Ophthalmate biosynthesis in hepatocytes (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Orlowski M, Wilk S; ''Synthesis of ophthalmic acid in liver and kidney in vivo.''; Biochem J, 1978 PubMed Europe PMC Scholia
2. Soga T, Baran R, Suematsu M, Ueno Y, Ikeda S, Sakurakawa T, Kakazu Y, Ishikawa T, Robert M, Nishioka T, Tomita M; ''Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
3. Oppenheimer L, Wellner VP, Griffith OW, Meister A; ''Glutathione synthetase. Purification from rat kidney and mapping of the substrate binding sites.''; J Biol Chem, 1979 PubMed Europe PMC Scholia
4. Huang CS, Moore WR, Meister A; ''On the active site thiol of gamma-glutamylcysteine synthetase: relationships to catalysis, inhibition, and regulation.''; Proc Natl Acad Sci U S A, 1988 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	134765	view	00:35, 27 July 2024	Eweitz	Mitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
	134764	view	00:33, 27 July 2024	Eweitz	Standardize case
	102376	view	13:07, 21 December 2018	Mkutmon	Layout
	102363	view	20:58, 20 December 2018	Egonw	Fixed a data source.
	102355	view	19:20, 20 December 2018	DeSl	Ontology Term : 'glutathione metabolic pathway' added !
	102354	view	19:19, 20 December 2018	DeSl	Ontology Term : 'hepatocyte' added !
	102353	view	19:18, 20 December 2018	DeSl	Modified description
	102352	view	19:15, 20 December 2018	DeSl	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
2AB	Metabolite	Q27104317 (Wikidata)	aka 2-aminobutyrate
Cys	Metabolite	Q186474 (Wikidata)
GCS	Protein	6.3.2.2 (Enzyme Nomenclature)	aka Glutamate Cysteine Ligase (GCL) (EC 6.3.2.2), previously known as gamma-glutamylcysteine synthetase (GCS)
GS	Protein	6.3.2.3 (Enzyme Nomenclature)	aka Glutathione synthetase (GSS)
GSH	Metabolite	Q116907 (Wikidata)	aka glutathione
MRP-transporter	Protein
gamma-Glu-2AB	Metabolite	78437958 (Wikidata)	aka gamma-Glutamyl-2-aminobutyrate
gamma-Glu-Cys	Metabolite	Q288236 (Wikidata)
ophthalmate	Metabolite	Q7098084 (TTD Drug)	aka ophthalmic acid
ophthalmate	Metabolite	Q7098084 (Wikidata)	aka ophthalmic acid

Annotated Interactions

No annotated interactions