GPR68 GNB3 GNRH2(24-33) MT-RNR2 GRK2EDN2 ANXA1 TACR2 GRP(24-50) AVP(20-28) 5HT TAC1(98-107) H+ EtCOO- or C2H5COO- NTS(151-163) UTP PROK2 ADRA1D P2RY6 HCRT(70-97) thrombin light chain P2RY10 DecS-GHRL-1(24-51) BRS3 GNA14 thrombin heavy chain GPR132 P2RY1 I(1,4,5)P3 GNA11 GHSR TBXA2R TACR1 NMBR EPA NPSR1 EDNRB TACR3 DPA CASR PAF NAd Bradykinin GNG10 NPFFR1 GNA15 CCK PIK3R2 PTAFR NMU NTSR2 LPAR3 CH3COO- TACR2 F2R(27-425) AVPR1B LPAR2 FFAR4 BUT PLCB3 GTP TRHR Photon GTP TAC1(98-107) PTGER1 GNA15 Photon FFAR1 ligands CYSLTR1 GNRHR2 GRM1 ADRA1A CASR PGE2 GPR68 GNGT2 OXT(20-28) GNG7 OPN4 Ca2+ GTP BDKRB1 UTS2R PMCH(147-165) F2RL1(37-397) Bombesin-like receptor G-protein alpha(q/11):PI3K alphaRGZ HCRTR1 HTR2A GNAQ P2RY11 BRS3 GNG5 P2RY6 L-Glu XCL1,XCL2 GNG13 UDP GPR39 GNA11 NPFFR1 PLC-beta:G-alpha(q/11):PIP2LPAR6 KISS1R GNA15 OXTR PROK2 Bradykinin PLC-betaZn2+ DecS-GHRL-1(24-50) RGS21 GPR132 TACR2 FFAR3 G-protein alpha(q/11):Trio familyRhoGEFsATP 8,11,14-Eicosatrienoic acid NTSR1 PLC beta:G alpha(q/11)BDKRB2 ADRA1A TRH(227-229) GNA14 GNB4 TRH(152-154) LTB4 ADP GNG11 HCRT(70-97) APP(672-713) PTAFR GNG4 Valerate PGF2a GPRC6A APP(672-713) GTP 5HT HTR2C TXA2 GNG7 GPR65 CHRM1 GNG3 GNG3 GNG11 GNA14 EDN2 RGS3 PLCB2 G-protein beta:gammasignallingGNG12 EDNRB GNA11 11,14,17-eicosatrienoic acid CYSLTR2 HXA QRFPR GNAQ Bradykinin MLNR HTR2B AcCho GTP PMCH(147-165) ARHGEF25 GNG12 OLEA GNA14 NPFFR2 FPR2 ligands MLN(26-47) HRH1 GPR17 BUT GTP GNB2 P2RY11 OXTR QRFPR HTR2B CCL23-2 FFAR4 L-Glu GNG4 TACR2 Zn2+ HCRT(70-97) ADR SAA1(19-122) RGS18 TAC1(58-68) GNG3 GRM5 PALM GPR132 Zn2+ ADRA1B DAG CYSLTR2 LPAR5 GRK5PTGFR 5HT LTC4 Gastrin-CREBsignalling pathwayvia PKC and MAPKUTP GPRC6A GNB5 ELDA LPAR6 NMBR CCK AcCho PTGFR DHA GNG4 RGS19 EDNRB LTD4 Bombesin-like peptide F2RL3(18-385) GNB5 thrombin light chain GPR65 LTB4 NMBR QRFP NTSR1 ADP PROKR2 HCRTR1 GRP(24-50) PROKR2 HCOOH PLCB4 UTS2B BDKRB2 AGT(34-41) FFAR1 GNRH1(24-33) PLCB3 pH sensing receptors G-protein alpha(q/11): GTPGPR68 LTE4 P2RY1 F2RL3(18-385) AVPR1B H+ HCRTR1 LPA GNA11 LPA BDKRB2 XCL2 GPCRs that activateGq/11thrombin heavy chain GNA11 GNB2 CCK GNB2 GRPR UDP XCR1 GNAQ F2R(27-425) PGE2 FFAR3 HCRT(70-97) Bradykinin L-Dopa FFAR2 P2RY2 HCRT(34-66) FFAR4 ligands KISS1(68-121) GNRH1(24-33) NMS TRIO NTSR1,NTSR2 GNG10 EDN1 LXA4 PLCB2 XCR1 STEA LTD4 ADR, NAd UTS2 ALA TAC1(98-107) QRFPR GPRC6A GPR4 TACR3 DTTA PGF2a ADRA1B CHRM3 UTS2B HCRTR2 GPR39 OXT(20-28) GNB1 PLCB4 GRM1 ADRA1B EDNRA P2RY2 XCR1 LPAR1 PMCH(147-165) HTR2A-C TRHR GDP XCL2 CH3COO- CCKAR OLEA EDN1 TRH(186-188) P2RY11 XCR1 BDKRB1 GNGT2 L-Glu TRHR GNRHR NTSR2 GNA11 GNB1 MCHR1 Effects of PIP2hydrolysisTBXA2R 11,14,17-eicosatrienoic acid HCRTR1 G-protein beta-gammacomplexGNG4 APP(672-713) PROKR1 GCG(53-81) GCG(53-81) HXA GNA15 FPR2 UTS2R GPRC6A ligands Pentadecanoic acid PTGER1 GRP(24-50) GNAQ TAC1(98-107) TAC3 CHRM1, 3, 5 NMS PIK3R1 GTPOXTR SAA1(19-122) GTP HCRT(34-66) TAC1(58-68) DDCX GCGR GNGT2 PLCB1 GRM1 FFAR2 GDP UTS2R O-octanoyl-L-serine-GHRL-1(24-51) GNG5 PIK3CA Hist Proteinase-activated receptors LTD4 MLN(26-47) GNA14 ELDA KISS1(68-121) LPAR6 FPR2 G-protein alpha(q/11):GDPGLA XCL1 XCL2 GNA11 GNB5 LTB4 LPAR3 thrombin heavy chain GNA15 HXA CCL23-2 GNGT1 NMU NPFF(69-76) EDN3(97-117) TRH(84-86) GNAQ LPAR3 thrombin light chain GNB3 QRFPR NTS(151-163) PIK3R3 GNA14 CYSLTR1,CYSLTR2 GTP HCOOH CHRM1 18, 2914, 19, 26, 341, 3718, 2918, 299, 2413, 23, 2732818, 29318, 2918, 2918, 29418, 29


