Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)

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61, 71, 82, 8451, 737, 79838, 183123, 5732, 4538, 5035, 6810, 43, 69, 71, 762, 58, 6528, 5949, 8646, 7015, 29, 933834, 6055, 7540, 8574, 8114, 24, 25, 41, 62...20, 26, 36, 37, 52...30, 34, 4856, 8817, 35, 682313, 51, 731, 22, 33, 9211, 77, 803, 54, 876, 9, 12, 27, 47...42, 789116, 2139, 895, 7, 42, 44, 79...endoplasmic reticulum lumenphagocytic cupcytosolIg heavy chain V-III region TRO BRK1 IGKV2-28 Ig kappa chain V-III region POM IgH heavy chain V-III region VH26 precursor Ig lambda chain V-I region VOR Ig kappa chain V-I region AU p-Y291-WAS Ig lambda chain V region 4A p-6Y-CD247-1 CDC42 WIPF2 Ig heavy chain V-III region CAM WIPF1 Ig heavy chain V-II region MCE IGLV4-69(1-?) Ig heavy chain V-II region MCE IGHV7-81(1-?) IGLV3-22(1-?) Ig lambda chain V-II region MGC ABI2 Ig kappa chain V-I region Gal BRK1 IGLV4-60(1-?) CYFIP2 Ig kappa chain V-III region B6 FCGR1A IGLV2-33(1-?) Ig lambda chain V-I region HA ACTR3 Ig heavy chain V-III region TRO IGKV2D-30 p-Y160,Y171-CD3G p-4S-ABI2 IGKV4-1(21-?) WIPF1 Ig kappa chain V-II region Cum IGLV3-16(1-?) Ig kappa chain V-I region Daudi Ig kappa chain V-I region BAN IGLV7-46(1-?) Antigen Ig lambda chain V-I region NEWM IGLC1 Ig kappa chain V-II region FR PI(3,4,5)P3 RAC1:GDPIg lambda chain V-VI region AR IGKV4-1(21-?) GTP ARPC3 VAV3 Ig kappa chain V-I region AU PPAPDC1A IGLV1-36(1-?) IGLC6 Ig lambda chain V-IV region Hil Ig kappa chain V-II region RPMI 6410 IGLV(23-?) Ig lambda chain V region 4A Ig kappa chain V-II region FR Ig heavy chain V-II region NEWM IGLV10-54(1-?) IGKV3D-20 H2OIg kappa chain V-II region RPMI 6410 IGLV7-46(1-?) PI(4,5)P2GTP IGHG4 Ig heavy chain V-II region NEWM IGKV3D-20 IGHV7-81(1-?) Ig lambda chain V-IV region Kern Ig lambda chain V-I region NEWM Ig kappa chain V-I region Wes Ig heavy chain V-III region TRO IGLV3-25(1-?) IGLV2-23(1-?) Ig heavy chain V-III region JON Ig lambda chain V-II region TOG Ig heavy chain V-II region MCE GDPIg lambda chain V-III region SH IGKV1-5(23-?) NCK1 PiIGLC3 p-Y291-WAS IGLV(23-?) CDC42:GDPIGLC7 WIPF3 Ig lambda chain V-I region VOR IGLV2-18(1-?) Myosin-X dimerIg lambda chain V region 4A Ig heavy chain V-III region WEA NCKAP1L IGLV7-46(1-?) VAV2 IGLV2-23(1-?) IGHG3 IGHG4 Ig heavy chain V-III region BUT IGKV2D-30 Ig lambda chain V-II region BOH IGHV7-81(1-?) FCGR1A BRK1 IGHG4 Ig heavy chain V-III region DOB IGHG1 ITPR3 IGLV8-61(1-?) Ig kappa chain V-I region AU IGKV1-5(23-?) Ig kappa chain V-II region FR CDC42 CYFIP1 p-Y150,S343,T346-WASF2 Ig lambda chain V-VI region AR IGLV3-22(1-?) GTPIg kappa chain V region EV15 Ig kappa chain V-I region Wes IGLV11-55(1-?) Ig heavy chain V-I region HG3 GTP CDC42 p-Y256-WASL Ig lambda chain V-II region NEI IGLV3-12(1-?) Ig heavy chain V-II region ARH-77 Ig heavy chain V-III region BUT Ig lambda chain V-II region MGC MYO5A IGHV(1-?) Ig heavy chain V-III region CAM FCGR3A Ig lambda chain V-II region NEI CRK Ig heavy chain V-III region WEA Ig lambda chain V-II region NEI Ig lambda chain V-VI region AR IGLV11-55(1-?) IGLV3-16(1-?) IGLV2-11(1-?) IGKV1-5(23-?) Ig lambda chain V region 4A Antigen IGLC6 IGKVA18(21-?) IGHG1 MYH2 Antigen Ig kappa chain V-I region Gal WIPF3 Ig heavy chain V-III region DOB IGLV8-61(1-?) ABL1IGLV4-60(1-?) Ig lambda chain V-II region TOG HSP90AB1 ITPR2 Ig kappa chain V-II region FR Ig lambda chain V-IV region Hil RAC1 p-Y151-WASF1 Ig heavy chain V-I region HG3 IGLV3-27(1-?) Ig kappa chain V-I region Wes IGLV2-33(1-?) Ig lambda chain V-I region NEW IGLV2-18(1-?) Ig lambda chain V-II region TOG Ig heavy chain V-II region MCE clusteredIgG-Ag:p-FCGRsPIK3CB Ig lambda chain V-I region HA IGHG1 ARPC5 IGKV1-12 IGLV1-36(1-?) Ig lambda chain V region 4A Ig lambda chain V-II region BOH Ig heavy chain V-II region MCE Ig kappa chain V-III region B6 IGLV4-60(1-?) p-Y160,Y171-CD3G Ig lambda chain V-IV region Kern p-T507,S645,S664-PRKCD(1-676) Ig heavy chain V-III region DOB Ig lambda chain V-II region TOG Ig heavy chain V-I region HG3 IGLC1 LYN IGLC6 IGKV2D-30 Ig kappa chain V-I region BAN IGLC1 PKC-delta/epsilonIg lambda chain V-III region SH Ig kappa chain V-I region HK101 IGLV11-55(1-?) IGLV1-44(1-?) ATP ADP IGLV2-11(1-?) Ig heavy chain V-I region EU Ig lambda chain V-III region LOI Ig heavy chain V-III region WEA p-6Y-CD247-1 ARPC4 Ig kappa chain V-I region AG Antigen IGLV3-16(1-?) IGLV2-23(1-?) Ig kappa chain V-III region B6 IGHG3 IGLV1-44(1-?) Ig kappa chain V-I region BAN Ig heavy chain V-III region BRO IGHV(1-?) Ig lambda chain V-II region NEI Ig kappa chain V-I region HK101 MyosinIg lambda chain V-III region LOI IGKC IGLV2-23(1-?) IGLC7 F-actin FGR IGKV1-5(23-?) Ig lambda chain V-I region VOR ACTB(1-375) Ig lambda chain V-I region VOR IGLV(23-?) ARPC2 Ig lambda chain V-II region MGC Ig heavy chain V-III region DOB PI(3,4)P2 Ig lambda chain V-II region TOG IgH heavy chain V-III region VH26 precursor IGHV7-81(1-?) Ig kappa chain V-I region Daudi Ig heavy chain V-III region JON IGLC6 IGKV4-1(21-?) IGHG1 Ig heavy chain V-II region ARH-77 Antigen p-Y288,Y304-FCGR2A PPAPDC1B Antigen Ig kappa chain V-I region HK101 IGLV3-16(1-?) p-6Y-SYK Ig lambda chain V-I region HA Ig heavy chain V-III region BRO IGKV2-28 SRC-1 IGLV4-60(1-?) Ig lambda chain V-I region NEW PLD2 IGLV3-12(1-?) F-actin IGLV1-44(1-?) Ig kappa chain V-III region B6 IGLV1-36(1-?) Ig kappa chain V region EV15 IGHV7-81(1-?) ARPC2 Ig heavy chain V-I region EU IGKC ACTR3 Ig heavy chain V-III region DOB GDPIGHG1 IGHV1-2 Ig heavy chain V-I region EU Ig heavy chain V-III region JON IGLV3-12(1-?) Ig heavy chain V-II region MCE Ig heavy chain V-III region JON Ig kappa chain V region EV15 Ig kappa chain V-II region RPMI 6410 Ig heavy chain V-I region EU p-5S-ABI1 IGLV2-33(1-?) Ig heavy chain V-III region BUT Ig lambda chain V-IV region Kern IGKV1-12 Ig heavy chain V-III region CAM Ig kappa chain V-III region POM HSP90AA1 Ig kappa chain V region EV15 Ig lambda chain V-IV region Bau p-S,T508-LIMK1 IGLV8-61(1-?) IGKV2-28 IGKV3D-20 Ig lambda chain V-II region BOH Ig heavy chain V-I region EU WASF3 IGLV2-33(1-?) Ig lambda chain V-I region NEWM ADPIGLV1-36(1-?) Ig lambda chain V-IV region Hil NCKAP1 IGLC6 IGHG3 IGLV4-60(1-?) IGLV3-12(1-?) PIK3R2 ADPIGLV3-25(1-?) NCKAP1L Ig lambda chain V-I region NEW Motherfilament:ARP2/3:actin:ADPIgH heavy chain V-III region VH26 precursor Ig heavy chain V-I region HG3 IGLV7-46(1-?) ARPC3 p-Y288,Y304-FCGR2A ARPC4 IGLV3-16(1-?) Myosin-ActinfilamentsARPC1A Ig lambda chain V-II region BOH ACTR2 Ig lambda chain V-I region NEWM Ig kappa chain V-III region VG RAC1 IGKV1-5(23-?) CYFIP1 YES1 clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVIGHV(1-?) Ig kappa chain V-II region RPMI 6410 IGLV7-43(1-?) ARPC2 IGLV4-3(1-?) ATPIGKC IGHV(1-?) IGLC7 IGLV11-55(1-?) Ig heavy chain V-III region BRO IGLV10-54(1-?) Ig heavy chain V-II region NEWM IGKV1-12 Ig lambda chain V-II region TOG Ig kappa chain V-II region RPMI 6410 IGHG4 IGKC Ig lambda chain V-II region BOH Ig lambda chain V-I region NEWM Ig lambda chain V-II region TOG IGLV(23-?) IGLC7 ACTR3 IGLV10-54(1-?) Ig lambda chain V region 4A IGLC6 IGLV3-22(1-?) ATP Ig heavy chain V-II region ARH-77 IGLV1-36(1-?) Ig heavy chain V-II region OU IGLC3 FCGR3A ARPC3 IGHG3 FCGR1A CYFIP1 p-Y256-WASL Ca2+pLIMK dimer:HSP-90IGHG4 IGLC3 IGLV4-3(1-?) Ig kappa chain V-I region Daudi Ca2+IGLV3-12(1-?) Ig lambda chain V-I region NEW IGLV3-16(1-?) IGHV7-81(1-?) Actin filament boundMyosin-XIg kappa chain V-III region B6 RAC1 Ig heavy chain V-III region KOL p-Y288,Y304-FCGR2A IGLV4-60(1-?) Antigen IGLV3-22(1-?) IGLV11-55(1-?) Ig kappa chain V-I region HK101 Ig heavy chain V-III region BUT ABI2 RAC1 MYH2 Ig heavy chain V-II region NEWM IgG-Ag:FCGRIA:CD3GhomodimerclusteredIgG-Ag:p-FCGRs:p-6Y-SYK:PLCGIg kappa chain V-I region Daudi IGLC7 Ig kappa chain V-I region Daudi Ig kappa chain V-I region AG PI(3,4,5)P3 Ig kappa chain V-III region VG IGKVA18(21-?) PI(4,5)P2 IGLV2-23(1-?) Ig kappa chain V-II region Cum IGLV7-46(1-?) PI(3,4,5)P3 IGLV5-37(1-?) Ig heavy chain V-III region TRO IGHG2 IGLV10-54(1-?) IGLV2-33(1-?) IGLC7 Ig lambda chain V-VI region AR IGKVA18(21-?) IGLV2-18(1-?) Ig kappa chain V-I region DEE Ig heavy chain V-III region DOB IGLV2-18(1-?) IGLV1-44(1-?) CYFIP2 ITPR2 IGKV1-5(23-?) Ig heavy chain V-II region OU IGHV(1-?) IGLV2-18(1-?) IGLC6 Ig lambda chain V-III region LOI IGLC7 Ig heavy chain V-II region MCE IGLV2-33(1-?) Ig kappa chain V-I region AU Ig heavy chain V-I region EU IGLV5-45(1-?) Ig kappa chain V-I region AU Ig kappa chain V-III region POM Ig lambda chain V-I region NEW IGLV1-36(1-?) IGLV3-27(1-?) IGKV2-28 IGLV4-3(1-?) Ig lambda chain V-II region NEI Ig heavy chain V-III region BUT Ig lambda chain V-II region TOG IGLV10-54(1-?) ATPIg kappa chain V-II region Cum IGLV3-27(1-?) IGHV7-81(1-?) clusteredIgG-Ag:p-FCGRsATPIg heavy chain V-II region MCE I(1,4,5)P3 IGHV1-2 NCKIPSD Ig lambda chain V-III region SH p-Y160,Y171-CD3G NCK1 IGLV2-11(1-?) IgH heavy chain V-III region VH26 precursor Ig kappa chain V-III region VG GRB2-1 Ig lambda chain V-I region VOR IGLV2-23(1-?) BRK1 Ig kappa chain V-III region VG IGLV4-69(1-?) Ig kappa chain V-I region AG IGLV7-46(1-?) Ig kappa chain V-I region AG Ig kappa chain V-I region Gal IGLV7-43(1-?) ATPIGLV1-44(1-?) IGLV8-61(1-?) CYFIP2 CRK:DOCK180:ELMO1,ELMO2ADPp-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3Ig heavy chain V-II region MCE IGKV2D-30 p-Y160,Y171-CD3G Ig heavy chain V-III region KOL IP3 receptorhomotetramerCDC42 IGKV4-1(21-?) PI3K:p-6Y-SYKIg heavy chain V-III region BRO ACTR3 IGLV4-69(1-?) IGKVA18(21-?) F-actin p-6Y-CD247-1 IGLV3-25(1-?) IGHV1-2 Ig kappa chain V-III region VG p-6Y-CD247-1 IGLV11-55(1-?) IGLV1-44(1-?) Ig kappa chain V-III region B6 IGLC7 Ig kappa chain V region EV15 Ig heavy chain V-III region JON IGKV3D-20 Ig heavy chain V-II region NEWM FCGR3A CYFIP1 IGLC2 PI(3,4,5)P3Ig heavy chain V-III region JON IGHG3 Antigen:IgGIGLV(23-?) Ig lambda chain V-II region MGC IGLV2-18(1-?) Ig lambda chain V-VI region AR IGLV4-60(1-?) Ig kappa chain V-I region Gal IGKV3D-20 IGLV2-18(1-?) IGLV3-25(1-?) HSP90AB1 Ig kappa chain V-I region AU p-4Y-PLCG1p-T566,T710,S729-PRKCE Ig heavy chain V-II region NEWM Ig kappa chain V-I region DEE CD3G Ig lambda chain V-II region MGC Ig kappa chain V-I region HK101 p-Y151,S,T-WASF3 Ig heavy chain V-II region WAH IGLV1-40(1-?) IGLV2-11(1-?) IGLV2-18(1-?) Ig kappa chain V-I region AG Ig heavy chain V-I region EU Ig lambda chain V-I region NEW Ig heavy chain V-III region BRO p-Y151-WASF3 Ig heavy chain V-III region TRO CYFIP1 Ig lambda chain V-I region HA IGLV5-45(1-?) Ig kappa chain V-I region AG WASF2 Ig lambda chain V-IV region Bau IGLV3-16(1-?) PI(4,5)P2 CDC42:GTPIGKV3D-20 IGHV(1-?) IGLC2 IGHG2 Ig kappa chain V region EV15 Ig lambda chain V-II region TOG Ig heavy chain V-II region ARH-77 p-Y288,Y304-FCGR2A ACTB(1-375) N-WASP IGKV1-5(23-?) IGLV4-3(1-?) WAS Ig heavy chain V-II region WAH Ig heavy chain V-III region KOL WIPF2 IGLV3-25(1-?) IGLV5-37(1-?) Ig heavy chain V-I region EU Ig kappa chain V-I region Daudi PLD1 Ig heavy chain V-II region MCE Ig lambda chain V region 4A PI(4,5)P2 p-Y753,Y759,Y1217-PLCG2 IGLV2-23(1-?) IGHG2 Ig lambda chain V-I region HA Ig lambda chain V-III region SH ITPR2 Ig kappa chain V-III region B6 IGHG3 IGKV2D-30 FCGR1A IGHG3 Ig kappa chain V-I region Daudi IGLV(23-?) Ig lambda chain V-III region SH Ig lambda chain V-VI region AR ARPC4 IGLV2-33(1-?) Ig kappa chain V-II region RPMI 6410 PI(4,5)P2IGLV4-69(1-?) Ig kappa chain V-III region VG Ig heavy chain V-II region WAH Ig lambda chain V-I region NEW Ig lambda chain V-III region SH IGLV3-27(1-?) Ig lambda chain V-I region HA Ig kappa chain V-I region Wes Ig lambda chain V-I region NEW Ig lambda chain V-II region BOH IGKV1-5(23-?) p-Y172-VAV2 Ig heavy chain V-II region OU RAC1 Ig lambda chain V-III region LOI Ig heavy chain V-II region MCE Ig lambda chain V-I region NEW Ig heavy chain V-II region ARH-77 Ig lambda chain V-II region MGC WASP/N-WASPIg lambda chain V-I region NEWM IGLC3 IGLV3-27(1-?) Ig lambda chain V-IV region Bau GDP Ig lambda chain V-II region BOH Ig heavy chain V-III region JON IGLV3-27(1-?) Ig lambda chain V-VI region AR Ig kappa chain V-I region AG Ig heavy chain V-III region CAM Ig kappa chain V-I region AU IGLV8-61(1-?) Ig kappa chain V-I region Wes Ig heavy chain V-I region HG3 ITPR1 Ig lambda chain V-II region NEI IGHV1-2 ARPC5 Ig heavy chain V-III region