LTF danger signal response pathway (Homo sapiens)

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1DNATrauma or InfectionNucleusCytosolTLR2IL1BCD14IL6TNFNFkBTRAF6IRAK4LTFIRAK1RAGEIFNBIFNATREM1IL1AMAPK1TLR4IL8MYD88


Description

Lactoferrin (LTF) activates NF-kB via danger signal receptors TLR2/4 and CD14. LTF may also activate NF-kB via addiotnal receptors RAGE and TREM1.

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Ontology Terms

 

Bibliography

  1. Kruzel ML, Zimecki M, Actor JK; ''Lactoferrin in a Context of Inflammation-Induced Pathology.''; Front Immunol, 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134979view22:04, 30 July 2024EweitzEconomize layout
134978view22:01, 30 July 2024EweitzModel stacked nodes as groups; horizontalize some nodes to economize layout
134977view21:58, 30 July 2024EweitzTailor node dimensions, economize layout
134976view21:53, 30 July 2024EweitzFlush cache
134975view21:52, 30 July 2024EweitzUpgrade adverse nodes, economize layout
134974view21:41, 30 July 2024EweitzUpgrade modeling: graphical group -> computable group
134973view21:40, 30 July 2024EweitzEconomize layout
129212view01:37, 16 March 2024EweitzModified description
129197view16:41, 15 March 2024EgonwOntology Term : 'signaling pathway' added !
121699view03:40, 26 February 2022EweitzFix gene symbol
103756view23:29, 3 April 2019KhanspersModified description
103754view23:15, 3 April 2019Khanspersfixed unconnected interactions
102252view10:39, 13 December 2018LaurentVisual aspects
102242view13:29, 12 December 2018LaurentUpdated visual aspects
102241view13:22, 12 December 2018LaurentChanged visual aspects
102237view12:31, 12 December 2018LaurentModified description
102232view09:44, 12 December 2018LaurentName NFkB fixed
102231view09:43, 12 December 2018Laurenttypo in entrezgene ID NFkB fixed
102230view09:13, 12 December 2018LaurentModified title
102229view09:08, 12 December 2018LaurentNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CD14GeneProduct929 (Entrez Gene)
IFNAGeneProduct3439 (Entrez Gene)
IFNBGeneProduct3456 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL8GeneProduct3576 (Entrez Gene)
IRAK1GeneProduct3654 (Entrez Gene)
IRAK4GeneProduct51135 (Entrez Gene)
LTFGeneProduct4057 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MYD88GeneProduct4615 (Entrez Gene)
NFkBGeneProduct4790 (Entrez Gene)
RAGEGeneProduct177 (Entrez Gene)
TLR2GeneProduct7097 (Entrez Gene)
TLR4GeneProduct7099 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TRAF6GeneProduct7189 (Entrez Gene)
TREM1GeneProduct54210 (Entrez Gene)

Annotated Interactions

No annotated interactions

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