Description

The classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides a path to calcium-regulated kinases and phosphatases, GEFs, MAP kinase cassettes and other proteins that mediate cellular responses ranging from granule secretion, integrin activation, and aggregation in platelets. Gq participates in many other signalling events including direct interaction with RhoGEFs that stimulate RhoA activity and inhibition of PI3K. Both in vitro and in vivo, the G-protein Gq seems to be the predominant mediator of the activation of platelets. Moreover, G alpha (q) can stimulate the activation of Burton tyrosine kinase (Ma Y C et al. 1998). Regulator of G-protein Signalling (RGS) proteins can regulate the activity of G alpha (z) (Soundararajan M et al. 2008). View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 416476
Reactome-version 
Reactome version: 64
Reactome Author 
Reactome Author: Jupe, Steve

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Bibliography

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History

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CompareRevisionActionTimeUserComment
116409view09:05, 7 May 2021EweitzModified title
113243view11:31, 2 November 2020ReactomeTeamReactome version 74
101713view14:51, 1 November 2018DeSlOntology Term : 'G protein mediated signaling pathway via Galphaq family' added !
101370view11:26, 1 November 2018ReactomeTeamreactome version 66
100908view21:01, 31 October 2018ReactomeTeamreactome version 65
100449view19:35, 31 October 2018ReactomeTeamreactome version 64
100273view16:57, 31 October 2018ReactomeTeamNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
11,14,17-eicosatrienoic acid MetaboliteCHEBI:53460 (ChEBI)
5HT MetaboliteCHEBI:28790 (ChEBI)
8,11,14-Eicosatrienoic acid MetaboliteCHEBI:53486 (ChEBI)
ADP MetaboliteCHEBI:16761 (ChEBI)
ADR MetaboliteCHEBI:28918 (ChEBI)
ADR, NAd R-ALL-390627 (Reactome)
ADRA1A ProteinP35348 (Uniprot-TrEMBL)
ADRA1A,B,D R-HSA-390684 (Reactome)
ADRA1B ProteinP35368 (Uniprot-TrEMBL)
ADRA1D ProteinP25100 (Uniprot-TrEMBL)
AGT(34-41) ProteinP01019 (Uniprot-TrEMBL)
AGTR1 ProteinP30556 (Uniprot-TrEMBL)
ALA MetaboliteCHEBI:27432 (ChEBI)
ANXA1 ProteinP04083 (Uniprot-TrEMBL)
APP(672-713) ProteinP05067 (Uniprot-TrEMBL)
ARHGEF25 ProteinQ86VW2 (Uniprot-TrEMBL)
ATP MetaboliteCHEBI:15422 (ChEBI)
AVP(20-28) ProteinP01185 (Uniprot-TrEMBL)
AVPR1A ProteinP37288 (Uniprot-TrEMBL)
AVPR1A,B R-HSA-388458 (Reactome)
AVPR1B ProteinP47901 (Uniprot-TrEMBL)
AcCho MetaboliteCHEBI:15355 (ChEBI)
Acyl Ghrelin R-HSA-422096 (Reactome)
BDKRB1 ProteinP46663 (Uniprot-TrEMBL)
BDKRB2 ProteinP30411 (Uniprot-TrEMBL)
BRS3 ProteinP32247 (Uniprot-TrEMBL)
BUT MetaboliteCHEBI:30772 (ChEBI)
Basic L-amino acids R-ALL-420746 (Reactome)
Bombesin-like peptide R-HSA-375360 (Reactome)
Bombesin-like receptor R-HSA-375362 (Reactome)
Bradykinin ProteinP01042 (Uniprot-TrEMBL)
Bradykinin receptor R-HSA-374323 (Reactome)
CASR ProteinP41180 (Uniprot-TrEMBL)
CCK ProteinP06307 (Uniprot-TrEMBL)
CCKAR ProteinP32238 (Uniprot-TrEMBL)
CCKAR,CCKBR R-HSA-388518 (Reactome)
CCKBR ProteinP32239 (Uniprot-TrEMBL)
CCL23-2 ProteinP55773-2 (Uniprot-TrEMBL)
CH3COO- MetaboliteCHEBI:15366 (ChEBI)
CHRM1 ProteinP11229 (Uniprot-TrEMBL)
CHRM1, 3, 5 R-HSA-390660 (Reactome)
CHRM3 ProteinP20309 (Uniprot-TrEMBL)
CHRM5 ProteinP08912 (Uniprot-TrEMBL)
CYSLTR1 ProteinQ9Y271 (Uniprot-TrEMBL)
CYSLTR1,CYSLTR2 R-HSA-416385 (Reactome)
CYSLTR2 ProteinQ9NS75 (Uniprot-TrEMBL)
Ca2+ MetaboliteCHEBI:29108 (ChEBI)
Cysteinyl leukotrienes R-ALL-416372 (Reactome)
DAG MetaboliteCHEBI:17815 (ChEBI)
DDCX MetaboliteCHEBI:30805 (ChEBI)
DHA MetaboliteCHEBI:28125 (ChEBI)
DPA MetaboliteCHEBI:53488 (ChEBI)
DTTA MetaboliteCHEBI:53487 (ChEBI)
DecS-GHRL-1(24-50) ProteinQ9UBU3-1 (Uniprot-TrEMBL)