BRO IGLC7 WIPF1 IGLV7-46(1-?) Ig lambda chain V-IV region Hil Ig kappa chain V-II region RPMI 6410 p-6Y-SYK Ig kappa chain V-I region Gal BAIAP2 PI3KIg lambda chain V-III region SH IGLV4-69(1-?) IGLV4-3(1-?) WIPF2 IGHG1 F-actin IGLC2 CD3G Ig lambda chain V-IV region Kern Ig lambda chain V region 4A p-6Y-SYK IGLV1-44(1-?) p-6Y-CD247-1 clusteredIgG-Ag:p-FCGRs:SYKIGLV7-43(1-?) IGHV1-2 IGLV7-43(1-?) Ig kappa chain V-I region HK101 FYN IGLV2-23(1-?) p-Y151-WASF3 ADPIGKV2D-30 GTP GDP IGLV1-36(1-?) Ig kappa chain V-I region AU Ig lambda chain V-III region SH Ig heavy chain V-II region ARH-77 Ig lambda chain V-II region BOH Ig kappa chain V-I region Gal IGKC IGKV2-28 Ig heavy chain V-I region HG3 ADPIg heavy chain V-III region CAM IgH heavy chain V-III region VH26 precursor p-5S-ABI1 clusteredIgG-Ag:p-FCGRs:p-6Y-SYKIGKVA18(21-?) NCK1 IGLV2-11(1-?) Ig kappa chain V-III region VG Ig kappa chain V-II region Cum IGKV2D-30 Ig heavy chain V-II region ARH-77 IGLV4-3(1-?) IGLV3-12(1-?) IGKV4-1(21-?) WAS Ig lambda chain V-VI region AR IGLV4-60(1-?) IGHG1 IGLC7 IGHV(1-?) Ig heavy chain V-III region TRO FCGR1A Ig kappa chain V-I region Gal IGHG2 IGKV1-12 IGLV11-55(1-?) IGHG1 p-5S-ABI1 Ig kappa chain V-I region Daudi IGLC2 Ig lambda chain V-II region MGC Ig kappa chain V-I region DEE IGHG1 Ig kappa chain V-II region Cum Ig kappa chain V-III region POM IGLV8-61(1-?) Ig heavy chain V-III region DOB Ig heavy chain V-III region CAM Ig lambda chain V-IV region Hil IGKC p-6Y-SYK Ig lambda chain V-I region VOR IGLV11-55(1-?) Ig heavy chain V-I region EU Ig lambda chain V-II region NEI p-Y151,S,T-WASF1 Ig kappa chain V-III region B6 Ig lambda chain V-I region VOR Ig kappa chain V-I region Wes IGKV1-5(23-?) p-Y160,Y171-CD3G GRB2-1 CRKII:DOCK180:ELMOcomplex recruitedto phagocytic cupIg heavy chain V-II region MCE NF2Ig heavy chain V-II region WAH IGLV3-27(1-?) Ig kappa chain V-I region AU p-Y151-WASF1 ATP I(1,4,5)P3 IGHV(1-?) IGKV2-28 CD247-1 IGLC2 DAGsp-Y150-WASF2 Ig lambda chain V-II region MGC ARPC3 IGLV10-54(1-?) Ig heavy chain V-II region NEWM Ig lambda chain V-IV region Hil CDC42:GTP, RAC1:GTPIg heavy chain V-II region NEWM IGKV4-1(21-?) Ig kappa chain V-I region AU ARPC1B IGHG2 IGLV4-69(1-?) IGKV1-5(23-?) Ig kappa chain V-I region HK101 PLDIg heavy chain V-III region WEA Ig lambda chain V-IV region Bau IGKV1-5(23-?) IGLC2 Ig heavy chain V-III region TRO WIPF2 Ig heavy chain V-I region HG3 Ig lambda chain V region 4A Ig kappa chain V region EV15 IGKV2D-30 p-Y160,Y171-CD3G IGLV3-27(1-?) MYO9B Ig heavy chain V-I region EU WIPF1 IGLV3-25(1-?) Motherfilament:branchingcomplexIg heavy chain V-II region NEWM Ig heavy chain V-II region OU Ig lambda chain V-IV region Kern Ig lambda chain V-III region LOI p-Y288,Y304-FCGR2A NCKAP1 Ig lambda chain V-IV region Bau Ig kappa chain V-I region Gal IGHG3 Ig heavy chain V-III region KOL IGHG2 HCK IGLC7 VAV1 p-Y151,S,T-WASF1 Ig kappa chain V region EV15 Ig lambda chain V-III region SH p-4S-ABI2 IGLV1-40(1-?) Ig kappa chain V-I region HK101 IGLC6 ATP Ig heavy chain V-II region ARH-77 FCGR3A ARPC5 IGHV(1-?) Ig kappa chain V-II region RPMI 6410 IGHG4 Ig lambda chain V-I region HA Ig lambda chain V-I region HA Ig heavy chain V-III region BUT Ig heavy chain V-III region DOB Active LIMK1Ig kappa chain V region EV15 IGLV8-61(1-?) ABI1 Ig kappa chain V-I region Wes BRK1 IGLV4-60(1-?) IGLV7-43(1-?) Ig kappa chain V-II region FR IGLV4-69(1-?) ATPIg kappa chain V-II region RPMI 6410 Ig kappa chain V-III region VG Ig heavy chain V-II region ARH-77 IGLC3 IGHV7-81(1-?) Ig kappa chain V-III region B6 ARPC4 IGKV1-12 I(1,4,5)P3PI(4,5)P2 IGKV1-12 IGLV2-23(1-?) IGLV3-16(1-?) IGLV8-61(1-?) Ig kappa chain V-III region VG ACTR2 IGLV1-36(1-?) IGKV2-28 Ig lambda chain V-I region VOR PAK1 dimerIg kappa chain V-III region VG IGLV7-46(1-?) ABI1 GTP Ig kappa chain V-I region Daudi IGLC3 IGLV1-40(1-?) IGHV7-81(1-?) Ig kappa chain V-II region Cum IGLV1-36(1-?) IGLV8-61(1-?) IgH heavy chain V-III region VH26 precursor p-Y256-WASL Ig heavy chain V-II region WAH CDC42 NCKAP1 FCGR1A H2OIg lambda chain V-II region BOH Ig lambda chain V-IV region Hil PIK3CB Ig lambda chain V-II region MGC Antigen IGLC2 IGHG4 FCGR3A IGLV2-18(1-?) IGLV(23-?) GTP IGLV10-54(1-?) Ig lambda chain V-III region SH Ig lambda chain V-III region SH Ig lambda chain V-II region NEI IGHG3 IGLV(23-?) Ig heavy chain V-I region HG3 Ig lambda chain V-I region HA IGHG3 PI(4,5)P2NCKAP1L IGLV1-40(1-?) ATP IGHG4 CYFIP1 WIPF3 p-T508-LIMK1 IGHG2 Ig heavy chain V-III region BUT IGLV5-45(1-?) IGHG2 IGKV3D-20 IGLV2-23(1-?) AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerIg lambda chain V-IV region Hil Ig heavy chain V-III region KOL Ig heavy chain V-I region HG3 Ig lambda chain V-III region LOI ELMO1 Ig kappa chain V-I region BAN Ig heavy chain V-II region WAH DAGsADP IGLC2 Ig heavy chain V-II region WAH IGLV1-36(1-?) Ig kappa chain V-II region Cum IGLV10-54(1-?) Ig heavy chain V-II region WAH Ig kappa chain V-III region B6 PI(3,4,5)P3 ABI2 VAV2 Ig lambda chain V-I region VOR N-WASP IGLV1-44(1-?) IGHG4 IGLV2-18(1-?) Ig heavy chain V-III region JON IGLV4-69(1-?) IGLC6 IGLV1-40(1-?) Ig heavy chain V-III region BUT Ig kappa chain V-II region FR IGKV1-5(23-?) IGLV5-45(1-?) Ig lambda chain V-II region MGC Ig heavy chain V-III region BUT IgH heavy chain V-III region VH26 precursor IGLV2-11(1-?) NCKIPSD Ig kappa chain V-I region Wes GRB2-1 ACTB(1-375) Ig heavy chain V-III region JON F-actin Ig heavy chain V-III region TRO FCGR3A IGLV1-36(1-?) IGLV2-23(1-?) N-WASP IGLC1 IGLV1-44(1-?) Ig kappa chain V-I region AG IGLV4-69(1-?) ChoIg lambda chain V-I region NEWM Ig kappa chain V-III region POM MYO10 WIPF1 IGLV3-27(1-?) IGHG2 IGHG4 BTK IGLV2-11(1-?) Ig heavy chain V-III region DOB PCIg heavy chain V-III region BRO Phospho-PKC-delta/epsilonFCGR3A Ig heavy chain V-III region WEA IGHV1-2 IGKC IGLC2 IGKVA18(21-?) IGKV1-12 IGKV4-1(21-?) WIPF2 ATP Ig heavy chain V-III region KOL Ig heavy chain V-III region CAM MYH9 IGHG3 IGLV1-40(1-?) IGKVA18(21-?) Ig heavy chain V-II region NEWM G-actinIGLV7-43(1-?) Ig kappa chain V-II region FR Ig heavy chain V-III region BRO Ig lambda chain V-IV region Bau IGKV3D-20 IGHV1-2 ADPIg lambda chain V-II region NEI Ig heavy chain V-III region TRO Ig kappa chain V region EV15 SH3 domain proteinsIg lambda chain V region 4A IGLV2-11(1-?) CDC42 Ig lambda chain V-I region HA WIP family proteinsFCGRIA:CD3GhomodimerIg heavy chain V-III region WEA Ig kappa chain V-II region Cum IGKV4-1(21-?) IGKV1-12 Ig heavy chain V-III region WEA IGLV2-11(1-?) IGLV5-37(1-?) Ig kappa chain V-II region RPMI 6410 IGKV2-28 Ig kappa chain V region EV15 ARPC1A IGLV7-43(1-?) IGLV2-23(1-?) ADPIg heavy chain V-III region TRO WIPF3 ARPC5 IGHG4 Ig lambda chain V-IV region Hil IGLV3-16(1-?) Ig lambda chain V-I region HA IGKVA18(21-?) IGKV3D-20 Ig heavy chain V-I region HG3 Ig heavy chain V-III region BUT ADP Ig lambda chain V-III region LOI Ig lambda chain V-VI region AR IGLV2-33(1-?) p-Y288,Y304-FCGR2A p-Y160,Y171-CD3G p-S3-CFL1 ACTG1 Ig kappa chain V-I region Gal Ig lambda chain V-IV region Bau Ig heavy chain V-III region DOB IGKV4-1(21-?) IGLV10-54(1-?) IGLV4-69(1-?) ABI2 Ig kappa chain V-I region AU IGLV8-61(1-?) Ig kappa chain V-II region Cum IGLV4-3(1-?) Ig kappa chain V-III region VG Ig lambda chain V-II region BOH IGKV2-28 Ig kappa chain V-II region FR IGHG2 IGLC3 Ig kappa chain V-I region HK101 IgH heavy chain V-III region VH26 precursor BRK1 IgH heavy chain V-III region VH26 precursor NCKAP1 Ig kappa chain V-II region FR IGKC p-Y288,Y304-FCGR2A HSP90AA1 IGLV(23-?) IGLV1-44(1-?) Ig kappa chain V-I region Wes p-6Y-CD247-1 Ig heavy chain V-I region HG3 ATPIg kappa chain V-I region BAN Ig lambda chain V-II region TOG F-actinIg heavy chain V-III region JON IGHG2 FCGR1A IGLV(23-?) IGLV2-18(1-?) IGLV3-16(1-?) IGKV1-5(23-?) IGLV7-46(1-?) Ig heavy chain V-III region DOB IGHG3 ITPR3 Ig heavy chain V-II region OU FCGR2A FCGR1A ADPBAIAP2 Ig lambda chain V-I region HA IGLV3-22(1-?) IGLV2-11(1-?) CYFIP2 IGLV5-37(1-?) IGLC6 IGLV(23-?) Ig lambda chain V-I region HA IGLV5-37(1-?) IGKV3D-20 IGKV2D-30 IGLV4-69(1-?) IGLV1-44(1-?) Ig kappa chain V-II region RPMI 6410 ATPIGLV7-46(1-?) Antigen Ig kappa chain V-I region AG Ig kappa chain V-I region AG Ig kappa chain V-I region AG MYO10 IGLV11-55(1-?) Ig lambda chain V-III region LOI Ig heavy chain V-II region OU Ig kappa chain V-I region Daudi IGLV3-27(1-?) Ig heavy chain V-II region MCE IGKV1-12 ATPIg heavy chain V-III region JON IGKV2-28 IGLV1-36(1-?) IGHG1 Ig kappa chain V region EV15 Ig kappa chain V-I region Wes Ig lambda chain V-VI region AR p-Y288,Y304-FCGR2A Ig kappa chain V-III region VG ARPC1B IGLV1-44(1-?) Ig lambda chain V-II region BOH G-actinATP GTP p-6Y-CD247-1 Ig lambda chain V-I region VOR IGLV2-33(1-?) IGLC1 IGHV7-81(1-?) IGLV10-54(1-?) IGKV3D-20 Ig heavy chain V-III region TRO Ig lambda chain V-II region NEI CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsNCKAP1 p-Y174-VAV1 IGLV5-45(1-?) Ig lambda chain V-II region TOG NCK1 IGLV1-44(1-?) IGLC3 IGLC2 IGHV1-2 ELMO1 IGLC1 IGLV1-36(1-?) PiIGKV4-1(21-?) IGLV7-43(1-?) Ig lambda chain V-II region TOG PLCG2 IGHV7-81(1-?) Ig lambda chain V-I region NEW IGLC2 IGLV4-69(1-?) IGLV3-22(1-?) Ig lambda chain V-I region NEWM IGLV3-25(1-?) Ig heavy chain V-III region CAM IGKV2-28 IGHG3 IGHV(1-?) Ig lambda chain V-II region NEI GTP IGKV1-12 ARPC5 Ig kappa chain V-I region DEE IGLV11-55(1-?) Ig heavy chain V-II region OU IGLV2-23(1-?) Ig lambda chain V-II region BOH Ig lambda chain V-VI region AR IGLV1-40(1-?) IGHV7-81(1-?) IGLC3 p-T,Y MAPK dimersIg lambda chain V-II region NEI WIPF3 ATP Ig kappa chain V-II region RPMI 6410 Ig heavy chain V-II region OU IGLV3-12(1-?) NAD+ Ig lambda chain V-II region TOG Ig lambda chain V-III region LOI Ig heavy chain V-III region TRO Ig lambda chain V-IV region Kern ADPIGLC6 Ig heavy chain V-II region ARH-77 Ig heavy chain V-III region KOL Ig lambda chain V-I region NEWM PLC gamma1,2IGLV3-16(1-?) IGLV5-45(1-?) ARPC3 Activated WAVE2 andWASP/N-WASP:ARP2/3complex:G-actinITPR:I(1,4,5)P3tetramerIGKV2D-30 IGLV7-43(1-?) IGLV1-36(1-?) IGLV3-27(1-?) IGLV5-45(1-?) Ig lambda chain V-III region SH PRKCE Ig lambda chain V region 4A Ig kappa chain V-III region POM NCK1 p-Y160,Y171-CD3G GRB2-1 Ig kappa chain V-II region FR IGHG1 IGLV4-3(1-?) Ig kappa chain V-II region Cum ACTR3 IGKV3D-20 IGLV4-60(1-?) ARPC4 IGLV3-25(1-?) Ig lambda chain V-III region LOI Ig kappa chain V-II region Cum Ig lambda chain V-IV region Bau Ig lambda chain V-II region NEI IGKV1-5(23-?) Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-IV region Bau IGLC7 Ig kappa chain V-I region Daudi IGLV4-3(1-?) AHCYL1 ARPC3 IGLV11-55(1-?) Ig heavy chain V-III region TRO Ig lambda chain V-I region VOR IGLV2-33(1-?) Ig kappa chain V-I region BAN p-Y150-WASF2 DOCK1 IGLV3-16(1-?) Ig heavy chain V-III region CAM FCGR3A Antigen IGKV1-5(23-?) Ig heavy chain V-III region KOL p-6Y-CD247-1 WASF1 Ig heavy chain V-III region WEA CD3G Ig kappa chain V-I region BAN IGLV3-22(1-?) IGLC6 Ig kappa chain V-I region Gal ELMO2 Ig kappa chain V-I region BAN Ig lambda chain V-I region NEWM Ig heavy chain V-II region NEWM Ig lambda chain V-I region HA clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGRAC1 Ig lambda chain V-I region HA Ig lambda chain V region 4A NCKAP1L BAIAP2 IGLV4-69(1-?) WAVE RegulatoryComplexIGLV3-22(1-?) IGLV1-44(1-?) IGLV10-54(1-?) IGKVA18(21-?) GTP ACTR3 Ig heavy chain V-III region DOB PLCG1 CFL1IGKV3D-20 ARP2/3 complex (ATPbound)IGLV3-12(1-?) IGKC Ig kappa chain V-III region VG Ig lambda chain V-IV region Hil Ig lambda chain V-II region BOH Ig heavy chain V-II region WAH IGKC RAC1 IgH heavy chain V-III region VH26 precursor Ig heavy chain V-III region BRO ARPC1A Ig heavy chain V-II region MCE Ig kappa chain V-I region Gal Ig kappa chain V-I region Wes IGKV3D-20 FCGR3A IGHV(1-?) Ig heavy chain V-II region OU Ig heavy chain V-III region BUT Ig lambda chain V-II region TOG Ig heavy chain V-III region CAM Ig kappa chain V-I region DEE IGLV4-69(1-?) WIPF2 Ig kappa chain V-II region FR Ig lambda chain V-IV region Kern Ig lambda chain V-III region LOI Ig kappa chain V-III region POM Ig lambda chain V-IV region Bau IGLV10-54(1-?) IGLV4-3(1-?) IGLV1-40(1-?) ARPC2 Ig kappa chain V-III region POM IGLV3-25(1-?) Ig lambda chain V-I region NEW IGLV4-3(1-?) IGLV1-40(1-?) Ig heavy chain V-III region BRO WAS IGKV2D-30 ACTR3 Antigen Ig kappa chain V-I region Wes IGLV4-3(1-?) GTP IGLV2-11(1-?) Ig heavy chain