Mevalonate arm of cholesterol biosynthesis pathway (Homo sapiens)

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1Endoplasmic reticulummitochondriaTransportCytosolPeroxisomeHMGCRMVKAcetyl-CoA3-hydroxy-3-methylglutaryl-CoAFDPSdimethylallyl-PPFDFT1HMGCS1Mitochondrial beta-oxidation of fatty acidscholesterol synthesisacetoacetateacetoacetyl-CoAACAT1IDI1HMGCLmevaldyl-CoAmevalonatemevalonate-Pmevalonate-PPisopenthyl-PPPMVKMVDgeranyl-PPfamesyl-PPgeranylgeranyl-PPpresqualene-PPsqualeneprotein prenylationGGPS1IDI2GGPS1famesyl-PP3-hydroxy-3-methylglutaryl-CoAmevalonateHMGCRAcetyl-CoAacetoacetyl-CoA3-hydroxy-3-methylglutaryl-CoAAcetyl-CoAacetoacetyl-CoAACAT1acetoacetateHMGCLMitochondrial beta-oxidation of fatty acidsACAT2HMGCS1


Description

The mevalonate arm of the cholesterol biosynthesis pathway within different cellular regions.

View more details on which drugs are related to these reactions at [1].

View the broader scope of cholesterol metabolism at [2].

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Quality Tags

Ontology Terms

 

Bibliography

  1. Haines BE, Wiest O, Stauffacher CV; ''The increasingly complex mechanism of HMG-CoA reductase.''; Acc Chem Res, 2013 PubMed Europe PMC Scholia
  2. Benson HE, Watterson S, Sharman JL, Mpamhanga CP, Parton A, Southan C, Harmar AJ, Ghazal P; ''Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway.''; Br J Pharmacol, 2017 PubMed Europe PMC Scholia
  3. Mazein A, Watterson S, Hsieh WY, Griffiths WJ, Ghazal P; ''A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway.''; Biochem Pharmacol, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124024view05:10, 14 September 2022EgonwThe neutral mevaldyl
123596view13:51, 4 August 2022DeSlOntology Term : 'isoprenoid biosynthetic pathway' added !
123595view13:50, 4 August 2022DeSlAdded more details to description.
123594view13:48, 4 August 2022DeSlAdded comments from overlapping content in WP3963
123593view13:45, 4 August 2022DeSlAdded PW link for beta-oxidation of FAs
118431view14:33, 27 May 2021Mkutmonremoved unused reference
117284view10:55, 20 May 2021DeSlUpdated all PW nodes to solid lines again
117283view10:54, 20 May 2021DeSlChecking clickability of double vs single shape PW nodes
116703view13:59, 10 May 2021DeSlUpdated HMGCS1 ID from wikidata to Uniprot
116702view13:57, 10 May 2021DeSlAnnotated ER and cytosol interactions
116701view11:40, 10 May 2021DeSlUpdated with Rhea info until squalene
116700view11:25, 10 May 2021DeSlConnected to Rhea untill geranylgeranyl-PP
116699view11:18, 10 May 2021DeSlUpdated PW DataNode visualisation
116356view18:35, 3 May 2021DeSlUpdated IDs until geranyl-PP
116355view18:30, 3 May 2021DeSlUpdated IDs untill IDI1+2
116354view18:18, 3 May 2021DeSlConnected unconnected lines without removing translocation interactionsheads
116353view18:17, 3 May 2021DeSlReverted to version '07:36, 29 April 2021' by DeSl
116339view12:27, 2 May 2021L DupuisConnected lines
116299view07:36, 29 April 2021DeSlUpdated with Rhea until mevalonate-PP
116298view15:11, 28 April 2021DeSlAdded side metabolites for 3-H-3-MG-CoA to mevalonate interactions
116297view14:57, 28 April 2021DeSlAdded mevaldyl intermediate, including annotation
116296view14:46, 28 April 2021DeSlAdded ID to mevaldyl-CoA, ref to accopanying interactions
116295view13:43, 28 April 2021DeSlAdded lit. refs. for mevaldyl-CoA conversion
116294view13:35, 28 April 2021DeSlReannotated part of PW according to info from Rhea
116293view13:00, 28 April 2021DeSlAdded legend, updated layout
116292view12:48, 28 April 2021DeSlAdded lit ref
104328view13:51, 17 May 2019DeSlModified description
104327view13:50, 17 May 2019DeSlModified description
101730view12:37, 2 November 2018DeSlModified description
101729view12:36, 2 November 2018DeSlModified description
97482view12:50, 23 May 2018Fehrhartfixed connection
96455view11:45, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95421view13:41, 14 December 2017DeSlOntology Term : 'metabolising cell' added !
95420view13:40, 14 December 2017DeSlOntology Term : 'cell' added !
95419view13:39, 14 December 2017DeSlOntology Term : 'mitochondria transport pathway' added !
95418view13:08, 14 December 2017DeSlOntology Term : 'cholesterol biosynthetic pathway' added !
95417view13:07, 14 December 2017DeSlAdded wikidata as database source where applicable
95416view13:00, 14 December 2017DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3-hydroxy-3-methylglutaryl-CoAMetaboliteQ27108899 (Wikidata)
ACAT1ProteinQ4650507 (Wikidata)
ACAT2ProteinQ21119315 (Wikidata)
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
FDFT1ProteinQ21108578 (Wikidata)
FDPSProteinQ21107439 (Wikidata)
GGPS1ProteinQ21106540 (Wikidata)
HMGCLProteinQ21118307 (Wikidata)
HMGCRProtein1.1.1.88 (Enzyme Nomenclature)
HMGCS1ProteinQ21118293 (Wikidata)
IDI1ProteinQ21151146 (Wikidata)
IDI2ProteinQ21132842 (Wikidata)
MVDProtein4.1.1.33 (Enzyme Nomenclature)
MVKProteinQ424031 (Wikidata)
Mitochondrial

beta-oxidation of

fatty acids		Pathway
PMVKProteinQ22676988 (Wikidata)
acetoacetateMetaboliteQ21559339 (Wikidata)
acetoacetyl-CoAMetaboliteQ2639429 (Wikidata)
cholesterol synthesisPathwayWP197 (WikiPathways)
dimethylallyl-PPMetaboliteQ417398 (Wikidata)
famesyl-PPMetaboliteQ45416123 (Wikidata)
geranyl-PPMetaboliteQ418125 (Wikidata)
geranylgeranyl-PPMetaboliteQ774795 (Wikidata)
isopenthyl-PPMetaboliteQ417403 (Wikidata)
mevaldyl-CoAMetabolite
mevalonate-PPMetaboliteQ45415198 (Wikidata)
mevalonate-PMetaboliteQ45414671 (Wikidata)
mevalonateMetaboliteQ27109878 (Wikidata)
presqualene-PPMetaboliteQ27088444 (Wikidata)
protein prenylationPathway
squaleneMetaboliteQ407560 (Wikidata)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4190"
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