DecS-GHRL-1(24-51) ProteinQ9UBU3-1 (Uniprot-TrEMBL)
EDN1 ProteinP05305 (Uniprot-TrEMBL)
EDN2 ProteinP20800 (Uniprot-TrEMBL)
EDN3(97-117) ProteinP14138 (Uniprot-TrEMBL)
EDNRA ProteinP25101 (Uniprot-TrEMBL)
EDNRA,EDNRB R-HSA-388547 (Reactome)
EDNRB ProteinP24530 (Uniprot-TrEMBL)
ELDA MetaboliteCHEBI:27997 (ChEBI)
EPA MetaboliteCHEBI:28364 (ChEBI)
Effects of PIP2 hydrolysisPathwayR-HSA-114508 (Reactome) Hydrolysis of phosphatidyl inositol-bisphosphate (PIP2) by phospholipase C (PLC) produces diacylglycerol (DAG) and inositol triphosphate (IP3). Both are potent second messengers. IP3 diffuses into the cytosol, but as DAG is a hydrophobic lipid it remains within the plasma membrane. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, while DAG activates the conventional and unconventional protein kinase C (PKC) isoforms, facilitating the translocation of PKC from the cytosol to the plasma membrane. The effects of DAG are mimicked by tumor-promoting phorbol esters. DAG is also a precursor for the biosynthesis of prostaglandins, the endocannabinoid 2-arachidonoylglycerol and an activator of a subfamily of TRP-C (Transient Receptor Potential Canonical) cation channels 3, 6, and 7.
Endothelin R-HSA-388544 (Reactome)
EtCOO- or C2H5COO- MetaboliteCHEBI:30768 (ChEBI)
F2R(27-425) ProteinP25116 (Uniprot-TrEMBL) This is the inactive form of the receptor, before protease activation. Proteinase (protease) activated receptors are activated by the cleavage of an N-terminal extracellular segment by serine proteases, particularly thrombin which activates PAR1, 3 and 4. The cleaved fragment is an activating ligand for the receptor; synthetic peptide mimics of the N-terminal fragment can activate uncleaved receptors.
F2RL1(37-397) ProteinP55085 (Uniprot-TrEMBL) This is the inactive form of the receptor, before protease activation. Proteinase (protease) activated receptors are activated by the cleavage of an N-terminal extracellular segment by serine proteases, particularly thrombin which activates PAR1, 3 and 4. The cleaved fragment is an activating ligand for the receptor; synthetic peptide mimics of the N-terminal fragment can activate uncleaved receptors.
F2RL2(22-374) ProteinO00254 (Uniprot-TrEMBL) This is the inactive form of the receptor, before protease activation. Proteinase (protease) activated receptors are activated by the cleavage of an N-terminal extracellular segment by serine proteases, particularly thrombin which activates PAR1, 3 and 4. The cleaved fragment is an activating ligand for the receptor; synthetic peptide mimics of the N-terminal fragment can activate uncleaved receptors.
F2RL3(18-385) ProteinQ96RI0 (Uniprot-TrEMBL) This is the inactive form of the receptor, before protease activation. Proteinase (protease) activated receptors are activated by the cleavage of an N-terminal extracellular segment by serine proteases, particularly thrombin which activates PAR1, 3 and 4. The cleaved fragment is an activating ligand for the receptor; synthetic peptide mimics of the N-terminal fragment can activate uncleaved receptors.
FFAR1 ProteinO14842 (Uniprot-TrEMBL)
FFAR1 ligands R-ALL-400427 (Reactome)
FFAR2 ProteinO15552 (Uniprot-TrEMBL)
FFAR2 ligands R-ALL-444210 (Reactome)
FFAR3 ProteinO14843 (Uniprot-TrEMBL)
FFAR3 ligands R-ALL-444074 (Reactome)
FFAR4 ProteinQ5NUL3 (Uniprot-TrEMBL)
FFAR4 ligands R-ALL-400551 (Reactome)
FPR2 ProteinP25090 (Uniprot-TrEMBL)
FPR2 ligands R-HSA-444472 (Reactome)
G-protein alpha (q):GRK2ComplexR-HSA-416515 (Reactome)
G-protein alpha (q):GRK5ComplexR-HSA-416517 (Reactome)
G-protein alpha (q/11): GTPComplexR-HSA-114534 (Reactome)
G-protein alpha (q/11):GDPComplexR-HSA-114556 (Reactome)
G-protein alpha (q/11):PI3K alphaComplexR-HSA-416356 (Reactome)
G-protein alpha