V-II region WAH Ig kappa chain V-I region BAN p-Y151-WASF1 Ig kappa chain V-III region POM ARPC5 ATPIg kappa chain V-I region DEE IGKC Ig lambda chain V-IV region Kern Ig lambda chain V-IV region Bau Ig lambda chain V-I region NEWM Ig lambda chain V-IV region Kern Ig lambda chain V-I region NEWM ARPC1A PLA2G6IgH heavy chain V-III region VH26 precursor Ig heavy chain V-II region OU IGLV5-45(1-?) IGLC1 p-5S-ABI1 Ig kappa chain V-I region DEE Ig lambda chain V-IV region Bau PiIGHV1-2 Ig lambda chain V-IV region Kern Ig kappa chain V-I region AG Ig kappa chain V-I region Gal NCKIPSD IGLV4-3(1-?) Ig kappa chain V-I region Wes CYFIP2 IgH heavy chain V-III region VH26 precursor FCGR1A CD247-1 IGKV2-28 MYO9B IGLV3-12(1-?) Ig heavy chain V-III region JON Ig heavy chain V-I region EU IGKV2-28 Ig kappa chain V-I region Gal ARPC1A IGLV10-54(1-?) IGLV(23-?) IGLV8-61(1-?) Ig kappa chain V-II region Cum Ig kappa chain V-I region DEE p-S144,T423-PAK1Ig heavy chain V-I region HG3 Ig heavy chain V-III region WEA ARPC2 p-Y256-WASL SYK BAIAP2 Ig heavy chain V-III region DOB IGKV2-28 Ig kappa chain V-I region AU ABI1 Ig heavy chain V-III region TRO Ig heavy chain V-II region ARH-77 Ig heavy chain V-III region JON Ig kappa chain V-I region Daudi ARAIg lambda chain V-II region MGC IGLV3-27(1-?) FCGRIIIA:CD3G/CD3ZdimersIGHG4 NCKIPSD FCGR1A p-Y753,Y759,Y1217-PLCG2 IGLV5-37(1-?) VAV3 pCofilin: ActiveLIMK-1CDC42:GTP:WASP/N-WASPPAK1Ig kappa chain V-II region FR ARPC1B ADPIg lambda chain V-IV region Kern IGLV1-40(1-?) MYO1C IGLV3-16(1-?) Ig kappa chain V region EV15 Ig kappa chain V-III region POM IGLV2-33(1-?) Ig heavy chain V-II region WAH IGLV5-45(1-?) IGHV(1-?) IGLV2-23(1-?) Ig kappa chain V-I region BAN Ig kappa chain V-III region B6 Ig heavy chain V-III region WEA Ig lambda chain V-III region SH IGLC1 Ig kappa chain V-I region Daudi IGKV1-5(23-?) Ig kappa chain V-I region DEE ARPC4 IGLV5-45(1-?) FCGR3A Ig kappa chain V-III region POM IGLC1 IGKC IGLV7-43(1-?) Ig kappa chain V-III region B6 IGKVA18(21-?) IGKV4-1(21-?) Ig lambda chain V-IV region Hil p-Y291-WAS PI(3,4)P2ATPIGKV2D-30 MYO5A ABI2 IGLV1-40(1-?) Ig heavy chain V-III region CAM Ig kappa chain V-III region POM Ig kappa chain V-I region HK101 Ig kappa chain V-III region POM p-Y151,S,T-WASF1 FCGR3A PCp-Y160,Y171-CD3G Ig lambda chain V-II region TOG Ig lambda chain V-II region MGC IGLC1 ABI1 PI(3,4,5)P3ARPC1B Ig lambda chain V region 4A Ig kappa chain V-II region Cum IGLV3-22(1-?) PI(3,4,5)P3 IGHG3 Ig kappa chain V-III region B6 ACTB(1-375) p-Y150-WASF2 Ig heavy chain V-III region BRO Ig kappa chain V-I region Wes IGLC3 Ig kappa chain V-I region HK101 Ig kappa chain V-I region Daudi WIPF3 IGLV3-12(1-?) IGHV7-81(1-?) IGLV2-33(1-?) IGLV3-27(1-?) PLCG2 Ig kappa chain V-I region Daudi IGLV1-40(1-?) WIPF1 Ig kappa chain V-II region FR Ig heavy chain V-II region NEWM Ig heavy chain V-III region BRO IGLV2-23(1-?) Ig lambda chain V-IV region Bau Ig kappa chain V-I region AU IGLV8-61(1-?) Ig heavy chain V-II region MCE p-4Y-PLCG1 IgH heavy chain V-III region VH26 precursor Ig lambda chain V-VI region AR Ig heavy chain V-III region BUT ABI2 Ig heavy chain V-III region BRO Ig lambda chain V-I region VOR IGLV3-25(1-?) Ig lambda chain V-II region NEI Ig kappa chain V-I region HK101 IGLV5-45(1-?) IGLC1 IGHV1-2 IGLV2-33(1-?) IGLV1-36(1-?) Antigen Ig heavy chain V-III region KOL Ig heavy chain V-I region HG3 PAK1 Ig kappa chain V-I region HK101 IGKV3D-20 p-Y288,Y304-FCGR2A IGHV1-2 PRKCD IGLV(23-?) Ig heavy chain V-II region NEWM Src family kinases(SFKs)Ig lambda chain V-I region NEW IGLV1-40(1-?) IGLV10-54(1-?) NCKAP1 Ig kappa chain V-I region AG Ig kappa chain V region EV15 clusteredIgG-Ag:p-FCGRsIg kappa chain V-I region Gal CRK IGKV4-1(21-?) IGLV3-12(1-?) Ig heavy chain V-III region BRO Ig kappa chain V-I region DEE Ig lambda chain V-II region NEI PhosphatidatephosphataseATPIg lambda chain V-I region NEWM IGHG1 IGLV3-12(1-?) IGKV2D-30 IGHV(1-?) CYFIP2 Ig heavy chain V-II region WAH ACTR2 Ig lambda chain V-I region VOR Ig heavy chain V-III region JON Ig kappa chain V-II region FR NCKAP1L Ig lambda chain V-III region LOI Ig heavy chain V-II region ARH-77 IGLV5-37(1-?) IGLV1-40(1-?) IgG-Ag:FCGRIIAFCGR1A IGLV5-45(1-?) GTP IGHG2 IGKV1-12 Ig kappa chain V-I region Gal FCGR3A Ig heavy chain V-III region WEA p-Y151-WASF3 Ig heavy chain V-II region MCE NCKAP1L Ig kappa chain V-III region B6 IGLV5-45(1-?) IGHG4 p-T202,Y204-MAPK3 IGHG3 ITPR1 IGLV5-37(1-?) Ig heavy chain V-II region NEWM IGLV3-22(1-?) IGHG1 PTK2 IGHG3 ARPC5 Ig lambda chain V-IV region Bau Ig heavy chain V-III region CAM p-4S-ABI2 IGLV4-3(1-?) IGLV1-44(1-?) Ig heavy chain V-III region BRO IGLV4-60(1-?) ACTG1 IGKV4-1(21-?) ACTG1 Ig kappa chain V-II region Cum CDC42 ARPC2 Unknown GEFIg lambda chain V-VI region AR Ig kappa chain V-II region FR Ig kappa chain V-II region RPMI 6410 Ig heavy chain V-III region KOL IGLC3 Ig heavy chain V-II region WAH PI(3,4,5)P3Ig lambda chain V-IV region Hil Ig heavy chain V-I region EU ARPC1A Ig heavy chain V-I region EU Ig heavy chain V-III region DOB p-Y150-WASF2 Ig kappa chain V-I region DEE Ig lambda chain V region 4A Ig lambda chain V-III region LOI Ig kappa chain V-I region AU IGLV3-22(1-?) Ig kappa chain V-III region VG FCGR1A IGLV5-45(1-?) IGLC1 PIK3CA IGLV11-55(1-?) Ig kappa chain V-I region HK101 IGHV1-2 IGHG4 Ig lambda chain V-IV region Hil Ig kappa chain V-I region BAN Ig lambda chain V-III region LOI H2OIg lambda chain V-III region LOI clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:VAVDOCK1 IGLV5-37(1-?) IGLV7-46(1-?) Ig kappa chain V-I region AU IgH heavy chain V-III region VH26 precursor Antigen Ig lambda chain V-II region MGC ACTR2 WASF2 Ig heavy chain V-II region OU p-Y288,Y304-FCGR2A Ig heavy chain V-I region HG3 p-6Y-SYK IGLV2-18(1-?) Ig lambda chain V-II region MGC H2OMYH9 IGLV11-55(1-?) Ig heavy chain V-III region BUT Antigen p-Y151,S,T-WASF1 Ig kappa chain V-I region DEE IGKC IGLC7 2-LysophosphatidylcholineIg lambda chain V region 4A Ig heavy chain V-II region ARH-77 HSP90AA1,HSP90AB1Ig lambda chain V-I region NEWM IGLC1 CD247-1 IGHG2 p-6Y-SYK p-4Y-PLCG1 Ig heavy chain V-II region OU IGLV5-37(1-?) IGLV4-69(1-?) ATPp-Y151-WASF3 Ig lambda chain V-IV region Kern IGLV8-61(1-?) Ig kappa chain V-I region BAN IGLC3 Ig heavy chain V-III region KOL IGLV7-43(1-?) RAC1:GTPARPC3 IGLV3-25(1-?) Ig heavy chain V-III region JON IGLC7 Ig kappa chain V-I region BAN IGLV2-18(1-?) Ig lambda chain V-IV region Kern IGLV2-11(1-?) IGLV(23-?) Ig heavy chain V-III region BRO NCKAP1L Ig heavy chain V-II region OU Ig heavy chain V-III region BUT IGLV4-60(1-?) Ig heavy chain V-III region TRO Ig kappa chain V-I region HK101 IGLV11-55(1-?) Ig kappa chain V-I region DEE PIK3R1 Ig heavy chain V-III region WEA IGHV1-2 IGLV3-16(1-?) FCGR1A FCGR2A GTP BRK1 RAC1 p-Y150,S343,T346-WASF2 ACTG1 Ig lambda chain V-II region BOH Ig kappa chain V-I region DEE IGLV2-18(1-?) Ig lambda chain V-I region VOR Ig heavy chain V-III region TRO PI(3,4,5)P3 IGHV(1-?) Ig lambda chain V-VI region AR ATPIg lambda chain V-I region VOR Ig heavy chain V-I region EU IGLV4-60(1-?) ITPR3 Ig lambda chain V-III region SH PAK1 FCGR3A IGLC3 IGLC2 IGLV5-37(1-?) ACTR2 p-Y151,S,T-WASF3 Ig heavy chain V-III region KOL Ig heavy chain V-III region WEA IGHG4 Ig kappa chain V-III region B6 p-6Y-CD247-1 IGKVA18(21-?) Ig heavy chain V-III region KOL IGLV3-25(1-?) IGKVA18(21-?) Ig lambda chain V-IV region Hil IGKV2-28 IGHG1 Ig heavy chain V-III region WEA IGLV4-60(1-?) Ig heavy chain V-III region CAM p-4S-ABI2 FCGR2AIg heavy chain V-II region ARH-77 IGLV7-43(1-?) Ig heavy chain V-I region HG3 IGLV10-54(1-?) Ig heavy chain V-II region WAH IGLC6 GRB2-1 p-Y288,Y304-FCGR2A IGKV4-1(21-?) IGLV2-33(1-?) IGLV3-12(1-?) GTP IGKV1-12 IGLV5-37(1-?) IGLC6 Ig kappa chain V-I region Wes IGLV4-69(1-?) p-Y150,S343,T346-WASF2 Ig kappa chain V-I region HK101 Ig kappa chain V region EV15 CDC42 CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsIg lambda chain V-I region NEW ARPC1B IGHG1 IGLV4-3(1-?) IGKVA18(21-?) IGHG2 IGLV2-23(1-?) IGLV3-12(1-?) Ig lambda chain V-III region SH PI(4,5)P2 Ig kappa chain V-I region AG ATP Ig lambda chain V-VI region AR IGLV4-60(1-?) IGHV1-2 IGKV1-12 Ig kappa chain V-III region POM IGKVA18(21-?) IGLV7-46(1-?) IGHG2 IGLC3 IGHG2 Ig heavy chain V-II region NEWM IGLV5-45(1-?) Ig heavy chain V-III region JON FCGR3A Ig lambda chain V-II region BOH Ig kappa chain V-II region Cum Ig heavy chain V-III region KOL PI(3,4,5)P3 IGKV2D-30 p-Y173-VAV3 IGLV1-40(1-?) IGLC2 IGLV(23-?) IGLV7-46(1-?) IGKV1-12 IGLV7-46(1-?) IGLV3-12(1-?) IGKVA18(21-?) ELMO2 IGLC1 IGLC6 IGLC3 IGLV1-40(1-?) IGLV7-46(1-?) CYFIP1 IGLV2-11(1-?) BAIAP2 Ig heavy chain V-II region WAH PABAIAP2 IGLV3-22(1-?) IGLV2-33(1-?) Ig heavy chain V-III region DOB IGLV5-37(1-?) Ig kappa chain V-I region AU Ig heavy chain V-III region KOL IGKC Ig kappa chain V-I region BAN Ig lambda chain V-III region SH Ig heavy chain V-II region OU VAV1 Ig kappa chain V-I region BAN IGLV8-61(1-?) Ig lambda chain V-I region NEWM Ig heavy chain V-II region ARH-77 NCKIPSD IGLV1-36(1-?) Ig lambda chain V-VI region AR Ig kappa chain V-III region VG Ig lambda chain V-I region NEW ATPIg lambda chain V-I region NEW Ig lambda chain V-II region TOG IGLV1-44(1-?) BAIAP2CD3G CD3G IGLV5-45(1-?) IGLV3-25(1-?) IGKV1-12 Ig kappa chain V-I region BAN Ig kappa chain V region EV15 Ig lambda chain V-I region VOR Ig lambda chain V-II region MGC IGKV2-28 IGLV(23-?) IGHV(1-?) IGKV3D-20 p-PLCGIGHV1-2 IGLV7-43(1-?) ABI1 IGLV3-22(1-?) Ig lambda chain V-III region LOI ARPC1A IGLV3-27(1-?) IGLV3-22(1-?) ARPC4 RAC1 Ig kappa chain V-I region Wes Ig kappa chain V-I region Gal ABI1 ADPIg heavy chain V-III region CAM IGLV4-60(1-?) IGKV2D-30 IGLC7 PI(3,4,5)P3 Ig heavy chain V-III region BUT PLCG1 p-Y291-WAS FCGR1A Ig lambda chain V-IV region Kern p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3IgH heavy chain V-III region VH26 precursor Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-I region Daudi IGHG1 CDC42 clusteredIgG-Ag:FCGRsIg lambda chain V-II region BOH Antigen Ig kappa chain V-II region FR Ig kappa chain V-III region POM p-Y151,S,T-WASF3 Ig lambda chain V-IV region Hil p-Y160,Y171-CD3G WRC:IRSp53/58:RAC1:GTP:PIP3Src-kinasesIg kappa chain V-I region DEE WASF1 IGLV5-37(1-?) Ig kappa chain V-III region B6 Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-IV region Kern Ig heavy chain V-II region WAH IGKC ARPC1B Ig heavy chain V-II region ARH-77 IGLC2 Antigen ADPIg lambda chain V-I region NEW IGLV2-33(1-?) Ig lambda chain V-I region HA Ig kappa chain V-III region VG p-6Y-SYK p-T508-LIMK1IGLC1 ITPR1 IGLV7-46(1-?) IGLV7-43(1-?) Ig heavy chain V-II region OU ARPC2 IGLV3-27(1-?) Ig kappa chain V-I region DEE IGLV3-16(1-?) p-T185,Y187-MAPK1 IGLV2-18(1-?) ACTR2 p-Y151,S,T-WASF3 GRB2-1 IGHV7-81(1-?) MYO1C Ig heavy chain V-III region KOL ACTR2 Ig heavy chain V-III region DOB IGLV2-11(1-?) Motherfilament:branchingcomplex:daughterfilamentIGKV2D-30 IGKC p-Y150,S343,T346-WASF2 Ig kappa chain V-III region POM IGLV2-11(1-?) IGLV8-61(1-?) LIMK1Ig lambda chain V-I region NEWM p-Y151-WASF1 NCKAP1 Ig heavy chain V-I region EU IGLC3 PLD3 IGLC6 RAC1:GTP,CDC42:GTP:PAK1IGKV4-1(21-?) IGKV1-12 WASF3 Ig lambda chain V-II region MGC IGLV5-37(1-?) Ig heavy chain V-III region CAM IGLC2 IGLV3-22(1-?) IGLV3-16(1-?) Ig kappa chain V-I region AG IGLC7 SYKPIK3CA PIK3R1 IGLV11-55(1-?) ATPPI(4,5)P2 IGLV3-25(1-?) IGLV3-25(1-?) IGHV(1-?) IGHG4 Ig lambda chain V-IV region Bau Ig heavy chain V-III region WEA IGKVA18(21-?) IGLV4-3(1-?) p-6Y-CD247-1 IGLV7-43(1-?) IGLV11-55(1-?) p-S,T508-LIMK1 IGKV4-1(21-?) Ig heavy chain V-III region CAM ARPC1B IGLV3-12(1-?) IGLV8-61(1-?) Ig lambda chain V-IV region Kern GTPPLD4 IGLV3-25(1-?) IGHV7-81(1-?) IGLC2 Ig kappa chain V-II region Cum IGHV1-2 Ig heavy chain V-I region HG3 p-Y160,Y171-CD3G Ig heavy chain V-II region NEWM NCK1 Ig lambda chain V-IV region Hil RAC1 Ig heavy chain V-II region OU IGLV3-27(1-?) IGLV5-37(1-?) Ig heavy chain V-I region EU p-6Y-CD247-1 Ig lambda chain V-IV region Bau Ig lambda chain V-II region NEI ADPIg heavy chain V-III region WEA IGLC1 IGHV7-81(1-?) IGLV3-22(1-?) Ig heavy chain V-III region BUT ACTG1 IGLV7-43(1-?) VAV1,2,3Ig kappa chain V-I region AG IGLV2-18(1-?) PIK3R2 IGLV2-11(1-?) IgG-Ag:FCGRIIIA:CD3G/CD3Z dimersACTB(1-375) NCKIPSD Ig lambda chain V region 4A IgH heavy chain V-III region VH26 precursor IGLV10-54(1-?) Activated WAVE2 andWASP/N-WASPCYFIP2 CDC42 1966196617, 66


