Activation of kainate receptors upon glutamate binding (Homo sapiens)

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51412, 316cytosolDLG3 GRIK2 GNG11 GRIK3 Cl- GRIK5 GNG7 L-Glu Kainatereceptor-glutamatecomplexGNGT1 GNGT1 CALM1 GRIK3 GRIK4 Edited GRIK2 (GluR6) GNG4 Edited GRIK2 (GluR6) GNG13 DLG3 Kainate ReceptorsGRIK 3 homomerL-Glu GNG3 Cl- GRIK5 PLCB3 DLG4 Edited GRIK 1 (GluR5) Edited KainatereceptorsGNB5 Ca2+GNG2 GRIK3 GNB5 PLCB1 L-GluGNB3 G-proteinbeta-gamma:PLC beta1/2/3GNG5 Kainatereceptor-glutamate-Gprotein complexGNG8 PLCB1 GNG5 GNG12 Ca2+GNG11 Edited GRIK 1 (GluR5) GNB1 GNB4 GRIK3 homomerglutamate complexPLCB2 GRIK3 GNG4 GNG2 Cl- L-Glu PLCB3 DLG1 GRIK2 GNG8 Cl- Na+GNB4 PLCB2 DLG1 DLG4 GRIK4 GNB2 GRIK1 Cl- GNGT2 GNG12 Na+GNG10 GNG10 GRIK3 L-Glu Cl- GRIK1 CALM1 Edited KainateReceptor-glutamatecomplexGNG7 GNB3 NCALD Cl- GNB1 GNGT2 GNG13 NCALD GNB2 GNG3


Description

Kainate receptors are found both in the presynaptc terminals and the postsynaptic neurons.
Kainate receptor activation could lead to either ionotropic activity (influx of Ca2+ or Na+ and K+) in the postsynaptic neuron or coupling of the receptor with G proteins in the presynaptic and the postsynaptic neurons.
Kainate receptors are tetramers made from subunits GRIK1-5 or GluR5-7 and KA1-2. Activation of kainate receptors made from GRIK1 or KA2 release Ca2+ from the intracellular stores in a G protein-dependent manner. The G protein involved in this process is sensitive to pertussis toxin. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 451326
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: Mahajan, SS

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Ontology Terms

 

Bibliography

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  1. Perrais D, Coussen F, Mulle C.; ''Atypical functional properties of GluK3-containing kainate receptors.''; PubMed Europe PMC Scholia
  2. Wilding TJ, Zhou Y, Huettner JE.; ''Q/R site editing controls kainate receptor inhibition by membrane fatty acids.''; PubMed Europe PMC Scholia
  3. Carver JM, Mansson PE, Cortes-Burgos L, Shu J, Zhou LM, Howe JR, Giordano T.; ''Cytotoxic effects of kainate ligands on HEK cell lines expressing recombinant kainate receptors.''; PubMed Europe PMC Scholia
  4. Bardoul M, Levallois C, König N.; ''Functional AMPA/kainate receptors in human embryonic and foetal central nervous system.''; PubMed Europe PMC Scholia
  5. Jane DE, Lodge D, Collingridge GL.; ''Kainate receptors: pharmacology, function and therapeutic potential.''; PubMed Europe PMC Scholia
  6. Gill MB, Vivithanaporn P, Swanson GT.; ''Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114901view16:41, 25 January 2021ReactomeTeamReactome version 75
113061view10:59, 2 November 2020ReactomeTeamReactome version 74
112295view15:12, 9 October 2020ReactomeTeamReactome version 73
102017view15:16, 26 November 2018Marvin M2Ontology Term : 'neuron-to-neuron signaling pathway via the chemical synapse' added !
101670view13:49, 1 November 2018DeSlOntology Term : 'signaling pathway' added !
101669view13:49, 1 November 2018DeSlOntology Term : 'neuron' added !
101657view11:51, 1 November 2018ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CALM1 ProteinP0DP23 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Cl- MetaboliteCHEBI:17996 (ChEBI)
DLG1 ProteinQ12959 (Uniprot-TrEMBL)
DLG3 ProteinQ92796 (Uniprot-TrEMBL)
DLG4 ProteinP78352 (Uniprot-TrEMBL)
Edited GRIK 1 (GluR5) ProteinP39086 (Uniprot-TrEMBL) Glutamine at position 636 is replaced by arginine in an editing step which occurs posttranscriptionally.
Edited GRIK2 (GluR6) ProteinQ13002 (Uniprot-TrEMBL) GRIK2 is edited at the Q/R site at 621 where the glutamine is edited to arginine. GRIK2 is also edited at 571 (Y/C) where a tyrosine residue is changed to cysteine and 567 (I/V) where an isoleucine is changed to valine. All three sites are edited postranscriptionally. A fully edited GRIK2 at all three sites is totally impermeable to calcium ions.
Edited Kainate