(q/11):Trio family

RhoGEFs
ComplexR-HSA-400608 (Reactome)
G-protein beta-gamma complexComplexR-HSA-167434 (Reactome)
G-protein beta:gamma signallingPathwayR-HSA-397795 (Reactome) The classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known that Gbeta/gamma subunits can directly modulate many effectors, including some also regulated by G alpha.
GAST(76-92) ProteinP01350 (Uniprot-TrEMBL)
GCG(53-81) ProteinP01275 (Uniprot-TrEMBL)
GCGR ProteinP47871 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GHSR ProteinQ92847 (Uniprot-TrEMBL)
GLA MetaboliteCHEBI:28661 (ChEBI)
GNA11 ProteinP29992 (Uniprot-TrEMBL)
GNA14 ProteinO95837 (Uniprot-TrEMBL)
GNA15 ProteinP30679 (Uniprot-TrEMBL)
GNAQ ProteinP50148 (Uniprot-TrEMBL)
GNB1 ProteinP62873 (Uniprot-TrEMBL)
GNB2 ProteinP62879 (Uniprot-TrEMBL)
GNB3 ProteinP16520 (Uniprot-TrEMBL)
GNB4 ProteinQ9HAV0 (Uniprot-TrEMBL)
GNB5 ProteinO14775 (Uniprot-TrEMBL)
GNG10 ProteinP50151 (Uniprot-TrEMBL)
GNG11 ProteinP61952 (Uniprot-TrEMBL)
GNG12 ProteinQ9UBI6 (Uniprot-TrEMBL)
GNG13 ProteinQ9P2W3 (Uniprot-TrEMBL)
GNG2 ProteinP59768 (Uniprot-TrEMBL)
GNG3 ProteinP63215 (Uniprot-TrEMBL)
GNG4 ProteinP50150 (Uniprot-TrEMBL)
GNG5 ProteinP63218 (Uniprot-TrEMBL)
GNG7 ProteinO60262 (Uniprot-TrEMBL)
GNG8 ProteinQ9UK08 (Uniprot-TrEMBL)
GNGT1 ProteinP63211 (Uniprot-TrEMBL)
GNGT2 ProteinO14610 (Uniprot-TrEMBL)
GNRH ligands R-HSA-873938 (Reactome)
GNRH1(24-33) ProteinP01148 (Uniprot-TrEMBL)
GNRH2(24-33) ProteinO43555 (Uniprot-TrEMBL)
GNRHR ProteinP30968 (Uniprot-TrEMBL)
GNRHR2 ProteinQ96P88 (Uniprot-TrEMBL)
GPCRs that activate Gq/11ComplexR-HSA-791493 (Reactome)
GPR132 ProteinQ9UNW8 (Uniprot-TrEMBL)
GPR143 ProteinP51810 (Uniprot-TrEMBL)
GPR17 ProteinQ13304 (Uniprot-TrEMBL)
GPR39 ProteinO43194 (Uniprot-TrEMBL)
GPR4 ProteinP46093 (Uniprot-TrEMBL)
GPR65 ProteinQ8IYL9 (Uniprot-TrEMBL)
GPR68 ProteinQ15743 (Uniprot-TrEMBL)
GPRC6A ProteinQ5T6X5 (Uniprot-TrEMBL)
GPRC6A ligands R-ALL-420706 (Reactome)
GRK2 ProteinP25098 (Uniprot-TrEMBL)
GRK2ProteinP25098 (Uniprot-TrEMBL)
GRK5 ProteinP34947 (Uniprot-TrEMBL)
GRK5ProteinP34947 (Uniprot-TrEMBL)
GRM1 ProteinQ13255 (Uniprot-TrEMBL)
GRM1,GRM5 R-HSA-420566 (Reactome)
GRM5 ProteinP41594 (Uniprot-TrEMBL)
GRP(24-50) ProteinP07492 (Uniprot-TrEMBL)
GRPR ProteinP30550 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
Gastrin-CREB