Description

Phagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phagocytosis is a complex process involving the recognition of invading foreign particles by specific types of phagocytic receptors and the subsequent internalization of the particles. Fc gamma receptors (FCGRs) are among the best studied phagocytic receptors that bind to Fc portion of immunoglobulin G (IgG). Through their antigen binding F(ab) end, antibodies bind to specific antigen while their constant (Fc) region binds to FCGRs on phagocytes. The clustering of FCGRs by IgG antibodies on the phagocyte initiates a variety of signals, which lead, through the reorganisation of actin cytoskeleton and membrane remodelling, to the formation of pseudopod and phagosome. Fc gamma receptors are classified into three classes: FCGRI, FCGRII and FCGRIII. Each class of these FCGRs consists of several individual isoforms. Among all these isoforms FCGRI, FCGRIIA and FCGRIIIA, are able to mediate phagocytosis (Joshi et al. 2006, Garcia Garcia & Rosales 2002, Nimmerjahn & Ravetch 2006). View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 2029480
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: Garapati, Phani Vijay

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Bibliography

View all...
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History

View all...
CompareRevisionActionTimeUserComment
118475view20:32, 27 May 2021FinterlyRemoved incorrect and duplicated openControlledVocabulary PW:0000234
114947view16:47, 25 January 2021ReactomeTeamReactome version 75
113391view11:46, 2 November 2020ReactomeTeamReactome version 74
112853view13:31, 12 October 2020DeSlFixing ontology tag error
112849view13:02, 12 October 2020DeSlOntology Term : 'innate immune response pathway' added !
112596view15:57, 9 October 2020ReactomeTeamReactome version 73
101512view11:37, 1 November 2018ReactomeTeamreactome version 66
101048view21:19, 31 October 2018ReactomeTeamreactome version 65
100579view19:52, 31 October 2018ReactomeTeamreactome version 64
100128view16:38, 31 October 2018ReactomeTeamreactome version 63
99678view15:07, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99271view12:45, 31 October 2018ReactomeTeamreactome version 62
94053view13:54, 16 August 2017ReactomeTeamreactome version 61
93681view11:30, 9 August 2017ReactomeTeamreactome version 61
89466view13:21, 15 September 2016Mkutmonfix ontology tag annotation
87448view13:50, 22 July 2016MkutmonOntology Term : 'PW:0000234' added !
86805view09:26, 11 July 2016ReactomeTeamreactome version 56
83122view10:02, 18 November 2015ReactomeTeamVersion54
81461view12:59, 21 August 2015ReactomeTeamVersion53
76936view08:20, 17 July 2014ReactomeTeamFixed remaining interactions
76641view12:01, 16 July 2014ReactomeTeamFixed remaining interactions
75971view10:02, 11 June 2014ReactomeTeamRe-fixing comment source
75674view10:59, 10 June 2014ReactomeTeamReactome 48 Update
75029view13:54, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74673view08:44, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-LysophosphatidylcholineMetaboliteCHEBI:17504 (ChEBI)
ABI1 ProteinQ8IZP0 (Uniprot-TrEMBL)
ABI2 ProteinQ9NYB9 (Uniprot-TrEMBL)
ABL1ProteinP00519 (Uniprot-TrEMBL)
ACTB(1-375) ProteinP60709 (Uniprot-TrEMBL)
ACTG1 ProteinP63261 (Uniprot-TrEMBL)
ACTR2 ProteinP61160 (Uniprot-TrEMBL)
ACTR3 ProteinP61158 (Uniprot-TrEMBL)
ADP MetaboliteCHEBI:16761 (ChEBI)
ADPMetaboliteCHEBI:16761 (ChEBI)
AHCYL1 ProteinO43865 (Uniprot-TrEMBL)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerComplexR-HSA-5226920 (Reactome)
ARAMetaboliteCHEBI:15843 (ChEBI)
ARP2/3 complex (ATP bound)ComplexR-HSA-1861670 (Reactome)
ARPC1A ProteinQ92747 (Uniprot-TrEMBL)
ARPC1B ProteinO15143 (Uniprot-TrEMBL)
ARPC2 ProteinO15144 (Uniprot-TrEMBL)
ARPC3 ProteinO15145 (Uniprot-TrEMBL)
ARPC4 ProteinP59998 (Uniprot-TrEMBL)
ARPC5 ProteinO15511 (Uniprot-TrEMBL)
ATP MetaboliteCHEBI:15422 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
Actin filament bound Myosin-XComplexR-HSA-1861625 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		ComplexR-HSA-442565 (Reactome)
Activated WAVE2 and WASP/N-WASPComplexR-HSA-2197675 (Reactome)
Active LIMK1ComplexR-HSA-419630 (Reactome)
Antigen R-ALL-173548 (Reactome)
Antigen:IgGComplexR-HSA-173552 (Reactome)
BAIAP2 ProteinQ9UQB8 (Uniprot-TrEMBL)
BAIAP2ProteinQ9UQB8 (Uniprot-TrEMBL)
BRK1 ProteinQ8WUW1 (Uniprot-TrEMBL)
BTK ProteinQ06187 (Uniprot-TrEMBL)
CD247-1 ProteinP20963-1 (Uniprot-TrEMBL)
CD3G ProteinP09693 (Uniprot-TrEMBL)
CDC42 ProteinP60953 (Uniprot-TrEMBL)
CDC42:GDPComplexR-HSA-418830 (Reactome)
CDC42:GTP, RAC1:GTPComplexR-HSA-389778 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsComplexR-HSA-2197683 (Reactome)
CDC42:GTP:WASP/N-WASPComplexR-HSA-442584 (Reactome)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsComplexR-HSA-2197680 (Reactome)
CDC42:GTPComplexR-HSA-182921 (Reactome)
CFL1ProteinP23528 (Uniprot-TrEMBL)
CRK ProteinP46108 (Uniprot-TrEMBL)
CRK:DOCK180:ELMO1,ELMO2ComplexR-HSA-2029141 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		ComplexR-HSA-2029130 (Reactome)
CYFIP1 ProteinQ7L576 (Uniprot-TrEMBL)
CYFIP2 ProteinQ96F07 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
ChoMetaboliteCHEBI:15354 (ChEBI)
DAGsMetaboliteCHEBI:18035 (ChEBI)
DOCK1 ProteinQ14185 (Uniprot-TrEMBL)
ELMO1 ProteinQ92556 (Uniprot-TrEMBL)
ELMO2 ProteinQ96JJ3 (Uniprot-TrEMBL)
F-actin R-HSA-201877 (Reactome)
F-actinR-HSA-201877 (Reactome)
FCGR1A ProteinP12314 (Uniprot-TrEMBL)
FCGR2A ProteinP12318 (Uniprot-TrEMBL)
FCGR2AProteinP12318 (Uniprot-TrEMBL)
FCGR3A ProteinP08637 (Uniprot-TrEMBL)
FCGRIA:CD3G homodimerComplexR-HSA-2029093 (Reactome)
FCGRIIIA:CD3G/CD3Z dimersComplexR-HSA-2029097 (Reactome)
FGR ProteinP09769 (Uniprot-TrEMBL)
FYN ProteinP06241 (Uniprot-TrEMBL)
G-actinComplexR-HSA-201857 (Reactome)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2-1 ProteinP62993-1 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HCK ProteinP08631 (Uniprot-TrEMBL)
HSP90AA1 ProteinP07900 (Uniprot-TrEMBL)
HSP90AA1,HSP90AB1ComplexR-HSA-419619 (Reactome)
HSP90AB1 ProteinP08238 (Uniprot-TrEMBL)
I(1,4,5)P3 MetaboliteCHEBI:16595 (ChEBI)
I(1,4,5)P3MetaboliteCHEBI:16595 (ChEBI)
IGHG1 ProteinP01857 (Uniprot-TrEMBL)
IGHG2 ProteinP01859 (Uniprot-TrEMBL)
IGHG3 ProteinP01860 (Uniprot-TrEMBL)
IGHG4 ProteinP01861 (Uniprot-TrEMBL)
IGHV(1-?) ProteinA2KUC3 (Uniprot-TrEMBL)
IGHV1-2 ProteinP23083 (Uniprot-TrEMBL)
IGHV7-81(1-?) ProteinQ6PIL0 (Uniprot-TrEMBL)
IGKC ProteinP01834 (Uniprot-TrEMBL)
IGKV1-12 ProteinA0A0C4DH73 (Uniprot-TrEMBL)
IGKV1-5(23-?) ProteinP01602 (Uniprot-TrEMBL)
IGKV2-28 ProteinA0A075B6P5 (Uniprot-TrEMBL)
IGKV2D-30 ProteinA0A075B6S6 (Uniprot-TrEMBL)
IGKV3D-20 ProteinA0A0C4DH25 (Uniprot-TrEMBL)
IGKV4-1(21-?) ProteinP06312 (Uniprot-TrEMBL)
IGKVA18(21-?) ProteinA2NJV5 (Uniprot-TrEMBL)
IGLC1 ProteinP0CG04 (Uniprot-TrEMBL)
IGLC2 ProteinP0CG05 (Uniprot-TrEMBL)
IGLC3 ProteinP0CG06 (Uniprot-TrEMBL)
IGLC6 ProteinP0CF74 (Uniprot-TrEMBL)
IGLC7 ProteinA0M8Q6 (Uniprot-TrEMBL)
IGLV(23-?) ProteinA2NXD2 (Uniprot-TrEMBL)
IGLV1-36(1-?) ProteinQ5NV67 (Uniprot-TrEMBL)
IGLV1-40(1-?) ProteinQ5NV69 (Uniprot-TrEMBL)
IGLV1-44(1-?) ProteinQ5NV81 (Uniprot-TrEMBL)
IGLV10-54(1-?) ProteinQ5NV86 (Uniprot-TrEMBL)
IGLV11-55(1-?) ProteinQ5NV87 (Uniprot-TrEMBL)
IGLV2-11(1-?) ProteinQ5NV84 (Uniprot-TrEMBL)
IGLV2-18(1-?) ProteinQ5NV65 (Uniprot-TrEMBL)
IGLV2-23(1-?) ProteinQ5NV89 (Uniprot-TrEMBL)
IGLV2-33(1-?) ProteinQ5NV66 (Uniprot-TrEMBL)
IGLV3-12(1-?) ProteinQ5NV85 (Uniprot-TrEMBL)
IGLV3-16(1-?) ProteinQ5NV64 (Uniprot-TrEMBL)
IGLV3-22(1-?) ProteinQ5NV75 (Uniprot-TrEMBL)
IGLV3-25(1-?) ProteinQ5NV90 (Uniprot-TrEMBL)
IGLV3-27(1-?) ProteinQ5NV91 (Uniprot-TrEMBL)
IGLV4-3(1-?) ProteinQ5NV61 (Uniprot-TrEMBL)
IGLV4-60(1-?) ProteinQ5NV79 (Uniprot-TrEMBL)
IGLV4-69(1-?) ProteinQ5NV92 (Uniprot-TrEMBL)
IGLV5-37(1-?) ProteinQ5NV68 (Uniprot-TrEMBL)
IGLV5-45(1-?) ProteinQ5NV82 (Uniprot-TrEMBL)
IGLV7-43(1-?) ProteinQ5NV80 (Uniprot-TrEMBL)
IGLV7-46(1-?) ProteinQ5NV83 (Uniprot-TrEMBL)
IGLV8-61(1-?) ProteinQ5NV62 (Uniprot-TrEMBL)
IP3 receptor homotetramerComplexR-HSA-169686 (Reactome)
ITPR1 ProteinQ14643 (Uniprot-TrEMBL)
ITPR2 ProteinQ14571 (Uniprot-TrEMBL)
ITPR3 ProteinQ14573 (Uniprot-TrEMBL)
ITPR:I(1,4,5)P3 tetramerComplexR-HSA-169696 (Reactome)
Ig heavy chain V-I region EU ProteinP01742 (Uniprot-TrEMBL)
Ig heavy chain V-I region HG3 ProteinP01743 (Uniprot-TrEMBL)
Ig heavy chain V-II region ARH-77 ProteinP06331 (Uniprot-TrEMBL)
Ig heavy chain V-II region MCE ProteinP01817 (Uniprot-TrEMBL)
Ig heavy chain V-II region NEWM ProteinP01825 (Uniprot-TrEMBL)
Ig heavy chain V-II region OU ProteinP01814 (Uniprot-TrEMBL)
Ig heavy chain V-II region WAH ProteinP01824 (Uniprot-TrEMBL)
Ig heavy chain V-III region BRO ProteinP01766 (Uniprot-TrEMBL)
Ig heavy chain V-III region BUT ProteinP01767 (Uniprot-TrEMBL)
Ig heavy chain V-III region CAM ProteinP01768 (Uniprot-TrEMBL)
Ig heavy chain V-III region DOB ProteinP01782 (Uniprot-TrEMBL)
Ig heavy chain V-III region JON ProteinP01780 (Uniprot-TrEMBL)
Ig heavy chain V-III region KOL ProteinP01772 (Uniprot-TrEMBL)
Ig heavy chain V-III region TRO ProteinP01762 (Uniprot-TrEMBL)
Ig heavy chain V-III region WEA ProteinP01763 (Uniprot-TrEMBL)
Ig kappa chain V region EV15 ProteinP06315 (Uniprot-TrEMBL)
Ig kappa chain V-I region AG ProteinP01593 (Uniprot-TrEMBL)
Ig kappa chain V-I region AU ProteinP01594 (Uniprot-TrEMBL)
Ig kappa chain V-I region BAN ProteinP04430 (Uniprot-TrEMBL)
Ig kappa chain V-I region DEE ProteinP01597 (Uniprot-TrEMBL)
Ig kappa chain V-I region Daudi ProteinP04432 (Uniprot-TrEMBL)
Ig kappa chain V-I region Gal ProteinP01599 (Uniprot-TrEMBL)
Ig kappa chain V-I region HK101 ProteinP01601 (Uniprot-TrEMBL)
Ig kappa chain V-I region Wes ProteinP01611 (Uniprot-TrEMBL)
Ig kappa chain V-II region Cum ProteinP01614 (Uniprot-TrEMBL)
Ig kappa chain V-II region FR ProteinP01615 (Uniprot-TrEMBL)
Ig kappa chain V-II region RPMI 6410 ProteinP06310 (Uniprot-TrEMBL)
Ig kappa chain V-III region B6 ProteinP01619 (Uniprot-TrEMBL)
Ig kappa chain V-III region POM ProteinP01624 (Uniprot-TrEMBL)
Ig kappa chain V-III region VG ProteinP04433 (Uniprot-TrEMBL)
Ig lambda chain V region 4A ProteinP04211 (Uniprot-TrEMBL)
Ig lambda chain V-I region HA ProteinP01700 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEW ProteinP01701 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEWM ProteinP01703 (Uniprot-TrEMBL)
Ig lambda chain V-I region VOR ProteinP01699 (Uniprot-TrEMBL)
