Statin pathway (Mus musculus)
From WikiPathways
Description
Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism.
Sources: PharmGKB and Wikipedia
Quality Tags
Ontology Terms
Bibliography
- Chen H, Ikeda U, Shimpo M, Shimada K; ''Direct effects of statins on cells primarily involved in atherosclerosis.''; Hypertens Res, 2000 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
Abca1 | GeneProduct | 11303 (Entrez Gene) | |
Acetyl-CoA | Metabolite | HMDB01206 (HMDB) | |
Apoa1 | GeneProduct | 11806 (Entrez Gene) | |
Apoa4 | GeneProduct | 11808 (Entrez Gene) | |
Apoc1 | GeneProduct | 11812 (Entrez Gene) | |
Apoc2 | GeneProduct | 11813 (Entrez Gene) | |
Apoc3 | GeneProduct | 11814 (Entrez Gene) | |
Apoe | GeneProduct | 11816 (Entrez Gene) | |
Cetp | GeneProduct | 1071 (Entrez Gene) | |
Cholesterol Ester | Metabolite | CHEBI:17002 (ChEBI) | |
Cholesterol | Metabolite | HMDB00067 (HMDB) | |
Cholic acid | Metabolite | HMDB00619 (HMDB) | |
Cyp7a1 | GeneProduct | 13122 (Entrez Gene) | |
Dgat1 | GeneProduct | 13350 (Entrez Gene) | |
Free FA | Metabolite | CHEBI:35366 (ChEBI) | |
Hmgcr | GeneProduct | 15357 (Entrez Gene) | |
Lcat | GeneProduct | 16816 (Entrez Gene) | |
Ldlr | GeneProduct | 16835 (Entrez Gene) | |
Lipc | GeneProduct | 15450 (Entrez Gene) | |
Lpl | GeneProduct | 16956 (Entrez Gene) | |
Lrp1 | GeneProduct | 16971 (Entrez Gene) | |
Mttp | GeneProduct | 17777 (Entrez Gene) | |
Phospholipid | Metabolite | CHEBI:16247 (ChEBI) | |
Pltp | GeneProduct | 18830 (Entrez Gene) | |
Scarb1 | GeneProduct | 20778 (Entrez Gene) | |
Soat1 | GeneProduct | 20652 (Entrez Gene) | |
Statin | Metabolite | 35664 (ChEBI) | |
Triglycerides | Metabolite | CHEBI:17855 (ChEBI) |
Annotated Interactions
No annotated interactions