signalling pathway

via PKC and MAPK
PathwayR-HSA-881907 (Reactome) Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17.Gastrin gene expression is upregulated in both a number of pre-malignant conditions and in established cancer through a variety of mechanisms. Depending on the tissue where it is expressed and the level of expression, differential processing of the polypeptide product leads to the production of different biologically active peptides. In turn, acting through the classical gastrin cholecystokinin B receptor CCK-BR, its isoforms and alternative receptors, these peptides trigger signalling pathways which influence the expression of downstream genes that affect cell survival, angiogenesis and invasion (Wank 1995, de Weerth et al. 1999, Grabowska & Watson 2007)
GnRH receptor R-HSA-391368 (Reactome)
H+ MetaboliteCHEBI:15378 (ChEBI)
HCOOH MetaboliteCHEBI:30751 (ChEBI)
HCRT(34-66) ProteinO43612 (Uniprot-TrEMBL)
HCRT(70-97) ProteinO43612 (Uniprot-TrEMBL)
HCRTR1 ProteinO43613 (Uniprot-TrEMBL)
HCRTR2 ProteinO43614 (Uniprot-TrEMBL)
HRH1 ProteinP35367 (Uniprot-TrEMBL)
HTR2A ProteinP28223 (Uniprot-TrEMBL)
HTR2A-C R-HSA-391030 (Reactome)
HTR2B ProteinP41595 (Uniprot-TrEMBL)
HTR2C ProteinP28335 (Uniprot-TrEMBL)
HXA MetaboliteCHEBI:17120 (ChEBI)
Heterotrimeric

G-protein Gq/11

(inactive)
ComplexR-HSA-114557 (Reactome)
Hist MetaboliteCHEBI:18295 (ChEBI)
I(1,4,5)P3 MetaboliteCHEBI:16595 (ChEBI)
KALRN ProteinO60229 (Uniprot-TrEMBL)
KISS1(68-121) ProteinQ15726 (Uniprot-TrEMBL)
KISS1R ProteinQ969F8 (Uniprot-TrEMBL)
L-Dopa MetaboliteCHEBI:15765 (ChEBI)
L-Glu MetaboliteCHEBI:29985 (ChEBI)
LPA MetaboliteCHEBI:52288 (ChEBI)
LPAR1 ProteinQ92633 (Uniprot-TrEMBL)
LPAR1,2,3,5 R-HSA-419369 (Reactome)
LPAR2 ProteinQ9HBW0 (Uniprot-TrEMBL)
LPAR3 ProteinQ9UBY5 (Uniprot-TrEMBL)
LPAR4 ProteinQ99677 (Uniprot-TrEMBL)
LPAR5 ProteinQ9H1C0 (Uniprot-TrEMBL)
LPAR6 ProteinP43657 (Uniprot-TrEMBL)
LTB4 MetaboliteCHEBI:15647 (ChEBI)
LTB4R ProteinQ15722 (Uniprot-TrEMBL)
LTB4R,LTB4R2 R-HSA-416401 (Reactome)
LTB4R2 ProteinQ9NPC1 (Uniprot-TrEMBL)
LTC4 MetaboliteCHEBI:16978 (ChEBI)
LTD4 MetaboliteCHEBI:28666 (ChEBI)
LTE4 MetaboliteCHEBI:15650 (ChEBI)
LXA4 MetaboliteCHEBI:6498 (ChEBI)
Ligand:GPCR

complexes that activate

Gq/11:Heterotrimeric G-protein Gq (active)
ComplexR-HSA-749447 (Reactome)
Ligand:GPCR

complexes that activate

Gq/11:Heterotrimeric G-protein Gq (inactive)
ComplexR-HSA-749451 (Reactome)
Ligand:GPCR