Ig lambda chain V-II region BOH ProteinP01706 (Uniprot-TrEMBL)
Ig lambda chain V-II region MGC ProteinP01709 (Uniprot-TrEMBL)
Ig lambda chain V-II region NEI ProteinP01705 (Uniprot-TrEMBL)
Ig lambda chain V-II region TOG ProteinP01704 (Uniprot-TrEMBL)
Ig lambda chain V-III region LOI ProteinP80748 (Uniprot-TrEMBL)
Ig lambda chain V-III region SH ProteinP01714 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Bau ProteinP01715 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Hil ProteinP01717 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Kern ProteinP01718 (Uniprot-TrEMBL)
Ig lambda chain V-VI region AR ProteinP01721 (Uniprot-TrEMBL)
IgG-Ag:FCGRIA:CD3G homodimerComplexR-HSA-2029132 (Reactome)
IgG-Ag:FCGRIIAComplexR-HSA-1861689 (Reactome)
IgG-Ag:FCGRIIIA:CD3G/CD3Z dimersComplexR-HSA-2029163 (Reactome)
IgH heavy chain V-III region VH26 precursor ProteinP01764 (Uniprot-TrEMBL)
LIMK1ProteinP53667 (Uniprot-TrEMBL)
LYN ProteinP07948 (Uniprot-TrEMBL)
MYH2 ProteinQ9UKX2 (Uniprot-TrEMBL)
MYH9 ProteinP35579 (Uniprot-TrEMBL)
MYO10 ProteinQ9HD67 (Uniprot-TrEMBL)
MYO1C ProteinO00159 (Uniprot-TrEMBL)
MYO5A ProteinQ9Y4I1 (Uniprot-TrEMBL)
MYO9B ProteinQ13459 (Uniprot-TrEMBL)
Mother filament:ARP2/3:actin:ADPComplexR-HSA-2197686 (Reactome)
Mother

filament:branching complex:daughter

filament		ComplexR-HSA-1861699 (Reactome)
Mother

filament:branching

complex		ComplexR-HSA-2029140 (Reactome)
Myosin-Actin filamentsComplexR-HSA-2029139 (Reactome)
Myosin-X dimerComplexR-HSA-1861665 (Reactome)
MyosinComplexR-HSA-2029109 (Reactome)
N-WASP ProteinO00401 (Uniprot-TrEMBL)
NAD+ MetaboliteCHEBI:15846 (ChEBI)
NCK1 ProteinP16333 (Uniprot-TrEMBL)
NCKAP1 ProteinQ9Y2A7 (Uniprot-TrEMBL)
NCKAP1L ProteinP55160 (Uniprot-TrEMBL)
NCKIPSD ProteinQ9NZQ3 (Uniprot-TrEMBL)
NF2ProteinP35240 (Uniprot-TrEMBL)
PAMetaboliteCHEBI:16337 (ChEBI)
PAK1 ProteinQ13153 (Uniprot-TrEMBL)
PAK1 dimerComplexR-HSA-445002 (Reactome)
PAK1ProteinQ13153 (Uniprot-TrEMBL)
PCMetaboliteCHEBI:16110 (ChEBI)
PI(3,4)P2 MetaboliteCHEBI:16152 (ChEBI)
PI(3,4)P2MetaboliteCHEBI:16152 (ChEBI)
PI(3,4,5)P3 MetaboliteCHEBI:16618 (ChEBI)
PI(3,4,5)P3MetaboliteCHEBI:16618 (ChEBI)
PI(4,5)P2 MetaboliteCHEBI:18348 (ChEBI)
PI(4,5)P2MetaboliteCHEBI:18348 (ChEBI)
PI3K:p-6Y-SYKComplexR-HSA-2029149 (Reactome)
PI3KComplexR-HSA-74693 (Reactome)
PIK3CA ProteinP42336 (Uniprot-TrEMBL)
PIK3CB ProteinP42338 (Uniprot-TrEMBL)
PIK3R1 ProteinP27986 (Uniprot-TrEMBL)
PIK3R2 ProteinO00459 (Uniprot-TrEMBL)
PKC-delta/epsilonComplexR-HSA-198276 (Reactome)
PLA2G6ProteinO60733 (Uniprot-TrEMBL)
PLC gamma1,2ComplexR-HSA-1169089 (Reactome)
PLCG1 ProteinP19174 (Uniprot-TrEMBL)
PLCG2 ProteinP16885 (Uniprot-TrEMBL)
PLD1 ProteinQ13393 (Uniprot-TrEMBL)
PLD2 ProteinO14939 (Uniprot-TrEMBL)
PLD3 ProteinQ8IV08 (Uniprot-TrEMBL)
PLD4 ProteinQ96BZ4 (Uniprot-TrEMBL)
PLDComplexR-HSA-2029102 (Reactome)
PPAPDC1A ProteinQ5VZY2 (Uniprot-TrEMBL)
PPAPDC1B ProteinQ8NEB5 (Uniprot-TrEMBL)
PRKCD ProteinQ05655 (Uniprot-TrEMBL)
PRKCE ProteinQ02156 (Uniprot-TrEMBL)
PTK2 ProteinQ05397 (Uniprot-TrEMBL)
Phosphatidate phosphataseComplexR-HSA-2029101 (Reactome)
Phospho-PKC-delta/epsilonComplexR-HSA-198265 (Reactome)
PiMetaboliteCHEBI:18367 (ChEBI)
RAC1 ProteinP63000 (Uniprot-TrEMBL)
RAC1:GDPComplexR-HSA-5674631 (Reactome)
RAC1:GTP,CDC42:GTP:PAK1ComplexR-HSA-2029159 (Reactome)
RAC1:GTPComplexR-HSA-442641 (Reactome)
SH3 domain proteinsComplexR-HSA-2197679 (Reactome)
SRC-1 ProteinP12931-1 (Uniprot-TrEMBL)
SYK ProteinP43405 (Uniprot-TrEMBL)
SYKProteinP43405 (Uniprot-TrEMBL)
Src family kinases (SFKs)ComplexR-HSA-1861597 (Reactome)
Src-kinasesComplexR-HSA-2197681 (Reactome)
Unknown GEFR-HSA-8939797 (Reactome)
VAV1 ProteinP15498 (Uniprot-TrEMBL)
VAV1,2,3ComplexR-HSA-430172 (Reactome)
VAV2 ProteinP52735 (Uniprot-TrEMBL)
VAV3 ProteinQ9UKW4 (Uniprot-TrEMBL)
WAS ProteinP42768 (Uniprot-TrEMBL)
WASF1 ProteinQ92558 (Uniprot-TrEMBL)
WASF2 ProteinQ9Y6W5 (Uniprot-TrEMBL)
WASF3 ProteinQ9UPY6 (Uniprot-TrEMBL)
WASP/N-WASPComplexR-HSA-201892 (Reactome)
WAVE Regulatory ComplexComplexR-HSA-2029154 (Reactome)
WIP family proteinsComplexR-HSA-2197678 (Reactome)
WIPF1 ProteinO43516 (Uniprot-TrEMBL)
WIPF2 ProteinQ8TF74 (Uniprot-TrEMBL)
WIPF3 ProteinA6NGB9 (Uniprot-TrEMBL)
WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2029147 (Reactome)
YES1 ProteinP07947 (Uniprot-TrEMBL)
clustered IgG-Ag:FCGRsComplexR-HSA-2029146 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKComplexR-HSA-2029129 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGComplexR-HSA-2029137 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVComplexR-HSA-2029133 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGComplexR-HSA-2029156 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVComplexR-HSA-2029131 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKComplexR-HSA-2029158 (Reactome)
clustered IgG-Ag:p-FCGRsComplexR-HSA-2029128 (Reactome)
clustered IgG-Ag:p-FCGRsComplexR-HSA-2029151 (Reactome)
p-4S-ABI2 ProteinQ9NYB9 (Uniprot-TrEMBL)
p-4Y-PLCG1 ProteinP19174 (Uniprot-TrEMBL)
p-4Y-PLCG1ProteinP19174 (Uniprot-TrEMBL)
p-5S-ABI1 ProteinQ8IZP0 (Uniprot-TrEMBL)
p-6Y-CD247-1 ProteinP20963-1 (Uniprot-TrEMBL)
p-6Y-SYK ProteinP43405 (Uniprot-TrEMBL)
p-PLCGComplexR-HSA-2029095 (Reactome)
p-S,T508-LIMK1 ProteinP53667 (Uniprot-TrEMBL)
p-S144,T423-PAK1ProteinQ13153 (Uniprot-TrEMBL)
p-S3-CFL1 ProteinP23528 (Uniprot-TrEMBL)
p-T,Y MAPK dimersComplexR-HSA-1268261 (Reactome)
p-T185,Y187-MAPK1 ProteinP28482 (Uniprot-TrEMBL)
p-T202,Y204-MAPK3 ProteinP27361 (Uniprot-TrEMBL)
p-T507,S645,S664-PRKCD(1-676) ProteinQ05655 (Uniprot-TrEMBL)
p-T508-LIMK1 ProteinP53667 (Uniprot-TrEMBL)
p-T508-LIMK1ProteinP53667 (Uniprot-TrEMBL)
p-T566,T710,S729-PRKCE ProteinQ02156 (Uniprot-TrEMBL)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2029148 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2130182 (Reactome)
p-Y150,S343,T346-WASF2 ProteinQ9Y6W5 (Uniprot-TrEMBL)
p-Y150-WASF2 ProteinQ9Y6W5 (Uniprot-TrEMBL)
p-Y151,S,T-WASF1 ProteinQ92558 (Uniprot-TrEMBL)
p-Y151,S,T-WASF3 ProteinQ9UPY6 (Uniprot-TrEMBL)
p-Y151-WASF1 ProteinQ92558 (Uniprot-TrEMBL)
p-Y151-WASF3 ProteinQ9UPY6 (Uniprot-TrEMBL)
p-Y160,Y171-CD3G ProteinP09693 (Uniprot-TrEMBL)
p-Y172-VAV2 ProteinP52735 (Uniprot-TrEMBL)
p-Y173-VAV3 ProteinQ9UKW4 (Uniprot-TrEMBL)
p-Y174-VAV1 ProteinP15498 (Uniprot-TrEMBL)
p-Y256-WASL ProteinO00401 (Uniprot-TrEMBL)
p-Y288,Y304-FCGR2A ProteinP12318 (Uniprot-TrEMBL)
p-Y291-WAS ProteinP42768 (Uniprot-TrEMBL)
p-Y753,Y759,Y1217-PLCG2 ProteinP16885 (Uniprot-TrEMBL)
pCofilin: Active LIMK-1ComplexR-HSA-399878 (Reactome)
pLIMK dimer:HSP-90ComplexR-HSA-419632 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
2-LysophosphatidylcholineArrowR-HSA-2029475 (Reactome)
ABL1mim-catalysisR-HSA-2130194 (Reactome)
ADPArrowR-HSA-198314 (Reactome)
ADPArrowR-HSA-2029268 (Reactome)
ADPArrowR-HSA-2029271 (Reactome)
ADPArrowR-HSA-2029449 (Reactome)
ADPArrowR-HSA-2029453 (Reactome)
ADPArrowR-HSA-2029454 (Reactome)
ADPArrowR-HSA-2029459 (Reactome)
ADPArrowR-HSA-2029460 (Reactome)
ADPArrowR-HSA-2029469 (Reactome)
ADPArrowR-HSA-2130194 (Reactome)
ADPArrowR-HSA-2197698 (Reactome)
ADPArrowR-HSA-399950 (Reactome)
ADPArrowR-HSA-419644 (Reactome)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerTBarR-HSA-169683 (Reactome)
ARAArrowR-HSA-2029475 (Reactome)
ARP2/3 complex (ATP bound)R-HSA-442592 (Reactome)
ATPR-HSA-1861595 (Reactome)
ATPR-HSA-198314 (Reactome)
ATPR-HSA-2029268 (Reactome)
ATPR-HSA-2029271 (Reactome)
ATPR-HSA-2029449 (Reactome)
ATPR-HSA-2029453 (Reactome)
ATPR-HSA-2029454 (Reactome)
ATPR-HSA-2029459 (Reactome)
ATPR-HSA-2029460 (Reactome)
ATPR-HSA-2029469 (Reactome)
ATPR-HSA-2029476 (Reactome)
ATPR-HSA-2130194 (Reactome)
ATPR-HSA-2197698 (Reactome)
ATPR-HSA-399950 (Reactome)
ATPR-HSA-419644 (Reactome)
Actin filament bound Myosin-XArrowR-HSA-1861595 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		ArrowR-HSA-442592 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		R-HSA-2029466 (Reactome)
Activated WAVE2 and WASP/N-WASPArrowR-HSA-2197690 (Reactome)
Activated WAVE2 and WASP/N-WASPR-HSA-442592 (Reactome)
Active LIMK1ArrowR-HSA-419644 (Reactome)
Active LIMK1R-HSA-399950 (Reactome)
Active LIMK1mim-catalysisR-HSA-399950 (Reactome)
Antigen:IgGR-HSA-1861621 (Reactome)
Antigen:IgGR-HSA-2029455 (Reactome)
Antigen:IgGR-HSA-2029457 (Reactome)
BAIAP2R-HSA-2029465 (Reactome)
CDC42:GDPR-HSA-2029445 (Reactome)
CDC42:GTP, RAC1:GTPArrowR-HSA-2029454 (Reactome)
CDC42:GTP, RAC1:GTPR-HSA-2029456 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsArrowR-HSA-2197691 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsR-HSA-2197698 (Reactome)
CDC42:GTP:WASP/N-WASPArrowR-HSA-442586 (Reactome)
CDC42:GTP:WASP/N-WASPR-HSA-2197691 (Reactome)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsArrowR-HSA-2197698 (Reactome)
CDC42:GTPArrowR-HSA-2029445 (Reactome)
CDC42:GTPR-HSA-442586 (Reactome)
CFL1R-HSA-399950 (Reactome)
CRK:DOCK180:ELMO1,ELMO2R-HSA-2197697 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		ArrowR-HSA-2197697 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		mim-catalysisR-HSA-2029467 (Reactome)
Ca2+ArrowR-HSA-169683 (Reactome)
Ca2+R-HSA-169683 (Reactome)
ChoArrowR-HSA-2029471 (Reactome)
DAGsArrowR-HSA-167686 (Reactome)
DAGsArrowR-HSA-198314 (Reactome)
DAGsArrowR-HSA-2029468 (Reactome)
F-actinR-HSA-2029466 (Reactome)
FCGR2AR-HSA-1861621 (Reactome)
FCGRIA:CD3G homodimerR-HSA-2029455 (Reactome)
FCGRIIIA:CD3G/CD3Z dimersR-HSA-2029457 (Reactome)
G-actinR-HSA-2029473 (Reactome)
G-actinR-HSA-442592 (Reactome)
GDPArrowR-HSA-2029445 (Reactome)
GDPArrowR-HSA-2029451 (Reactome)
GDPArrowR-HSA-2029467 (Reactome)
GTPR-HSA-2029445 (Reactome)
GTPR-HSA-2029451 (Reactome)
GTPR-HSA-2029467 (Reactome)
H2OR-HSA-167686 (Reactome)
H2OR-HSA-2029468 (Reactome)
H2OR-HSA-2029471 (Reactome)
H2OR-HSA-2029475 (Reactome)
HSP90AA1,HSP90AB1ArrowR-HSA-419644 (Reactome)
HSP90AA1,HSP90AB1R-HSA-419645 (Reactome)
I(1,4,5)P3ArrowR-HSA-167686 (Reactome)
I(1,4,5)P3ArrowR-HSA-169683 (Reactome)
I(1,4,5)P3R-HSA-169680 (Reactome)
IP3 receptor homotetramerR-HSA-169680 (Reactome)
ITPR:I(1,4,5)P3 tetramerArrowR-HSA-169680 (Reactome)
ITPR:I(1,4,5)P3 tetramermim-catalysisR-HSA-169683 (Reactome)
IgG-Ag:FCGRIA:CD3G homodimerArrowR-HSA-2029455 (Reactome)
IgG-Ag:FCGRIIAArrowR-HSA-1861621 (Reactome)
IgG-Ag:FCGRIIIA:CD3G/CD3Z dimersArrowR-HSA-2029457 (Reactome)
LIMK1R-HSA-2029460 (Reactome)
Mother filament:ARP2/3:actin:ADPArrowR-HSA-2197690 (Reactome)
Mother filament:ARP2/3:actin:ADPR-HSA-2029473 (Reactome)
Mother

