Major receptors targeted by epinephrine and norepinephrine (Homo sapiens)

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1Vasoconstrictionα2 receptorRelease from brainA proteinα1 receptors:PLCLiver or muscle cellProtein phosphorylationβ2 receptorReleases calcium into cytoplasmβ1 receptorNorepinephrineNeurotransmitterscalciumATPEpinephrineα1A receptorDAGSerineADCY1Glycolysisα2A receptorPKAPIP3Glycogen synthesisProtein kinase cACProtein phosphorylationα1B receptorα1D receptorα2B receptorα2C receptorIP3ACpyro-phosphatecAMPACADCY2ADCY3ADCY4ADCY5ADCY6ADCY7ADCY8ADCY9ADCY10A proteinThreonineA proteinSerinePA proteinThreoninePLiver cellsLiver cellsGlycogen breakdown


Description

The physiologic actions of adrenergic receptors when stimulated by epinephrine/norepinephrine

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Quality Tags

Ontology Terms

 

Bibliography

  1. Glen D. Lawrence; ''The Fats of Life: Essential Fatty Acids in Health and Disease''; Rutgers University Press; ISBN 978-0-8135-4677-3, 2010

History

View all...
CompareRevisionActionTimeUserComment
134727view21:50, 26 July 2024EweitzRefine label
134726view21:49, 26 July 2024EweitzMitigate striking graphical discrepancy between PathVisio and Kaavio / Pvjs
134725view21:47, 26 July 2024EweitzRegularize angles
134724view21:46, 26 July 2024EweitzReduce entangling among interaction
134723view21:42, 26 July 2024EweitzFix occluded elements
134722view21:40, 26 July 2024EweitzSimplify group, obsoleting bespoke interaction type
134721view21:35, 26 July 2024EweitzRefine legend
134718view12:33, 26 July 2024EweitzModified description
134717view12:33, 26 July 2024EweitzOntology Term : 'cardiac muscle cell' added !
134716view12:32, 26 July 2024EweitzOntology Term : 'cell of skeletal muscle' added !
134715view12:32, 26 July 2024EweitzOntology Term : 'hepatocyte' added !
127758view09:23, 3 December 2023EgonwChEBI id for Ca2+ instead of the "Ca" atom
123422view06:17, 26 July 2022EgonwMade more pathways clickable
119266view07:54, 23 June 2021FinterlyAdded ISBN for book citation
105272view21:21, 25 July 2019Khanspersconverted interactions in legend to graphical lines
105097view19:09, 5 July 2019AlexanderPicoModified description
105096view19:06, 5 July 2019AlexanderPicoModified title
104814view11:57, 19 June 2019ChrisAdded a legend
104630view05:48, 7 June 2019EgonwRemoved the RHEA: prefix from the identifier.
104482view19:18, 28 May 2019DeSlLayout changes
104481view19:18, 28 May 2019DeSlConnected PKC part (left hand side) again properly.
104480view19:05, 28 May 2019DeSlAdded PW links
104479view18:56, 28 May 2019DeSlAdded phosphorylation reaction conversion by PKA and regulation by cAMP.
104477view18:41, 28 May 2019DeSlAdded reactions for AC catalysing cAMP production
104473view14:52, 28 May 2019DeSlStarted updating pw with more biological content.
104454view15:38, 27 May 2019DeSlAdded IDs to adrenergic receptors.
104453view15:31, 27 May 2019DeSlAdded cellular compartment
104452view15:30, 27 May 2019DeSlAdded lit. ref for whole PW.
104451view15:29, 27 May 2019DeSlAdding special characters again, with UTF-8 encoding...
104450view15:23, 27 May 2019DeSlFixing special characters (again)
104449view15:17, 27 May 2019DeSlAdded neurotransmitter PW node, changed labels into Protein nodes (updated special characters) and connected with MIM-binding.
104445view11:49, 27 May 2019Chrischecking for special characters
104428view06:20, 25 May 2019EgonwRemoved broken identifier
104427view06:15, 25 May 2019EgonwModified title
104333view13:57, 17 May 2019FehrhartOntology Term : 'norepinephrine signaling pathway' added !
104332view13:56, 17 May 2019FehrhartOntology Term : 'epinephrine signaling pathway' added !
104178view05:37, 9 May 2019EgonwFixed the type of an metabolite; updated the sec cAMP identifiers to primary ChEBI identifiers.
104133view13:00, 6 May 2019ChrisModified title
104132view12:59, 6 May 2019ChrisOntology Term : 'classic metabolic pathway' added !
104131view12:55, 6 May 2019ChrisNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACProtein4.6.1.1 (Enzyme Nomenclature) "There are ten known isoforms of adenylyl cyclases in mammals" [https://en.wikipedia.org/wiki/Adenylyl_cyclase]
ADCY10ProteinQ96PN6 (Uniprot-TrEMBL)
ADCY1ProteinQ08828 (Uniprot-TrEMBL)
ADCY2ProteinQ08462 (Uniprot-TrEMBL)
ADCY3ProteinO60266 (Uniprot-TrEMBL)
ADCY4ProteinQ8NFM4 (Uniprot-TrEMBL)
ADCY5ProteinO95622 (Uniprot-TrEMBL)
ADCY6ProteinO43306 (Uniprot-TrEMBL)
ADCY7ProteinP51828 (Uniprot-TrEMBL)
ADCY8ProteinP40145 (Uniprot-TrEMBL)
ADCY9ProteinO60503 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:30616 (ChEBI)
DAGMetaboliteQ161466 (Wikidata) diacylglycerol
EpinephrineMetaboliteQ132621 (Wikidata) AKA adrenaline
Glycogen breakdownPathwayWP500 (WikiPathways)
Glycogen synthesisPathwayWP500 (WikiPathways)
GlycolysisPathwayWP534 (WikiPathways)
IP3Metaboliteinositol triphosphate
NeurotransmittersPathwayWP4220 (WikiPathways)
NorepinephrineMetabolite
PIP3Metaboliteinositol 4,5-biphosphate
PKAProtein2.7.11.11 (Enzyme Nomenclature) Protein Kinase A
Protein kinase cMetaboliteQ420877 (Wikidata)
SerineMetaboliteCHEBI:17115 (ChEBI)
ThreonineMetaboliteCHEBI:57926 (ChEBI)
cAMPMetaboliteCHEBI:58165 (ChEBI)
calciumMetaboliteCHEBI:22984 (ChEBI)
pyro- phosphateMetaboliteCHEBI:33019 (ChEBI)
α1A receptorProteinP3548 (Uniprot-TrEMBL)
α1B receptorProteinP3568 (Uniprot-TrEMBL)
α1D receptorProteinP25100 (Uniprot-TrEMBL)
α2A receptorProteinP08913 (Uniprot-TrEMBL)
α2B receptorProteinP18089 (Uniprot-TrEMBL)
α2C receptorProteinP18825 (Uniprot-TrEMBL)
β1 receptor ProteinP08588 (Uniprot-TrEMBL) G protein–coupled receptor (GPCR)
β2 receptor ProteinP07550 (Uniprot-TrEMBL) G protein–coupled receptor (GPCR)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
ATPcAMPmim-conversionRHEA:15390 (Rhea)
pyro- phosphatemim-conversionRHEA:15390 (Rhea)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4589"
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