complexes that

activate Gq/11
ComplexR-HSA-380110 (Reactome)
Ligands of GPCRs that activate Gq/11ComplexR-HSA-791492 (Reactome)
MCHR1 ProteinQ99705 (Uniprot-TrEMBL)
MCHR1,MCHR2 R-HSA-947667 (Reactome)
MCHR2 ProteinQ969V1 (Uniprot-TrEMBL)
MLN(26-47) ProteinP12872 (Uniprot-TrEMBL)
MLNR ProteinO43193 (Uniprot-TrEMBL)
MT-RNR2 ProteinQ8IVG9 (Uniprot-TrEMBL)
MYSA MetaboliteCHEBI:28875 (ChEBI)
NAd MetaboliteCHEBI:18357 (ChEBI)
NMB(47-56) ProteinP08949 (Uniprot-TrEMBL)
NMBR ProteinP28336 (Uniprot-TrEMBL)
NMS ProteinQ5H8A3 (Uniprot-TrEMBL)
NMU ProteinP48645 (Uniprot-TrEMBL)
NMUR1 ProteinQ9HB89 (Uniprot-TrEMBL)
NMUR1,NMUR2 R-HSA-964805 (Reactome)
NMUR2 ProteinQ9GZQ4 (Uniprot-TrEMBL)
NPFF(69-76) ProteinO15130 (Uniprot-TrEMBL)
NPFFR1 ProteinQ9GZQ6 (Uniprot-TrEMBL)
NPFFR1,NPFFR2 R-HSA-389406 (Reactome)
NPFFR2 ProteinQ9Y5X5 (Uniprot-TrEMBL)
NPS ProteinP0C0P6 (Uniprot-TrEMBL)
NPSR1 ProteinQ6W5P4 (Uniprot-TrEMBL)
NTS(151-163) ProteinP30990 (Uniprot-TrEMBL)
NTSR1 ProteinP30989 (Uniprot-TrEMBL)
NTSR1,NTSR2 R-HSA-388917 (Reactome)
NTSR2 ProteinO95665 (Uniprot-TrEMBL)
O-octanoyl-L-serine-GHRL-1(24-50) ProteinQ9UBU3-1 (Uniprot-TrEMBL)
O-octanoyl-L-serine-GHRL-1(24-51) ProteinQ9UBU3-1 (Uniprot-TrEMBL)
OLEA MetaboliteCHEBI:16196 (ChEBI)
OPN4 ProteinQ9UHM6 (Uniprot-TrEMBL)
OXT(20-28) ProteinP01178 (Uniprot-TrEMBL)
OXTR ProteinP30559 (Uniprot-TrEMBL)
P2RY1 ProteinP47900 (Uniprot-TrEMBL)
P2RY10 ProteinO00398 (Uniprot-TrEMBL)
P2RY11 ProteinQ96G91 (Uniprot-TrEMBL)
P2RY2 ProteinP41231 (Uniprot-TrEMBL)
P2RY6 ProteinQ15077 (Uniprot-TrEMBL)
PAF MetaboliteCHEBI:52450 (ChEBI)
PALM MetaboliteCHEBI:15756 (ChEBI)
PGE2 MetaboliteCHEBI:15551 (ChEBI)
PGF2a MetaboliteCHEBI:15553 (ChEBI)
PI(4,5)P2 MetaboliteCHEBI:18348 (ChEBI)
PI3K alphaComplexR-HSA-198379 (Reactome)
PIK3CA ProteinP42336 (Uniprot-TrEMBL)
PIK3R1 ProteinP27986 (Uniprot-TrEMBL)
PIK3R2 ProteinO00459 (Uniprot-TrEMBL)
PIK3R3 ProteinQ92569 (Uniprot-TrEMBL)
PLC beta:G alpha (q/11)ComplexR-HSA-398158 (Reactome)
PLC-beta:G-alpha(q/11):DAG:IP3ComplexR-HSA-8983509 (Reactome)
PLC-beta:G-alpha(q/11):PIP2ComplexR-HSA-8983508 (Reactome)
PLC-betaComplexR-HSA-111854 (Reactome)
PLCB1 ProteinQ9NQ66 (Uniprot-TrEMBL)
PLCB2 ProteinQ00722 (Uniprot-TrEMBL)
PLCB3 ProteinQ01970 (Uniprot-TrEMBL)
PLCB4 ProteinQ15147 (Uniprot-TrEMBL)
PMCH(147-165) ProteinP20382 (Uniprot-TrEMBL)
PROK1 ProteinP58294 (Uniprot-TrEMBL)
PROK1,PROK2 R-HSA-444692 (Reactome)
PROK2 ProteinQ9HC23 (Uniprot-TrEMBL)
PROKR1 ProteinQ8TCW9 (Uniprot-TrEMBL)
PROKR1,PROKR2 R-HSA-444628 (Reactome)
PROKR2 ProteinQ8NFJ6 (Uniprot-TrEMBL)
PTAFR ProteinP25105 (Uniprot-TrEMBL)
PTGER1 ProteinP34995 (Uniprot-TrEMBL)
PTGFR ProteinP43088 (Uniprot-TrEMBL)
Pentadecanoic acid MetaboliteCHEBI:42504 (ChEBI)
Photon R-ALL-419777 (Reactome)
Pmoa MetaboliteCHEBI:28716 (ChEBI)
Proteinase-activated receptors R-HSA-389458 (Reactome)
QRFP ProteinP83859 (Uniprot-TrEMBL)
QRFPR ProteinQ96P65 (Uniprot-TrEMBL)
RGS proteins active for G alpha (q)ComplexR-HSA-921123 (Reactome)
RGS18 ProteinQ9NS28 (Uniprot-TrEMBL)
RGS19 ProteinP49795 (Uniprot-TrEMBL)
RGS2 ProteinP41220 (Uniprot-TrEMBL)
RGS21 ProteinQ2M5E4 (Uniprot-TrEMBL)
RGS3 ProteinP49796 (Uniprot-TrEMBL)
RGSL1 ProteinA5PLK6 (Uniprot-TrEMBL)
RGZ MetaboliteCHEBI:50122 (ChEBI)
SAA1(19-122) ProteinP0DJI8 (Uniprot-TrEMBL)
STEA MetaboliteCHEBI:9254 (ChEBI)
TAC1(58-68) ProteinP20366 (Uniprot-TrEMBL)
TAC1(98-107) ProteinP20366 (Uniprot-TrEMBL)
TAC3 ProteinQ9UHF0 (Uniprot-TrEMBL)
TACR1 ProteinP25103 (Uniprot-TrEMBL)
TACR2 ProteinP21452 (Uniprot-TrEMBL)
TACR3 ProteinP29371 (Uniprot-TrEMBL)
TBXA2R ProteinP21731 (Uniprot-TrEMBL)
TRH R-HSA-444529 (Reactome)
TRH(114-116) ProteinP20396 (Uniprot-TrEMBL)
TRH(135-137) ProteinP20396 (Uniprot-TrEMBL)
TRH(152-154) ProteinP20396 (Uniprot-TrEMBL)
TRH(186-188) ProteinP20396 (Uniprot-TrEMBL)
TRH(227-229) ProteinP20396 (Uniprot-TrEMBL)
TRH(84-86) ProteinP20396 (Uniprot-TrEMBL)
TRHR ProteinP34981 (Uniprot-TrEMBL)
TRIO ProteinO75962 (Uniprot-TrEMBL)
TRIO family RhoGEFsComplexR-HSA-399963 (Reactome)
TXA2 MetaboliteCHEBI:15627 (ChEBI)
UDP MetaboliteCHEBI:17659 (ChEBI)
UTP MetaboliteCHEBI:15713 (ChEBI)
UTS2 ProteinO95399 (Uniprot-TrEMBL)
UTS2,UTS2B R-HSA-445115 (Reactome)
UTS2B ProteinQ765I0 (Uniprot-TrEMBL)
UTS2R ProteinQ9UKP6 (Uniprot-TrEMBL)
Valerate MetaboliteCHEBI:31011 (ChEBI)
XCL1 ProteinP47992 (Uniprot-TrEMBL)
XCL1,XCL2 R-HSA-373356 (Reactome)
XCL2 ProteinQ9UBD3 (Uniprot-TrEMBL)
XCR1 ProteinP46094 (Uniprot-TrEMBL)
Zn2+ MetaboliteCHEBI:29105 (ChEBI)
pH sensing receptors R-HSA-444736 (Reactome)
thrombin heavy chain ProteinP00734 (Uniprot-TrEMBL)
thrombin light chain ProteinP00734 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
G-protein alpha (q):GRK2ArrowR-HSA-416516 (Reactome)
G-protein alpha (q):GRK5ArrowR-HSA-416510 (Reactome)
G-protein alpha (q/11): GTPArrowR-HSA-749452 (Reactome)
G-protein alpha (q/11): GTPR-HSA-398188 (Reactome)
G-protein alpha (q/11): GTPR-HSA-400586 (Reactome)
G-protein alpha (q/11): GTPR-HSA-416358 (Reactome)
G-protein alpha (q/11): GTPR-HSA-416510 (Reactome)
G-protein alpha (q/11): GTPR-HSA-416516 (Reactome)
G-protein alpha (q/11): GTPR-HSA-418582 (Reactome)
G-protein alpha (q/11): GTPmim-catalysisR-HSA-418582 (Reactome)
G-protein alpha (q/11):GDPArrowR-HSA-418582 (Reactome)
G-protein alpha (q/11):GDPR-HSA-750993 (Reactome)
G-protein alpha (q/11):PI3K alphaArrowR-HSA-416358 (Reactome)
G-protein alpha