filament:branching complex:daughter

filament		ArrowR-HSA-2029473 (Reactome)
Mother

filament:branching complex:daughter

filament		R-HSA-1861595 (Reactome)
Mother

filament:branching complex:daughter

filament		R-HSA-2029476 (Reactome)
Mother

filament:branching

complex		ArrowR-HSA-2029466 (Reactome)
Mother

filament:branching

complex		R-HSA-2197690 (Reactome)
Myosin-Actin filamentsArrowR-HSA-2029476 (Reactome)
Myosin-X dimerR-HSA-1861595 (Reactome)
Myosin-X dimermim-catalysisR-HSA-1861595 (Reactome)
MyosinR-HSA-2029476 (Reactome)
NF2TBarR-HSA-2029456 (Reactome)
PAArrowR-HSA-2029471 (Reactome)
PAK1 dimerR-HSA-2029456 (Reactome)
PAK1ArrowR-HSA-2029456 (Reactome)
PAK1mim-catalysisR-HSA-2029454 (Reactome)
PAR-HSA-2029468 (Reactome)
PCR-HSA-2029471 (Reactome)
PCR-HSA-2029475 (Reactome)
PI(3,4)P2R-HSA-1861595 (Reactome)
PI(3,4,5)P3ArrowR-HSA-2029271 (Reactome)
PI(3,4,5)P3ArrowR-HSA-2029272 (Reactome)
PI(3,4,5)P3R-HSA-2029268 (Reactome)
PI(3,4,5)P3R-HSA-2029458 (Reactome)
PI(3,4,5)P3R-HSA-2029465 (Reactome)
PI(4,5)P2R-HSA-167686 (Reactome)
PI(4,5)P2R-HSA-2029271 (Reactome)
PI(4,5)P2R-HSA-442586 (Reactome)
PI3K:p-6Y-SYKArrowR-HSA-2029273 (Reactome)
PI3K:p-6Y-SYKmim-catalysisR-HSA-2029271 (Reactome)
PI3KR-HSA-2029273 (Reactome)
PKC-delta/epsilonR-HSA-198314 (Reactome)
PKC-delta/epsilonmim-catalysisR-HSA-198314 (Reactome)
PLA2G6mim-catalysisR-HSA-2029475 (Reactome)
PLC gamma1,2R-HSA-2029270 (Reactome)
PLDmim-catalysisR-HSA-2029471 (Reactome)
Phosphatidate phosphatasemim-catalysisR-HSA-2029468 (Reactome)
Phospho-PKC-delta/epsilonArrowR-HSA-198314 (Reactome)
PiArrowR-HSA-1861595 (Reactome)
PiArrowR-HSA-2029468 (Reactome)
PiArrowR-HSA-2029476 (Reactome)
R-HSA-167686 (Reactome) Inositol 1,4,5-triphosphate (IP3) is a second messenger produced by phospholipase C (PLC) metabolism of phosphoinositol 4,5-bisphosphate (PIP2) (Canossa et al. 2001).
R-HSA-169680 (Reactome) The IP3 receptor (IP3R) is an IP3-gated calcium channel. It is a large, homotetrameric protein, similar to other calcium channel proteins such as ryanodine. The four subunits form a 'four-leafed clover' structure arranged around the central calcium channel. Binding of ligands such as IP3 results in conformational changes in the receptor's structure that leads to channel opening.
R-HSA-169683 (Reactome) IP3 promotes the release of intracellular calcium.
R-HSA-1861595 (Reactome) Myosin-X (Myosin 10) is one of the downstream effectors of PI3K in FCGR-phagocytosis and is involved in pseudopod extension and closure of phagocytic cups. It is recruited to the forming phagosome by binding, through its second PH domain to membrane PIP3, a major product of PI3-kinase (Cox et al. 2002). Myosin-X may act as a motor to transport membrane cargo molecules to the forming pseudopods, influencing actin dynamics. It is not understood with certainty how myosin X contributes to the mechanism of pseudopod extension. It selectively binds to actin bundle such that each head may bind, in an ATP-sensitive manner, to two adjacent actin filaments within the actin bundle. Myosin X hydrolyze ATP and converts this chemical energy to mechanical energy moving toward the plus end/barbed end of the actin filament facing towards the tip of the growing pseudopods (Araki 2006, Chavrier 2003, Watanabe et al 2010).
R-HSA-1861621 (Reactome) FCGRII (CD32) is a low-affinity receptor encoded by three different genes (A, B and C) (Brooks et al. 1989). FCGRIIA functions as a single-chain transmembrane receptor containing both the ligand-binding extracellular domain and a signal transducing cytoplasmic domain that contains distinct immunoreceptor tyrosine-based activation motif (ITAM). This ITAM-like domain in FCGRIIA contains two YXXL motifs with a spacer sequence of 12 amino acids instead of the usual 7. Isoform FCGRIIB is expressed in various leukocytes, including human monocytes and, as opposed to the activating Fc receptors it has an immunoreceptor tyrosine-based inhibitory motif (ITIM) and negatively regulates phagocytosis (Van den Herik-Oudijk IE et al. 1995, Mitchell et al. 1994, Tridandapani et al. 2002).
The first step in Fc-gamma receptor (FCGR) phagocytosis is binding and clustering of FCGRs by IgG-coated foreign particles. FCGR are clustered at the cell surface by multivalent antigen-antibody complexes and recruited to lipid raft micro domains; monovalent ligand binding is insufficient to generate a signal. This cross-linking results in the localization of FCGRs into lipid rafts and this may aid in recruiting and complexing with additional signalling proteins associated with lipid rafts (Bournazos et al. 2009, Kwiatkowska & Sobota 2001, Kono et al. 2002). This is followed by phosphorylation of the tyrosine residues within the ITAM located on the cytoplasmic portion of FCGRIIA by membrane-associated tyrosine kinases of the Src family (Mitchell et al. 1994).
R-HSA-198314 (Reactome) Diacylglycerol (DAG) positively regulates the autophosphorylation of protein kinase C-delta (PKC-delta), which stimulates ERK1/2 and triggers neurite outgrowth. DAG also stimulates the translocation of PKC from the cytosol to the plasma membrane. PKC-delta contributes to growth factor specificity and response to neuronal cells by promoting cell-type-specific differences in growth factor signalling. DAG can also activate PKC-epsilon in the same manner (Newton 2001).
R-HSA-2029268 (Reactome) PLCG is tyrosine phosphorylated by either SYK or Src kinases on three tyrosine residues and this phosphorylation enhances the activity of PLCG. Although maximal activation requires binding of PLCG to PIP3 with its plecstrin homology (PH) domain.
R-HSA-2029270 (Reactome) PLCgamma (PLCG) is recruited to FCGR and the phosphorylated Y342 and Y346 in SYK have been reported to be involved in the interaction of PLCG (Law et al. 1996). PLCG accumulates at the phagocytic cup during FCGR, but the exact role of PLCG in the regulation of phagocytosis is not clear. It may be involved in FCGR signaling by activating PKC through DAG production (Garcia-Garcia & Rosales 2002 )
R-HSA-2029271 (Reactome) Activated PI3K phosphorylates phosphatidylinositol (PI) 4-phosphate and PI 4,5-bisphosphate (PIP2) to generate PI 3,4-bisphosphate and PI 3,4,5-triphosphate (PIP3) and these second messengers recruit other signaling proteins containing plecstrin homology (PH) domain. PIP3 rapidly accumulates at sites of phagocytosis and disappears after the phagosome has been sealed off from the plasma membrane.
R-HSA-2029272 (Reactome) Activated PLCG translocates to the plasmamembrane and interacts with the inositol ring of the membrane bound phosphatidylinositol 4,5-bisphosphate (PIP2) with its PH domain. The active enzyme promotes intracelllular signaling by catalysing the hydrolysis of PIP2 to generate the second messengers IP3 and DAG.
R-HSA-2029273 (Reactome) PI3K is one of the downstream effector of activated SYK. The p85 alpha regulatory subunit of PI3K have been shown to interact with SYK and FCGRs, and transient and restricted accumulation of lipid products of the kinase have been observed at sites of the phagosomal cup (Yanagi et al. 1994, Marshall et al. 2001). Leverrier at al. has demonstrated that p110beta is the major class I catalytic isoform required for FCGR-mediated phagocytosis by primary macrophages (Leverrier at al. 2003). p85 alpha subunit interacts with phosphorylated SYK at tyrosine 317 with its C-terminal SH2 domain, whereas other tyrosine residues like 342 and 346 in the linker region may contribute to the interaction with N-terminal SH2 domain (Moon et al, 2005). The main role of PI3K in phagocytosis appears to be the regulation of pseudopod extension necessary for particle internalization and may also regulate phagocytosis through activation of ERK (Garcia-Garcia & Rosales. 2002).
R-HSA-2029445 (Reactome) FCGR mediated phagocytosis requires CDC42 to stimulate actin polymerization, generating the force for phagocytic cup protrusion or pseudopod extension. CDC42 activation is restricted at the advancing edge of the phagocytic cup, where actin is concentrated, and is deactivated at the base of the phagocytic cup (Beemiller et al 2010). The mechanism behind the recruitment and activation of CDC42 during FCGR phagocytosis is unknown. VAV regulates the activation of RAC1 but not CDC42 and the GEF responsible for CDC42 activation during FCGR-mediated phagocytosis remains unidentified (Adam et al 2004, Patel et al 2002).
R-HSA-2029449 (Reactome) Multiple sites of phosphorylation are known to exist in SYK, which both regulate its activity and also serve as docking sites for other proteins. Some of these sites include Y131 of interdomain A, Y323, Y348, and Y352 of interdomain B, and Y525 and Y526 within the activation loop of the kinase domain and Y630 in the C-terminus (Zhang et al. 2002, Lupher et al. 1998, Furlong et al. 1997). Phosphorylation of these tyrosine residues disrupts autoinhibitory interactions and results in kinase activation even in the absence of phosphorylated ITAM tyrosines (Tsang et al. 2008). SYK is primarily phosphorylated by Src family kinases and this acts as an initiating trigger by generating few molecules of activated SYK which are then involved in major SYK autophosphorylation (Hillal et al. 1997).
R-HSA-2029451 (Reactome) The organized movements of membranes and the actin cytoskeleton are coordinated in phagocytosis by small GTPases of the Rho family. Specifically, RAC1 and CDC42 are known to be stimulated upon engagement of FCGR and are essential for the extension of the pseudopods that surround and engulf the phagocytic particle (Scott et al 2005). RAC1 is known to regulate actin dynamics. It is active throughout the phagocytic cup and activated RAC1 is necessary to assemble F actin. However, closing the phagocytic cup requires RAC1 to be deactivated (Naakaya et al 2007). Deletion of RAC1 prevents FCGR mediated phagocytosis (Hall et al 2006). RAC1 activation involves transition from an inactive GDP bound to an active GTP bound state catalysed by guanine exchanges factors (GEFs). VAV has been implicated in the activation of RAC1 (Patel et al 2002).
R-HSA-2029452 (Reactome) SYK is a tyrosine kinase related to ZAP70 that is expressed in all hematopoietic cells and coimmunoprecipitates with the gamma chain associated with FCGRIIIA in macrophages and with FCERI in mast cells. SYK is very important for FCGR phagocytosis and is recruited to these phosphorylated ITAM residues through its two SRC homology 2 (SH2) domains (Agarwal et al. 1993). When SYK kinase expression is inhibited with antisense oligonucleotides both in vitro and in vivo, phagocytosis and inflammation are abolished (Matsuda et al. 1997). The domain structure of SYK comprises a regulatory region at the N-terminus consisting of a pair of SH2 domains separated by an inter-SH2 linker called interdomain A, an SH2-domain-kinase linker termed interdomain B, and a C-terminal kinase domain (Arias-Palomo et al. 2009). In resting state SYK exists in an auto-inhibited conformation by the interactions between the SH2-SH2 regulatory region and the inter-SH2 linker and the catalytic domain. This interdomain interaction reduces the conformational flexibility required by the kinase domain for catalysis (Arias-Palomo et al. 2007). Changes in the orientation of the SH2 domains could control the disruption of the auto inhibitory interactions and the activation of SYK. These movements could be totally or partially induced by the binding to phosphorylated ITAMs and/or phosphorylation of tyrosine residues in interdomain A or B (Arias-Palomo et al. 2009). Tsang et al. suggested that SYK functions as an OR-gate switch with respect to phosphorylation and ITAM binding, as either one stimulus OR the other is sufficient to cause full activation (Tsang et al. 2008).
R-HSA-2029453 (Reactome) VAV proteins exist in an auto-inhibitory state folded in such a way as to inhibit the GEF activity of its DH domain. This folding is mediated through binding of tyrosines in the acidic domain to the DH domain and through binding of the CH domain to the C1 region. Activation of VAV may involve at least three different events to relieve this auto-inhibition. Phosphorylation of the tyrosines in the acidic domain causes them to be displaced from the DH domain, binding of a ligand to the CH domain may cause it to release the C1 domain and binding of PIP3 to PH domain may alter its conformation. VAV1 is phosphorylated on Y174 in the acidic domain, and this is mediated by Syk and Src-family tyrosine kinases. Once activated, VAV1 is then involved in the activation of RAC and CDC42 downstream of FCGR.
R-HSA-2029454 (Reactome) PAK1 needs autophosphorylation for complete activation. PAK1 is autophosphorylated at several sites, but S144 flanking the kinase inhibitor region and T423 within the catalytic domain are the two conserved sites that regulate the catalytic activity (Chong et al. 2001, Parrini et al. 2001).