Receptor-glutamate

complex		ComplexR-HSA-451304 (Reactome)
Edited Kainate receptorsComplexR-HSA-451279 (Reactome) Kainate receptors are formed by the assembly of four subunits. GluR5-7 (GRIK, glutamate receptor, ionotropic Kainate 1-3) form functional homomers whereas, KA1 and KA2 or GRIK4,5 form functional heteromers with GRIK1/2/3. Kainate receptor subunits bind Cl- ion in the anion binding site in the ligand binding domain. The dimer is stabilized by the presence of one Cl- ion which binds within the dimer interface.
G-protein

beta-gamma:PLC beta

1/2/3		ComplexR-HSA-398037 (Reactome)
GNB1 ProteinP62873 (Uniprot-TrEMBL)
GNB2 ProteinP62879 (Uniprot-TrEMBL)
GNB3 ProteinP16520 (Uniprot-TrEMBL)
GNB4 ProteinQ9HAV0 (Uniprot-TrEMBL)
GNB5 ProteinO14775 (Uniprot-TrEMBL)
GNG10 ProteinP50151 (Uniprot-TrEMBL)
GNG11 ProteinP61952 (Uniprot-TrEMBL)
GNG12 ProteinQ9UBI6 (Uniprot-TrEMBL)
GNG13 ProteinQ9P2W3 (Uniprot-TrEMBL)
GNG2 ProteinP59768 (Uniprot-TrEMBL)
GNG3 ProteinP63215 (Uniprot-TrEMBL)
GNG4 ProteinP50150 (Uniprot-TrEMBL)
GNG5 ProteinP63218 (Uniprot-TrEMBL)
GNG7 ProteinO60262 (Uniprot-TrEMBL)
GNG8 ProteinQ9UK08 (Uniprot-TrEMBL)
GNGT1 ProteinP63211 (Uniprot-TrEMBL)
GNGT2 ProteinO14610 (Uniprot-TrEMBL)
GRIK 3 homomerComplexR-HSA-450196 (Reactome)
GRIK1 ProteinP39086 (Uniprot-TrEMBL)
GRIK2 ProteinQ13002 (Uniprot-TrEMBL)
GRIK3 ProteinQ13003 (Uniprot-TrEMBL)
GRIK3 homomer glutamate complexComplexR-HSA-500705 (Reactome)
GRIK4 ProteinQ16099 (Uniprot-TrEMBL)
GRIK5 ProteinQ16478 (Uniprot-TrEMBL)
Kainate

receptor-glutamate

complex		ComplexR-HSA-451281 (Reactome)
Kainate receptor-glutamate-Gprotein complexComplexR-HSA-500703 (Reactome)
Kainate ReceptorsComplexR-HSA-450885 (Reactome) Kainate receptors are formed by the assembly of four subunits. GluR5-7 (GRIK, glutamate receptor, ionotropic Kainate 1-3) form functional homomers whereas, KA1 and KA2 or GRIK4,5 form functional heteromers with GRIK1/2/3. Kainate receptor subunits bind Cl- ion in the anion binding site in the ligand binding domain. The dimer is stabilized by the presence of one Cl- ion which binds within the dimer interface.
L-Glu MetaboliteCHEBI:29985 (ChEBI)
L-GluMetaboliteCHEBI:29985 (ChEBI)
NCALD ProteinP61601 (Uniprot-TrEMBL)
Na+MetaboliteCHEBI:29101 (ChEBI)
PLCB1 ProteinQ9NQ66 (Uniprot-TrEMBL)
PLCB2 ProteinQ00722 (Uniprot-TrEMBL)
PLCB3 ProteinQ01970 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
Ca2+ArrowR-HSA-451311 (Reactome)
Ca2+R-HSA-451311 (Reactome)
Edited Kainate

Receptor-glutamate

complex		ArrowR-HSA-451309 (Reactome)
Edited Kainate

Receptor-glutamate

complex		mim-catalysisR-HSA-451310 (Reactome)
Edited Kainate receptorsR-HSA-451309 (Reactome)
G-protein

beta-gamma:PLC beta

1/2/3		R-HSA-500717 (Reactome)
GRIK 3 homomerR-HSA-500708 (Reactome)
GRIK3 homomer glutamate complexArrowR-HSA-500708 (Reactome)
GRIK3 homomer glutamate complexR-HSA-500717 (Reactome)
GRIK3 homomer glutamate complexmim-catalysisR-HSA-500717 (Reactome)
Kainate

receptor-glutamate

complex		ArrowR-HSA-451283 (Reactome)
Kainate

receptor-glutamate

complex		mim-catalysisR-HSA-451311 (Reactome)
Kainate receptor-glutamate-Gprotein complexArrowR-HSA-500717 (Reactome)
Kainate ReceptorsR-HSA-451283 (Reactome)
L-GluR-HSA-451283 (Reactome)
L-GluR-HSA-451309 (Reactome)
L-GluR-HSA-500708 (Reactome)
Na+ArrowR-HSA-451310 (Reactome)
Na+R-HSA-451310 (Reactome)
R-HSA-451283 (Reactome) Kainate receptors bind glutamate in the ligand binding domain in the extracellular, N terminal region.
R-HSA-451309 (Reactome) Kainate receptors bind glutamate in the ligand binding domain in the extracellular, N terminal region.
R-HSA-451310 (Reactome) The activation of Kainate receptors by glutamate in the postsynaptic neuron leads to influx of Na+ ions resulting in depolarization of the postsynaptic membrane.
R-HSA-451311 (Reactome) Kainate receptors that are assembled with subunits GRIK1-5, are Ca2+ permeable if GRIK1 and GRIK2 are not edited at the Q/R or other sites.
These channels permit Ca2+ upon activation by glutamate or other agonists.
R-HSA-500708 (Reactome) Kainate receptors bind glutamate in the ligand binding domain in the extracellular, N terminal region.
R-HSA-500717 (Reactome) Kainate receptor activation activates G protein coupled receptors involving the release of Ca2+ from the intracellular stores. This activity of Kainate receptors is independent of ionic influx and regulates both glutamate release by the pyramidal neurons and gama-aminobutyric acid release by the internuerons.
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