(q/11):Trio family

RhoGEFs
ArrowR-HSA-400586 (Reactome)
G-protein beta-gamma complexArrowR-HSA-749452 (Reactome)
G-protein beta-gamma complexR-HSA-750993 (Reactome)
GDPArrowR-HSA-379048 (Reactome)
GPCRs that activate Gq/11ArrowR-HSA-749452 (Reactome)
GRK2R-HSA-416516 (Reactome)
GRK5R-HSA-416510 (Reactome)
GTPR-HSA-379048 (Reactome)
Heterotrimeric

G-protein Gq/11

(inactive)
ArrowR-HSA-750993 (Reactome)
Heterotrimeric

G-protein Gq/11

(inactive)
R-HSA-749448 (Reactome)
Ligand:GPCR

complexes that activate

Gq/11:Heterotrimeric G-protein Gq (active)
ArrowR-HSA-379048 (Reactome)
Ligand:GPCR

complexes that activate

Gq/11:Heterotrimeric G-protein Gq (active)
R-HSA-749452 (Reactome)
Ligand:GPCR

complexes that activate

Gq/11:Heterotrimeric G-protein Gq (inactive)
ArrowR-HSA-749448 (Reactome)
Ligand:GPCR

complexes that activate

Gq/11:Heterotrimeric G-protein Gq (inactive)
R-HSA-379048 (Reactome)
Ligand:GPCR

complexes that activate

Gq/11:Heterotrimeric G-protein Gq (inactive)
mim-catalysisR-HSA-379048 (Reactome)
Ligand:GPCR