R-HSA-2029455 (Reactome) FCGRI is coded by three different genes (A, B, and C) and is expressed on most myeloid cells including monocytes, macrophages and dendritic cells (Allen & Seed 1988). FCGRI is a high affinity IgG receptor capable of binding monomeric IgG. FCGRI exists as a complex containing ligand (IgG) binding extracellular alpha-chain and homodimer of signal transducing FcR gamma (CD3G) chains, or a heterodimer of signal transducing FcR gamma and zeta chains (Ernst et al. 1993, Scholl & Geha 1993, van Vugt et al. 1996). The cytoplasmic domain of FCGRI does not have signaling motifs, however it is suggested that the gamma-subunit might be required for generating the phagocytic signal (Duchemin et al. 1994, Indik et al. 1995).
The first step in Fc-gamma receptor (FCGR) phagocytosis is binding and clustering of FCGRs by IgG-coated foreign particles. FCGR are clustered at the cell surface by multivalent antigen-antibody complexes and recruited to lipid raft micro domains; monovalent ligand binding is insufficient to generate a signal. This cross-linking results in the localization of FCGRs into lipid rafts and this may aid in recruiting and complexing with additional signalling proteins associated with lipid rafts (Bournazos et al. 2009, Kwiatkowska & Sobota 2001, Kono et al. 2002). This is followed by phosphorylation of the tyrosine residues with in the immuno tyrosine activation motif (ITAM) located on the cytoplasmic portion of accessory gamma/zeta chains by membrane-associated tyrosine kinases of the Src family (Duchemin et al. 1994, van Vugt et al. 1996).
R-HSA-2029456 (Reactome) PAK1, a downstream effector of CDC42 and RAC1, is found localized in phagosomes. Upon activation, PAK1 phosphorylates LIMK, which directly phosphorylates and inactivates cofilin, a protein that mediates depolymerization of actin filaments. Thus, RAC and CDC42 coordinate actin dynamics by inducing actin polymerization via ARP2/3 on one hand, and inhibiting actin depolyerization via LIMK and cofilin on the other (Garcia-Garcia & Rosales 2002).
PAK1 exists as homodimer in a trans-inhibited conformation. The kinase inhibitory (KI) domain of one PAK1 molecule binds to the C-terminal catalytic domain of the other and inhibits catalytic activity. GTPases RAC1/CDC42 bind the GBD domain of PAK1 thereby altering the conformation of the KI domain, relieving inhibition of its catalytic domain, and allowing PAK1 autophosphorylation that is required for full kinase activity (Parrini et al. 2002, Zhao & Manser 2005).
R-HSA-2029457 (Reactome) FCGRIII (CD16) is a low affinity Fc gamma receptor and is encoded by two genes (A and B), the transmembrane form FCGRIIIA and the GPI anchored FCGRIIIB (Edberg et al. 1989). Between the two isoforms FCGRIIIA is involved in phagocytosis whereas FCGRIIIB is capable of inducing calcium signalling and actin polymerisation, but its role in phagocytosis is still not clear (Garcia Garcia & Rosales 2002). FCGRIIIA is expressed in macrophages and natural killer cells as a multi chain complex consisting of a single alpha chain containing IgG binding domains and a signal transducing gamma and/or zeta dimer (Wirthmuller et al. 1992, Lanier et al. 1989). Both gamma and zeta chains contain a conserved immunoreceptor tyrosine based activation motif (ITAM), which has 2 copies of the YXXL sequence (Isakov 1997). However, the gamma chain of FCGRIIIA is approximately sixfold more efficient in mediating phagocytosis than the zeta subunit (Park & Schreiber 1995). Phosphorylation of the conserved tyrosine residues of the ITAM in these accessory proteins is required for the phagocytic signal mediated by FCRGIIIA.
The first step in Fc-gamma receptor (FCGR) phagocytosis is binding and clustering of FCGRs by IgG-coated foreign particles. FCGR are clustered at the cell surface by multivalent antigen-antibody complexes and recruited to lipid raft micro domains; monovalent ligand binding is insufficient to generate a signal.
This cross linking results in the localisation of FCGRs into lipid rafts and this may aid in their recruiting and complexing with additional signalling proteins associated with lipid rafts (Kono et al. 2002). This is followed by phosphorylation of the tyrosine residues within the ITAM located on the cytoplasmic portion of accessory gamma/zeta chains by membrane associated tyrosine kinases of the Src family (Park et al. 1993).
R-HSA-2029458 (Reactome) VAV family members are cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho-family GTPases (RAC, RHO and CDC42). VAV1 is found predominantly in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. VAV proteins link the cell surface receptors like FCGR to the intracellular Rho GTPases and the actin cytoskeleton during phagocytosis (Hall et al 2006). Experiments using two-hybrid system suggest that VAV1 with its SH2 domain directly binds to the phosphorylated Y342 of SYK (Deckert et al. 1996). VAV proteins are also recruited to membrane through their PH domain by binding PI(3,4,5)P3 produced by PI3K.
R-HSA-2029459 (Reactome) After cross linking, Fc gamma receptors are sequestered to lipid rafts where they are complexed with some of the tyrosine kinases of Src family and undergo phosphorylation on the tyrosine residues contained in conserved ITAM sequences. At least six out of nine members of the Src family kinases (SRC, FYN, FGR, HCK, YES and LYN ) have been identified in the phagocytic cells and are implicated in the initiation of Fc gamma mediated signaling. (Suzuki et al. 2000, Majeed et al. 2001, Kwiatkowska et al. 2003). Some of these kinases have been found associated with specific receptors. In monocytes HCK and LYN have been found associated with FCGRI (Durden et al. 1995), whereas only HCK with FCGRIIA (Ghazizadeh et al. 1994) while FGR in neutrophils (Hamada et al. 1993) and LCK in NK cells with FCGRIIIA (Pignata et al. 1993)
The implication of Src kinases in phosphorylation was first supported by pharmacological findings that herbimycin A, a tyrosine kinase inhibitor relatively specific for Src-family kinases, potently suppressed Fc receptor mediated functions (Greenberg et al. 1993, Suzuki et al. 2000). However, their particular involvement in phagocytosis remains unclear, as targeted disruption of single or multiple Src family genes did not result in significant alterations in phagocytosis (Hunter et al. 1993, Fitzer Attas et al. 2000, Suzuki et al. 2000). HCK, FGR and LYN triple-deficient (-/-) macrophages have shown significant delays in FCGR mediated phagocytosis, but these deficiencies do not completly disrupt the process (Fitzer Attas et al. 2000).
Tyrosine residues Y288 and Y304 (Y282 and Y298 according to the literature reference, it is 6 residues shorter compared to uniprot entry due to an alternate initiation codon usage), within ITAM sequence in the cytoplasmic domain of FCGRIIA are the key target sites that are phosphorylated by Src family kinases (Mitchell et al, 1994). In case of FCGRIA and FCGRIIIA the specific tyrosine residues within ITAMs of the associated gamma/zeta chains are phosphorylated by activated Src family kinases (SFKs) (Park et al. 1993).
R-HSA-2029460 (Reactome) LIM kinases are serine protein kinases with a unique combination of two N-terminal LIM motifs, a central PDZ domain, and a C-terminal protein kinase domain. LIMK1 is one of the downstream targets of PAK1 and is activated through phosphorylation by PAK1 on T508 within its activation loop (Edwards et al. 1999, Aizawa et al. 2001). LIM-kinase is responsible for the tight regulation of the activity of cofilin (a protein that depolymerizes actin filaments) and thus maintains the balance between actin assembly and disassembly. Phosphorylated cofilin is inactive, resulting in stabilization of the actin cytoskeleton.
R-HSA-2029465 (Reactome) WASP family verprolin-homologous proteins (WAVEs) function downstream of RAC1 and are involved in activation of the ARP2/3 complex. The resulting actin polymerization mediates the projection of the plasma membrane in lamellipodia and membrane ruffles. WAVEs exist as a pentameric hetero-complex called WAVE Regulatory Complex (WRC). The WRC consists of a WAVE family protein (WASF1, WASF2 or WASF3 - commonly known as WAVE1, WAVE2 or WAVE3), ABI (Abelson-interacting protein), NCKAP1 (NAP1, p125NAP1), CYFIP1 (SRA1) or the closely related CYFIP2 (PIR121), and BRK1 (HSPC300, BRICK). Of the three structurally conserved WAVEs in mammals, the importance of WAVE2 in activation of the ARP2/3 complex and the consequent formation of branched actin filaments is best established. WAVEs in the WRC are intrinsically inactive and are stimulated by RAC1 GTPase and phosphatidylinositols (PIP3). The C-terminal VCA domain of WAVE2 (and likely WAVE1 and WAVE3) which can bind both the ARP2/3 complex and actin monomers (G-actin) is masked in the inactive state. After PIP3 binds to the polybasic region of WAVE2 (and likely WAVE1 and WAVE3) and RAC1:GTP binds to the CYFIP1 (or CYFIP2) subunit of the WRC, allosteric changes most likely occur which allow WAVEs to interact with the ARP2/3 complex. The interactions between WAVEs and RAC1 are indirect. BAIAP2/IRSp53, an insulin receptor substrate, acts as a linker, binding both activated RAC1 and the proline-rich region of WAVE2 (and likely WAVE1 and WAVE3) and forming a trimolecular complex. CYFIP1 (or CYFIP2) in the WAVE regulatory complex binds directly to RAC1:GTP and links it to WAVE2 (and likely WAVE1 and WAVE3) (Derivery et al. 2009, Yamazaki et al. 2006, Takenawa & Suetsugu 2007, Chen et al. 2010, Pollard 2007, Lebensohn & Kirschner 2009).
R-HSA-2029466 (Reactome) Once activated, the ARP2/3 complex nucleates new actin filaments that extend from the sides of pre-existing mother actin filaments at a 70-degree angle to form Y-branched networks (Firat-Karalar & Welch 2010). These branched actin filaments push the cell membrane forward to form a pseudopod. The ARP2/3 complex is composed of two Arps (actin-related proteins), ARP2 and ARP3, and five unique proteins ARPC1, ARPC2, ARPC3, ARPC4 and ARPC5 (Gournier et al. 2001). Both ARP2 and ARP3 subunits bind ATP. There are two proposed models to explain the process of actin nucleation by ARP2/3 complex: the barbed-end branching model and the dendritic nucleation/side branching model (Le Clainche & Carlier 2008).
In barbed-end branching model, the branching/ternary complex (G-actin-WASP/WAVE-Arp2/3 complex) binds to the barbed end of the mother filament. G-actin bound to VCA domain or one of the Arp subunits incorporates into the mother filament at the barbed end, thus positioning ARP2/3 complex to initiate the daughter branch on the side of the mother filament. ARP2/3 nucleates the formation of new actin filament branches, which elongate at the barbed ends (Le Clainche & Carlier 2008, Pantaloni et al 2000, Le Clainche et al. 2003, Egile et al. 2005). In side branching model, the branching complex binds to the side of the mother actin filament mimicking an actin nucleus and initiates a lateral branch (Le Clainche & Carlier 2008, Amann & Pollard 2001).
R-HSA-2029467 (Reactome) RAC1 is activated from inactive GDP-bound state to active GTP-bound form by the GEF activity of DOCK180:ELMO complex.
R-HSA-2029468 (Reactome) Phosphatidic acid phosphatase (PAP) bound to the plasma membrane catalyzes the dephosphorylation of phosphatidic acid (PA), yielding diacylglycerol (DAG) and inorganic phosphate. In humans, Diacylglycerol pyrophosphate (DPPL1 and DPPL2) perform this reaction.
R-HSA-2029469 (Reactome) The ARP2/3 complex shows higher affinity for the phosphorylated VCA domain of WAVE2 than for the unphosphorylated VCA domain. WAVE proteins can be phosphorylated by various kinases. Active ERK (Mitogen activated protein kinase 3) phosphorylates the WAVE regulatory complex (WRC) on multiple serine/threonine sites within the proline-rich domains (PRDs) of WAVE2 and ABI1. Phosphorylation of the PRDs would disrupt their interaction with SH3 and PLP binding domains, potentially altering WRC activation. ERK phosphorylates both S343 and T346 in WAVE2 and S183, S216, S225, S392, and S410 in ABI1. Cumulatively, the phosphorylation of both WAVE2 and ABI in the WAVE regulatory complex (WRC) contributes to the RAC-induced WRC conformational change that exposes the VCA domain, leading to binding and activation of ARP2/3 (Mendoza et al. 2011, Nakanishi et al. 2007). ERK phosphorylation sites in WAVE2 are not strictly conserved in WAVE1 and WAVE3 but, based on the amino acid sequence, other potential ERK phosphorylation sites exist.
R-HSA-2029471 (Reactome) Phospholipase D (PLD) catalyses the hydrolysis of the membrane phospholipid, phosphatidylcholine (PC) to generate choline and metabolically active phosphatidic acid (PA) (Lennartz 1999). Pharmacological inhibition studies show that PLD participates in FCGR-mediated phagocytosis (Kusner et al. 1996). There is an increase in the activity of PLD following the activation of phagocytosis via FCGR (Kusner et al. 1999). Following activation of FCGR, PLD translocates to the plasma membrane at the phagocytic cup and generate PA. This PA can be converted to DAG through the action of phosphatidic acid phosphatase-1 (PAP-1). Thus activation of PLD may be an additional pathway leading to PKC activation.
The two isoforms PLD1 and PLD2 are both shown to be essential for the formation of phagosome at different stages. PLD1 is localized on the endosomal/lysosomal compartment and PLD2 is localized at the plasma membrane. PLD2 may be linked to phagosome formation whereas PLD1 may be involved in the focal exocytosis at the plasma membrane and also in the maturation process (Carrotte et al. 2006).