complexes that

activate Gq/11
R-HSA-749448 (Reactome)
Ligands of GPCRs that activate Gq/11ArrowR-HSA-749452 (Reactome)
PI3K alphaR-HSA-416358 (Reactome)
PLC beta:G alpha (q/11)ArrowR-HSA-398188 (Reactome)
PLC beta:G alpha (q/11)mim-catalysisR-HSA-114688 (Reactome)
PLC-beta:G-alpha(q/11):DAG:IP3ArrowR-HSA-114688 (Reactome)
PLC-beta:G-alpha(q/11):PIP2R-HSA-114688 (Reactome)
PLC-betaR-HSA-398188 (Reactome)
R-HSA-114688 (Reactome) Phospholipase C (PLC) isozymes are a group of related proteins that cleave the polar head group from inositol phospholipids, typically in response to signals from cell surface receptors. They hydrolyze the highly phosphorylated lipid phosphatidylinositol 4,5-bisphosphate (PIP2) generating two products: inositol 1,4,5-trisphosphate (IP3), a universal calcium-mobilizing second messenger, and diacylglycerol (DAG), an activator of protein kinase C. PLC-beta isoforms are regulated by heterotrimeric GTP-binding proteins. PLC-beta 1 and 3 are widely expressed, with the highest concentrations found in (differing) specific regions of the brain. PLC-beta 2 is expressed at highest levels in cells of hematopoeitic origin; it is involved in leukocyte signaling and host defense. PLC-beta 4 is highly concentrated in cerebellar Purkinje and granule cells, the median geniculate body, whose axons terminate in the auditory cortex, and the lateral geniculate nucleus, where most retinal axons terminate in a visuotopic representation of each half of the visual field.
R-HSA-379048 (Reactome) G alpha q protein (or Gq/11) consists of four family members (G-alpha 11, -alpha 14, -alpha 15 and -alpha q). It activates phospholipase C (PLC) (Dowal L et al, 2006). PLC hydrolyzes phosphatidylinositol (PIP2) to diacyl glycerol (DAG) and inositol triphosphate (IP3). DAG acts as a second messenger that activates protein kinase C (PKC) and IP3 can bind to IP3 receptors, particular calcium channels in the endoplasmic reticulum (ER). Calcium flow causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.
R-HSA-398188 (Reactome) The active form of G protein alpha subunit q (Gq-alpha) was found to activate phospholipase C beta-1 (PLC-beta1), in investigations using bovine membranes. Subsequently, all 4 human isoforms have been shown to be activated by Gq, though activation of PLCbeta-4 is limited. In recombinant assays, several activated rat G alpha q family members were found to stimulate human PLC-beta isoforms with the same rank order of decreasing potency. PLC-beta1 stimulation was slightly more than for PLC-beta3; PLC-beta3 stimulation was 10-fold greater than for beta-2. PLC-beta2 is expressed specifically in hematopoietic cells. PLC-beta acts directly on Gq to accelerate hydrolysis of bound GTP, thus PLC-betas are GTPase activating proteins (GAPs). The crystal structure of the C-terminal region from Turkey PLC-beta, revealed a novel fold composed almost entirely of three long helices forming a coiled-coil that dimerizes along its long axis in an antiparallel orientation. The extent of the dimer interface and gel exclusion chromatography data suggest that PLC-betas are functionally dimeric.
R-HSA-400586 (Reactome) The Trio family of RhoA guanine nucleotide exchange factors (RhoGEFs) are directly activated by G alpha (q), possibly within a Gq:Trio:RhoA signalling complex, thereby linking Gq to RhoA-mediated processes such as cell migration, proliferation, and contraction. Like most other RhoGEFs, they have a tandem motif consisting of a Dbl homology (DH) and a pleckstrin homology (PH) domain. Trio and Duet have a number of other domains including an immunoglobin domains that may be involved in interacting with Rho, but the considerably smaller GEFT (p63RhoGEF) does not have any identifiable additional domains yet appears to be sufficient to mediate the activation of RhoA by G alpha (q). The structure represented by GEFT is proposed to represent the core of an ancient signal transduction pathway.
R-HSA-416358 (Reactome) Phospholipase C activation is the classical signalling route for G alpha (q) but an additional mechanism is an inhibitory interaction between G alpha (q) and phosphatidylinositol 3-kinase alpha (PI3K alpha). There are several PI3K subtypes but only the p85 alpha/p110 alpha subtype (PI3K alpha) is a G alpha (q) effector (PMID: 18515384). Activated G alpha (q) inhibits PI3K alpha directly, in a GTP-dependent manner. G alpha(q) binding of PI3K competes with Ras, a PI3K activator (PMID: 16268778).
R-HSA-416510 (Reactome) GRKs are serine/threonine kinases that phosphorylate GPCRs leading to receptor desensitization. GRK5 appears to be the predominant regulator of PAR1 desensitization in endothelial cells.
R-HSA-416516 (Reactome) GRK2 can inhibit GPCR signaling via phosphorylation-independent sequestration of Gq/11/14 subunits utilising its RGS homology (RH) domain. GRK2 may be an effector of activated Gq, initiating signalling cascades other than the classical PLC beta signalling associated with Gq.
R-HSA-418582 (Reactome) When a ligand activates a G protein-coupled receptor, it induces a conformational change in the receptor (a change in shape) that allows the receptor to function as a guanine nucleotide exchange factor (GEF), stimulating the exchange of GDP for GTP on the G alpha subunit. In the traditional view of heterotrimeric protein activation, this exchange triggers the dissociation of the now active G alpha subunit from the beta:gamma dimer, initiating downstream signalling events. The G alpha subunit has intrinsic GTPase activity and will eventually hydrolyze the attached GTP to GDP, allowing reassociation with G beta:gamma. Additional GTPase-activating proteins (GAPs) stimulate the GTPase activity of G alpha, leading to more rapid termination of the transduced signal. In some cases the downstream effector may have GAP activity, helping to deactivate the pathway. This is the case for phospholipase C beta, which possesses GAP activity within its C-terminal region (Kleuss et al. 1994).
R-HSA-749448 (Reactome) Numerous functionally unrelated GPCRs couple with the Gq G-protein subtype.
R-HSA-749452 (Reactome) The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (q) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).
R-HSA-750993 (Reactome) The classical model of G-protein signaling suggests that the G-protein dissociates upon GPCR activation. The active G alpha (q) subunit then participates in signaling, until its intrinsic GTPase activity degrades the bound GTP to GDP. The inactive G alpha (q):GDP complex has much higher affinity for the G beta:gamma complex and consequently reassociates.
RGS proteins active for G alpha (q)ArrowR-HSA-418582 (Reactome)
TRIO family RhoGEFsR-HSA-400586 (Reactome)
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