R-HSA-2029473 (Reactome) ATP bound G-actin monomers are added to the fast growing barbed ends of both mother and daughter filaments. The polymerization of these filaments drives membrane protrusion. In the process of phagocytosis, pseudopodia extend around the antibody-bound particle to form the phagocytic cup. This elongation continues until the filament reaches steady state equilibrium with free G-actin monomers (Millard et al. 2004, Le Clainche et al. 2008).
R-HSA-2029475 (Reactome) Several members of phospholipase A (PLA) are involved in phagocytosis. Macrophages express three classes of PLA2: secreted Ca-dependent (sPLA2), cytosolic Ca-dependent (cPLA2) and cytosolic Ca-independent (iPLA2) of which iPLA2 is involved in FCGR mediated arachidonic acid (AA) production. Aggregation of FCGR triggers phosphorylation and membrane translocation of iPLA2. Protein kinase C (PKC), ERK and p38MAPK seems to regulate iPLA2 in monocytes, neutrophils and macrophages. Phosphorylated iPLA2 then mediates production of AA and lysoophospholipids from phosphatidylcholine. iPLA2 inhibitors (bromoenol lactone) block AA release and phagocytosis which can be restored upon addition of exogenous AA, suggesting a critical role for iPLA2 in FCGR phagocytosis (Lennartz et al. 1993, Tay & Melendez). Release of AA by activated iPLA2 changes the physical characteristic of the membrane which may facilitate pseudopod extension.
R-HSA-2029476 (Reactome) In addition to the membrane remodeling for pseudopod extension, particle internalization requires a contractility force pulling the forming phagosome into the cytoplasm. Myosin motor proteins are the actin-binding proteins, with ATPase activity move along actin fibers, and produce the driving force for phagosome formation and transport. Several myosin motors including myosins IC, II, V, IXb are involved in FCGR-mediated phagocytosis as force generators and actin-based transport motors (Swanson et al. 1999). Nonmuscle myosin II, is a motor protein known to generate intracellular contractile forces and tension by associating with F-actin. It has been observed to localize around forming phagosomes and suggested a role in phagocytic-cup squeezing during FCGR-mediated phagocytosis. Each myosin II motor protein exists as a complex consisting of two copies each of myosin II heavy chain (MHC), essential light chains (ELC), and myosin regulatory light chain (MRLC). Selective inhibition of myosin II by ML-7, a myosin light-chain kinase (MLCK) inhibitor, prevents phagocytic cup closure, but not pseudopod extension for the formation of phagocytic cups in FCGR-mediated phagocytosis (Grooves et al. 2008, Araki 2006). Tight ring of actin filaments within the elongating pseudopodia squeezes the deformable particles. In the classical zipper model for phagocytosis, the pseudopod extends over the IgG-coated particles, in which FCGRs in the phagocyte plasma membrane interact sequentially with Fc portions of IgG molecules zippering the membrane along the particle. This sequential IgG-FCGR binding might not occur by itself, but requires forced zipper closure, where myosin-II contractile activity may promote the binding between the FCGR and its ligands, to facilitate the efficient extension and subsequent closure of phagocytic cups (Araki 2006, ). Myosin IC mediates the purse-string-like contraction that closes phagosomes. Myosin-V has been implicated in membrane trafficking events (Swanson et al. 1999).
R-HSA-2130194 (Reactome) Abelson interactor-1 (ABL) tyrosine kinase phosphorylates the strictly conserved tyrosine 150 in WAVE2 (Y151 in WAVE1 and WAVE3) (Leng et al. 2003, Chen et al. 2010).
R-HSA-2197690 (Reactome) After incorporation at the branch, the actin bound to VCA domain of WASP/WAVE undergoes ATP hydrolysis and this destabilizes its interaction with WASP/WAVE. This dissociates the branched junction from the membrane-bound WASP/WAVE (Kovar 2006).
R-HSA-2197691 (Reactome) WASP interacting proteins (WIP) family includes WIPF1 (WIP), WIPF2 (WIRE,WICH) and WIPF3 (CR16, corticosteroids and regional expression-16). WIPs share a specific proline rich sequence that interacts with the WH1 domain of WASP and N-WASP (WASL). WIPs form heterocomplexes with WASPs and may contribute to the WASP protein stability (Aspenstrom 2002, Kato et al. 2002, Ho et al. 2001, Moreau et al. 2000).
SH3 domain containing adaptor proteins like GRB2 (Carlier et al. 2000), NCK (Rohatgi et al. 2001) and WISH (DIP/SPIN90) (Fukuoka et al. 2001) bind to the proline rich domain in WASPs and activate the ARP2/3 complex. By binding simultaneously to N-WASP and the ARP2/3 complex, GRB2 works synergistically with CDC42 in the activation of ARP2/3 complex-mediated actin assembly (Carlier et al. 2000).
R-HSA-2197697 (Reactome) Macrophages lacking all the three isoforms of VAV did not affect FCGR-mediated phagocytosis suggesting that RAC1 is regulated by GEFs other than VAV downstream of the FCGR (Hall et al 2006). DOCK180, a member of GEFs, is found to be involved in the activation of RAC1. DOCK180 associates with the adaptor protein CRKII and the complex is found to accumulate at the phagocytic cup. DOCK180 is recruited to the sites of phagocytosis by binding to SH3 domain of CRKII through its proline-rich motif (Hasegawa et al 1996). CRKII is likely recruited to the activated FCGR complex by binding phosphorylated ITAM tyrosines on the receptor or through other phosphotyrosines on ancillary proteins that are recruited to the receptor complex (Lee et al 2007). Unlike the usual GEFs, DOCK180 does not contain the conserved Dbl homology (DH) domain. Instead, it has a DHR-2 or DOCKER domain capable of loading RAC with GTP (Brugnera et al 2002). Binding of DOCK180 to RAC alone is insufficient for GTP loading, and a DOCK180-ELMO interaction is required. ELMO1, as well as ELMO2, form a complex with DOCK180 and they function together as a bipartite GEF to optimally activate RAC (Gumienny et al 2001, Brugnera et al 2002).
R-HSA-2197698 (Reactome) WASP is phosphorylated on Tyr291 (Cory et al. 2002) and N-WASP (WASL) on Tyr256 (Wu et al. 2004) by Src family of tyrosine kinases and this phosphorylation may release the autoinhibitory intramolecular interactions. The phosphorylation seems to be enhanced by the activation of CDC42. WASP phosphorylation and binding of CDC42 have a synergistic effect on the activation of the ARP2/3 complex (Takenawa & Suetsugu 2007). In N-WASP, the phosphorylation may reduce its nuclear translocation and may sustain it in its functional site in the cytoplasm (Wu et al. 2004).
R-HSA-399950 (Reactome) The EPHB2-FAK pathway partially promotes dendritic spine stability through LIMK-mediated cofilin (CFL1) phosphorylation (Shi et al. 2009). CFL1 is a member of the ADF (actin-depolymerizing factor) protein family that is involved in regulating actin dynamics in the growth cone. It binds to actin in a one-to-one molar ratio, and stimulates both the severing of actin filaments and depolymerization of actin subunits from the actin filament end. Activated LIMK phosphorylates CFL1 on the conserved serine 3 residue located near the actin-binding site. After phosphorylation, CFL1 is inactive, loses its affinity for actin and dissociates from G-actin monomers. Once freed, ADP-actin monomers can exchange ADP with cytoplasmic ATP, ready for reincorporation at the barbed end of a growing filament (Gungabissoon & Bamburg 2003).
R-HSA-419644 (Reactome) Binding of Hsp90 to the LIMK proteins protects them from degradation and promotes their dimer formation and transphosphorylation. It is estimated that LIMK1 contains at least 5 phospho-amino acids primarily phospho-serines, in its kinase domain. The positions of these serine residues are not known. Transphosphorylation of these serine residues in LIMK1 increases its stability.
R-HSA-419645 (Reactome) After phosphorylation on Thr 508, LIMK undergoes homodimerization. Homodimer formation is promoted by the binding of heat shock protein 90 (Hsp90) to a short sequence in the kinase domain of LIMKs. LIMKs are further phosphorylated after homodimer formation and transphosphorylation of the kinase domain.
R-HSA-442586 (Reactome) Wiskott-Aldrich syndrome protein (WASP) and Neural-WASP (N-WASP, WASL) proteins are scaffolds that transduce signals from cell surface receptors to the activation of the ARP2/3 complex and actin polymerization. WASP and N-WASP possess a central GTPase binding domain (GBD) and an NH2-terminal WASP homology domain 1 (WH1) followed by a basic region (B), and a C-terminal VCA region that contains: a V domain (verprolin homology/WASP homology 2), a C domain (connecting), and an A motif (acidic). The VCA region is responsible for binding to and activating the ARP2/3 complex (Bompard & Caron 2004, Callebaut et al 1998). Under resting conditions, WASP and N-WASP are maintained in an autoinhibited state via interaction of the GBD and the VCA domains. This prevents access of the ARP2/3 complex and G-actin to the VCA region. Activated CDC42 binds to the GBD region of WASPs and this interaction releases the VCA region from autoinhibition, enabling binding of the ARP2/3 complex and stimulating actin polymerization (Kim et al 2000, Park & Cox 2009). Phosphoinositides (PtdIns(4,5)P2) interact with the basic (B) region in WASPs and this interaction is important for activation of the WASPs and the ARP2/3 complex (Higgs & Pollard 2000).
R-HSA-442592 (Reactome) Once WASPs (WASP and N-WASP) and WAVEs (WAVE2 and probably WAVE1 and WAVE3) are activated, their VCA region becomes available for binding to the ARP2/3 complex and actin monomer (G-actin). The actin monomer binds to the V domain and ARP2/3 complex binds to the CA domain. The simultaneous binding of G-actin and the ARP2/3 complex to the VCA region contributes to the activation of the ARP2/3-complex-mediated actin polymerization. The VCA module acts as a platform on which an actin monomer binds to the ARP2/3 complex to trigger actin polymerization (Takenawa & Suetsugu 2007).
RAC1:GDPR-HSA-2029451 (Reactome)
RAC1:GDPR-HSA-2029467 (Reactome)
RAC1:GTP,CDC42:GTP:PAK1ArrowR-HSA-2029456 (Reactome)
RAC1:GTP,CDC42:GTP:PAK1R-HSA-2029454 (Reactome)
RAC1:GTPArrowR-HSA-2029451 (Reactome)
RAC1:GTPArrowR-HSA-2029467 (Reactome)
RAC1:GTPR-HSA-2029465 (Reactome)
SH3 domain proteinsR-HSA-2197691 (Reactome)
SYKR-HSA-2029452 (Reactome)
Src family kinases (SFKs)mim-catalysisR-HSA-2029459 (Reactome)
Src-kinasesmim-catalysisR-HSA-2197698 (Reactome)
Unknown GEFmim-catalysisR-HSA-2029445 (Reactome)
VAV1,2,3R-HSA-2029458 (Reactome)
WASP/N-WASPR-HSA-442586 (Reactome)
WAVE Regulatory ComplexR-HSA-2029465 (Reactome)
WIP family proteinsR-HSA-2197691 (Reactome)
WRC:IRSp53/58:RAC1:GTP:PIP3ArrowR-HSA-2029465 (Reactome)
WRC:IRSp53/58:RAC1:GTP:PIP3R-HSA-2130194 (Reactome)
clustered IgG-Ag:FCGRsR-HSA-2029459 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKArrowR-HSA-2029452 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKR-HSA-2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKmim-catalysisR-HSA-2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGArrowR-HSA-2029270 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGR-HSA-2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGmim-catalysisR-HSA-2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVArrowR-HSA-2029458 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVR-HSA-2029453 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGArrowR-HSA-2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGR-HSA-2029272 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVArrowR-HSA-2029453 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVmim-catalysisR-HSA-2029451 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKArrowR-HSA-2029272 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKArrowR-HSA-2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKR-HSA-2029270 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKR-HSA-2029273 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKR-HSA-2029458 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKR-HSA-2197697 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKmim-catalysisR-HSA-2029453 (Reactome)
clustered IgG-Ag:p-FCGRsArrowR-HSA-2029459 (Reactome)
clustered IgG-Ag:p-FCGRsArrowR-HSA-2029476 (Reactome)
clustered IgG-Ag:p-FCGRsR-HSA-2029452 (Reactome)
clustered IgG-Ag:p-FCGRsR-HSA-2029476 (Reactome)
p-4Y-PLCG1mim-catalysisR-HSA-167686 (Reactome)
p-PLCGArrowR-HSA-2029272 (Reactome)
p-S144,T423-PAK1ArrowR-HSA-2029454 (Reactome)
p-S144,T423-PAK1mim-catalysisR-HSA-2029460 (Reactome)
p-T,Y MAPK dimersmim-catalysisR-HSA-2029469 (Reactome)
p-T508-LIMK1ArrowR-HSA-2029460 (Reactome)
p-T508-LIMK1R-HSA-419645 (Reactome)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3ArrowR-HSA-2029469 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3ArrowR-HSA-2130194 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3R-HSA-2029469 (Reactome)
pCofilin: Active LIMK-1ArrowR-HSA-399950 (Reactome)
pLIMK dimer:HSP-90ArrowR-HSA-419645 (Reactome)
pLIMK dimer:HSP-90R-HSA-419644 (Reactome)
pLIMK dimer:HSP-90mim-catalysisR-HSA-419644 (Reactome)
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